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美国25~64岁成年人的心血管疾病住院率及死亡率

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中华高血压杂志 2024年第1期32卷 96-96页

作者： Henry cm Oseran AS Zheng Z Dong H Wadhera RK 袁源(译) 郑武洪(审校) 不详

自2011年以来,美国心血管死亡率并未减少。人们越来越担心这样的形势反映了年轻人心血管健康的恶化。然而,该人群中急性心血管疾病住院率及死亡率负担的变化尚不明确。本研究从总体及不同社区收入水平,评估了25~64岁成年人心血管住院率... 详细信息

自2011年以来,美国心血管死亡率并未减少。人们越来越担心这样的形势反映了年轻人心血管健康的恶化。然而,该人群中急性心血管疾病住院率及死亡率负担的变化尚不明确。本研究从总体及不同社区收入水平,评估了25~64岁成年人心血管住院率及死亡率变化。方法:采用国家住院样本,在25~64岁成年人中,评估急性心肌缺血(acute myocardial infarction,AMI)、心力衰竭和缺血性脑卒中的年龄标准化年住院率及住院死亡率。

关键词：住院率心血管健康住院死亡率急性心血管疾病急性心肌缺血缺血性脑卒中心力衰竭收入水平

MONOTONE PIECEWISE CURVE FITTING ALGORITHMS

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Journal of Computational Mathematics 1994年第2期12卷 163-172页

作者： ZHANG, ZJ YANG, ZQ ZHANG, cm CHINESE ACAD SCI CTR COMPBEIJINGPEOPLES R CHINA

A piecewise cubic curve fitting algorithm preserving monotonicity of the data without modification of the assigned slopes is proposed. The algorithm has the same order of convergence as Yan's algorithm[8] and Gasparo-Morandi's algorithm[5] for accurate or 0(h(q)) accUrate given data, but it has a more visually pleasing curve than those two algorithms. We also discuss the convergence order of cubic rational interpolation for 0(h(q)) accurate data.

关键词： interpolation piecewise cubic preserving monotone proof explicit rational fitting partition

STM Study on the Surface Relief and Mechanism of Bainite Transformation

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Journal of Materials Science & Technology 1996年第4期12卷 249-254页

作者： Yang, ZG Fang, HS Wang, JJ Zheng, YK Li, cm Dept. of Materials Science and Engineering Tsinghua University Beijing 100084 China

Scanning tunneling microscopy (STM) has been first employed to study the surface relief accompanying bainite transformation in a Fe-2.17C-12.18Cr-0.31Si-0.26Mn (wt pct) steel. With the exclusive vertical resolution of STM, we observed that the surface relief associated with bainite is a group of surface reliefs related to subplates, subunits and sub-subunits. As a whole, the relief group is in a tent shape, not of invariant plane strain (IPS) type, which is obviously different from that of martensite, and implying that bainite is not formed by shear mechanism. The fine structure of bainite in Fe-1.0C-4Cr-2.0Si (wt pct) alloy has also been studied with STM and TEM. It is found that the bainite plate is composed of subplates, subunits and sub-subunits. On the basis of the fine structure inside a bainitic ferrite plate observed under STM, a sympathetic-ledgewise mechanism of bainite formation is proposed.

关键词： Steel

A　NEW　DITERPENOID　FROM　COLEUS　SCUTELLARIOIDES

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Chinese Chemical Letters 1996年第5期7卷 441-442页

作者： Mu, Q Zhang, HJ Li, cm Sun, HD ACAD SINICA KUNMING INST BOTLAB PHYTOCHEMKUNMING 650204PEOPLES R CHINA

Abstract: From the herbs of Coleus sculellarioides, a new diterpenoid was isolated and identified as 2-(2'ξ-methoxypropy)-3-hydroxy-5,7,8-trimethylphenanthrene-1,4--dione,named as scutequinone(1).

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INFRARED STUDIES OF LITHIUM OXYSULFIDE GLASSES

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Chinese Chemical Letters 1996年第3期7卷 271-272页

作者： Gao, HC Sun, cm Huo, Y Jin, SZ ACAD SINICA QINGHAI INST SALT LAKESXINING 810008PEOPLES R CHINA ACAD SINICA INST CHEMBEIJING 100080PEOPLES R CHINA

The FTIR spectra of the ternary Li2S-B2O3-LiBr oxysulfide glasses have been recorded. Assignment of main bands obtained in the spectra indicates the formation of so-called semi-thio-tetraborate groups and transformati...

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Cancer gene therapy targeting angiogenesis:An updated review

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World Journal of Gastroenterology 2006年第43期12卷 6941-6948页

作者： Ching-Chiu Liu Zan Shen Hsiang-Fu Kung Marie cm Lin Institute of MolecularTechnology for Drug Discovery and Synthesis Department ofChemistry The University of Hong Kong Pokfulam Hong KongChina Centre for Emerging Infectious Diseases TheChinese University of Hong Kong Shatin Hong Kong China

Since the relationship between angiogenesis and tumor growth was established by Folkman in 1971, scientists have made efforts exploring the possibilities in treating cancer by targeting angiogenesis. Inhibition of angiogenesis growth factors and administration of angiogenesis inhibitors are the basics of anti- angiogenesis therapy. Transfer of anti-angiogenesis genes has received attention recently not only because of the advancement of recombinant vectors, but also because of the localized and sustained expression of therapeutic gene product inside the tumor after gene transfer. This review provides the up-to-date information about the strategies and the vectors studied in the field of anti-angiogenesis cancer gene therapy.

关键词： Anti-angiogenesis Tumor growth Cancergene therapy

In-situ Observation of Initiation and Propagation of Cleavage Microcrack in TiAl

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Journal of Materials Science & Technology 1995年第1期11卷 11-14页

作者： GAO, KW CHEN, QH CHU, WY HSIAO, cm

Nucleating and propagating of nanocrack formed in dislocation free zone (DFZ) for the brittle TiAl alloy has been studied through in-situ tensile test in TEM and analyzed using microfracture mechanics. The results show that a lot of dislocations can be emitted from a crack tip when the applied stress intensity K-la is larger than the stress intensity for dislocation emission K-le = 1.4 MPa . m(1/2) and a dislocation free zone, which sometimes is a close zone, can form after reaching equilibrium. The DFZ is a elastic zone with large strain and then the stress in the DFZ might equal to the cohesive strength sigma(th) because the crack tip is still sharp. When K-la is larger than the stress intensity for nanocrack nucleation K-li = 2.4 MPa . m(1/2), the stress within a certain range in the DFZ would equal to sigma(th) and then a nanocrack initiates in the DFZ or sometimes at the notch tip. The nanocrack formed in the DFZ is stable and can propagate a small distance in cleavage mode through multiplication and movement of dislocation in the plastic zone, during keeping constant displacement. Increasing K-la, can make the crack stably propagate continuously or discontinuously and it means that the stress intensify for crack propagation, K-lp, is larger than K-li. Therefore, K-le [K-li [K-lp [K-lC.

关键词： BRITTLE DUCTILE

Islet separation and islet cell culture in vitro from human embryo-pancreas

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World Journal of Gastroenterology 1999年第5期5卷 458-460页

作者： Yuan Z Wu GY He YS Shao cm Zhan Y Kunming Med Coll Dept Histol & Embryol Kunming 650031 Yunnan Province Peoples R China First Affiliated Hosp Kunming Med Coll Dept Nucl Med Kunming 650032 Yunnan Province Peoples R China Kunming Med Coll Dept Biol Kunming 650031 Yunnan Province Peoples R China

INTRODUCTIONDiabetes mellitus is the most common disease and its death rate ranks the 8th in the world. Up to now, its incidence has a tendency to increase[1]. Since disorder of sugar metabolism might result in microvascular degeneration and injury of important human organs, it will endanger human health seriously. In 1969, Younszai first reported the method that could decrease diabetes symptoms by islet tissue transplantation. In 1981, our country began to treat diabetes type Ⅰ by transplanting cultured islet tissues. In our study, we digested the pieces of pancreas with collagenase and made morphological observation on islet cells cultured for 3d, 5d, 7d, 9d and 13d respectively, and the contents of insulin and C-peptide in the supernatant were detected by radioimmunoassay. The experimental model of rabbit diabetes was established, and certain curative effect was achieved in the treatment of experimental diabetes in rats.

关键词： cell culture islet cell islets of langerhans transplantetion pancreas/ embryology

Diet and microbiota in inflammatory bowel disease: The gut in disharmony

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World Journal of Gastroenterology 2017年第12期23卷 2124-2140页

作者： Davy cm Rapozo Claudio Bernardazzi Heitor Siffert Pereira de Souza Coordenacao de Pesquisa Instituto Nacional de Cancer Servico de Gastroenterologia e Laboratório Multidisciplinar de Pesquisa Departamento de Clínica MédicaHospital Universitário Clementino Fraga FilhoUniversidade Federal do Rio de Janeiro D’Or Institute for Research and Education Rua Diniz Cordeiro 30BotafogoRio de JaneiroRJ 22281-100Brazil

Bacterial colonization of the gut shapes both the local and the systemic immune response and is implicated in the modulation of immunity in both healthy and disease states. Recently, quantitative and qualitative changes in the composition of the gut microbiota have been detected in Crohn's disease and ulcerative colitis, reinforcing the hypothesis of dysbiosis as a relevant mechanism underlying inflammatory bowel disease(IBD) pathogenesis. Humans and microbes have coexisted and co-evolved for a long time in a mutually beneficial symbiotic association essential for maintaining homeostasis. However, the microbiome is dynamic, changing with age and in response to environmental modifications. Among such environmental factors, food and alimentary habits, progressively altered in modern societies, appear to be critical modulators of the microbiota, contributing to or co-participating in dysbiosis. In addition, food constituents such as micronutrients are important regulators of mucosal immunity, with direct or indirect effects on the gut microbiota. Moreover, food constituents have recently been shown to modulate epigenetic mechanisms, which can result in increased risk for the development and progression of IBD. Therefore, it is likely that a better understanding of the role of different food components in intestinal homeostasis and the resident microbiota will be essential for unravelling the complex molecular basis of the epigenetic, genetic and environment interactions underlying IBD pathogenesis as well as for offering dietary interventions with minimal side effects.

关键词： Diet Microbiota Epigenetics Crohn’s disease Ulcerative colitis