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Ferrite features in simulated transition zone of EH36 shipbuilding steel submerged arc welded by CaF_(2)-SiO_(2)-MnO fluxes

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Journal of Iron and Steel Research International 2024年第4期31卷 790-796页

作者： Ming Zhong Dong Hu da-ming Guo Somnath Basu Cong Wang Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819LiaoningChina School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Department of Metallurgical Engineering and Materials Science Indian Institute of Technology BombayMumbai 400076MaharashtraIndia

Ferrite features in the simulated transition zone welded with CaF_(2)-SiO_(2)-MnO fluxes containing various MnO contents have been *** laser scanning microscopy has been applied to simulate the thermal cycling of the transition zone and the phase transformations during cooling have been in-situ *** has been found that the appearance temperature for ferrite side plate decreases with increasing Mn content in the weld metals caused by MnO content ***,growth rates for both ferrite side plate and acicular ferrite are significantly enhanced with a higher Mn content of weld ***,from the statistical fractions of salient microstructures,for all samples,the acicular ferrite,grain boundary ferrite,and polygonal ferrite take over more than 90%.It has also been demonstrated that with the increase in Mn content,the ferrite side plate fraction increases slightly from 5%to 10%and the acicular ferrite fraction shows a tendency of first increasing and then decreasing,which experiences the maximum with the flux containing 30 wt.%*** phenomenon is believed to be controlled by the O and Mn contents in weld metals synergistically.

关键词： Submerged arc welding Transition zone Phase transformation Microstructure

Intelligent structured nanocomposite adhesive for bioelectronics and soft robots

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Nano Research 2024年第2期17卷 534-549页

作者： Yeon Soo Lee Min-Seok Kim da Wan Kim Changhyun Pang School of Chemical Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Mechanical Metrology Group Korea Research Institute of Standards and ScienceDaejeon 34113Republic of Korea Department of Electronic Engineering Korea National University of TransportationChungbuk 27469Republic of Korea Samsung Advanced Institute for Health Sciences and Technology Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea

The remarkable functionality of biological systems in detecting and adapting to various environmental conditions has inspired the design of the latest electronics and robots with advanced *** review focuses on intelligent bio-inspired strategies for developing soft bioelectronics and robotics that can accommodate nanocomposite adhesives and integrate them into biological *** underlying principles of the material and structural design of nanocomposite adhesives were investigated for practical applications with excellent functionalities,such as soft skin-attachable health care sensors,highly stretchable adhesive electrodes,switchable adhesion,and untethered soft *** addition,we have discussed recent progress in the development of effective fabrication methods for micro/nanostructures for integration into devices,presenting the current challenges and prospects.

关键词： biomimetics bio-adhesive switchable adhesion bioelectronics nanocomposite soft robotics

The BTB/TAZ domain-containing protein CmBT1-mediated CmANR1 ubiquitination negatively regulates root development in chrysanthemum

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Journal of Integrative Plant Biology 2024年第2期66卷 285-299页

作者： Lian-da Du Zhang-Ji Guan Yan-Hong Liu Hui-Dong Zhu Quan Sun da-Gang Hu Cui-Hui Sun Shandong Collaborative Innovation Center of Fruit&Vegetable Quality and Efficient Production College of Horticulture Science and EngineeringShandong Agricultural UniversityTaian 271018China

Roots are fundamental for plants to adapt to variable environmental *** development of a robust root system is orchestrated by numerous genetic determinants and,among them,the MADS-box gene ANR1 has garnered substantial *** research has demonstrated that,in chrysanthemum,CmANR1positively regulates root system ***,the upstream regulators involved in the CmANR1-mediated regulation of root development remain *** this study,we successfully identified bric-a-brac,tramtrack and broad(BTB)and transcription adapter putative zinc finger(TAZ)domain protein CmBT1 as the interacting partner of CmANR1 through a yeasttwo-hybrid(Y2H)screening ***,we validated this physical interaction through bimolecular fluorescence complementation and pull-down *** assays revealed that CmBT1 exerted a negative influence on root development in *** both in vitro and in vivo assays,it was evident that CmBT1mediated the ubiquitination of CmANR1 through the ubiquitin/26S proteasome *** ubiquitination subsequently led to the degradation of the CmANR1 protein and a reduction in the transcription of CmANR1-targeted gene CmPIN2,which was crucial for root development in *** analysis suggested that CmBT1 modulated root development,at least in part,by regulating the level of CmANR1 ***,these findings shed new light on the regulatory role of CmBT1 in degrading CmANR1 through ubiquitination,thereby repressing the expression of its targeted gene and inhibiting root development in chrysanthemum.

关键词： chrysanthemum MADS-box transcription factor root development

Expression of cyclin-dependent kinase 9 is positively correlated with the autophagy level in colon cancer

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 314-330页

作者： Lei Zheng Jia Lu da-Lu Kong Department of Colorectal Cancer Surgery National Clinical Research Center for CancerKey Laboratory of Cancer Immunology and Biotherapy of TianjinTianjin Key Laboratory of Digestive CancerKey Laboratory of Cancer Prevention and Therapy of TianjinTianjin’s Clinical Research Center for CancerTianjin Medical University Cancer Institute and HospitalTianjin 300060China Department of Infection Management National Clinical Research Center for CancerKey Laboratory of Cancer Immunology and Biotherapy of TianjinTianjin Key Laboratory of Digestive CancerKey Laboratory of Cancer Prevention and Therapy of TianjinTianjin’s Clinical Research Center for CancerTianjin Medical University Cancer Institute and HospitalTianjin 300060China

BACKGROUND Cyclin-dependent kinase 9(CDK9)expression and autophagy in colorectal cancer(CRC)tissues has not been widely ***9,a key regulator of transcription,may influence the occurrence and progression of *** expression of auto-phagy-related genes BECN1 and drug resistance factor ABCG2 may also play a role in *** normal physiological conditions,autophagy can inhibit tumorigenesis,but once a tumor forms,autophagy may promote tumor ***,understanding the relationship between autophagy and cancer,partic-ularly how autophagy promotes tumor growth after its formation,is a key motivation for this *** To investigate the relationship between CDK9 expression and autophagy in CRC,assess differences in autophagy between left and right colon cancer,and analyze the associations of autophagy-related genes with clinical features and *** We collected tumor tissues and paracarcinoma tissues from colon cancer patients with liver metastasis to observe the level of autophagy in tissues with high levels of CDK9 and low levels of *** also collected primary tissue from left and right colon cancer patients with liver metastasis to compare the autophagy levels and the expression of BECN1 and ABCG2 in the tumor and paracarcinoma *** The incidence of autophagy and the expression of BECN1 and ABCG2 were different in left and right colon cancer,and autophagy might be involved in the occurrence of chemotherapy *** analysis of the rela-tionship between the expression of autophagy-related genes CDK9,ABCG2,and BECN1 and the clinical features and prognosis of colorectal cancer showed that the high expression of CDK9 indicated a poor prognosis in colorectal *** This study laid the foundation for further research on the combination of CDK9 inhibitors and autophagy inhibitors in the treatment of patients with CRC.

关键词： Autophagy Tumorigenesis Tumor tissue Paracarcinoma tissue Expression Left/right colon cancer

Molecular and cellular mechanisms of neuroprotection by oligopeptides from snake venoms

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BIOCELL 2024年第6期48卷 897-904页

作者： CARLOS ALBERTO-SILVA BRENda RUFINO da SILVA Natural and Humanities Sciences Center Experimental Morphophysiology LaboratoryFederal University of ABC(UFABC)São Bernardo do CampoSão PauloBrazil

Venom snake-derived peptides have multiple biochemical,pharmacological,and toxicological proﬁles,allowing for the discovery of new medicinal products and therapeutic *** review speciﬁcally examines the fundamental elements of neuroprotection offered by different oligopeptides derived from snake *** also includes a brief evaluation of short peptides that are being considered as potential therapeutic ***-rich peptides and tryptophyllin family peptides isolated from the crude venom of Viperidae family snakes,speciﬁcally Bothrops atrox,Bothrops jararaca,and Bothrops moojeni,have been shown to have pro-survival properties,the ability to reduce oxidative stress,and the ability to promote cell viability and mitochondrial *** signiﬁcant mechanisms are related to the neuroprotection mediated by snake venom oligopeptides:(1)Activation of the L-arginine metabolite pathway,such as polyamines from ornithine metabolism,which reduces N-methyl-D-aspartate(NMda)-type glutamate receptor activity;(2)Enhancement of cell viability by activating the nerve growth factor-signaling pathway;and(3)Activation of the Muscarinic acetylcholine receptor subtype M1(mAChR-M1).These small peptides show promise as neuroprotective agents against a variety of neurodegenerative disorders.

关键词： Neuroprotective peptides Neurodegenerative disease Oxidative stress Reactive oxygen species Biopeptides

Robust Space-Time Adaptive Track-Before-Detect Algorithm Based on Persymmetry and Symmetric Spectrum

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Journal of Beijing Institute of Technology 2024年第1期33卷 65-74页

作者： Xiaojing Su da Xu Dongsheng Zhu Zhixun Ma Institute of Acoustics Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Underwater monopulse space-time adaptive track-before-detect method,which combines space-time adaptive detector(STAD)and the track-before-detect algorithm based on dynamic programming(DP-TBD),denoted as STAD-DP-TBD,can effectively detect low-speed weak ***,due to the complexity and variability of the underwater environment,it is difficult to obtain sufficient secondary data,resulting in a serious decline in the detection and tracking performance,and leading to poor robustness of the *** this paper,based on the adaptive matched filter(AMF)test and the RAO test,underwater monopulse AMF-DP-TBD algorithm and RAO-DP-TBD algorithm which incorporate persymmetry and symmetric spectrum,denoted as PSAMF-DP-TBD and PS-RAO-DP-TBD,are proposed and compared with the AMF-DP-TBD algorithm and RAO-DP-TBD algorithm based on persymmetry array,denoted as P-AMF-DP-TBD and *** simulation results show that the four methods can work normally with sufficient secondary data and slightly insufficient secondary data,but when the secondary data is severely insufficient,the P-AMF-DP-TBD and P-RAO-DP-TBD algorithms has failed while the PSAMF-DP-TBD and PS-RAO-DP-TBD algorithms still have good detection and tracking capabilities.

关键词： space-time adaptive detection track before detect robustness persymmetric property symmetric spectrum AMF test RAO test

Variations and future projections of glacial discharge of Urumqi River Headwaters,eastern Tien Shan(1980s-2017)

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Advances in Climate Change Research 2024年第3期15卷 537-546页

作者： Hui ZHANG Fei-Teng WANG Ping ZHOU Yi-da XIE State Key Laboratory of Cryospheric Science Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Key Laboratory of Cryospheric Science and Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China

To address data scarcity on long-term glacial discharge and inadequacies in simulating and predicting hydrological processes in the Tien Shan,this study analysed the observed discharge at multiple timescales over 1980se2017 and projected changes within a representative glacierized high-mountain region:eastern Tien Shan,Central *** processes were simulated to predict changes under four future scenarios(SSP1,SSP2,SSP3,and SSP5)using a classical hydrological model coupled with a glacier dynamics *** rates at annual,monthly(June,July,August)and daily timescales were obtained from two hydrological gauges:Urumqi Glacier No.1 hydrological station(UGH)and Zongkong station(ZK).Overall,annual and summer discharge increased significantly(p<0.05)at both stations over the study *** intra-annual variations mainly resulted from differences in their recharge *** simulations show that a tipping point in annual discharge at UGH may occur between 2018 and 2024 under the four SSPs *** discharge is predicted to cease earlier at ZK than at *** relates to glacier type and size,suggesting basins with heavily developed small glaciers will reach peak discharge sooner,resulting in an earlier freshwater supply *** findings serve as a reference for research into glacial runoff in Central Asia and provide a decision-making basis for planning local water-resource projects.

关键词： Observed glacial discharge Temporal variations Urumqi River Headwaters Eastern Tien Shan Simulation and projection

Experimental study on seismic reinforcement of bridge foundation on silty clay landslide with inclined interlayer

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 193-207页

作者： Lei da Xiao Hanmo Ran Jianhua Luo Bin Jiang Guanlu Xue Tianlang College of Civil Engineering Sichuan Agricultural UniversityDujiangyan 611830China Sichuan Higher Education Engineering Research Center for Disaster Prevention and Mitigation of Village Construction Dujiangyan 611830China School of Civil Engineering Southwest Jiaotong UniversityChengdu 610031China

A shaking table test for a bridge foundation reinforced by anti-slide piles on a silty clay landslide model with an inclined interlayer was *** deformation characteristics of the bridge foundation piles and anti-slide piles were analyzed in different loading *** dynamic response law of a silty clay landslide with an inclined interlayer was *** spacing between the rear anti-slide piles and bridge foundation should be reasonably controlled according to the seismic fortification requirements,to avoid the two peaks in the forced deformation of the bridge foundation ***“blocking effect”of the bridge foundation piles reduced the deformation of the forward anti-slide *** stress-strain response of silty clay was intensified as the vibration wave field appeared on the *** the vibration intensified,the thrust distribution of the landslide underwent a process of shifting from triangle to inverted trapezoid,the difference in the acceleration response between the bearing platform and silty clay landslide tended to decrease,and the spectrum amplitude near the natural vibration frequency *** rear anti-slide piles were able to slow down the shear deformation of the soil in front of the piles and avoid excessive acceleration response of the bridge foundation piles.

关键词： silty clay landslide inclined interlayer shaking table test anti-slide pile bridge foundation pile

Restraint effect of partition wall on the tunnel floor heave in layered rock mass

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Journal of Mountain Science 2024年第7期21卷 2462-2479页

作者： YANG Yunyun HUANG da ZHONG Zhu LIU Yang PENG Jianbing School of Civil and Transportation Engineering Hebei University of TechnologyTianjin 300401China College of Geology Engineering and Geomatics Chang’an UniversityXi’an 710054China College of Civil Engineering&Architecture China Three Gorges UniversityYichang 443002China.

The presence of horizontal layered rocks in tunnel engineering significantly impacts the stability and strength of the surrounding rock mass,leading to floor heave in the *** study focused on preparing layered specimens of rock-like material with varying thickness to investigate the failure behaviors of tunnel *** results indicate that thin-layered rock mass exhibits weak interlayer bonding,causing rock layers near the surface to buckle and break upwards when subjected to horizontal *** an increase in the layer thickness,a transition in failure mode occurs from upward buckling to shear failure along the plane,leading to a noticeable reduction in floor heave *** primary cause of significant deformation in floor heave is upward buckling *** address this issue,the study proposes the installation of a partition wall in the middle of the floor to mitigate heave deformation of the rock *** results demonstrate that the partition wall has a considerable stabilizing effect on the floor,reducing the zone of buckling failure and minimizing floor heave *** is crucial for the partition wall to be sufficiently high to prevent buckling failure and ensure *** simulation calculations on an engineering example,it is confirmed that implementing a partition wall can effectively reduce floor heave and enhance the stability of tunnel floor.

关键词： Layered rock Floor heave Horizontal compression test Failure behavior Partition wall