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Synthesis of Spirostanol Saponins via Gold(Ⅰ)-Catalyzed Glycosylation in the Presence of Ga(Otf)3, In(Otf)3, or HOTf

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Chinese Journal of Chemistry 2019年第8期37卷 827-833页

作者： Teddy Stephen Ehianeta dacheng shen Peng Xu Biao Yu State Key Laboratory of Bio-organic and Natural Products Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryChinese Academy of Sciencesand University of Chinese Academy of Sciences345 Lingling RoadShanghai 200032China

Summary of main observation and conclusion An effective approach relying on a Lewis acid-or Brφnsted acid-assisted gold(Ⅰ)-catalyzed glycosylation has been reported in the synthesis of a panel of the representative natural spirostanol saponins,namely polyphyllin D (1),polyphyllin V (2),dioscin (3),formosanin C (4),and a derivative of polyphyllin D bearing a terminal azide group (5).This approach highlights the engagement of low Ioadings of Ph3AuPOTf (≤ 0.5mol%) in the presence of Ga(OTf)3,In(OTf)3,or HOTf (~10 mol%) as a co-catalyst,at practical reaction rates as an alternative to the conventional ~10 mol%Ioadings of the gold(Ⅰ) catalyst in the *** D (1) was obtained in 41% overall yield over six steps compared to the maximum 30% yield in previous syntheses,where conventional donors and promoters were *** exploiting a regioselective rhamnosylation,a "one-pot" approach was adopted to assemble 1 and 5,thus further strengthening the efficiency of the gold(Ⅰ)-catalyzed glycosylation.

关键词： Presence via practical presence catalyst mol was has

单纯C3沉积的感染后肾小球肾炎与C3肾小球肾炎比较

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肾脏病与透析肾移植杂志 2018年第3期27卷 208-213,244页

作者：徐峰张明超朱小东谌达程梁少姗梁丹丹曾彩虹刘志红第二军医大学金陵医院(南京总医院)国家肾脏疾病临床医学研究中心全军肾脏病研究所博士研究生南京210016

目的:分析单纯C3沉积的感染后肾小球肾炎(C3-PIGN)的临床、病理和肾脏预后特点,并和C3肾小球肾炎(C3GN)进行比较。方法:回顾性分析2009年至2015行肾活检诊断为感染后肾小球肾炎(PIGN)和C3肾小球肾炎(C3GN)患者的临床、病理及随访资料,... 详细信息

目的:分析单纯C3沉积的感染后肾小球肾炎(C3-PIGN)的临床、病理和肾脏预后特点,并和C3肾小球肾炎(C3GN)进行比较。方法:回顾性分析2009年至2015行肾活检诊断为感染后肾小球肾炎(PIGN)和C3肾小球肾炎(C3GN)患者的临床、病理及随访资料,分别对C3-PIGN和免疫球蛋白合并补体沉积的感染后肾小球肾炎(Ig+C3-PIGN)、C3-PIGN和C3肾小球肾炎(C3GN)的患者进行比较。结果:(1)共纳入89例PIGN和52例C3GN,PIGN患者中43例(48.3%)为C3-PIGN,46例(51.7%)Ig+C3-PIGN。(2)与Ig+C3-PIGN相比,C3-PIGN肾病范围的蛋白尿和低白蛋白血症比例、新月体比例、肾小管萎缩间质纤维化(IFTA)的比例及系膜区和内皮下的电子致密物沉积的比例较低。(3)与C3GN比较,C3-PIGN患者未成年人比例更高,病程更短,尿红细胞计数更多,肾病范围蛋白尿比例和低白蛋白血症发生率更低;C3-PIGN患者球性硬化、IFTA、动脉透明变性、肾小球系膜区和内皮下电子致密物沉积的比例更低,而驼峰比例更高。C3-PIGN和C3GN患者肾小球均存在C3b、C3c和C3g沉积。(4)C3-PIGN患者的临床转归总体预后良好,39例患者随访>1年,其中32例患者1年内尿检转阴,7例患者尿检持续阳性>1年,其中5例患者尿检逐渐转阴,而2例患者尿检持续不缓解,提示可能存在补体旁路途径活化失衡,符合C3GN的诊断。结论:与Ig+C3-PIGN和C3GN相比,C3-PIGN的临床和组织形态学病变较轻,但是C3-PIGN和C3GN肾小球内有相同的补体片段沉积,提示两者肾小球局部的补体活化和裂解失活过程有相似之处。对C3-PIGN患者要进行长期追踪随访,以便发现这些以感染为诱因,临床诊断为"C3-PIGN",而实际是C3GN患者。

关键词：单纯C3沉积感染后肾小球肾炎 C3肾小球肾炎肾脏病理补体片段

China Antihypertensive Trial in Acute Ischemic Stroke II (CATIS-2): rationale and design

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Stroke & Vascular Neurology 2021年第2期6卷 286-290页

作者： Liping Liu Yilong Wang Xuewei Xie dacheng Liu Aili Wang Penglian Wang Suwen shen Chongke Zhong Yufei Wei Tan Xu Yuesong Pan Yong Jiang Xia Meng David Wang Yonghong Zhang Jiang He Yongjun Wang Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Department of Epidemiology School of Public HealthMedical College of Soochow UniversitySuzhouChina Neurovascular Division Department of NeurologyBarrow Neurological InstituteSt Joseph's Hospital and Medical CenterPhoenixArizonaUSA Department of Epidemiology Tulane University School of Public Health and Tropical MedicineNew OrleansLouisianaUSA

Backgrounds Increased blood pressure(BP)for patients who had an acute ischaemic stroke is associated with poor functional outcome,however the optimal timing of antihypertensive therapy is *** We aim to compare early antihypertensive treatment to delayed antihypertensive treatment for reducing the risk of composite major disability and mortality at 3 months in acute ischaemic *** The China Antihypertensive Trial in Acute Ischemic Stroke II(CATIS-2)trial is a multicentre,randomised,open-label,blinded-endpoints trial that will be conducted in 100 hospitals in *** primary outcome is the composite of death and major disability(modified Rankin Scale score≥3)at 3 months of *** treatment will be received immediately after randomisation in the early treatment group,aimed at average systolic BP by 10%-20%reduction within the first 24 hours,and achieving an average BP level of<140/90 mm Hg within 5 *** in the delayed treatment group will discontinue any antihypertension medications for the first 7 days of randomisation,and will receive antihypertensive therapy achieving a BP goal of<140/90 mm Hg after 7 *** The CATIS-2 trial will be testing the hypotheses that early BP lowering leads to improved functional outcome without any other harms,and developing clinical guidelines of the BP management for patients who had an acute ischaemic stroke.

关键词： hypertensive acute mortality

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模糊免疫PID控制在淀粉生产线中的应用

农业机械学报 2008年第10期39卷 109-112,118页

作者：沈刚丛大成韩俊伟哈尔滨工业大学电液伺服仿真及试验系统研究所

在分析比较传统PID、Smith预估PID和模糊免疫PID原理的基础上,提出了利用模糊免疫PID调节淀粉生产线中的液位。通过对淀粉生产线中某一液位回路进行数学建模,然后对传统PID、Smith预估PID和模糊免疫PID3种控制器进行了设计与仿真。仿真... 详细信息

在分析比较传统PID、Smith预估PID和模糊免疫PID原理的基础上,提出了利用模糊免疫PID调节淀粉生产线中的液位。通过对淀粉生产线中某一液位回路进行数学建模,然后对传统PID、Smith预估PID和模糊免疫PID3种控制器进行了设计与仿真。仿真结果表明,模糊免疫PID在控制效果上明显优于传统PID并且其鲁棒性高于Smith预估PID。最后,利用Matlab的DDE协议和ActiveX与淀粉生产线的上位机RSView32进行了数据交换,将Matlab中模糊免疫PID控制算法准确传输到上位机上。

关键词：淀粉生产线模糊免疫PID控制 RSView32 Smith预估PID

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山溪性强潮河口围垦工程对潮流的影响

水力发电学报 2005年第2期24卷 25-29,59页

作者：姚炎明沈益锋周大成李佳浙江大学港口海岸与近海工程研究所杭州310028

本文以山溪性强潮河口———鳌江河口为例 ,采用平面二维有限元数学模型模拟计算不同水文条件下鳌江口外南岸边滩围垦前后的区域潮波与潮流变化分布。据此 ,分析了围垦工程对山溪性强潮河口潮流的影响。

关键词：水力学河流与海岸动力学河口围垦数学模型潮流影响

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半导体性光刻胶及其在有机集成芯片中的应用

科学通报 2024年第27期69卷 3995-3998页

作者：张申刘云圻魏大程复旦大学高分子科学系聚合物分子工程国家重点实验室上海200433 复旦大学分子材料与器件实验室上海200433 中国科学院化学研究所北京100190

随着信息技术的快速发展,现代社会已经进入了一个“信息爆炸”的时代.作为各类电子设备的核心元件,电子芯片的集成度也需要不断提高,以满足对更多并行信号的处理需求.硅基芯片的特征尺寸已经进入几纳米的节点,可以在每平方厘米的尺寸上... 详细信息

随着信息技术的快速发展,现代社会已经进入了一个“信息爆炸”的时代.作为各类电子设备的核心元件,电子芯片的集成度也需要不断提高,以满足对更多并行信号的处理需求.硅基芯片的特征尺寸已经进入几纳米的节点,可以在每平方厘米的尺寸上集成数以亿计的器件.然而,无机半导体固有的刚性,导致传统硅基器件很难用在一些需要弯曲、折叠和伸缩的场景中,例如柔性显示器、可穿戴设备、人工假体和仿生机器人系统.在这些新兴应用领域,有机半导体则备受青睐.

关键词：可穿戴设备仿生机器人信息技术信息爆炸有机半导体无机半导体人工假体电子芯片

Tectonic Setting of the Cu-Ni Sulfide-Bearing Mafic-Ultramafic Complexes in Northern Jilin Province, NE China

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International Journal of Geosciences 2013年第2期4卷 317-328页

作者： dacheng Jia shen Liu Hong Zhong Guangying Feng Youqiang Qi Wen Gao Xiao Zhang Tao Jiang Yongxin Mao College of Geo-Exploration and Science and Technology Jilin University Changchun China State Key Laboratory of Ore Deposit Geochemistry Institute of Geochemistry Chinese Academy of Sciences Guiyang China

There are series of Cu-Ni sulfide-bearing mafic-ultramafic intrusions widespread in north JilinProvince,Northeastern China. The intrusions formed in Xing’an-Mongolian Orogenic Belt near to the northeastern margin of North China Craton. The complexes were formed in almost same period according to the zircon U-Pb dating reported recently, which means that the complexes were formed in same tectonic period and belong to one tectonic magmatic event. The rock assemblages are different from the ophiolite type and Yidun type in orogenic belt. The mafic-ultramafic complexes formed in the range from 217 Ma to 232 Ma coeval with A-type granites in the area, which formed bimodal igneous rock assemblage. According to the regional angular unconformities, there were existed the orogenies of Caledonian, Hercynian, Early Indosinian, Late Indosinian and Yanshanian. The Early Indosinian coeval with orogenic I-type granites and sanukitie that suggesting the lithosphere thickening in the extrusion tectonic setting of orogenic processes, however the Late Indosinian coeval with bimodal igneous rock assemblage that suggesting the lithosphere thinning in the extension tectonic setting of post-orogenic processes in the Xing’an-Mongolian Orogenic Belt. Chemical composition of the mafic-ultramafic rocks has the characteristics of high-Mg and low-K tholeiites related with inter-continental post-orogenic tectonic setting. The trace elements indicate their formed in conditions of continental extension belt or initial rift and has the characteristics of revolution from oceanic island arc, volcanic arc of continental margin to continental extended belt. The low initial Sr isotopic ratios and positive εNd(t) values suggest that the initial magma of the complexes come from the parting melting of depleted lithospheric mantle. The depleted ithospheric mantle was new formed supported by zircon Hf isotope in Hongqiling complex. The depleted lithospheric mantle may be caused by the asthenosheric mantle up

关键词： Mafic-Ultramafic Intrusions Tectonic Setting Post-Orogenic Processes Lithospheric Extension

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基于谐振原理的微机械疲劳试验装置的研究

机械强度 2006年第5期28卷 684-689页

作者：丁雷尚德广张大成沈通贾冠华阎楚良北京工业大学机电学院北京100022 北京大学微电子学系北京100871

设计出一种基于梳状驱动器原理的静电力驱动的微机械疲劳试验装置,该装置可由典型的表面牺牲层标准工艺制作。对所设计的MEMS(micro-electro-mechanical system)疲劳试验装置中的圆弧梳状驱动器的电容及静电驱动力进行理论分析,并采用AN... 详细信息

设计出一种基于梳状驱动器原理的静电力驱动的微机械疲劳试验装置,该装置可由典型的表面牺牲层标准工艺制作。对所设计的MEMS(micro-electro-mechanical system)疲劳试验装置中的圆弧梳状驱动器的电容及静电驱动力进行理论分析,并采用ANSYS机电耦合单元对装置的振动过程进行模拟,模拟结果与理论分析相吻合。研究结果表明在一定范围交流电压的驱动下试样能达到MEMS疲劳测试所要求的应力水平,并对该电压范围进行预测。

关键词：微机电系统疲劳梳状驱动器有限元方法机电耦合分析

Enhanced store-operated Ca2+ signal of small intestinal smooth muscle cells accelerates small bowel transit speed in type 1 diabetic mouse

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Enhanced store-operated Ca2+ signal of small intestinal smoo...