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Nano Research 2024年第2期17卷 788-796页

作者： Yang Song Xiaoli Cai Mingming Wang dan Du Yuehe Lin chun-Long chen Department of Mechanical and Materials Engineering Washington State UniversityPullmanWA 99164USA Division of Physical Sciences Pacific Northwest National LaboratoryRichlandWA 99352USA Department of Chemical Engineering University of WashingtonSeattleWA 98195USA

Precisely controlled spatial distributions of artificial light-harvesting systems in aqueous media are of significant importance for mimicking natural light-harvesting systems;however,they are often restrained by the solubility and the aggregation-caused quenching effect of the hydrophobic ***,we report one highly efficient artificial light-harvesting system based on peptoid nanotubes that mimic the hierarchical cylindrical structure of natural *** high crystallinity of these nanotubes enabled the organization of arrays of donor chromophores with precisely controlled spatial distributions,favoring an efficient Förster resonance energy transfer(FRET)process in aqueous *** FRET system exhibits an extremely high efficiency of 98.6%with a fluorescence quantum yield of 40%and an antenna effect of *** further demonstrated the use of this artificial light-harvesting system for quantifying miR-210 within cancer *** fluorescence intensity ratio of donor to acceptor is linearly related to the concentration of intercellular miR-210 in the range of 3.3–156 copies/*** high sensitivity in intracellular detection of miR-210 using this artificial light-harvesting system offers a great opportunity and pathways for biological imaging and detection,and for the further creation of microRNA(miRNA)toolbox for quantitative epigenetics and personalized medicine.

关键词： light-harvesting peptoid nanotube Förster resonance energy transfer intracellular RNA detection

Quasi-two dimensional Ruddlesden−Popper halide perovskites for laser applications

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Frontiers of physics 2024年第2期19卷 53-71页

作者： Kun chen Qianpeng Zhang Yin Liang Jiepeng Song chun Li Shi chen Fang Li Qing Zhang School of Mechanical and Electrical Engineering Wuhan Institute of TechnologyWuhan 430205China School of Materials Science and Engineering Peking UniversityBeijing 100871China Institute of Applied Physics and Materials Engineering Macao UniversityMacao 999078China

Quasi-two-dimensional(2D)Ruddlesden‒Popper(RP)halide perovskites,as a kind of emerged two-dimensional layered materials,have recently achieved great attentions in lasing materials field owing to their large exciton binding energy,high emission yield,large optical gain,and wide-range tuning of optical *** review will introduce research progresses of RP halide perovskites for lasing applications in aspects of materials,photophysics,and devices with emphasis on emission and lasing properties tailored by the molecular composition and *** materials,structures and fabrications are introduced in the first ***,the optical transitions and amplified spontaneous emission properties are discussed from the aspects of electronic structure,exciton,gain dynamics,and interface ***,the research progresses on lasing devices are summarized and several types of lasers including VCSEL,DFB lasers,microlasers,random lasers,plasmonic lasers,and polariton lasers are *** last,the challenges and perspectives would be provided.

关键词： two-dimensional materials metal halide perovskite Ruddlesden−Popper halide perovskites lasing emission

Regulating ion transport behaviors toward dendrite-free potassium metal batteries:recent advances and perspectives

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Rare Metals 2024年第4期43卷 1435-1460页

作者： Lu-Kang Zhao Xuan-Wen Gao Tian-Zhen Ren da Wang da-Wei Wang Zhao-Meng Liu Hong chen Wen-Bin Luo School of Metallurgy Northeastern UniversityShenyang110819China School of Chemical Engineering The University of New South WalesSydneyNSW2052Australia

With abundant potassium resources and high capacity,potassium metal batteries(PMBs)present a compelling option for the next generation of energy storage ***,PMBs suffer from an unstable anode interface caused by uncontrolled dendrite growth,which results in unsatisfactory cyclability and safety *** investigations suggest that significant progress has been made in enhancing the interfacial stability of *** various effective strategies for stabilizing interfaces can ultimately be attributed to the regulation of the sluggish ion transfer kinetics and irregular deposition,i.e.,the arrangement of ion transport behaviors at the *** modulation of ions transport rate and ions deposition directions makes it possible to obtain a dendrite-free and smooth deposition ***,the influencing factors and action mechanism of K^(+)interface transport behaviors are discussed to understand the nature of material design for constructing stable anode interfaces,including regulating the solvation and desolvation structures,accelerating K^(+)transport kinetics and controlling K^(+)deposition *** addition,the deficiencies and prospects of the research on electrolyte,separators and designed electrode involved in the manufacturing and testing and ion transport process of PMBs are *** review is expected to provide some possible directions for constructing dendrite-free interfaces in advanced PMBs-related research and offer significant insights for prospective experimental research and commercial applications.

关键词： Ion transport rate Ion transport direction Interface Potassium metal batteries Dendrites growth

Elastic three-dimensional phononic topological insulators with Dirac hierarchy

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 54-62页

作者： Shao-Yong Huo Qiu-Shuang Yang Jiu-Jiu chen Hong-Kang Li Long-Chao Yao Fu-chun He chun-Ming Fu College of Mechanical Engineering University of South ChinaHengyang 421001China State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body College of Mechanical and Vehicle EngineeringHunan UniversityChangsha 410082China

Three-dimensional(3D)phononic topological insulators(TIs)featuring two-dimensional(2D)surface states and one-dimensional(1D)hinge states have opened up a new route for multi-dimensional robust wave transport,providing unprecedented methods for integrated acoustic sensors and energy harvesting ***,aiming at the elastic 3D phononic TI with gapless surface states and hinge states,the realization of elastic 3D phononic TIs with gapless surface states and hinge states is a significant challenge due to the complicated multi-mode polarization of elastic waves in 3D *** this study,we demonstrate an elastic 3D phononic TI with a Dirac hierarchy by elaborately operating the corresponding spatial symmetries of the chiral honeycomb ***,a 3D double Dirac cone of elastic wave can be achieved by doubling the lattice along the outof-plane direction to fold two iso-frequency Weyl *** topological phase transitions and 2D gapless two-fold Dirac surface states of elastic wave are realized by breaking the half-lattice spatial translation ***,based on the Brillouin zone folding along the in-plane direction,the 2D gapless two-fold surface Dirac cones are folded into four-fold surface Dirac ***,by inducing the relative radius of adjacent holes to break the in-plane spatial inversion symmetry,the fourfold surface Dirac cones are gapped and associated with a surface state inversion,in which the gapless 1D hinge Dirac dispersion is *** research offers a route for engineering the hierarchies of TIs in 3D elastic wave systems and provides new possibilities for designing 3D ultrasonic devices with unconventional functions.

关键词： Dirac topological hierarchy

Triterpenoids-templated self-assembly nanosystem for biomimetic delivery of CRISPR/Cas9 based on the synergy of TLR-2 and ICB to enhance HCC immunotherapy

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3205-3217页

作者： Bing-chen Zhang chun-Mei Lai Bang-Yue Luo Jing-Wei Shao Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy College of ChemistryFuzhou UniversityFuzhou 350116China Department of Laboratory Medicine Dongguan Institute of Clinical Cancer Researchthe Tenth Affiliated Hospital of Southern Medical University(Dongguan People’s Hospital)Dongguan 523058China College of Materials and Chemical Engineering MinjiangUniversityFuzhou350108China

Combination immunotherapy has shown promising potential for enhancing the objective response rate compared to immune checkpoint blockade(ICB)***,combination therapy with multi-drugs is limited by the different properties of the agents and inconsistent synergistic targeted ***,based on a universal triterpene template and the anticancer active agent ursolic acid(UA),a cytomembrane-coated biomimetic delivery nanoplatform(UR@M)prepared by the selfassembly of a PD-L1 targeted CRISPR/Cas9 system and UA was designed for hepatocellular carcinoma(HCC)***@M showed enhanced tumor accumulation in vivo with homologous tumor targeting,and CRISPR in the nanosystem exhibited potent gene-editing efficiency of 76.53% in vitro and 62.42% in vivo with no off-target *** activated the natural immune system through the TLR-2-MyD88-TRAF6 pathway,which synergistically enhanced the proliferation of natural killer cells and dendritic cells and realized excellent immune cytotoxic T cell infiltration by combining with the ICB of *** strategy of work along both lines based on innate immune and adaptive immunity displayed a significant effect in tumor ***,the UA-templated strategy“killed three birds with one stone”by establishing a self-assembly nanosystem,inducing tumor cell death,and promoting synergistic immunostimulation for HCC treatment.

关键词： Ursolic acid Self-assembly Biomimetic nanoplatform Hepatocellular carcinoma CRISPR/Cas9 Immune checkpoint blockade Gene therapy Immunotherapy

From Acupoints to Mylohyoid: Revealing the Neural Circuitry Basis of Electroacupuncture for Dysphagia

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Neuroscience Bulletin 2024年第1期40卷 139-142页

作者： Xiaoli da Xuhong Jiang Lihong Li Cenglin Xu Zhong chen Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical ScienceZhejiang Chinese Medical UniversityHangzhou 310053China Department of Neurology the First Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310003China Department of Acupuncture the Second Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou 310000China

Acupuncturea representative and historical treatment in traditional Chinese medicine(TCM),has been used to cure diseases for Chinese people in the past *** the late 1990s,acupuncture has been further accepted *** World Health Organization(WHO)proposed Clinical Research Specification for acupuncture in 1995 and the US Food and Drug Administration(Fda)approved acupuncture as a complementary and alternative therapy for various kinds of diseases in 1996,with clinical advantages such as convenience and effectiveness[1].Cumulative evidence has proved that acupuncture could produce different degrees of efficacy for treating various kinds of diseases(such as neuropathic pain,migraine,Parkinson's disease et al.)and alleviate symptoms[2-4].However,unlike its evidence-based efficacies.

关键词： medicine(TCM) acupuncture Acupuncture

SHEL:a semantically enhanced hardware-friendly entity linking method

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High Technology Letters 2024年第1期30卷 13-22页

作者：亓东林 chen Shudong DU Rong TONG da YU Yong Institute of Microelectronics of Chinese Academy of Sciences Beijing 100029P.R.China University of Chinese Academy of Sciences Beijing 100190P.R.China

With the help of pre-trained language models,the accuracy of the entity linking task has made great strides in recent ***,most models with excellent performance require fine-tuning on a large amount of training data using large pre-trained language models,which is a hardware threshold to accomplish this *** researchers have achieved competitive results with less training data through ingenious methods,such as utilizing information provided by the named entity recognition *** paper presents a novel semantic-enhancement-based entity linking approach,named semantically enhanced hardware-friendly entity linking(SHEL),which is designed to be hardware friendly and efficient while maintaining good ***,SHEL's semantic enhancement approach consists of three aspects:(1)semantic compression of entity descriptions using a text summarization model;(2)maximizing the capture of mention contexts using asymmetric heuristics;(3)calculating a fixed size mention representation through pooling *** series of semantic enhancement methods effectively improve the model's ability to capture semantic information while taking into account the hardware constraints,and significantly improve the model's convergence speed by more than 50%compared with the strong baseline model proposed in this *** terms of performance,SHEL is comparable to the previous method,with superior performance on six well-established datasets,even though SHEL is trained using a smaller pre-trained language model as the encoder.

关键词： entity linking(EL) pre-trained models knowledge graph text summarization semantic enhancement

Improving link prediction models through a performance enhancement scheme:a study on semi-supervised learning and model soup

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The Journal of China Universities of Posts and Telecommunications 2024年第4期31卷 43-53页

作者： Qi Donglin chen Shudong Du Rong Yu Yong Tong da Intelligent Manufacturing Electronics Research and Development Center Institute of Microelectronics of the Chinese Academy of SciencesBeijing 100029China School of Integrated Circuits University of Chinese Academy of SciencesBeijing 100049China

As an important method for knowledge graph(KG)complementation,link prediction has become a hot research topic in recent *** this paper,a performance enhancement scheme for link prediction models based on the idea of semi-supervised learning and model soup is proposed,which effectively improves the model performance on several mainstream link prediction models with small changes to their *** novel scheme consists of two main parts,one is predicting potential fact triples in the graph with semi-supervised learning strategies,the other is creatively combining semi-supervised learning and model soup to further improve the final model performance without adding significant computational *** validate the effectiveness of the scheme for a variety of link prediction models,especially on the dataset with dense *** terms of CompGCN,the model with the best overall performance among the tested models improves its Hits@1 metric by 14.7%on the FB15K-237 dataset and 7.8%on the WN18RR dataset after using the enhancement ***,it is observed that the semi-supervised learning strategy in the augmentation scheme has a significant improvement for multi-class link prediction models,and the performance improvement brought by the introduction of the model soup is related to the specific tested models,as the performances of some models are improved while others remain largely unaffected.

关键词： natural language processing knowledge graph(KG) link prediction model soup semi-supervised learning

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Distribution of per-and polyfluoroalkyl substances in blood,serum,and urine of patients with liver cancer and associations with liver function biomarkers

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Journal of Environmental Sciences 2024年第5期139卷 418-427页

作者： Cao dai Lin Peng Yanjie Li Zhendong Li da chen Fei Wang Nan Lin Department of Hepatobiliary Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China School of Environment Guangdong Key Laboratory of Environmental Pollution and HealthJinan UniversityGuangzhou 510632China State Key Laboratory of Environmental and Biological Analysis Department of ChemistryHong Kong Baptist UniversityHong Kong 999077China South China Institute of Environmental Sciences MEEGuangzhou 510655China

Studies have shown that per-and polyfluoroalkyl substances(PFASs)may be hepatotoxic in animals or ***,data on clinical epidemiology are very *** this study,21PFASs were determined in patients with liver diseases,with the highest median concentrations detected in the serum sample(26.7 ng/mL),followed by blood(10.7 ng/mL)and urine(5.02 ng/mL).Higher total PFAS concentrations were found in hepatocellular carcinoma(HCC)patients compared to non-HCC patients,with significant discrepancies in serum and blood ***,significant correlations were also found among PFAS concentrations and age,gender,body mass index(BMI),and liver function biomarkers *** example,PFAS concentrations are significantly higher in males than in females;Several serum PFASs concentrations increase with age and BMI,while the serum perfluorohexane sulfonic acid(PFHxS)concentrations are negatively correlated with *** addition,multiple regression models adjusted for age,gender and BMI found that increased serum perfluorobutane sulfonic acid(PFBS),perfluoroheptane sulfonic acid(PFHpS)and perfluorohexylphosphonic acid(PFHxPA)conentrations are correlated with elevated alkaline phosphatase(ALP),aspartate aminotransferase(AST),and alpha-fetoprotein(AFP)(p<0.05).Our results provide epidemiological support for the future study on the potential clinical hepatotoxicity of PFAS.

关键词： Per-and polyfluoroalkyl substances(PFASs) Liver cancer Serum Blood Urine Liver function biomarkers

Satellite glial cells in sensory ganglia play a wider role in chronic pain via multiple mechanisms

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Neural Regeneration Research 2024年第5期19卷 1056-1063页

作者： Xiaoyun Qiu Yuanzhi Yang Xiaoli da Yi Wang Zhong chen Cenglin Xu Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical ScienceZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina

Satellite glial cells are unique glial cells that surround the cell body of primary sensory *** increasing body of evidence suggests that in the presence of inflammation and nerve damage,a significant number of satellite glial cells become activated,thus triggering a series of functional *** suggests that satellite glial cells are closely related to the occurrence of chronic *** this review,we first summarize the morphological structure,molecular markers,and physiological functions of satellite glial ***,we clarify the multiple key roles of satellite glial cells in chronic pain,including gap junction hemichannel Cx43,membrane channel Pannexin1,K channel subunit 4.1,ATP,purinergic P2 receptors,and a series of additional factors and their receptors,including tumor necrosis factor,glutamate,endothelin,and ***,we propose that future research should focus on the specific sorting of satellite glial cells,and identify genomic differences between physiological and pathological *** review provides an important perspective for clarifying mechanisms underlying the peripheral regulation of chronic pain and will facilitate the formulation of new treatment plans for chronic pain.

关键词： chronic pain primary sensory neurons satellite glial cells sensory ganglia