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CAD/CAM for scalable nanomanufacturing:A network-based system for hybrid 3D printing

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Microsystems & Nanoengineering 2017年第1期3卷 135-145页

作者： Hae-Sung Yoon Hyun-Taek Lee Ki-Hwan Jang Chung-Soo kim Hyunseo Park dae-wook kim Kunwoo Lee Sangkee Min Sung-Hoon Ahn BK21 Plus Transformative Training Program for Creative Mechanical and Aerospace Engineers Seoul National UniversitySeoul 08826Republic of Korea Department of Mechanical and Aerospace Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Mechanical Engineering University of Wisconsin-MadisonMadisonWI 53706USA Institute of Advanced Machines and Design Seoul National UniversitySeoul 08826Republic of Korea

Micro-and nano-structuring have been highlighted over several decades in both science and engineering *** addition to continuous efforts in fabrication techniques,investigations in scalable nanomanufacturing have been pursued to achieve reduced feature size,fewer constraints in terms of materials and dimensional complexity,as well as improved process *** this study,based on recent micro-/nanoscale fabrication processes,characteristics and key requirements for computer-aided design and manufacturing(CAD/CAM)systems for scalable nanomanufacturing were *** include a process knowledge database,standardized processing,active communication,adaptive interpolation,a consistent coordinate system,and management of peripheral *** scalable nanomanufacturing,it is important to consider the flexibility and expandability of each process,because hybrid and bridging processes represent effective ways to expand process *** an example,we describe a novel CAD/CAM system for hybrid three-dimensional(3D)printing at the *** novel hybrid process was developed by bridging aerodynamically focused nanoparticle printing,focused ion beam milling,micromachining,and spincoating *** system developed can print a full 3D structure using various inorganic materials,with a minimum process scale of 50 *** most obvious difference versus CAD/CAM at‘conventional’scales is that our system was developed based on a network to promote communication between users and process *** the network-based system,it is also possible to narrow the gap among different processes/*** anticipate that this approach can contribute to the development of CAD/CAM for scalable nanomanufacturing and a wide range of hybrid processes.

关键词： Computer-aided design and manufacturing(CAD/CAM) nanomanufacturing network-based 3D printing

Suppression of pheromone biosynthesis and mating behavior by RNA interference of pheromone gland-specific fatty acyl reductase in Maruca vitrata

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Insect Science 2022年第4期29卷 1135-1144页

作者： wook Hyun Cha dae-Weon Lee Department of Biosafety Kyungsung UniversityBusanRepublic of Korea Metabolomics Research Center for Functional Materials Kyungsung UniversityBusanRepublic of Korea

In moths,various enzymes,such as fatty acid synthases,fatty acyl desaturases,and fatty acyl reductases(FARs),are involved in pheromone *** particular,pheromone gland-specific FAR(pgFAR)plays an important role in converting the functional group from carboxylic to alcohol during pheromone biosynthesis.A novel pgFAR of Maruca vitrata,Mvi-pgFAR,was identified through transcriptome sequencing of its pheromone *** investigate the involvement of Mvi-pgFAR in pheromone biosynthesis,Mvi-pgFAR was cloned from the pheromone gland and suppressed by RNA interference(RNAi).Mvi-pgFAR harbored several conserved motifs related to NAD(P)H-binding,N-glycosylation,and adenosine/guanosine triphosphate *** analysis revealed that Mvi-pgFAR with other lepidopteran pgFARs formed an independent ***-pgFAR was specifically expressed only in the pheromone *** real-time polymerase chain reaction showed that the diurnal expression levels of Mvi-pgFAR in the pheromone gland were the highest at 2 h before the *** primarily confirming Mvi-pgFAR suppression by RNAi,(E,E)-10,12-hexadecadienal(E10E12-16:Ald),a major sex pheromone component,was quantified by gas *** Mvi-pgFAR was successfully suppressed,E10E12-16:Ald production was reduced by up to half of that of the control,and the mating rate was subsequently *** results demonstrate that Mvi-pgFAR downregulation can suppress mating behavior by changing the relative sex pheromone component ratio,suggesting that Mvi-pgFAR can be used as a novel control target.

关键词： (EE)-10,12-hexadecadienal gas chromatography Maruca viruta pgFAR RNAi sex pheromone

Citron kinase interacts with LATS2 and inhibits its activity by occluding its hydrophobic phosphorylation motif

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Journal of Molecular Cell Biology 2019年第11期11卷 1006-1017页

作者： Thi Hai Yen Tran dae-wook Yang Minchul kim Da-Hye Lee Marta Gai Ferdinando Di Cunto Kwang-wook Choi dae-Sik Lim Department of Biological Sciences KAIST 291 Daehak-roYuseong-guDaejeon 34141Republic of Korea Department of Molecular Biotechnology and Health Sciences University of Turin10126 TurinItaly

The inhibitory effect of large tumor suppressor kinase(LATS1/2)on the activity of the oncoprotein yes-associated protein(YAP)is crucial to maintain tissue *** studies have identified several new regulators of this ***,citron kinase(CIT)was listed as a potential binding candidate of Hippo-related components,suggesting a new connection between CIT and the Hippo *** from CITs role in cytokinesis,the molecular crosstalk between CIT and the Hippo pathway is largely ***,we demonstrate a role for CIT as a scaffold protein Unking LATS2 and *** importantly,CIT interacts with LATS2 to directly suppress LATS2 phosphorylation at the hydrophobic motif—targeted by MST1,leading to LATS2 inactivation and YAP *** studying their genetic interactions,we found that Sticky,the CIT homolog in Drosophila melanogaster,functions with Warts to control Drosophila eye ***,our study confirms citron kinase as a novel regulator of the Hippo pathway.

关键词： citron kinase LATS2-YAP interaction LATS2 inhibition sticky-warts Hippo pathway

Microstructures and Mechanical Properties of Rapidly Solidified Mg-Al-Zn-MM Alloys

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Journal of Materials Science & Technology 2008年第1期24卷 89-92页

作者： Yeon-wook kim Department of Advanced Materials Engineering Keimyung University Daegu 704-701Korea

Mg-Al-Zn-M M （misch metal） alloy powders were manufactured by inert gas atomization and the characteristics of alloy powders were *** spite of the low fluidity and easy oxidation of the magnesium melt,the spherical powder was made successfully with the improved three piece nozzle systems of gas atomization unit. It was found that most of the solidified powders with particles size of less than 50μm in diameter were single crystal and the solidification structure of rapidly solidified powders showed a typical dendritic morphology because of supercooling prior to *** spacing of secondary denrite arms was deceasing as the size of powders was *** rapidly solidified powders were consolidated by vacuum hot extrusion and the effects of misch metal addition to AZ91 on mechanical properties of extruded bars were also *** extrusion of the rapidly solidified powders,their dendritic structure was broken into fragments and remained as grains of about 3μm in *** Mg-Al-Ce intermetallic compounds formed in the interdendritic regions of powders were finely broken,*** tensile strength and ductility obtained in as-extruded Mg-9 wt pct Al-1 wt pct Zn-3 wt pct MM alloy wereσ-（T.S.） =383 MPa andε=10.6%,*** of these improvements on mechanical properties were resulted from the refined microstructure and second-phase dispersions.

关键词： Mg alloy Gas atomization Misch metal Hot extrusion

Understanding of the Relationship between the Properties of Cu(In,Ga)Se_(2) Solar Cells and the Structure of Ag Network Electrodes

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Energy & Environmental Materials 2024年第6期7卷 246-253页

作者： Hyesun Yoo Hoang Van Quy Inpyo Lee Seung Taek Jo Tae Ei Hong JunHo kim dae-Hwang Yoo Jinwook Shin Walter Commerell dae-Hwan kim Jong wook Roh Regional Leading Research Center(RLRC)of Smart Energy System Kyungpook National UniversityGyeongsangbuk-do 37224Korea Division of Energy Technology DaeguGyeongbuk Institute of Science and Technology(DGIST)Daegu 42988Korea Department of Hydrogen and Renewable Energy Kyungpook National UniversityDaegu 47922Korea Nano Photoelectronic Device Lab Department of PhysicsIncheon National UniversityIncheon 22012Korea Institute for Energy and Drive Technology Technische Hochschule Ulm(THU)Ulm 89081Germany Department of Nano&Advanced Materials Science and Engineering Kyungpook National UniversityGyeongsangbuk-do 37224Korea

The relation between the structure of the silver network electrodes and the properties of Cu(In,Ga)Se_(2)(CIGS)solar cells is systemically *** Ag network electrode is deposited onto an Al:ZnO(AZO)thin film,employing a self-forming cracked *** control over the cracked template's structure is achieved through careful adjustment of temperature and *** Ag network electrodes with different coverage areas and network densities are systemically applied to the CIGS solar *** is revealed that predominant fill factor(FF)is influenced by the figure of merit of transparent conducting electrodes,rather than sheet resistance,particularly when the coverage area falls within the range of 1.3–5%.Furthermore,a higher network density corresponds to an enhanced FF when the coverage areas of the Ag networks are *** utilizing a thinner AZO film,CIGS solar cells with a surface area of 1.0609 cm^(2)exhibit a notable performance improvement,with efficiency increasing from 10.48%to 11.63%.This enhancement is primarily attributed to the increase in FF from 45%to 65%.These findings underscore the considerable potential for reducing the thickness of the transparent conductive oxide(TCO)in CIGS modules with implications for practical applications in photovoltaic technology.

关键词： CIGS large-area solar cell metal mesh metallic network transparent electrode

Assessment of disease activity by fecal immunochemical test in ulcerative colitis

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World Journal of Gastroenterology 2016年第48期22卷 10617-10624页

作者： dae Gon Ryu Hyung wook kim Su Bum Park dae Hwan Kang Cheol Woong Choi Su Jin kim Hyeong Seok Nam Department of Internal Medicine Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital

AIM To evaluate the efficacy of quantitative fecal immunochemical test(FIT) as biomarker of disease activity in ulcerative colitis(UC).METHODS Between February 2013 and November 2014, a total of 82 FIT results, obtained in conjunction with colonoscopies, were retrospectivelyevaluated for 63 patients with UC. The efficacy of FIT for evaluation of disease activity was compared to colonoscopic findings. Quantitative fecal blood with automated equipment examined from collected feces. Endoscopic disease severity were assessed using the Mayo endoscopic subscore(MES) classification. The extent of disease were classified by proctitis(E1), left sided colitis(E2), and extensive colitis(E3). Clinical activity were subgrouped by remission or *** All of 21 patients with MES 0 had negative FIT( 134.89 ng/m L. The sensitivity, specificity, positive predictive value(PPV), negative predictive value(NPV) and accuracy of negative FIT about mucosal healing were 73.33%, 81.82%, 91.49%, 51.43% and 73.17%, respectively. The sensitivity, specificity, PPV, NPV and accuracy of predictive value of positive FIT(cutoff value > 100 ng/mL) about active disease status were 45.45%, 93.33%, 71.43%, 82.35%and 26.83%, respectively. Among patients with clinical remission, FIT was negative in 31(81.6%) of 38 cases, with a mean fecal hemoglobin concentration of 6.12 ng/mL(range, negative to 80.9 ng/mL) for this group of patients. Among patients with clinical active disease, FIT was negative in 16(36.4%) out of 44 cases, with a mean fecal hemoglobin concentration > 167.4 ng/mL for this group of patients. FIT was positively correlated with endoscopic activity(r = 0.626, P < 0.01) and clinical activity(r = 0.496, P < 0.01). But, FIT did not correlate with the extent of disease(r =-0.047, P = 0.676)CONCLUSION Quantitative FIT can be a non-invasive and effective biomarker for evaluation of clinical and endoscopic activity in UC, but not

关键词： Ulcerative colitis Fecal immunochemical test Mayo endoscopic subscore Biomarker Disease activity

Efficacy and safety of limited endoscopic sphincterotomy before self-expandable metal stent insertion for malignant biliary obstruction

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World Journal of Gastroenterology 2017年第9期23卷 1627-1636页

作者： Hyeong Seok Nam dae Hwan Kang Hyung wook kim Cheol Woong Choi Su Bum Park Su Jin kim dae Gon Ryu Department of Internal Medicine Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and TechnologyPusan National University Yangsan HospitalYangsan-siGyeongsangnam-do 50612South Korea

To evaluate the safety and efficacy of limited endoscopic sphincterotomy (ES) before placement of self-expandable metal stent (SEMS).METHODSThis was a retrospective analysis of 244 consecutive patients with unresectable malignant biliary obstruction, who underwent placement of SEMSs following limited ES from December 2008 to February 2015. The diagnosis of malignant biliary obstruction and assessment of patient eligibility for the study was established by a combination of clinical findings, laboratory investigations, imaging and pathological results. All patients were monitored in the hospital for at least 24 h following endoscopic retrograde cholangio pancreatography (ERCP). The incidence of immediate or early post-ERCP complications such as post-ERCP pancreatitis (PEP) and bleeding related to limited ES were considered as primary outcomes. Also, characteristics and complications according to the cancer type were *** the 244 patients included, the underlying diagnosis was cholangiocarcinoma in 118 patients, pancreatic cancer in 79, and non-pancreatic or non-biliary malignancies in the remaining 47 patients. Early post-ERCP complications occurred in 9 patients (3.7%), with PEP in 7 patients (2.9%; mild, 6; moderate, 1) and mild bleeding in 2 patients (0.8%). There was no significant association between the incidence of post-ERCP complications and the type of malignancy (cholangiocarcinoma vs pancreatic cancer vs others, P = 0.696) or the type of SEMS used (uncovered vs covered, P = 1.000). Patients who had more than one SEMS placed at the first instance were at a significantly higher risk of post-ERCP complications (one SEMS vs two SEMS, P = 0.031). No other factors were predictive of post-ERCP *** ES is feasible and safe, and effectively facilitates the placement of SEMS, without any significant risk of PEP or severe bleeding.

关键词： Endoscopic sphincterotomy Endoscopic retrograde cholangio pancreatography Complications Pancreatitis Bleeding Cholestasis Self-expandable metal stent

Network-Aided Intelligent Traffic Steering in 5G Mobile Networks

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Computers, Materials & Continua 2020年第10期65卷 243-261页

作者： dae-Young kim Seokhoon kim School of Computer Software Daegu Catholic UniversityGeyongsan38430Korea Department of Computer Software Engineering Soonchunhyang UniversityAsan31538Korea

Recently,the fifth generation(5G)of mobile networks has been deployed and various ranges of mobile services have been *** 5G mobile network supports improved mobile broadband,ultra-low latency and densely deployed massive *** allows multiple radio access technologies and interworks them for services.5G mobile systems employ traffic steering techniques to efficiently use multiple radio access ***,conventional traffic steering techniques do not consider dynamic network conditions *** this paper,we propose a network aided traffic steering technique in 5G mobile network architecture.5G mobile systems monitor network conditions and learn with network *** a machine learning algorithm such as a feed-forward neural network,it recognizes dynamic network conditions and then performs traffic *** proposed scheme controls traffic for multiple radio access according to the ratio of measured ***,it can be expected to improve traffic steering *** performance of the proposed traffic steering scheme is evaluated using extensive computer simulations.

关键词： Mobile network 5G traffic steering machine learning MEC

Adaptive Data Transmission Method According to Wireless State in Long Range Wide Area Networks

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Computers, Materials & Continua 2020年第7期64卷 1-15页

作者： Seokhoon kim dae-Young kim Department of Computer Software Engineering Soonchunhyang UniversityAsan-si31538Korea School of Computer Software Daegu Catholic UniversityGyeongsan-si38430Korea

The Internet of Things(IoT)has enabled various intelligent services,and IoT service range has been steadily extended through long range wide area communication technologies,which enable very long distance wireless data ***-nodes are connected to a gateway with a single *** consume very low-power,using very low data rate to deliver *** long transmission time is consequently needed for each data packet transmission in long range wide area networks,data transmission should be efficiently ***,this paper proposes a multicast uplink data transmission mechanism particularly for bad network *** delay will be increased if only retransmissions are used under bad network ***,employing multicast techniques in bad network conditions can significantly increase packet delivery ***,retransmission can be reduced and hence transmission efficiency ***,the proposed method adopts multicast uplink after network condition *** predict network conditions,the proposed method uses a deep neural network *** proposed method performance was verified by comparison with uplink unicast transmission only,confirming significantly improved performance.

关键词： IoT wide area communication machine learning uplink transmission.