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Artificial Nanoscale Erythrocytes from Clinically Relevant Compounds for Enhancing Cancer Immunotherapy

Nano-Micro Letters 2020年第7期12卷 156-174页

作者： Wenquan Ou Kang Sik Nam dae hoon park Jungho Hwang Sae Kwang Ku Chul Soon Yong Jong Oh Kim Jeong hoon Byeon College of Pharmacy Yeungnam UniversityGyeongsan 38541Republic of Korea School of Mechanical Engineering Yonsei UniversitySeoul 03722Republic of Korea College of Korean Medicine Daegu Haany UniversityGyeongsan 38610Republic of Korea School of Mechanical Engineering Yeungnam UniversityGyeongsan 38541Republic of Korea

Because of enhanced e cacy and lower side e ects,cancer immunotherapies have recently been extensively investigated in clinical trials to overcome the limitations of conventional cancer *** engineering attempts have been made to build nanosystems even including stimulus nanomaterials for the e cient delivery of antigens,adjuvants,or anticancer drugs to improve immunogenic cancer cell death,this requires huge R&D e orts and investment for clinically relevant findings to be approved for translation of the *** this end,in this study,an air–liquid two-phase electrospray was developed for stable bubble pressing under a balance between mechanical and electrical parameters of the spray to continuously produce biomimetic nanosystems consisting of only clinically relevant compounds[paclitaxel-loaded fake blood cell Eudragit particle(Eu-FBCP/PTX)]to provide a conceptual leap for the timely development of translatable chemo-immunotherapeutic *** was pursued as the e cacy of systems for delivering anticancer agents that has been mainly influenced by nanosystem shape because of its relevance to transporting behavior to organs,blood circulation,and cell–membrane *** resulting Eu-FBCP/PTX nanosystems exhibiting phagocytic and micropinocytic uptake behaviors can confer better e cacy in chemo-immunotherapeutics in the absence and presence of anti-PD-L1 antibodies than similar sized PTX-loaded spherical Eu particles(Eu-s/PTX).

关键词： Cancer immunotherapies Air–liquid two-phase electrospray Paclitaxel-loaded fake blood cell Eudragit particle Translatable chemo-immunotherapeutic nanosystems Anti-PD-L1 antibodies

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Nasal cavity fungus ball discovered accidentally:A case report

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World Journal of Clinical Cases 2025年第5期13卷 44-48页

作者： dae-Neung Lee Dong hoon Lee Sang Chul Lim Department of Otolaryngology-Head and Neck Surgery Chonnam National University Medical SchoolChonnam National University Hwasun HospitalHwasun 58128South Korea Department of Otolaryngology-Head and Neck Surgery Chonnam National University Medical SchoolHwasun HospitalChonnam National University Hwasun HospitalHwasun 58128South Korea Department of Otolaryngology-Head and Neck Surgery Chonnam National University Medical SchoolKwangju 501190South Korea

BACKGROUND Fungal balls within the nasal cavity are an exceedingly rare clinical entity,typically presenting with nonspecific symptoms or being identified *** SUMMARY This report presents an incidental discovery of a fungal ball in the nasal cavity during routine imaging,with no associated clinical *** This case underscores the importance of considering the possibility of asympto-matic presentations of nasal fungal balls,which may be detected incidentally during imaging evaluations.

关键词： Fungi Mycoses Fungus ball Nasal cavity Nasal surgical procedures Case report

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Exploration of cobalt selenite-carbon composite porous nanofibers as anode for sodium-ion batteries and unveiling their conversion reaction mechanism

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Journal of Materials Science & Technology 2021年第30期89卷 24-35页

作者： Jin-Sung park Gi dae park Yun Chan Kang Department of Materials Science and Engineering Korea UniversityAnam-DongSeongbuk-GuSeoul136-713Republic of Korea

Efforts have been made to develop a promising anode material with a novel composition for sodiumion batteries(SIBs).In this study,the sodium-ion storage mechanism of transition metal selenite that comprises transition metal cation coupled with two anions is *** cobalt selenite(CoSeO_(3))-carbon composite nanofibers containing numerous pores are synthesized via electrospinning *** heat treatment of the electrospun nanofibers containing selenium,CoSe_(2)nanoclusters are *** the subsequent oxidation,CoSe_(2)transformed into amorphous CoSeO_(3)and some part of carbon was oxidized into CO_(2),leaving the pores inside the *** unveil the electrochemical reaction mechanism,analytical methods including cyclic voltammetry,ex-situ X-ray photoelectron spectroscopy,ex-situ transmission electron microscopy,and in-situ electrochemical impedance spectroscopy techniques were *** on the analyses,the following conversion reaction from the second cycle onward is suggested:CoO+xSeO_(2)+(1-x)Se+4(x+1)Na^(+)+4(x+1)e~-?Co+(2x+1)Na_(2)O+Na_(2)***,the electrochemical properties of porous CoSeO_(3)-carbon composite nanofibers are analyzed in *** anode material exhibited stable cycle stability up to 200 cycles at 0.5 A g^(-1)and high rate performance up to 5 A g^(-1).

关键词： Anode materials Sodium-ion batteries Conversion reaction Metal selenite Electrospinning

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Risk factors of electrocoagulation syndrome after esophageal endoscopic submucosal dissection

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World Journal of Gastroenterology 2018年第10期24卷 1144-1151页

作者： dae Won Ma Young hoon Youn Da Hyun Jung Jae Jun park Jie-Hyun Kim Hyojin park Department of Internal Medicine Gangnam Severance Hospital Yonsei University College of Medicine

AIM To investigate post endoscopic submucosal dissection electrocoagulation syndrome(PEECS) of the *** We analyzed 55 consecutive cases with esophageal endoscopic submucosal dissection for superficial esophageal squamous neoplasms at a tertiary referral hospital in South Korea. Esophageal PEECS was defined as "mild" meeting one of the following criteria without any obvious perforation: fever(≥ 37.8 ℃), leukocytosis(> 10800 cells/μl), or regional chest pain more than 5/10 points as rated on a numeric pain intensity scale. The grade of PEECS was determined as "severe" when meet two or more of above *** We included 51 cases without obvious complications in the analysis. The incidence of mild and severe esophageal PEECS was 47.1% and 17.6%, respectively. Risk factor analysis revealed that resected area, procedure time, and muscle layer exposure were significantly associated with PEECS. In multivariate analysis, a resected area larger than 6.0 cm^2(OR = 4.995, 95%CI: 1.110-22.489, P = 0.036) and muscle layer exposure(OR = 5.661, 95%CI: 1.422-22.534, P = 0.014) were independent predictors of esophageal PEECS. All patients with PEECS had favorable outcomes with conservative management approaches, such as intravenous hydration or *** Clinicians should consider the possibility of esophageal PEECS when the resected area exceeds 6.0 cm^2 or when the muscle layer exposure is noted.

关键词： Electrocoagulation Endoscopic submucosal dissection Esophageal neoplasm Syndrome

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Rational design and synthesis of hierarchically structured SnO2 microspheres assembled from hollow porous nanoplates as superior anode materials for lithium-ion batteries

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Nano Research 2018年第3期11卷 1301-1312页

作者： Gi dae park Yun Chan Kang Department of Materials Science and Engineering Korea University Anam-Dong Seongbuk-Gu Seoul 136-713 Republic of Korea

Herein, hierarchically structured SnO2 microspheres are designed and synthesized as an efficient anode material for lithium-ion batteries using hollow SnO2 nanoplates. Three-dimensionally ordered macroporous （3-DOM） SnOx-C microspheres synthesized by spray pyrolysis are transformed into hierarchically structured SnO2 microspheres by a two-step post-treatment process. Sulfidation produces hierarchically structured SnS-SnS2-C microspheres comprising tin sulfide nanoplate and carbon building blocks. A subsequent oxidation process produces SnO2 microspheres from hollow SnO2 nanoplate building blocks, which are formed by Kirkendall diffusion. The discharge capacity of the hierarchically structured SnO2 microspheres at a current density of 5 Ag^-1 for the 600th cycle is 404 mA·h·g^-1. The hierarchically structured SnO2 microspheres have reversible discharge capacities of 609 and 158 mA·h·g^-1 at current densities of 0.5 and 30 Ag^-1, respectively. The ultrafine nanosheets contain empty voids that allow excellent lithium-ion storage performance, even at high current densities.

关键词： Kirkendall diffusion nanoplate tin oxide lithium-ion batter spray pyrolysis

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Visualization of flow structures inside a conical spouted bed by electrical capacitance volume tomography

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Particuology 2019年第1期17卷 15-25页

作者： hoon Chae park Hang Seok Choi Department of Environmental Engineering Yonsei UniversityWonju 26493Republic of Korea

Electrical capacitance volume tomography (ECVT) was conducted to measure instantaneous gas–solid flow structures in a conical spouted bed. The sensor has 24 electrodes/channels and was used to make three-dimensional measurements of the solid volume fraction. Flow structures in the conical spouted bed were analyzed using quantitative ECVT images. Three-dimensional images of gas–solid flow structures and time-averaged vertical and radial solid volume fraction profiles are presented. Different fluidization regimes in spouted beds were characterized by analyzing pressure fluctuation signals and ECVT images. ECVT was shown to be robust and powerful for the three-dimensional visualization and quantitative measurement of a gas–solid fluidization system.

关键词： Conical spouted bed Electrical capacitance volume tomography Multiphase flow

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Design and Demonstration of a Locust-Like Jumping Mechanism for Small-Scale Robots

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Journal of Bionic Engineering 2012年第3期9卷 271-281页

作者： Quoc-Viet Nguyen hoon Cheol park Department of Advanced Technology Fusion Konkuk University Seoul 143-701 Republic of Korea

A jumping mechanism can be an efficient mode of motion for small robots to overcome large obstacles on the ground and rough terrain. In this paper, we present a 7 g prototype of locust-inspired jumping mechanism that uses springs, wire, reduction gears, and a motor as the actuation components. The leg structure and muscles of a locust or grasshopper were mimicked using springs and wire, springs for passive extensor muscles, and a wire as a flexor muscle. A small motor was used to slowly charge the spring through a lever and gear system, and a cam with a special profile was used as a clicking mechanism for quick release of elastic energy stored in the springs to create a sudden kick for a quick jump. Performance analysis and experiments were conducted for comparison and performance estimation of the jumping mechanism prototype. Our prototype could produce standing jumps over obstacles that were about 14 times its own size （approximate to 71 cm） and a jumping distance of 20 times its own size （approximate to 100 cm）.

关键词： biomimetics locust jumping mechanism passive tibia extensor muscle

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Generation of Control Moments in an Insect-like Tailless Flapping-wing Micro Air Vehicle by Changing the Stroke-plane Angle

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Journal of Bionic Engineering 2016年第3期13卷 449-457页

作者： Hoang Vu Phan hoon Cheol park Artificial Muscle Research Center Konkuk University Seoul 143-701 South Korea Deptment of Advanced Technology Fusion Konkuk University Seoul 143-701 South Korea

We propose a control moment generator to control the attitude of an insect-like tailless Flapping-wing Micro Air Vehicle （FW-MAV）, where the flapping wings simultaneously produce the flight force and control moments. The generator tilts the stroke plane of each wing independently to direct the resultant aerodynamic force in the desired direction to ultimately generate pitch and yaw moments. A roll moment is produced by an additional mechanism that shifts the trailing edge, which changes the wing rotation angles of the two flapping wings and produces an asymmetric thrust. Images of the flapping wings are captured with a high-speed camera and clearly show that the FW-MAV can independently change the stroke planes of its two wings. The measured force and moment data prove that the control moment generator produces reasonable pitch and yaw moments by tilting the stroke plane and realizes a roll moment by shifting the position of the trailing edge at the wing root.

关键词： insect-like Flapping-wing Micro Air Vehicle (FW-MAV) control mechanism stroke plane beetle flight

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Robotic versus laparoscopic distal pancreatectomy for pancreatic ductal adenocarcinoma: A propensity score-matched analysis

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Hepatobiliary & Pancreatic Diseases International 2023年第2期22卷 154-159页

作者： Dakyum Shin Jaewoo Kwon Jae hoon Lee Seo Young park Yejong park Woohyung Lee Ki Byung Song dae Wook Hwang Song Cheol Kim Division of Hepato-Biliary and Pancreatic Surgery Department of SurgeryAsan Medical CenterUniversity of Ulsan College of Medicine88 Olympic-ro 43-gilSongpa-guSeoul 05505Korea Department of Surgery Kangbuk Samsung HospitalSungkyunkwan University School of Medicine29 Saemunan-roJongno-guSeoul 03181Korea Department of Statistics and Data Science Korea National Open University86 Daehak-roJongno-guSeoul 03087Korea

Background: Minimally invasive surgery is becoming increasingly popular in the field of pancreatic surgery. However, there are few studies of robotic distal pancreatectomy(RDP) for pancreatic ductal adenocarcinoma(PDAC). This study aimed to investigate the efficacy and feasibility of RDP for PDAC. Methods: Patients who underwent RDP or laparoscopic distal pancreatectomy(LDP) for PDAC between January 2015 and September 2020 were reviewed. Propensity score matching analyses were performed. Results: Of the 335 patients included in the study, 24 underwent RDP and 311 underwent LDP. A total of 21 RDP patients were matched 1:1 with LDP patients. RDP was associated with longer operative time(209.7 vs. 163.2 min;P = 0.003), lower open conversion rate(0% vs. 4.8%;P < 0.001), higher cost(15 722 vs. 12 699 dollars;P = 0.003), and a higher rate of achievement of an R0 resection margin(90.5% vs. 61.9%;P = 0.042). However, postoperative pancreatic fistula grade B or C showed no significant intergroup difference(9.5% vs. 9.5%). The median disease-free survival(34.5 vs. 17.3 months;P = 0.588) and overall survival(37.7 vs. 21.9 months;P = 0.171) were comparable between the groups. Conclusions: RDP is associated with longer operative time, a higher cost of surgery, and a higher likelihood of achieving R0 margins than LDP.

关键词： Minimally invasive surgery Robotic distal pancreatectomy Laparoscopic distal pancreatectomy Pancreatic ductal adenocarcinoma Propensity score matching

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Influence of Center of Gravity Location on Flight Dynamic Stability in a Hovering Tailless FW-MAV: Lateral Motion

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Journal of Bionic Engineering 2020年第1期17卷 148-160页

作者： Loan Thi Kim Au hoon Cheol park Department of Smart Vehicle Engineering and Artificial Muscle Research Center Konkuk UniversitySeoul 05029Korea

This paper reports the effect of the Center of Gravity(CG)position on lateral flight dynamic stability of hovering KUBeetle,a tailless FW-MAV,providing further insights on the effects of asymmetries in body mass distribution and wing *** the current study,the standard linearized equations of motion were applied as in the previous work on longitudinal dynamic *** stability derivatives were acquired using the computational fluid dynamic methods via the commercial software of ANSYS *** exists a stable region for CG between 2.6%and 3.5%of the mean chord below the wing pivot point,in which the lateral motion of hovering KUBeetle is passively *** CG below the stable region,because of an unstable oscillatory mode,the lateral motion of the FW-MAV is unstable but can be stabilized using rolling rate *** CG above the stable region,because of a divergence mode,the system remains unstable even with the rolling rate *** with other works on an FW-MAV based on a quasi-steady aerodynamic model and on insect showed similar characteristics for flapping *** is also interesting to note that the asymmetries in body mass and wing kinematics can enlarge the stable region of the system by a non-zero Ixz which approaches the root square of√IxIz,a negative LrNp,and a positive Ix2(Ir+Np).Combining the current result with that of the previous work on longitudinal motion,the most beneficial region of the CG for full 6-DOF flight dynamic stability of hovering KUBeetle was suggested.

关键词： FW-MAV center of gravity flight dynamic stability lateral motion asymmetry computational fluid dynamics bioinspired flight

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