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短时程脊髓电刺激与双极脉冲射频治疗带状疱疹后神经痛的临床研究

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中国疼痛医学杂志 2024年第9期30卷 664-670页

作者：陈嘉芳何龙林鹏莫海兵谢恬庄国雄林章雅江昊福建医科大学附属第一医院疼痛科福州350000 福建医科大学附属第一医院神经外科福州350000 福建医科大学附属第一医院滨海院区国家区域医疗中心福州350212 福建医科大学神经外科研究所福州350005 福建医科大学附属第一医院闽南医院麻醉科泉州362801

目的:比较短时程脊髓电刺激(short-term spinal cord stimulation,stSCS)和双极脉冲射频(bipolar pulse radiofrequency,bPRF)治疗带状疱疹后神经痛(postherpetic neuralgia,PHN)的临床疗效。方法:选取2021年9月至2022年12月福建医科大学附属第一医院收治的108例PHN病人为研究对象,按手术方式分为st SCS组(40例)和b PRF组(68例)。采用视觉模拟评分法(visual analogue scale,VAS)、匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)、焦虑自评量表(self-rating anxiety scale,SAS)和抑郁自评量表(self-rating depression scale,SDS)等指标评估临床疗效。结果:两组病人术后各时间点VAS、PSQI、SAS和SDS评分均较术前(T0)显著降低(P<0.05)。术后6个月(T7)、9个月(T8)、12个月(T9)时st SCS组VAS评分显著低于b PRF组(P<0.05),术后1天(T1)、7天(T2)、14天(T3)、28天(T4)、2个月(T5)、3个月(T6)两组VAS评分无显著差异;T8和T9时st SCS组病人PSQI、SAS和SDS评分显著低于b PRF组(P<0.05),但T1至T7时,这些评分两组之间差异无统计学意义。结论:st SCS组和b PRF组在近期疗效上相当,均可安全有效地治疗PHN。在远期疗效上st SCS组显示出更明显的优势。

关键词：带状疱疹后神经痛短时程脊髓电刺激双极脉冲射频临床疗效

Impacts of Nutlin-3a and exercise on murine double minute 2-enriched glioma treatment

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Neural Regeneration Research 2025年第4期20卷 1135-1152页

作者： Yisheng Chen Zhongcheng Fan Zhiwen Luo Xueran Kang Renwen Wan Fangqi Li Weiwei lin Zhihua Han Beijie Qi Jinrong lin Yaying Sun Jiebin Huang Yuzhen Xu Shiyi Chen Department of Sport Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Orthopedic Surgery Hainan Province Clinical Medical CenterHaikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikouHainan ProvinceChina Department of Basic Medicine Shanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Orthopedics Shanghai General HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina

Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural *** role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of *** used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other *** demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by *** underscores the intricate relationship between natural compounds such as nutlin-3 and immune *** comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma *** also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic ***-3a inhibited glioma cell proliferation and activated the p53 *** efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or *** using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway ***,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing *** results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma *** research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.

关键词： exercise and SUMO-related gene signatures(ESLRS) glioblastoma management low-grade glioma natural bioactives neural regeneration physical exercise

Interdecadal variability of summer precipitation in the Three River Source Region: Influences of SST and zonal shifts of the East Asian subtropical westerly jet

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Atmospheric and Oceanic Science Letters 2024年第5期17卷 47-53页

作者： Yumeng Liu Xianhong Meng lin Zhao S-Y.Simon Wang Lixia Zhang Zhaoguo Li Chan Wang Yingying An Key Laboratory of Cryospheric Science and Frozen Soil Engineering Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouChina Zoige Plateau Wetlands Ecosystem Research Station Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhouChina University of Chinese Academy of Sciences BeijingChina Utah Climate Center Utah State UniversityLoganUSA The State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina

Summer precipitation in the Three Rivers Source Region(TRSR)of China is vital for the headwaters of the Yellow,Yangtze,and Lancang rivers and exhibits significant interdecadal *** study investigates the influence of the East Asian westerly jet(EAWJ)on TRSR rainfall.A strong correlation is found between TRSR summer precipitation and the Jet Zonal Position Index(JZPI)of the EAWJ from 1961 to 2019(R=0.619,phen a positive JZPI indicates a westward shift in the EAWJ,enhanced water vapor anomalies,warmer air,and low-level convergence anomalies contribute to increased TRSR summer *** empirical orthogonal function and regression analyses,this research identifies the influence of large-scale circulation anomalies associated with the Atlantic–Eurasian teleconnection(AEA)from the North Atlantic(NA).The interdecadal variability between the NA and central tropical Pacific(CTP)significantly affects TRSR *** influence is mediated through the AEA via a Rossby wave train extending eastward along the EAWJ,and another south of 45°***,the NA–CTP Opposite Phase Index(OPI),which quantifies the difference between the summer mean sea surface temperatures of the NA and the CTP,is identified as a critical factor in modulating the strength of this teleconnection and influencing the zonal position of the EAWJ.

关键词： Summer precipitation East Asian subtropical westerly jet Three River Source Region Atlantic-Eurasian teleconnection

Ultrasomics in liver cancer: Developing a radiomics model for differentiating intrahepatic cholangiocarcinoma from hepatocellular carcinoma using contrast-enhanced ultrasound

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World Journal of Radiology 2024年第7期16卷 247-255页

作者： Li-Ya Su Ming Xu Yan-lin Chen Man-Xia lin Xiao-Yan Xie Department of Medical Ultrasound The First Affiliated HospitalInstitute of Diagnostic and Interventional UltrasoundSun Yat-Sen UniversityGuangzhou 510000Guangdong ProvinceChina

BACKGROUND hepatocellular carcinoma(HCC)and intrahepatic cholangiocarcinoma(ICC)represent the predominant histological types of primary liver cancer,comprising over 99%of *** their differing biological behaviors,prognoses,and treatment strategies,accurately differentiating between HCC and ICC is crucial for effective clinical ***,an emerging image processing technology,can automatically extract various quantitative image features that may elude the human *** on the application of ultrasound(US)-based radiomics methods in distinguishing HCC from ICC are *** In our retrospective study,we included a total of 280 patients who were diagnosed with ICC(n=140)and HCC(n=140)between 1999 and *** patients were divided into training(n=224)and testing(n=56)groups for *** images and relevant clinical characteristics were *** utilized the XGBoost method to extract and select radiomics features and further employed a random forest algorithm to establish ultrasomics *** compared the diagnostic performances of these ultrasomics models with that of *** Four distinct ultrasomics models were constructed,with the number of selected features varying between models:13 features for the US model;15 for the contrast-enhanced ultrasound(CEUS)model;13 for the combined US+CEUS model;and 21 for the US+CEUS+clinical data *** US+CEUS+clinical data model yielded the highest area under the receiver operating characteristic curve(AUC)among all models,achieving an AUC of 0.973 in the validation cohort and 0.971 in the test *** performance exceeded even the most experienced radiologist(AUC=0.964).The AUC for the US+CEUS model(training cohort AUC=0.964,test cohort AUC=0.955)was significantly higher than that of the US model alone(training cohort AUC=0.822,test cohort AUC=0.816).This finding underscored the significant benefit of incorporating CEUS information in accurately distin-guishing ICC from HC

关键词： Cholangiocarcinoma hepatocellular carcinoma Contrast-enhanced ultrasound Radiomics Primary liver tumor

Plant growth and metabolism of exotic and native Crotalaria species for mine land rehabilitation in the Amazon

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Journal of Forestry Research 2024年第1期35卷 143-154页

作者： hemelyn Soares das Chagas Rafael Silva Guedes Markus Gastauer Paula Godinho Ribeiro Allan Klynger da Silva Lobato Cecílio Frois Caldeira Fabrício William deÁvila AndréRodrigues dos Reis Silvio Junio Ramos Instituto Tecnológico Vale Rua Boaventura da Silva955BelémPA 66055-090Brazil Universidade Federal do Sul e Sudeste do Pará XinguaraPABrazil Núcleo de Pesquisa Vegetal Básica e Aplicada Universidade Federal Rural da AmazôniaParagominasPABrazil Departamento de Engenharia Florestal Universidade Estadual do Centro-Oeste/UNICENTROIratiPRBrazil School of Sciences and Engineering São Paulo State University(UNESP)TupãSP.CEP 17602-496Brazil

Despite its enormous benefits,mining is respon-sible for intense changes to vegetation and soil ***,after extraction,it is necessary to rehabilitate the mined areas,creating better conditions for the establishment of plant species which is *** study evaluated mineral and organic fertilization on the growth,and carbon and nitrogen(N)metabolism of two Crotalaria species[Cro-talaria spectabilis(exotic species)and Crotalaria maypu-rensis(native species from Carajás Mineral Province(CMP)]established on a waste pile from an iron mine in CMP.A control(without fertilizer application)and six fertilization mixtures were tested(i=NPK;ii=NPK+micronutrients;iii=NPK+micronutrients+organic compost;iv=PK;v=PK+micronutrients;vi=PK+micronutrients+organic compost).Fertilization contributed to increased growth of both species,and treatments with NPK and micronutrients had the best results(up to 257%***),while organic fertilization did not show *** Crotalaria had a greater number of nodules,higher nodule dry mass,chlorophyll a and b contents and showed free ammonium as the predominant N form,reflecting greater increments in biomass compared to native *** having lower growth,the use of this native species in the rehabilitation of mining areas should be considered,mainly because it has good development and meets current government legislation as an opportunity to restore local biodiversity.

关键词： Biological nitrogen fixation Mining Nitrogen metabolism Plant nutrition

Toluene Processed All-Polymer Solar Cells with 18% Efficiency and Enhanced Stability Enabled by Solid Additive:Comparison Between Sequential-Processing and Blend-Casting

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Energy & Environmental Materials 2024年第4期7卷 247-254页

作者： Guoping Zhang Chaoyue Zhao Liangxiang Zhu Lihong Wang Wenzhao Xiong Huawei Hu Qing Bai Yaping Wang Chen Xie Peng You he Yan dan Wu Tao Yang Mingxia Qiu Shunpu Li Guangye Zhang College of New Materials and New Energies Shenzhen Technology University Department of Chemistry and Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction The Hong Kong University of Science and Technology State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Center for Advanced Low-dimension Materials College of Materials Science and Engineering Donghua University Julong College Shenzhen Technology University

The emergence of polymerized small molecule acceptors (PSMAs) has significantly improved the performance of all-polymer solar cells (all-PSCs).However,the pace of device engineering lacks behind that of materials deve... 详细信息

关键词： all-polymers solar cells sequential processing solid additive

The genomic and immunogenomic landscape of mechanics pathway informs clinical prognosis and response to mechanotherapy

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Science China(Life Sciences) 2024年第8期67卷 1549-1562页

作者： Peidong Zhang Peiwei Li Muya Tang Ryan CGimple Liang Huang Jing Yue Qiuhong Shen Yiwei Du Qian Zhang Zhengnan Yang Haihuai he Kailin Yang linjie Zhao Shengtao Zhou Department of Obstetrics and Gynecology Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOEState Key Laboratory of BiotherapyWest China Second HospitalSichuan University and Collaborative Innovation CenterChengdu 610041China Physician Scientist Training Program Department of MedicineWashington University School of MedicineSt.Louis 63110USA Department of Neurosurgery State Key Laboratory of BiotherapyWest China HospitalSichuan University and Collaborative Innovation CenterChengdu 610041China Department of Radiation Oncology Taussig Cancer CenterCleveland ClinicCleveland 44106USA

Mechanics shape cell and tissue plasticity and maintain their *** cancers,mechanical signals regulate cancer hallmarks via mechanotransduction pathways,such as proliferation,metastasis and metabolic ***,comprehensive characterization of mechanotransduction pathway genes and their clinical relevance across different cancer types remains ***,we systematically portrayed the alterations of mechanotransduction pathway genes across 31 cancer types using The Cancer Genome Atlas(TCGA)*** the cancer types could be categorized into 6 subtypes based upon the transcriptional pattern of mechanics pathway *** subtype has its own unique molecular expression pattern,mutation landscapes,immune infiltrates,and patient clinical *** further found that the responses of two subtypes of cancers,one with the optimal outcome and the other with the worst prognosis,to a classical mechanotherapeutic agent(Fasudil,RhoA/ROCK inhibitor)were totally different,indicating that our cancer stratification system based upon mechanotransduction pathway genes could inform clinical responses of patients to mechanotherapeutic ***,our study provides a novel pan-cancer landscape of the mechanotransduction pathways and underscores its potential clinical significance in the prediction of clinical prognosis and therapeutic responses to mechanotherapy among cancer patients.

关键词： pan-cancer cancer mechanics multi-omics immunology

父母应对社会化如何影响儿童青少年适应:基于长时与实时时间轴的视角

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心理科学进展 2024年第8期32卷 1342-1353页

作者：何婷胡惠南乔璐杨靓靓李明英蔺秀云南京师范大学心理学院南京210097 北京师范大学心理学部北京100875 北京市海淀区花园路学区管理中心北京100080 重庆市秀山县东风路小学重庆409900

父母应对社会化是指父母向儿童青少年提供认知、情感和行为策略以应对压力的过程。实证研究从长时程发展时间轴、具体情境下的实时时间轴及不同时间轴的结合等角度探讨父母应对社会化的作用,揭示了父母应对社会化对于儿童青少年适应的... 详细信息

父母应对社会化是指父母向儿童青少年提供认知、情感和行为策略以应对压力的过程。实证研究从长时程发展时间轴、具体情境下的实时时间轴及不同时间轴的结合等角度探讨父母应对社会化的作用,揭示了父母应对社会化对于儿童青少年适应的独特效应。对于其中的心理机制,应对社会化过程理论模型探讨了儿童青少年应对过程在父母应对社会化与儿童青少年适应之间的中介作用,教养×压力放大和差异效应模型考察了应对社会化作用过程的边界条件。本研究将此两种模型进行整合,并基于动态系统视角提出应对社会化动态过程理论模型,从长时程发展时间轴和具体情境下的实时时间轴两个层面、儿童个体和亲子二元两个水平完善父母应对社会化对儿童青少年适应的作用机制。未来研究可进一步考察父母应对社会化作用效果的普遍性,深化探索父母应对社会化影响儿童青少年适应的机制,为父母应对社会化在家庭教育与临床干预领域的应用与推广提供科学依据。

关键词：父母应对社会化儿童青少年适应应对社会化动态过程理论模型长时程发展时间轴具体情境下实时时间轴

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Mechanism of inflammatory response and therapeutic effects of stem cells in ischemic stroke:current evidence and future perspectives

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Neural Regeneration Research 2025年第1期20卷 67-81页

作者： Yubo Wang Tingli Yuan Tianjie Lyu ling Zhang Meng Wang Zhiying he Yongjun Wang Zixiao Li Vascular Neurology Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Shanghai Engineering Research Center of Stem Cells Translational Medicine ShanghaiChina National Center for healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Institute for Regenerative Medicine Shanghai East HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghaiChina Chinese Institute for Brain Research BeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital healthcare for Neurological Diseases BeijingChina

Ischemic stroke is a leading cause of death and disability worldwide,with an increasing trend and tendency for onset at a younger ***,in particular,bears a high burden of stroke *** recent years,the inflammatory response after stroke has become a research hotspot:understanding the role of inflammatory response in tissue damage and repair following ischemic stroke is an important direction for its *** review summarizes several major cells involved in the inflammatory response following ischemic stroke,including microglia,neutrophils,monocytes,lymphocytes,and ***,we have also highlighted the recent progress in various treatments for ischemic stroke,particularly in the field of stem cell ***,understanding the complex interactions between inflammation and ischemic stroke can provide valuable insights for developing treatment strategies and improving patient *** cell therapy may potentially become an important component of ischemic stroke treatment.

关键词： cell therapy immune cell inflammatory ischemic stroke stem cell