检索结果-南通市图书馆

特级教师专业核心素养的现状、特点与启示——基于江西省特级教师的调查分析

在线全文

学校读者我要写书评

暂无评论

课程．教材．教法 2024年第3期44卷 140-146页

作者：何齐宗范维江西省高校人文社会科学重点研究基地江西师范大学教师教育研究中心南昌330022 江西师范大学教育学院南昌330022

专业核心素养是衡量特级教师综合素质的重要指标,并对其教育教学质量具有重要影响。通过对江西省218位特级教师的调查发现,特级教师专业核心素养总体处于优秀水平,不同性别、不同年龄、不同教龄、不同学历、任教不同课程与学段,以及是... 详细信息

专业核心素养是衡量特级教师综合素质的重要指标,并对其教育教学质量具有重要影响。通过对江西省218位特级教师的调查发现,特级教师专业核心素养总体处于优秀水平,不同性别、不同年龄、不同教龄、不同学历、任教不同课程与学段,以及是否担任班主任的特级教师在专业核心素养水平上存在差异。特级教师专业核心素养的特点主要体现在:追求平衡发展,专业素养全面;加强品格涵养,提升精神境界;重视文献阅读,知识广博深厚;持续改进教学,教学能力突出;积极投入科研,主动自我反思。特级教师专业核心素养的发展给我们以重要启示:一是内外结合,充分发挥特级教师的示范和引领作用;二是整体强化,全面提升教师的专业核心素养;三是上下联动,为教师的专业发展创设良好的条件。

关键词：特级教师专业核心素养教师发展

Synthesis of Inorganic Silica Grafted Three-arm PLLA and Their Behaviors for PLA Matrix

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2019年第3期37卷 216-226页

作者： da-wei Shi Xiang-Ling Lai Yuan-Ping Jiang Cong Yan Zheng-Ying Liu wei Yang Ming-Bo Yang State Key Laboratory of Polymer Materials Engineering College of Polymer Science and Engineering Sichuan University

The low melt strength and poor crystallization behavior severely limit the processing and application of poly(lactic acid)(PLA) as biodegradable film materials. In this work, three-arm poly(L-lactic acid)(3A-PLLA) grafted silica nanoparticles with two kinds of topology structures were introduced into PLA matrix to improve the biodegradation performance. Different methods were used to characterize the structure of the grafted 3A-PLLA chains, the grafting density, and the thermal decomposition behavior of the nanoparticles. By varying the mass ratios of raw materials and altering the order of dropping solution in the reaction, high grafting densitytangled 3A-PLLA grafted SiO_2 was synthesized as "3A-PLLA grafting to SiO_2"(GTS), while low grafting density-stretched 3A-PLLA grafted SiO_2 was obtained as "SiO_2 grafting to 3A-PLLA"(GTA). Topology of nanoparticles as well as the filler-matrix interaction is critically important to structure bio-nanocomposites with desirable properties. Thus, the GTS and GTA nanoparticles were introduced into PLA matrix to assess the effect. The SEM images showed the uniform dispersion of the modified nanoparticles, while the shear rheology results revealed that GTA nanoparticles made a more significant contribution on the melt-strengthening and relaxation time-extension of PLA. Moreover, it is suggested that GTA nanoparticles were more effective to act as a nucleating agent for PLA, which was proved by differential scanning calorimetry(DSC) and polarized optical microscopy(POM) researches. All of the improvements mentioned above of GTA nanocomposites can be ascribed to stronger entanglements between 3A-PLLA stretched by nano-SiO_2 and PLA matrix.

关键词： Poly(lactic acid) Nanocomposites Surface grafting Topology Crystallization

好氧颗粒污泥中硫酸化多糖的生成、提取及表征

在线全文

学校读者我要写书评

暂无评论

中国环境科学 2024年第6期44卷 3160-3166页

作者：魏子涵卢毅鹏高品东华大学环境科学与工程学院上海201620

以厌氧颗粒污泥作为接种污泥,在序批式活性污泥反应器(SBR)中驯化培养好氧颗粒污泥,通过好氧颗粒污泥胞外聚合物(EPS)提取和硫酸化多糖纯化方法的优化,探究好氧颗粒污泥SBR反应器中硫酸化多糖的生成变化.结果表明,好氧颗粒污泥SBR反应... 详细信息

以厌氧颗粒污泥作为接种污泥,在序批式活性污泥反应器(SBR)中驯化培养好氧颗粒污泥,通过好氧颗粒污泥胞外聚合物(EPS)提取和硫酸化多糖纯化方法的优化,探究好氧颗粒污泥SBR反应器中硫酸化多糖的生成变化.结果表明,好氧颗粒污泥SBR反应器运行效果稳定,对污水COD、NH_(4)^(+)-N、TN和TP的去除效果分别可达90%、97%、70%和93%以上.采用超声、水浴和碱处理的组合方法可有效地提取好氧颗粒污泥EPS和硫酸化多糖,经脱蛋白纯化后,硫酸化多糖可达56.6mg/g EPS,约为接种厌氧颗粒污泥中硫酸化多糖含量的1.4倍,表明好氧颗粒污泥有助于生成硫酸化多糖,为污水污泥有机质的高值转化和资源化提供了一种有效途径.

关键词：好氧颗粒污泥硫酸化多糖胞外聚合物污水资源化

在线全文

学校读者我要写书评

暂无评论

基于迁移学习的滚动轴承剩余使用寿命预测

哈尔滨工程大学学报 2024年第4期45卷 665-673页

作者：姜苗向阳魏建红武汉理工大学船海与能源动力工程学院湖北武汉430000 高性能船舶技术教育部重点实验室(武汉理工大学) 湖北武汉430000

为解决轴承剩余使用寿命预测模型预测泛化能力低,不能准确预测出未训练轴承剩余使用寿命的问题,本文提出了一种迁移轴承状态知识的剩余使用寿命的方法。利用计算时域、频域特征以及模糊熵作为预测特征,使用“3σ”准则将轴承全寿命过程... 详细信息

为解决轴承剩余使用寿命预测模型预测泛化能力低,不能准确预测出未训练轴承剩余使用寿命的问题,本文提出了一种迁移轴承状态知识的剩余使用寿命的方法。利用计算时域、频域特征以及模糊熵作为预测特征,使用“3σ”准则将轴承全寿命过程划分为正常阶段、退化阶段,以实现对退化阶段轴承剩余使用寿命的预测。构建基于门控循环单元的轴承剩余使用寿命预测模型,并使用某一轴承的全寿命周期数据进行训练,使模型学习到新轴承的状态信息。研究表明:相较于未使用迁移学习的方法,其预测所有轴承的轴承剩余使用寿命平均均方根误差减小了52.53%,平均百分比误差减少了68.87%。本文提出的方法可以有效、准确地预测出轴承的轴承剩余使用寿命。

关键词：门控循环单元剩余使用寿命预测滚动轴承迁移学习预训练模糊熵退化阶段特征融合

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

2023年乳腺癌临床研究进展年终盘点

中国普通外科杂志 2024年第5期33卷 669-682页

作者：郑薇刘强中山大学孙逸仙纪念医院乳腺肿瘤中心广东广州510120

乳腺癌作为全球发病例数第一的恶性肿瘤,多年来一直是研究的热点。2023年,乳腺癌临床研究在局部治疗和系统治疗方面取得显著进展。在局部治疗方面,如何评估腋窝肿瘤负荷及选择合适的治疗手段是研究焦点。SOUND研究发现前哨淋巴结活检(SL... 详细信息

乳腺癌作为全球发病例数第一的恶性肿瘤,多年来一直是研究的热点。2023年,乳腺癌临床研究在局部治疗和系统治疗方面取得显著进展。在局部治疗方面,如何评估腋窝肿瘤负荷及选择合适的治疗手段是研究焦点。SOUND研究发现前哨淋巴结活检(SLNB)与无腋窝手术对于术前腋窝超声淋巴结阴性早期乳腺癌患者的5年无远处转移生存率相似,在术前超声对腋窝淋巴结筛查结果明确的情况下可避免SLNB。SENOMAC研究提供证据支持低负荷前哨淋巴结患者不进行腋窝淋巴结清扫(ALND)的可能性。OPBC05研究指出新辅助治疗后残留孤立肿瘤细胞(ITCs)的患者中ALND不改善长期生存,暗示豁免ALND的可行性。NSABP B-51研究显示,新辅助化疗(NAC)后腋窝淋巴结阴性(ypN0)患者的局部淋巴结放疗(RNI)并未显著改善主要研究终点。这些研究强调了个体化治疗方案的重要性,为乳腺癌的外科治疗和后续治疗提供重要指导。在系统治疗方面,早期激素受体阳性[HR(+)]乳腺癌治疗主要依赖手术、放疗及术后辅助内分泌治疗,但约30%的中高危患者仍面临复发和转移风险。MoHER2narchE和NATALEE研究证实了CDK4/6抑制剂(CDK4/6i)在早期HR(+)/人表皮生长因子受体2阴性[HER-2(-)]乳腺癌患者中的效果。此外,有关免疫治疗的研究,如KEYNOTE-756和CheckMate 7FL试验,探讨了PD-1单抗联合NAC在提高病理完全缓解(pCR)率和降低高危患者复发风险中的潜力。晚期HR(+)乳腺癌的标准治疗已从单一内分泌治疗发展为CDK4/6i联合内分泌治疗,但仍存在耐药问题,新型药物如ADC药物、PI3K/Akt/mTOR抑制剂正在被探索以提供更多治疗选项。TROPiCS-02和TROPION-Breast01研究验证了TROP2靶向ADC药物在治疗耐药HR(+)/HER-2(-)晚期乳腺癌患者中的有效性。同时,INAVO 120和Capitello-291研究突显了PI3K/Akt/mTOR信号通路抑制剂在提高治疗效果方面的潜力,尤其是对PIK3CA突变患者。在早期HER-2(+)乳腺癌治疗方面,PHERGain研究表明,基于18F-FDG PET/CT和根据pCR调整的降阶梯化疗在早期HER-2(+)乳腺癌新辅助治疗中有效。APTneo研究发现阿替利珠单抗联合化疗对新辅助治疗的pCR率提升有限,需进一步研究以优化疗效和安全性。在晚期HER-2(+)乳腺癌方面,PHILA和HER2CLIMB-02研究展示了TKI药物在一线和二线治疗中的有效性。DESTINY-Breast系列研究证明了德曲妥珠单抗(T-DXd)对HER-2(+)转移性乳腺癌各年龄段患者都有效且展现出良好的安全性。同时其对经治/稳定和未经治/活动性脑转移患者均有显著的疗效。早期三阴性乳腺癌(TNBC)的研究重点在于免疫治疗与化疗的联合应用,KEYNOTE-522研究显示化疗联合帕博利珠单抗的新辅助治疗及其作为后续辅助治疗显著提高了pCR率和无事件生存率,美国食品药品管理局和欧洲药物管理局已批准其用于高危早期TNBC的治疗。然而,IMpassion030研究表明,术后辅助免疫治疗可能并非所有早期TNBC患者的有效选项。对于晚期TNBC,KEYLYNK-009研究结果显示帕博利珠单抗联合PARP抑制剂奥拉帕利与帕博利珠单抗加化疗相比,并未显著改善预后,但在具有tBRCA突变的患者群体中,该联合疗法显著提高了中位无进展生存期(PFS),表明其可作为这一患者群体的晚期一线维持治疗。BEGONIA研究的结果表明,dato-DXd和度伐利尤单抗联合治疗显示出高反应率和较长的PFS,可能为晚期TNBC患者提供新的治疗选择。综上,2023年乳腺癌治疗领域的研究不仅在治疗方法上取得了突破,也在治疗理念上进行了革新,为乳腺癌患者带来了新的希望。

关键词：乳腺肿瘤临床研究肿瘤负荷 ErbB受体抗肿瘤联合化疗方案

Broadband and fabrication-tolerant 3-dB couplers with topological valley edge modes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2024年第8期13卷 1623-1630页

作者： Guo-Jing Tang Xiao-Dong Chen Lu Sun Chao-Heng Guo Meng-Yu Li Zhong-Tao Tian Hou-Hong Chen Hong-wei Wang Qi-Yao Sun Ying-Di Pan Xin-Tao He Yi-Kai Su Jian-Wen Dong School of Physics&State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat-sen UniversityGuangzhou 510275China State Key Laboratory of Advanced Optical Communication Systems and Networks Department of Electronic EngineeringShanghai Jiao Tong UniversityShanghai 200240China

3-dB couplers,which are commonly used in photonic integrated circuits for on-chip information processing,precision measurement,and quantum computing,face challenges in achieving robust performance due to their limited 3-dB bandwidths and sensitivity to fabrication *** address this,we introduce topological physics to nanophotonics,developing a framework for topological 3-dB *** couplers exhibit broad working wavelength range and robustness against fabrication dimensional *** leveraging valley-Hall topology and mirror symmetry,the photonic-crystal-slab couplers achieve ideal 3-dB splitting characterized by a wavelength-insensitive scattering *** analysis confirms the superiority on broad bandwidth of 48 nm and robust splitting against dimensional errors of 20 *** further propose a topological interferometer for on-chip distance measurement,which also exhibits robustness against dimensional *** extension of topological principles to the fields of interferometers,may open up new possibilities for constructing robust wavelength division multiplexing,temperature-drift-insensitive sensing,and optical coherence tomography applications.

关键词： topological splitting insensitive

Treatment of a patient with severe cerebral malaria during the COVID-19 pandemic in China:A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第20期12卷 4419-4426页

作者： Yan-Fang Zhu Wen-Jing Xia wei Liu Ju-Min Xie Department of Critical Care Medicine Huangshi Hospital of TCM(Infectious Disease Hospital)Huangshi 435000Hubei ProvinceChina Hubei Key Laboratory of Renal Disease Occurrence and Intervention Medical SchoolHubei Polytechnic UniversityHuangshi 435003Hubei ProvinceChina

BACKGROUND On June 30,2021,China received certification from the World Health Organization for malaria ***,this certification does not signify the absence of malaria within *** to the increasing frequency of international exchanges and collaborations,the threat of imported malaria persists in ***,the prevention and control of imported malaria have become a primary focus for our country to maintain its malaria elimination *** SUMMARY Herein,we present a case report of a 53-year-old Chinese man who worked in Africa for nearly two *** was diagnosed with malaria in the Democratic Republic of the Congo between November 19 and November 23,*** receiving effective treatment with oral antimalarial drugs,his condition improved,allowing him to return to *** was later admitted to our hospital on January 12,2023,during the coronavirus disease 2019 pandemic in Huangshi,*** a thorough evaluation of the patient's symptoms,clinical signs,imaging and laboratory test results,and epidemiological data,he was rapidly diagnosed with severe cerebral *** patient underwent successful treatment through a series of intensive care unit *** The successful treatment of this imported case of severe cerebral malaria provides a valuable reference for managing patients with similar malaria infections and has significant clinical implications.

关键词： Pernicious malaria Severe cerebral malaria Imported patients Traditional Chinese medicine Angong niuhuang Pill Case report

EPSPS regulates cell elongation by disrupting the balance of lignin and flavonoid biosynthesis in cotton

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2024年第10期23卷 3437-3456页

作者： Qingdi Yan wei Hu Chenxu Gao Lan Yang Jiaxian Yang Renju Liu Masum Billah Yongjun Lin Ji Liu Pengfei Miao Zhaoen Yang Fuguang Li Wenqiang Qin State Key Laboratory of Cotton Bio‑breeding and Integrated Utilization/Institute of Cotton Research Chinese Academy ofAgricultural SciencesAnyang 455000China National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research Huazhong AgriculturalUniversityWuhan 430070China State Key Laboratory of Cotton Bio-breeding and Integrated Utilization/Zhengzhou University Zhengzhou 450066China National Nanfan Research Institute(Sanya) Chinese Academy of Agricultural SciencesSanya 572025China

EPSPS is a key gene in the shikimic acid synthesis pathway that has been widely used in breeding crops with herbicide ***,its role in regulating cell elongation is poorly *** the overexpression of EPSPS genes,we generated lines resistant to glyphosate that exhibit an unexpected dwarf phenotype.A representative line,DHR1,exhibits a stable dwarf phenotype throughout its entire growth *** for plant height,the other agronomic traits of DHR1 are similar to its transgenic explants *** section observations showed that DHR1 internodes are shortened due to reduced elongation and division of the internode *** hormones confirmed that DHR1 is not a classical brassinolide(BR)-or gibberellin(GA)-related dwarfing *** analysis and fine mapping confirmed that the EPSPS gene is the causal gene for dwarfism,and the phenotype can be inherited in different *** and metabolome analyses showed that genes associated with the phenylpropanoid synthesis pathway are enriched in DHR1 compared with *** metabolites are enriched in DHR1,whereas lignin metabolites are *** enhancement of flavonoids likely results in differential expression of auxin signal pathway genes and alters the auxin response,subsequently affecting cell *** study provides a new strategy for generating dwarfs and will accelerate advancements in light simplification in the cultivation and mechanized harvesting of cotton.

关键词： EPSPS cotton T-DNA dwarfism herbicide resistance

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

海德格尔虚无主义批判思想的学理透视

江西社会科学 2024年第3期44卷 5-13,206页

作者：王平龚玮同济大学马克思主义学院上海200092

海德格尔是最早解析虚无主义产生根源的思想家之一。海德格尔非常犀利地指出,虚无主义是西方文明的内在法则,虚无主义要素隐含在作为西方文明基础的西方形而上学之中,随着西方文明的传播,虚无主义不断蔓延,人类终将陷入无根基状态,无家... 详细信息

海德格尔是最早解析虚无主义产生根源的思想家之一。海德格尔非常犀利地指出,虚无主义是西方文明的内在法则,虚无主义要素隐含在作为西方文明基础的西方形而上学之中,随着西方文明的传播,虚无主义不断蔓延,人类终将陷入无根基状态,无家可归最终将成为世界的命运。为了抗拒西方文明所带来的虚无主义后果,海德格尔主张返魅化运动,这种返魅化运动通过物之返魅、人之返魅、世界之返魅等维度展开。海德格尔的思考是苦心孤诣的,体现了一个大思想家悲天悯人的情怀,我们应该注意倾听海德格尔的声音。

关键词：海德格尔虚无主义形而上学无根状态返魅