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舒必利治疗精神分裂症37例

新药与临床 1987年第4期 205-207页

作者：江开达蔡庆旗王耀华上海医科大学精神医学教研室福建省泉州市第三医院四川省渡口市第三人民医院上海 200032

本文报道用舒必利治疗37例精神分裂症剂量为800-1400mg/d,疗程4-6wk。结果发现起病于中壮年,发病有精神或躯体诱因者疗效好;紧张型和偏执型患者的疗效非常显著优于其它型。本品有较强的抗幻党妄想和振奋作用,对激活性增高的治疗作用较差。

关键词：舒必利精神分裂症精神状态判断表精神病紧张型类偏狂病

Geometry of time-dependent PT-symmetric quantum mechanics

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Chinese Physics B 2021年第10期30卷 47-55页

作者： da-Jian Zhang qing-hai wang Jiangbin Gong Department of Physics Shandong UniversityJinan 250100China Department of Physics National University of Singapore117551Singapore

A new type of quantum theory known as time-dependent𝒫PT-symmetric quantum mechanics has received much attention *** has a conceptually intriguing feature of equipping the Hilbert space of a𝒫PT-symmetric system with a time-varying inner *** this work,we explore the geometry of time-dependent𝒫𝒯PT-symmetric quantum *** find that a geometric phase can emerge naturally from the cyclic evolution of a PT-symmetric system,and further formulate a series of related differential-geometry concepts,including connection,curvature,parallel transport,metric tensor,and quantum geometric *** findings constitute a useful,perhaps indispensible,tool to investigate geometric properties of𝒫PT-symmetric systems with time-varying system’s *** exemplify the application of our findings,we show that the unconventional geometric phase[***.91187902(2003)],which is the sum of a geometric phase and a dynamical phase proportional to the geometric phase,can be expressed as a single geometric phase unveiled in this work.

关键词： time-dependent𝒫PT-symmetric quantum mechanics geometry time-varying inner product unconventional geometric phase

Complexity analysis of precipitation in changing environment in Chien River Basin,China

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Water Science and Engineering 2011年第2期4卷 133-142页

作者： qing-hua LUAN Hao wang da-zhong XIA College of Water Conservancy and Hydropower Hebei University of Engineering Handan 056021 P. R. China Department of Water Resources China htstitute of Water Resources and Hydropower Research Beijing 100038 P. R. China College of Hydrology and Water Resources Hohai University Nanjing 210098 P. R. China

The hydrological processes influenced by the multiple factors of climate, geography, vegetation, and human activities are becoming more and more complex, which is an important characteristic of hydrological systems. The different complexity distributions of precipitation processes of the Chien River Basin （a sub-basin of the Minjiang Basin） in two periods （from 1952 to 1980, and from 1981 to 2009） are illustrated using the fractal based on the continuous wavelet transform （CWT）. The results show that （1） at the basin scale the precipitation process in the latter period is more complex than in the former period; （2） the maximum value of the complexity distribution moved from the east to the middle; and （3） through analysis of the time-information and space-information concealed in this complexity change, the precipitation characteristics in the changing environment in the basin can be illuminated. This study could provide a reference for research on disaster pre-warning in changing environments and for integrated water resources management in the local basin.

关键词： characteristic analysis precipitation complexity continuous wavelet transform fractal: Chien River Basin

Frequency dependence of magnetization and giant magneto impedance effect of amorphous wires

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International Journal of Minerals,Metallurgy and Materials 2013年第4期20卷 375-378页

作者： Shu-ling Zhang Jian-fei Sun da-wei Xing da-qing Fang Lu-cai wang School of Materials Science and Engineering Taiyuan University of Science and Technology School of Materials Science and Engineering Harbin Institute of Technology

The frequency dependence of magnetization process and giant magneto impedance （GMI） effect of Co-rich melt-extracted amorphous wires was studied by Kerr effect and impedance analyzer, respectively. It is demonstrated that the transverse Kerr intensity and the corresponding GMI response increase with increasing frequency, which contributes to the upgraded skin effect. However, the skin depth has a slothful trend with frequency when it is up to the megahertz range, which gives rise to the transformation of magnetization. The process is much more sensitive to the direct current magnetic field and the sensitive change of the circular permeability, and GMI response is observed as its consequence. This proves that the evolution of circumferential magnetization and the corresponding permeability with the direct current magnetic field is the essence of GMI response, and a much more sensitive magnetization promises a better GMI response.

关键词： amorphous wires magnetization giant magneto impedance Kerr magneto-optical effect melt extraction

灯盏花素对大鼠实验性脑缺血再灌注损伤的保护作用

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中华老年心脑血管病杂志 2017年第7期19卷 749-754页

作者：郝丕达吴庆建王松梅杨明峰孙保亮单县东大医院神经内科菏泽274300 济宁市第一人民医院急诊科泰山医学院

目的探讨灯盏花素对大鼠局灶性脑缺血再灌注性损伤的保护作用及机制。方法选择健康成年雄性SD大鼠40只,随机分为4组:假手术组;生理盐水组:生理盐水+大脑中动脉栓塞;硫酸镁组:硫酸镁+大脑中动脉栓塞;灯盏花素组:灯盏花素75mg/kg+大脑中... 详细信息

目的探讨灯盏花素对大鼠局灶性脑缺血再灌注性损伤的保护作用及机制。方法选择健康成年雄性SD大鼠40只,随机分为4组:假手术组;生理盐水组:生理盐水+大脑中动脉栓塞;硫酸镁组:硫酸镁+大脑中动脉栓塞;灯盏花素组:灯盏花素75mg/kg+大脑中动脉栓塞,每组10只。3、7、14d采用Longa评分、圆筒实验对各组大鼠进行神经功能评分;TTC染色测量脑梗死体积比以及干湿称重法测量脑组织含水量;免疫荧光染色法检测缺血脑组织半胱氨酸天冬氨酸蛋白酶3(caspase-3)阳性细胞表达。结果灯盏花素组大鼠3、7d神经功能评分脑组织含水量明显低于生理盐水组和硫酸镁组,3、7、14d脑梗死体积百分比和caspase-3阳性细胞表达明显低于生理盐水组和硫酸镁组,差异有统计学意义(P<0.05)。灯盏花素组3、7、14d圆筒实验前肢使用不对称性改善明显优于生理盐水组和硫酸镁组[(37.60±6.54)分vs(60.28±7.26)分、(58.56±5.61)分,(12.64±2.67)分vs(52.67±2.86)分、(39.63±5.06)分,(7.62±5.30)分vs(30.33±2.16)分、(30.73±5.64)分,P<0.05]。结论灯盏花素注射液可显著减少缺血再灌注脑损伤体积,减轻脑水肿,抑制caspase-3表达,显著改善脑缺血后神经功能损伤。

关键词：脑缺血再灌注损伤梗死,大脑中动脉蛋白激酶C 灯盏细辛半胱氨酸天冬氨酸蛋白酶3

Polyethylenimine-cyclodextrin-tegafur conjugate shows anti-cancer activity and a potential for gene delivery

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第9期12卷 720-729页

作者： Qi-da HU Hui FAN Wei-jian LOU qing-qing wang Gu-ping TANG Institute of Chemical Biology and Pharmaceutical Chemistry Zhejiang UniversityHangzhou 310028China Department of Pharmacy Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016China Institute of Immunology Zhejiang UniversityHangzhou 310058China The First Affiliated Hospital School of MedicineZhejiang UniversityHangzhou 310003China

Polyethylenimine-cyclodextrin-tegafur(PEI-CyD-tegafur) conjugate was synthesized as a novel multifunctional prodrug of tegafur for co-delivery of chemotherapeutic agent tegafur and enhanced green fluorescent protein(EGFP) reporter plasmid *** of tegafur to PEI-CyD via chemical linkage was characterized by 1 H NMR spectrometry and ultraviolet(UV) ***-CyD-tegafur was able to condense plasmid DNA into complexes of around 150 nm with positive charge at the N/P ratio of 25,in accordance with electron microscopy observation of compact and monodisperse *** results of in vitro experiments showed enhanced cytotoxicity and considerable transfection efficiency in B16F10 cell ***,PEI-CyD-tegafur may have great potential as a co-delivery system with anti-cancer activity and potential for gene delivery.

关键词： Polyethylenimine β-Cyclodextrin Tegafur Co-delivery Gene therapy

Effect of atmosphere and basicity on softening-melting behavior of primary slag formation in cohesive zone

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Journal of Iron and Steel Research International 2023年第2期30卷 227-235页

作者： Bin-bin Lyu Guang wang Lian-da Zhao Hai-bin Zuo qing-guo Xue Jing-song wang State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing100083China

The softening-melting characteristics of ferrous burden play a crucial role in the thickness and position of the cohesive *** influence of the basicity and experimental atmosphere on the softening-melting behavior of primary slag under slag-coke interaction was investigated using in situ visualization *** mechanism was analyzed using the FactSage software,X-ray diffraction,and electron probe *** softening and melting temperatures of the samples increased with increasing basicity under different *** difference between softening and melting temperatures is smaller in a H_(2) atmosphere than in a CO atmosphere;in H_(2) atmosphere,the range of softening zone in the cohesive zone was significantly *** formed low-melting-point FeO-bearing phases decrease when H_(2) was used as the reducing *** addition,according to FactSage calculations,the high content of metallic iron reduced in the H_(2) atmosphere raised the softening temperature of the primary *** also narrowed and moved downward the cohesive zone due to an increase in softening and melting ***,the increase in basicity promoted the decrease in liquid ratio and improved the permeability of cohesive zone.

关键词： Primary slag Cohesive zone Softening-melting behavior Coke bed Interface characteristic

Application value of biofluid-based biomarkers for the diagnosis and treatment of spinal cord injury

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Neural Regeneration Research 2022年第5期17卷 963-971页

作者： Hong-da wang Zhi-Jian Wei Jun-Jin Li Shi-qing Feng Department of Orthopedics Tianjin Medical University General HospitalTianjinChina International Science and Technology Cooperation Base of Spinal Cord Injury Tianjin Key Laboratory of Spine and Spinal CordTianjin Medical University General HospitalTianjinChina Department of Orthopedics Qilu HospitalCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Shandong University Center for Orthopedics Cheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina

Recent studies in patients with spinal cord injuries(SCIs)have confirmed the diagnostic potential of biofluid-based biomarkers,as a topic of increasing interest in relation to SCI diagnosis and *** paper reviews the research progress and application prospects of recently identified SCI-related *** structural proteins,such as glial fibrillary acidic protein,S100-β,ubiquitin carboxy-terminal hydrolase-L1,neurofilament light,and tau protein were correlated with the diagnosis,American Spinal Injury Association Impairment Scale,and prognosis of SCI to different *** factors,including interleukin-6,interleukin-8,and tumor necrosis factorα,are also good biomarkers for the diagnosis of acute and chronic SCI,while non-coding RNAs(micro RNAs and long non-coding RNAs)also show diagnostic potential for *** elements(Mg,Se,Cu,Zn)have been shown to be related to motor recovery and can predict motor function after SCI,while humoral markers can reflect the pathophysiological changes after *** factors have the advantages of low cost,convenient sampling,and ease of dynamic tracking,but are also associated with disadvantages,including diverse influencing factors and complex level *** various proteins have been verified as potential biomarkers for SCI,more convincing evidence from large clinical and prospective studies is thus required to identify the most valuable diagnostic and prognostic biomarkers for SCI.

关键词： biomarker diagnosis inflammatory cytokine motor recovery non-coding RNA prognosis spinal cord injury structural protein trace element

Reliability of DC-link capacitor in pulsed power supply for accelerator magnet

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Nuclear Science and Techniques 2024年第9期35卷 28-40页

作者： Jie wang da-qing Gao Wan-Zeng Shen Hong-Bin Yan Li-Jun Mao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology Lanzhou UniversityLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China

Capacitors are widely used in pulsed magnet power supplies to reduce ripple voltage,store energy,and decrease power *** this study,DC-link capacitors in pulsed power supplies were *** deriving an analytical method for the capacitor current on the H-bridge topology side,the root-mean-square value of the capacitor current was calculated,which helps in selecting the DC-link *** proposed method solves this problem quickly and with high *** current reconstruction of the DC-link capacitor is proposed to avoid structural damage in the capacitor’s current measurement,and the capacitor’s hotspot temperature and temperature rise are calculated using the FFT *** test results showed that the error between the calculated and measured temperature increases was within 1.5℃.Finally,the lifetime of DC-link capacitors was predicted based on Monte Carlo *** proposed method can evaluate the reliability of DC-link capacitors in a non-isolated switching pulsed power supply for accelerators and is also applicable to film capacitors.

关键词： Aluminum electrolytic capacitor DC-link current DC–DC power converter Hotspot temperature