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Changes in the Non-targeted Metabolomic Profile of Three-year-old Toddlers with Elevated Exposure to Polycyclic Aromatic Hydrocarbons

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Biomedical and Environmental Sciences 2024年第5期37卷 479-493页

作者： LI Yang LIN Dan ZHANG Xiu Qin JU Guang Xiu SU Ya ZHANG Qian duan hai ping YU Wei Sen WANG Bing Ling PANG Shu Tao Department of Epidemiology and Health Statistics School of Public HealthQingdao UniversityQingdao 266021ShandongChina Department of Environmental Health Qingdao Municipal Center for Disease Control and PreventionQingdao Institute of Preventive MedicineQingdao 266033ShandongChina Physicochemical Laboratory Qingdao Municipal Center for Disease Control and PreventionQingdao Institute of Preventive MedicineQingdao 266033ShandongChina Section of Child Health Care Huangdao Maternity and Child Health Care Hospital of QingdaoQingdao 266499ShandongChina Qingdao Blood Center Qingdao 266071ShandongChina

Objective To investigate changes in the urinary metabolite profiles of children exposed to polycyclic aromatic hydrocarbons(PAHs)during critical brain development and explore their potential link with the intestinal *** Liquid chromatography-tandem mass spectrometry was used to determine ten hydroxyl metabolites of PAHs(OH-PAHs)in 36-month-old ***,37 children were categorized into low-and high-exposure groups based on the sum of the ten ***-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was used to identify non-targeted metabolites in the urine ***,fecal flora abundance was assessed by 16S rRNA gene sequencing using Illumina *** The concentrations of 21 metabolites were significantly higher in the high exposure group than in the low exposure group(variable importance for projection>1,P<0.05).Most of these metabolites were positively correlated with the hydroxyl metabolites of naphthalene,fluorine,and phenanthrene(r=0.336–0.531).The identified differential metabolites primarily belonged to pathways associated with inflammation or proinflammatory states,including amino acid,lipid,and nucleotide ***,these distinct metabolites were significantly associated with specific intestinal flora abundances(r=0.34–0.55),which were mainly involved in *** Higher PAH exposure in young children affected metabolic homeostasis,particularly that of certain gut microbiota-derived *** investigation is needed to explore the potential influence of PAHs on the gut microbiota and their possible association with neurodevelopmental outcomes.

关键词： Child Gut microbiota Non-targeted metabolomics Polycyclic aromatic hydrocarbons Urinary metabolite profile

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2018—2021年青岛市公共场所空气微生物监测结果分析

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环境与健康杂志 2024年第4期41卷 342-345页

作者：徐春生李丹丹王寅张秀芹王炳玲段海平青岛市疾病预防控制中心青岛市预防医学研究院环境卫生所山东266033

目的了解青岛市公共场所空气微生物污染状况,评估其健康风险,为加强公共场所卫生管理和传染病防控提供依据。方法根据国家公共场所健康危害因素监测工作方案,按照《公共场所卫生检验方法第3部分:空气微生物》(GB/T 18204.3—2013)于2018... 详细信息

目的了解青岛市公共场所空气微生物污染状况,评估其健康风险,为加强公共场所卫生管理和传染病防控提供依据。方法根据国家公共场所健康危害因素监测工作方案,按照《公共场所卫生检验方法第3部分:空气微生物》(GB/T 18204.3—2013)于2018—2021年对宾馆酒店、候车室、商场超市、健身房开展夏季和(或)冬季室内空气中细菌总数与真菌总数的监测。结果共监测173家次公共场所、451个监测点,真菌总数的合格率(77.6%)低于细菌总数的合格率(91.4%);不同类别公共场所微生物监测结果显示,宾馆酒店的合格率最低(68.7%);季度比较显示,夏季的合格率(69.7%)低于冬季(76.7%);年度比较显示,2019年合格率最低(54.5%),2021年最高(81.2%);上述差异均有统计学意义(P<0.05)。宾馆酒店结果显示,三星以下宾馆酒店微生物合格率最低(60.7%);夏季的合格率(61.7%)低于冬季(74.1%);2019年合格率最低(53.8%),2020年最高(76.6%);上述差异均有统计学意义(P<0.05)。结论青岛市公共场所细菌总数与真菌总数均有一定的超标现象,存在健康风险。需重点关注酒店、夏季、真菌的微生物超标问题,需采取措施降低公共场所空气微生物浓度。

关键词：公共场所空气微生物细菌总数真菌总数

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新型建筑用铸态硅橡胶/聚苯胺屏蔽复合材料的研究

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铸造技术 2006年第5期27卷 517-520页

作者：刘永海段海平段玉平辽宁石油化工大学发展建设办公室辽宁抚顺113001 大连理工大学材料工程系辽宁大连116024

随着电磁渡干扰的日益加重，电磁功能材料在建筑业也越来越受到重视。本文分析了以掺杂态聚苯胺为填料、硅橡胶为基体的铸态复合材料的导电性以及在300～1500MHz频段下的屏蔽效能。研究结果表明，当聚苯胺与基体以1：1复合时，屏蔽效能... 详细信息

随着电磁渡干扰的日益加重，电磁功能材料在建筑业也越来越受到重视。本文分析了以掺杂态聚苯胺为填料、硅橡胶为基体的铸态复合材料的导电性以及在300～1500MHz频段下的屏蔽效能。研究结果表明，当聚苯胺与基体以1：1复合时，屏蔽效能达到16．0～19．3dB，体电阻率与原橡胶相比下降13个数量级．可以作为很好的建筑暗室用新型屏蔽材料来应用。

关键词：建筑铸态橡胶屏蔽效能体电阻率

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2018—2021年青岛市公共场所公共用品用具微生物指标监测结果分析

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环境卫生学杂志 2024年第3期14卷 270-272页

作者：张秀芹徐春生李丹丹王寅潘璐段海平王炳玲青岛市疾病预防控制中心/青岛市预防医学研究院青岛266033

目的基于青岛市公共场所公共用品用具微生物监测数据,分析评估青岛市公共场所卫生状况。方法 2018—2021年间对青岛市公共场所用品用具开展随机抽样监测,将抽取的样本在不同公共场所间、不同公共用品用具间、不同微生物指标间的检测结... 详细信息

目的基于青岛市公共场所公共用品用具微生物监测数据,分析评估青岛市公共场所卫生状况。方法 2018—2021年间对青岛市公共场所用品用具开展随机抽样监测,将抽取的样本在不同公共场所间、不同公共用品用具间、不同微生物指标间的检测结果进行比较。结果四年共抽取公共用品用具2 295份,总合格率为91.94%,2018—2021年达标率呈逐年升高趋势。不同类型公共场所间,理发店的达标率最高(95.35%),其次是宾馆/酒店(93.28%),沐浴场所最低(84.50%)。抽取的公共用品用具里,电梯的达标率最高(100%),拖鞋的总体合格率最低(50.00%)。不同微生物监测指标中,金黄色葡萄球菌均未检出,真菌总数的四年总达标率最低(60.00%)。以上数据结果差异均具有统计学意义(P<0.05)。结论青岛市公共场所公共用品用具卫生状况较好,2018—2021年呈逐年向好趋势,但个别监测指标超标,需继续加强对公共场所的卫生监测和管理。

关键词：公共场所公共用品用具卫生状况

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PEPFL:A framework for a practical and efficient privacy-preserving federated learning

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Digital Communications and Networks 2024年第2期10卷 355-368页

作者： Yange Chen Baocang Wang Hang Jiang Pu duan Yuan ping Zhiyong Hong State Key Laboratory of Integrated Service Networks Xidian UniversityXi'an710071China School of Information Engineering Xuchang UniversityXuchang461000China School of Telecommunications Engineering Xidian UniversityXi'an710071China Secure Collaborative Intelligence Laboratory Ant GroupHangzhou310000China Facility of Intelligence Manufacture Wuyi UniversityJiangmen529020China

As an emerging joint learning model,federated learning is a promising way to combine model parameters of different users for training and inference without collecting users’original ***,a practical and efficient solution has not been established in previous work due to the absence of efficient matrix computation and cryptography schemes in the privacy-preserving federated learning model,especially in partially homomorphic *** this paper,we propose a Practical and Efficient Privacy-preserving Federated Learning(PEPFL)***,we present a lifted distributed ElGamal cryptosystem for federated learning,which can solve the multi-key problem in federated ***,we develop a Practical Partially Single Instruction Multiple Data(PSIMD)parallelism scheme that can encode a plaintext matrix into single plaintext for encryption,improving the encryption efficiency and reducing the communication cost in partially homomorphic *** addition,based on the Convolutional Neural Network(CNN)and the designed cryptosystem,a novel privacy-preserving federated learning framework is designed by using Momentum Gradient Descent(MGD).Finally,we evaluate the security and performance of *** experiment results demonstrate that the scheme is practicable,effective,and secure with low communication and computation costs.

关键词： Federated learning Partially single instruction multiple data Momentum gradient descent ElGamal Multi-key Homomorphic encryption

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Designing Bioorthogonal Reactions for Biomedical Applications

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Research 2024年第3期2023卷 625-650页

作者： Qingfei Zhang Gaizhen Kuang Li Wang ping duan Weijian Sun Fangfu Ye Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325001China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China. Department of Obstetrics and Gynecology The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325027China. Department of Gastrointestinal Surgery The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou325027China.

Bioorthogonal reactions are a class of chemical reactions that can be carried out in living organisms without interfering with other reactions, possessing high yield, high selectivity, and high efficiency. Since the first proposal of the conception by Professor Carolyn Bertozzi in 2003, bioorthogonal chemistry has attracted great attention and has been quickly developed. As an important chemical biology tool, bioorthogonal reactions have been applied broadly in biomedicine, including bio-labeling, nucleic acid functionalization, drug discovery, drug activation, synthesis of antibody–drug conjugates, and proteolysis-targeting chimeras. Given this, we summarized the basic knowledge, development history, research status, and prospects of bioorthogonal reactions and their biomedical applications. The main purpose of this paper is to furnish an overview of the intriguing bioorthogonal reactions in a variety of biomedical applications and to provide guidance for the design of novel reactions to enrich bioorthogonal chemistry toolkits.

关键词： orthogonal summarized chemistry

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改良超声引导"三叶草法"腰丛神经阻滞应用于单侧下肢手术患者的麻醉效果分析

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现代生物医学进展 2024年第14期24卷 2728-2731页

作者：段海萍唐宏图李曙波哈思远苑广超王芳张维义武汉市中医医院麻醉科湖北武汉430014 湖北中医药大学针灸骨伤学院湖北武汉430065

目的:观察单侧下肢手术患者应用改良超声引导"三叶草法"腰丛神经阻滞后的麻醉效果。方法:根据随机数字表法,将我院2020年12月~2023年3月期间收治的86例单侧下肢手术患者分为A组(n=43)和B组(n=43)。A组手术期间接受超声引导"三叉戟"LPB... 详细信息

目的:观察单侧下肢手术患者应用改良超声引导"三叶草法"腰丛神经阻滞后的麻醉效果。方法:根据随机数字表法,将我院2020年12月~2023年3月期间收治的86例单侧下肢手术患者分为A组(n=43)和B组(n=43)。A组手术期间接受超声引导"三叉戟"LPB技术定位,B组手术期间接受改良超声引导"三叶草法"定位。对比两组一次神经阻滞成功率、调整穿刺针方向次数、定位时间、穿刺时间、麻醉效果优良率、疼痛视觉模拟评分(VAS),同时观察两组治疗期间不良反应发生情况。结果:B组的一次神经阻滞成功率高于A组,调整穿刺针方向次数少于A组,定位时间、穿刺时间短于A组(P0.05)。结论:与超声引导"三叉戟"LPB技术应用于单侧下肢手术患者相比,改良超声引导"三叶草法"定位可缩短定位时间、穿刺时间,减少调整穿刺针方向次数,减轻术后疼痛,提高麻醉效果。

关键词：超声引导三叶草法定位腰丛神经阻滞单侧下肢手术麻醉

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Frontiers and future perspectives of neuroimmunology

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Fundamental Research 2024年第2期4卷 206-217页

作者： hai Qi Shumin duan Yanying Xu Hongliang Zhang School of Medicine Tsinghua UniversityBeijing 100084China Faculty of Medicine and Pharmaceutical Sciences Zhejiang UniversityHangzhou 310014China Department of Life Sciences National Natural Science Foundation of ChinaBeijing 100085China

Neuroimmunology is an interdisciplinary branch of biomedical science that emerges from the intersection of studies on the nervous system and the immune *** complex interplay between the two systems has long been *** efforts directed at the underlying functional interface and associated pathophysiology,however,have garnered attention only in recent *** this narrative review,we highlight significant advances in research on neuroimmune interplay and modulation.A particular focus is on early-and middle-career neuroimmunologists in China and their achievements in frontier areas of"neuroimmune interface","neuro-endocrine-immune network and modulation","neuroimmune interactions in diseases","meningeal lymphatic and glymphatic systems in health and disease",and"tools and methodologies in neuroimmunology research".Key scientific questions and future directions for potential breakthroughs in neuroimmunology research are proposed.

关键词： Neuroimmunology Neuroimmune interplay Neuro-endocrine-immune network Basic research Key scientific questions

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Surgical techniques to prevent delayed gastric emptying after pancreaticoduodenectomy

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 449-457页

作者： Peng duan Lu Sun Kai Kou Xin-Rui Li ping Zhang Department of Hepatobiliary and Pancreatic Surgery General Surgery Centerthe First Hospital of Jilin UniversityChangchun 130021China Department of Dental Implantology Hospital of StomatologyJilin UniversityChangchun 130021China

Background: Delayed gastric emptying(DGE) is one of the most common complications after pancreaticoduodenectomy(PD). DGE represents impaired gastric motility without significant mechanical obstruction and is associated with an increased length of hospital stay, increased healthcare costs, and a high readmission rate. We reviewed published studies on various technical modifications to reduce the incidence of DGE. Data sources: Studies were identified by searching Pub Med for relevant articles published up to December 2022. The following search terms were used: “pancreaticoduodenectomy”, “pancreaticojejunostomy”, “pancreaticogastrostomy”, “gastric emptying”, “gastroparesis” and “postoperative complications”. The search was limited to English publications. Additional articles were identified by a manual search of references from key articles. Results: In recent years, various surgical procedures and techniques have been explored to reduce the incidence of DGE. Pyloric resection, Billroth II reconstruction, Braun's enteroenterostomy, and antecolic reconstruction may be associated with a decreased incidence of DGE, but more high-powered studies are needed in the future. Neither laparoscopic nor robotic surgery has demonstrated superiority in preventing DGE, and the use of staplers is controversial regarding whether they can reduce the incidence of DGE. Conclusions: Despite many innovations in surgical techniques, there is no surgical procedure that is superior to others to reduce DGE. Further larger prospective randomized studies are needed.

关键词： Pancreaticoduodenectomy Delayed gastric emptying Postoperative complications Surgical techniques

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Responses of Nutrients to the Precipitation Variation and Land Use in Subtropical Monsoonal Small Mountainous Rivers:A Case Study of Baixi Watershed

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Journal of Ocean University of China 2024年第2期23卷 383-391页

作者： TIAN Yuan GAO Fei CAO Ke LV Shenghua duan Xiaoyong YIN ping Qingdao Institute of Marine Geology China Geological SurveyMinistry of Natural ResourcesQingdao 266237China Laboratory for Marine Geology Laoshan LaboratoryQingdao 266237China

Small mountainous rivers are characterized by large instantaneous fluxes and susceptible to extreme weather events,which can rapidly transport materials into the sea and have a significant impact on the ecological environment of estuaries and *** order to investigate the seasonal characteristics of nutrients in small mountainous rivers in the subtropical monsoon region and the output pattern to the sea during heavy precipitation,surveys on the mountainous rivers were carried out in Baixi watershed in August 2020(wet season),March 2021(dry season)and June 2021(Meiyu period).The results showed that the dissolved inorganic nitrogen(DIN)of the rivers has an average concentration of 752μg L^(−1)in the wet season and 1472μg L^(−1)in the dry *** concentrations of dissolved inorganic phosphorus(DIP)in wet season and dry season were 63μg L^(−1)and 51μg L^(−1),*** by the changes of land use in sub-watersheds,DIN concentrations in the mainstream increased from 701μg L^(−1)in the upper reaches to 1284μg L^(−1)in the middle *** rainstorms during the Meiyu period in the watershed caused the pulse runoff in the *** maximum daily runoff reached 70 times that before *** maximum daily fluxes of DIN and DIP were 109 and 247 times that before rains,*** view that the watershed experienced several rainstorms in the wet season,the river,with pulse runoff,carries a large amount of nutrients into the sea in a short time,which will have a significant impact on the environment of Sanmen bay and its adjacent sea.

关键词： small mountainous river uneven precipitation rainstorm pulse runoff nitrogen and phosphorus

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