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Microglia:a promising therapeutic target in spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 454-463页

作者： Xiaowei zha.guoli Zheng Thomas Skutella Karl Kiening Andreas Unterberg Alexander Younsi Department of Neurosurgery Heidelberg University HospitalHeidelbergGermany Department of Neuroanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal *** a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal *** this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor *** a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive *** review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.

关键词： astrocytes cytokines functional recovery immune regulation M1/M2 activation macrophages microglia neuroinflammation spinal cord injury therapy

糖尿病肾病模型:动物模型、二维细胞模拟及三维类器官模型

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中国组织工程研究 2025年第17期29卷 3632-3640页

作者：钱足平陈勇冉燕达静静查艳遵义医科大学贵州省遵义市563000 贵州省人民医院肾内科贵州省贵阳市550002

背景:近几年来,人类多能干细胞衍生的肾类器官及糖尿病肾病啮齿动物模型取得了一定的进展。然而,由于糖尿病肾病发病受环境因素及遗传因素共同作用,发病机制复杂,并且对于此类患者的临床治疗方法需要因人而异。因此,需要开发更灵活和综... 详细信息

背景:近几年来,人类多能干细胞衍生的肾类器官及糖尿病肾病啮齿动物模型取得了一定的进展。然而,由于糖尿病肾病发病受环境因素及遗传因素共同作用,发病机制复杂,并且对于此类患者的临床治疗方法需要因人而异。因此,需要开发更灵活和综合的方法,从而发现强有力的临床前证据,以支持对糖尿病肾病患者进行更有针对性的干预。目的:从动物模型、二维细胞培养模拟及三维类器官模型等方面综述了糖尿病肾病模型的研究进展,为进一步的研究提供线索和思路。方法:以“糖尿病,糖尿病肾病,糖尿病肾病模型,糖尿病肾病动物模型,类器官,肾脏类器官,糖尿病肾病细胞模型,糖尿病肾病病证结合动物模型”为中文检索词,“Diabetes,diabetic nephropathy,diabetic kidney diseases,diabetic nephropathy models,diabetic nephropathy animal models,organoids,diabetic and organoids,diabetic and kidney organoids,kidney organoids,diabetic nephropathy cell models,diabetic nephropathy syndrome combined animal models”为英文检索词,检索中国知网及PubMed数据库,最终纳入101篇文献进行综述分析。结果与结论:糖尿病肾病体内模型和体外模型是深入研究糖尿病肾病发病机制的有力工具。动物模型可以观察到多系统之间的相互作用;二维细胞培养操作简便且成本较低;新兴的肾类器官填补了二维和整体水平之间的空白,无种属差异且一定程度模拟了人肾脏的复杂性。随着类器官技术的不断发展,肾类器官有望为探索糖尿病肾病的发病机制、病理生理过程和药物筛选提供一个新的视角。

关键词：糖尿病肾病肾脏类器官糖尿病肾病类器官细胞模型动物模型中医病证结合糖尿病肾病模型工程化组织构建

Squeezing More Past Knowledge for Online Class-Incremental Continual Learning

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IEEE/CAA Journal of Automatica Sinica 2023年第3期10卷 722-736页

作者： da Yu Mingyi zha.g Mantian Li Fusheng zha Junge zha.g Lining Sun Kaiqi Huang the State Key Laboratory of Robotics and System Harbin Institute of Technology(HIT)Harbin 150080China Center for Research on Intelligent System and Engineering Institute of AutomationChinese Academy of Sciences(CASIA)Beijing 100190 School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Center for Research on Intelligent System and Engineering Institute of AutomationChinese Academy of Sciences(CASIA)Beijing 100190the School of Artificial IntelligenceUniversity of Chinese Academy of SciencesBeijing 100049 the CAS Center for Excellence in Brain Science and Intelligence Technology Shanghai 200031China IEEE

Continual learning(CL)studies the problem of learning to accumulate knowledge over time from a stream of data.A crucial challenge is that neural networks suffer from performance degradation on previously seen data,known as catastrophic forgetting,due to allowing parameter *** this work,we consider a more practical online class-incremental CL setting,where the model learns new samples in an online manner and may continuously experience new ***,prior knowledge is unavailable during training and *** works usually explore sample usages from a single dimension,which ignores a lot of valuable supervisory *** better tackle the setting,we propose a novel replay-based CL method,which leverages multi-level representations produced by the intermediate process of training samples for replay and strengthens supervision to consolidate previous ***,besides the previous raw samples,we store the corresponding logits and features in the ***,to imitate the prediction of the past model,we construct extra constraints by leveraging multi-level information stored in the *** the same number of samples for replay,our method can use more past knowledge to prevent *** conduct extensive evaluations on several popular CL datasets,and experiments show that our method consistently outperforms state-of-the-art methods with various sizes of episodic *** further provide a detailed analysis of these results and demonstrate that our method is more viable in practical scenarios.

关键词： Catastrophic forgetting class-incremental learning continual learning(CL) experience replay

Multi‐branch angle aware spatial temporal graph convolutional neural network for model‐based gait recognition

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IET Cyber-Systems and Robotics 2022年第2期4卷 97-106页

作者： Liyang Zheng Yuheng zha da Kong Hanqing Yang Yu zha.g College of Control Science and Engineering Zhejiang UniversityHangzhouChina

Model‐based gait recognition with skeleton data input has attracted more attention in recent *** model‐based gait recognition methods take skeletons constructed by body joints as input,which are invariant to changing carrying and clothing ***,previous methods limitedly model the skeleton information in either spatial or temporal domains and ignore the pose variety under different view angles,which results in poor performance for gait *** solve the above problems,we propose the Multi‐Branch Angle Aware Spatial Temporal graph Convolutional Neural Network to better depict the spatial‐temporal relationship while minimising the interference from the view *** model adopts the legacy Spatial Temporal graph Neural Network(ST‐gCN)as its backbone and relocates it to create independent ST‐gCN *** novel Angle Estimator module is designed to predict the skeletons'view angles,which enables the network robust to the changing *** balance the weights of different body parts and sequence frames,we build a Part‐Frame‐Importance module to redis-tribute *** experiments on the challenging CASIA‐B dataset have proved the efficacy of the proposed method,which achieves state‐of‐the‐art performance under different carrying and clothing conditions.

关键词： deep learning machine intelligence vision

The compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li Chengyan Wang Ke Chai Fanru Yuan Huijuan Zheng Yuxing Yao Chenlu Li Zu-Cheng Ye daijun zha Department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina Department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

geology and mineralization of the Dongping supergiant alkalic-hosted Au-Te deposit(>100 t Au)in Northern Hebei Province,China:A review

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China geology 2024年第3期7卷 533-550页

作者： Shi-min Zhen da-zhao Wang Zhong-jian zha Hai-jun Bai Jiang Wang Development and Research Center of China geological Survey Ministry of Natural ResourcesBeijing 100037China Technical guidance Center for Mineral Resources Exploration Ministry of Natural ResourcesBeijing 100037China State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China Institute of geological Surveying and Mapping Technology of Anhui Province Hefei 230022China Third geological Brigade of Hebei Bureau of geology and Mineral Resources Zhangjiakou 075000China Ulanqab Real Estate Registration Center Ulanqab 012099China

The Dongping deposit is the largest alkalic-hosted gold deposit in China containing>100 t of *** paper presents a new understanding for Dongping ore system,based on the previous *** mineralization originally occurred at 400-380 Ma,simultaneous with emplacement of the Shuiquangou alkaline complex,and was overprinted by the hydrothermal activity in the *** compositions of ores indicate metals of the deposit are mainly provided by the Shuiquangou ***-forming fluids are characterized by increasing oxygen fugacity and decreasing sulfur fugacity,while tellurium fugacity increased in the Stage II-2 and decreased in Stage *** systematic changes are closely related to the processes of mineral precipitation and fluid *** precipitation from Stage Ⅰ to Stage Ⅱ was triggered by fluid boiling,which leads to the precipitation of Pb-Bi-Te,due to decrement of sulfur *** of gas phase containing high concentration of H_2Te leads to precipitation of Te-Au-Ag minerals and native *** on these hypotheses,this paper present a polyphase metallogenic model as *** the Devonian,fluids were released from alkaline magmas,which carried ore-forming materials form the surrounding rocks and precipitate the early *** the Jurassic-Cretaceous,fluorine-rich fluids exsolved from highly factionated Shangshuiquan granite,which extracted and concentrated Au from the Shuiquangou complex and the Sanggan group metamorphic rocks,and finally formed the Dongping gold deposit.

关键词： Mineralization and alteration Alkaline intrusion Au deposit Physicochemical conditions Metallogenic model Oxygen fugacity Sulfur fugacity Mechanisms of mineral precipitation Fluid boiling Fluorine-enriched fluid Dongping gold deposit North China Craton Mineral exploration engineering

Neutrophil extracellular traps mediate the crosstalk between glioma progression and the tumor microenvironment via the HMgB1/RAgE/IL-8 axis

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Cancer Biology & Medicine 2020年第1期17卷 154-168页

作者： Caijun zha Xiangqi Meng Lulu Li Shan Mi da Qian Ziwei Li Pengfei Wu Shaoshan Hu Shihong zhao Jinquan Cai Yanhong Liu Department of Laboratory Diagnosis The Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086China Department of Neurosurgery The Second Affiliated Hospital of Harbin Medical UniversityHarbin 150086China Neuroscience Institute Heilongjiang Academy of Medical SciencesHarbin 150086China

Objective:Neutrophil extracellular traps(NETs)produced by tumor-infiltrating neutrophils(TINs)are associated with poor prognosis in patients with several types of ***,the mechanisms underlying the involvement of NETs in glioma progression remain largely *** study aimed to elucidate the roles of NETs in biological processes that drive the crosstalk between glioma progression and the tumor ***:Neutrophil infiltration and NETs formation were investigated in glioma tissue through immunohistochemistry,and their relationships with clinicopathological features and outcomes were statistically *** effects of NETs on glioma cell progression were studied in a co-culture *** vivo and in vitro experiments validated the reactive oxygen species activity and cytokine production of TINs,as well as the ERK signaling pathway activation and the metastasis of ***:Neutrophil infiltration and NETs formation were induced in high-grade glioma compared with low-grade *** induced by TINs were determined to be an oncogenic marker of high-grade gliomas and to be involved in cell proliferation and *** overproduction promoted glioma cell proliferation,migration,and ***,HMgB1 was found to bind to RAgE and activate the NF-κB signaling pathway in *** addition,NETs stimulated the NF-κB signaling pathway,thus promoting IL-8 secretion in ***,IL-8 recruited neutrophils which in turn mediated NETs formation via the PI3 K/AKT/ROS axis in ***:Our results suggest that NETs produced by TINs mediate the crosstalk between glioma progression and the tumor microenvironment by regulating the HMgB1/RAgE/IL-8 *** NETs formation or IL-8 secretion may be an effective approach to inhibit glioma progression.

关键词： Neutrophil extracellular traps HMgB1 IL-8 NF-κB glioma microenvironment

晋西黄土区不同植被恢复阶段土壤生态化学计量特征

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水土保持研究 2025年第1期32卷 30-38,47页

作者：高连炜张红丽查同刚北京林业大学水土保持学院北京100083 水利部水土保持监测中心北京100000

[目的]开展土壤生态化学计量特征随植被恢复进程的变化研究,探究植被恢复引起土壤养分变化规律及其作用机制,对认识植被恢复与土壤养分的关系,指导植被恢复实践具有重要意义。[方法]以晋西黄土区不同植被恢复阶段(撂荒地、草地、灌木林... 详细信息

[目的]开展土壤生态化学计量特征随植被恢复进程的变化研究,探究植被恢复引起土壤养分变化规律及其作用机制,对认识植被恢复与土壤养分的关系,指导植被恢复实践具有重要意义。[方法]以晋西黄土区不同植被恢复阶段(撂荒地、草地、灌木林、先锋阔叶林、针叶林)的5种林(草)地为研究对象,通过调查采样和室内分析,探究土壤生态化学计量特征随植被恢复的进程变化及其影响因素。[结果](1)随着植被的恢复,先锋阔叶林和针叶林阶段的SOC含量较上一阶段增加19.8%,土壤TN含量较上一阶段增加17.6%,而土壤TP含量较上一阶段减少12.4%;(2)随着植被恢复的发展,土壤C∶P和N∶P显著增加,C∶N的变化无明显规律,在先锋阔叶林和针叶林阶段的土壤C∶P较上一阶段增加26.6%;先锋阔叶林和针叶林阶段在0-40 cm土层的土壤N∶P较上一阶段增加40.2%,40-100 cm土层的土壤N∶P较上一阶段增加35.7%;土壤C∶N在不同植被恢复阶段间的变化未见明显规律,研究区土壤逐渐由C,N的限制转变为P的限制;(3)各植被恢复阶段土壤C∶P和N∶P主要与砂粒含量呈显著负相关,与孔隙度呈显著正相关,土壤C∶N与其他因子的相关性不明显。[结论]植被恢复有利于土壤C,N含量增加,改善土壤理化性质,在植被恢复过程应同时注重P元素的调控,以提高晋西黄土区植被生态恢复水平。

关键词：植被恢复土壤养分生态化学计量特征

Human pluripotent stem cell-derived kidney organoids:Current progress and challenges

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World Journal of Stem Cells 2024年第2期16卷 114-125页

作者： Hong-Yan Long Zu-Ping Qian Qin Lan Yong-Jie Xu Jing-Jing da Fu-Xun Yu Yan zha graduate School Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Laboratory Medicine Guizhou Provincial People’s HospitalGuiyang 550002Guizhou ProvinceChina Department of Nephrology Guizhou Provincial People’s HospitalGuiyang 550002Guizhou ProvinceChina Key Laboratory of Diagnosis and Treatment of Pulmonary Immune Diseases National Health CommissionGuizhou Provincial People’s HospitalGuiyang 550002Guizhou ProvinceChina

Human pluripotent stem cell(hPSC)-derived kidney organoids share similarities with the fetal ***,the current hPSC-derived kidney organoids have some limitations,including the inability to perform nephrogenesis and lack of a corticomedullary definition,uniform vascular system,and coordinated exit path-way for urinary ***,further studies are required to produce hPSC-derived kidney organoids that accurately mimic human kidneys to facilitate research on kidney development,regeneration,disease modeling,and drug *** this review,we discussed recent advances in the generation of hPSC-derived kidney organoids,how these organoids contribute to the understanding of human kidney development and research in disease ***,the limitations,future research focus,and applications of hPSC-derived kidney organoids were highlighted.

关键词： Kidney Organoids Human pluripotent stem cell Development Vascular system Disease modeling