检索结果-南通市图书馆

Analyzing stem cell dynamics： use of cutting edge genetic approaches in model organisms

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers in Biology 2015年第1期10卷 1-10页

作者： gary R. HIME Nicole SIDdaLL Katja HORVAY Helen E. abud Department of Anatomy and Neuroseienee University of Melbourne VIC 3010 Australia Department of Anatomy and Developmental Biology Monash University Clayton VIC 3800 Australia

Regeneration of many cell types found in adult organs relies upon the presence of relatively small pools of undifferentiated stem cells. Initial studies that attempted to isolate stem cells and propagate them in vitro have been complemented by analysis of stem cells in their endogenous tissues where they are subject to a variety of regulatory cues. This has been facilitated by the advent of new methods for lineage tracing and genetic manipulation of stem cells and their associated niche cells. The picture that is emerging is that different stem cell populations utilize diverse processes to ensure maintenance of the stem cell pool accompanied by production of cells committed to regenerate differentiated cells.

关键词： stem cells Drosophila mouse testis intestine lineage tracing

The Effect of the Hemofiltration-Body Surface Area on the Mortality and Morbidity during Cardiopulmonary Bypass

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Cardiovascular Surgery 2018年第8期8卷 140-149页

作者： Kadir Burhan Karadem Burcin abud Ayse gül Kunt Cardiovascular Surgery Department Isparta City Hospital Isparta Turkey Cardiovascular Surgery Department Izmir Tepecik Research and Education Hospital Izmir Turkey

The aim of this study is to investigate the effect of the hemofiltration-body surface area on mortality and morbidity during cardiopulmonary bypass (CBP). A total of 226 patients were divided into two groups as hemofiltration (HF) performed or not performed. The patients to whom hemofiltration was performed were also divided into three subgroups after the distribution analysis which was done according to body surface area. All patients were compared according to the relationship of hemofiltration-body surface area during cardiopulmonary bypass in the interms of mortality and morbidity. There was no statistically significant relationship between the subgroups according to the amount of hemofiltration by square meters (p = 0.818). There was statistically significant difference in total perfusion times and total hospital stay (p = 0.025;p = 0.038) between the subgroups which were divided by the amount of hemofiltration in square meters. As a result, no effect was observed on the mortality of the relationship between the amount of hemofiltration applied during CBP and body surface area.

关键词： Hemofiltration Body Surface Area Cardiopulmonary Bypass

Prediction of Pulmonary Arterial Pressure Level after Repair of Congenital Cardiac Communications and Discharge from the Hospital: Role of Down Syndrome and Early Postoperative Hemodynamics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Congenital Heart Disease 2022年第3期17卷 351-363页

作者： Eloisa Sassa Carvalho Maria Francilene SSouza Kelly Cristina O.abud Claudia R.P.Castro Juliano g.Penha Ana Maria Thomaz Vanessa A.guimaraes Antonio Augusto Lopes Heart Institute(InCor) University of Sao Paulo School of MedicineSão PauloBrazil

Background:Postoperative pulmonary hypertension limits the success of surgical treatment in some patients with unrestrictive congenital cardiac *** patients at risk of developing postoperative pulmonary hypertension is important to individualize follow-up ***:We analyzed a prospective cohort of 52 pediatric patients(age 3 to 35 months)looking for perioperative predictors of mildly elevated pulmonary arterial pressure 6 months after surgery,defined as a systolic pressure greater than 30 mmHg by transthoracic *** corresponds to a mean pulmonary arterial pressure of>20 ***,echocardiographic and hemodynamic parameters were *** hemodynamics was assessed by directly measuring pulmonary and systemic arterial pressures using indwelling *** postoperative pulmonary hemodynamics was defined as the mean pulmonary/systemic mean arterial pressure ratio(PAP/SAP)obtained per patient during the first 6 h of postoperative ***:Among the factors that were investigated as possible predictors,perioperative hemodynamics and the presence of Down syndrome were initially selected using univariate analysis(pg room just after cardiopulmonary bypass(r=0.70,pgher in subjects with Down syndrome than in nonsyndromic individuals(p=0.003).Early postoperative PAP/SAP was the only predictor selected using multivariate *** was characterized as an independent predictor after adjustments for possible *** early postoperative PAP/SAP of>0.35 was 76%sensitive and 74%specific at predicting a systolic pulmonary arterial pressure of>30 mmHg 6 months after surgery(hazard ratio with 95%CI 8.972[2.428–33.158],p=0.002).Conclusion:The hypertensive early postoperative behavior of the pulmonary circulation was strongly but not exclusively associated with Down syndrome,and it was char

关键词： Pulmonary hypertension congenital heart disease Down syndrome pediatric cardiac surgery

Synthesis and Characterization of green Potassium Nanoparticles from Sideroxylon Capiri and Evaluation of Their Potential Antimicrobial

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Renewable Materials 2021年第10期9卷 1699-1706页

作者： Judith Constantino-Alcazar Miguel abud-Archila Benjamín Valdez-Salas Federico gutierrez-Miceli Carlos Ceceña-Duran Blanca López-Valenzuela da.iel gonzalez-Mendoza Tecnológico Nacional de México Instituto Tecnológico de Tuxtla GutiérrezTuxtlaGutiérrezC.P.03940México Instituto de Ciencias Agrícolas de la Universidad Autónoma de Baja California(ICA-UABC) Ejido Nuevo LeónC.P.21705México Instituto de Ingeniería de la Universidad Autónoma de Baja California Mexicali21100México

In the present study,the green synthesis of potassium nanoparticles(K-NPs)was assessed using aqueous extract of Sideroxylon *** potassium nanoparticles were analyzed by UV-visible spectroscopic techniques,X-ray spectrometers of energy dispersive(SEM-EDS)and dynamic light *** results showed high values at 3.5 keV confirming the formation of potassium nanoparticles and the SEM analysis showed an agglomerated particles size between 360 to 200 nm with a spherical *** K-NPs showed an effective antibacterial activity against the test organisms mainly with Bacillus cereus,Enterobacter aerogenes,Fusarium solani and Botrytis *** further studies about nanotoxicity of K-NPs are needed to confirm their potential in the control of the pathogen microorganisms under field conditions.

关键词： Antimicrobial effect green synthesis Sideroxylon capiri biocontrol

Chromium Differentially Affects Hydrogen Peroxide Distribution in Primary and Adventitious Roots of Arabidopsis thaliana L.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Phyton-International Journal of Experimental Botany 2020年第1期89卷 35-43页

作者： Aaron giovanni Munguia-Rodriguez Jose Lopez-Bucio gerardo Rangel Sanchez Leon Francisco Ruiz-Herrera Yazmin Carreon-abud Miguel Martinez-Trujillo Instituto de Investigaciones Quimico-Biológicas Universidad Michoacana de San Nicolas de HidalgoEdificio B3Ciudad UniversitariaC.P58030MoreliaMichoacanMexico Facultad de Biologia Universidad Michoacana de San Nicolas de Hidalgo.Edificio RCiudad UniversitariaC.P58030 MoreliaMichoacanMexico

The post-embryonic growth of the Arabidopsis thaliana root system can be modified by different types of stress,such as sublethal concentrations of metals,which may induce the production of reactive oxygen species(ROS).In this study,the effects of different concentrations of potassium chromate(K_(2)CrO_(4))on the distribution and relative quantity of hydrogen peroxide(H_(2)O_(2))were determined in primary and adventitious roots in *** HyPer line *** line has a biosensor that specifically reports H_(2)O_(2) levels within tissues as *** root growth was inhibited at 100μM Cr(VI);in contrast,adventitious root formation was induced over the main root growth *** structures proliferated from 100-160μM Cr(VI),and much higher concentrations(180-200μM)of K_(2)CrO_(4) were required to affect their *** H_(2)O_(2) distributions were observed in the columella and lateral root cap of primary roots of plants grown in medium lacking dichromate,but following the development of toxicity symptoms,H_(2)O_(2) changed its distribution to the meristem and differentiation ***,adventitious roots had comparable H_(2)O_(2) distribution patterns in untreated plants and those exposed to Cr(VI)***,differential H_(2)O_(2) distribution correlates with the resistance of adventitious roots,but not primary roots,to dichromate and underlies cell reorganization at the apex to support growth.

关键词： Chromate hydrogen peroxide root growth meristem ion toxicity adaptation

Identification of patients at-risk for Lynch syndrome in a hospital-based colorectal surgery clinic

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of gastroenterology 2011年第6期17卷 766-773页

作者： Patrícia Koehler-Santos Patricia Izetti Jamile abud Carlos Eduardo Pitroski Silvia Liliana Cossio Suzi Alves Camey Cláudio Tarta da.iel C damin Paulo Carvalho Contu Mario Antonello Rosito Patricia Ashton-Prolla Joāo Carlos Prolla genomic Medicine Laboratory Experimental Research CenterHospital de Clínicas de Porto Alegre Post-graduate Program in Medical Sciences Federal University of Rio Grande do Sul National Institute for Populational Medical genetics Medical School Federal University of Rio Grande do Sul Post-graduate Program in gastroenterological Sciences Federal University of Rio Grande do Sul Department of Statistics Federal University of Rio Grande do Sul Post-graduate Program in Epidemiology Federal University of Rio Grande do Sul Research and Post-graduation group Hospital de Clínicas de Porto Alegre Division of Coloproctology Hospital de Clínicas de Porto Alegre Department of Surgery Federal University of Rio Grande do Sul Medical genetics Service Hospital de Clínicas de Porto Alegre Department of genetics Federal University of Rio Grande do Sul Service of Pathology Hospital de Clínicas de Porto AlegrePorto Alegre-RS90035-903Brazil

AIM:To determine the prevalence of a family history suggestive of Lynch syndrome (LS) among patients with colorectal cancer (CRC) followed in a coloproctology outpatient clinic in Southern ***:A consecutive sample of patients with CRC were interviewed regarding personal and family histories of *** data and pathology features of the tumor were obtained from chart ***:Of the 212 CRC patients recruited,61 (29%) reported a family history of CRC,45 (21.2%) were diagnosed under age 50 years and 11 (5.2%) had more than one primary *** histories consistent with Amsterdam and revised Bethesda criteria for LS were identified in 22 (10.4%) and 100 (47.2%) patients,*** percent of the colorectal tumors had features of the high microsatellite instability phenotype,which was associated with younger age at CRC diagnosis and with Bethesda criteria (P ge 50 years had been previously submitted for CRC screening and only 4% of patients with suspected LS were referred for genetic risk ***:A significant proportion of patients with CRC were at high risk for *** and training of health care professionals are essential to ensure proper management.

关键词： Colorectal cancer Family history Hereditary cancer Lynch syndrome Microsatellite instability phenotype

High Altitude: A Possible Reason for Postoperative Bleeding after Coronary Artery Bypass graft Operations

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Cardiovascular Diseases 2015年第4期5卷 79-86页

作者： Burcin abud Süreyya Talay Kemal Karaarslan Soysal Turhan Celal Selcuk ünal Emre Kubat Cardiovascular Surgery Department Izmir Tepecik Research and Teaching Hospital Izmir Turkey Cardiovascular Surgery Department Canakkale State Hospital Izmir Turkey Cardiovascular Surgery Department Karabük University Research and Teaching Hospital Karabük Turkey

Background: This study evaluated the possible hypothesis that high altitude might be a reason of excessive postoperative drainage after coronary artery bypass graft operations (CABg). Methods: 212 patients were operated by the same surgical team and included to the study with retrospective data scan on postoperative bleeding after elective CABg with cardiopulmonary bypass (CPB). Study was derived from two different altitude centers: group A patients (n = 107) from the center at an altitude of 1985 meters and group B patients (n = 105) from the center in approximately sea level with 150 meters altitude. Multiple preoperative, intraoperative and postoperative characteristics with postoperative bleeding amounts were reviewed and calculated to determine a result through the aim of our study. Results: Preoperative, operative and intraoperative parameters for both groups were almost identical. Statistically significance occurred on intensive care unit treatment period, total hospitalization days, usage of erythrocyte suspension and fresh frozen plasma among postoperative periods on behalf of group B. Parameters such as CABg numbers, Cross clamp and CPB time were not significant. High altitude patients were considered to be with a higher outcome in preoperative hematocrit (Htc) levels which did not occur in the study group. Htc levels presented a slight elevation for group A as in the preoperative values but a statistically significance was not calculated. Postoperative bleeding volumes and calculated mean values were statistically significantly different among both groups in days of 1, 2 and 3. Reoperations for hemorrhage occurred in 9 cases (8.4%) in group A and 4 cases (3.8%) in group B. Conclusions: We want to attract attention to the relation between high altitude and postoperative bleeding after CABg surgery. But yet uncertain and unidentified physiological and biochemical conditions can be a reason as an uncontrollable perioperative factor in this patients. Operatio

关键词： High Altitude Postoperative Bleeding Elective Coronary Artery Bypass graft Surgery

Comparison of the Modified Eversion Carotid Endarterectomy Technique with the Conventional Carotid Endarterectomy Technique: Early Results

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Cardiovascular Diseases 2015年第4期5卷 87-94页

作者： Burcin abud Süreyya Talay Celal Selcuk ünal Emre Kubat Kemal Karaarslan Soysal Turhan Cardiovascular Surgery Department Izmir Tepecik Research and Teaching Hospital Izmir Turkey Cardiovascular Surgery Department Canakkale State Hospital Izmir Turkey Cardiovascular Surgery Department Karabük University Research and Teaching Hospital Karabük Turkey

Objectives: In this study, we aimed to compare early results of the modified eversion carotid endarterectomy technique with the conventional carotid endarterectomy technique. The modified eversion carotid endarterectomy technique consisted of a longitudinal arteriotomy that was begun from the common carotid artery proximally to the origin of external carotid artery. We also avoided applying a carotid shunt during surgery in both techniques. Methods: Each patient was evaluated for coronary artery stenosis and valve replacement indications. Diagnosis of significant coronary artery stenosis or valve disease directed us to a combination of CEA and cardiac surgery (CABg/Valvular). We generally had a tendency to perform these two surgical procedures separately. Patients which had surgery for both at the same session were excluded in this study. As a result, our study included 120 patients and 137 carotid interventions. We performed the modified eversion carotid endarterectomy technique in 61 patients (68 carotid interventions) (group A) and the conventional CEA technique in 59 patients (69 carotid interventions) (group B). At follow-up, the patients were evaluated by physical examination and color Doppler USg. Results: There was no significant difference between the groups in terms of demographic data. Statistically significant difference was observed in one operative parameter between group A and group B;patchplasty requirements during surgery (12 carotid interventions in group B and 4 carotid interventions in group A, p = 0.036). We recorded temporary tongue deviation in five cases, facial asymmetry in eight cases, hoarseness in four cases, neurocognitive impairment in three cases and transient neurologic in two cases with no significant difference between the groups. There was in one case of permanent neurologic deficit (1 in group B). There were two postoperative deaths (1 in group A and 1 in group B). The death in group A occurred because of subarachnoid haemorrhage

关键词： Conventional Carotid Endarterectomy Modified Eversion Carotid Endarterectomy Technique Avoiding Carotid Shunt

Preoperative rectal tumor embolization as an adjunctive tool for bloodless abdominoperineal excision:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Oncology 2020年第12期11卷 1070-1075页

作者： Marley Ribeiro Feitosa Lucas Fernandes de Freitas Antonio Balestrim Filho guilherme Seizem Nakiri da.iel giansante abud Ligia Magnani Landell Mariângela Ottoboni Brunaldi Jose Joaquim Ribeiro da Rocha Omar Feres Rogério Serafim Parra Department of Surgery and Anatomy Medicine School of Ribeirão PretoUniversity of São PauloRibeirão Preto 14048900São PauloBrazil Department of Internal Medicine Medical School of Ribeirão PretoUniversity of São PauloRibeirão Preto 14048900São PauloBrazil Department of Pathology and Forensic Medicine Medicine School of Ribeirão PretoUniversity of São PauloRibeirão Preto 14048900São PauloBrazil

BACKgROUND Abdominoperineal excision(APE)-related hemorrhage can be challenging due to difficult access to pelvic organs and the risk of massive blood *** objective of the present study was to demonstrate the use of preoperative embolization(PE)as a strategy for blood preservation in a patient with a large low rectal tumor with a high risk of bleeding,scheduled for *** SUMMARY A 56-year-old man presented to our institution with a one-year history of anal bleeding and rectal *** patient was diagnosed with bulky adenocarcinoma limited to the *** the patient refused any clinical treatment,surgery without previous neoadjuvant chemoradiation was *** patient underwent a tumor embolization procedure,two days before surgery performed via the right common femoral *** tumor was successfully devascularized and no major bleeding was noted during *** recovery was uneventful and a one-year follow-up showed no signs of *** Therapeutic tumor embolization may play a role in bloodless surgeries and increase surgical and oncologic *** describe a patient with a bulky low rectal tumor who successfully underwent preoperative embolization and bloodless abdominoperineal resection.

关键词： Rectal neoplasms Proctectomy Bloodless medical and surgical procedures Embolization,therapeutic Colorectal surgery Case report