检索结果-南通市图书馆

Effect of Histone Deacetylase Inhibition on the Expression of Multidrug Resistance-associated Protein 2 in a Human Placental Trophoblast Cell Line

引用

chinese Medical Journal 2017年第11期130卷 1352-1360页

作者： Hong-Yu duan Dan Ma Kai-Yu Zhou Tao wang yi Zhang yi-Fei Li Jin-Lin Wu yi-Min Hua Chuan wang Department of Pediatric Cardiology West China Second University Hospital Sichuan University Chengdu Sichuan 610041 China The Cardiac Development and Early Intervention Unit West China Institute of Women and Children's Health West China Second University Hospital Sichuan University Chengdu Sichuan 610041 China Department of Pediatric Rehabilitation West China Second University Hospital Sichuan University Chengdu Sichuan 610041 China key laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education Chengdu Sichuan 610041 China key laboratory of Development and Diseases of Women and Children of Sichuan Province West China Second University Hospital Sichuan University Chengdu Sichuan 610041 China Department of Pediatrics West China Second University Hospital Sichuan University Chengdu Sichuan 610041 China

Background： Placental multidrug resistance-associated protein 2 （MRP2）, encoded by ABCC2 gene in human, plays a significant role in regulating drugs＇ transplacental transfer rates. Studies o11 placental MRP2 regulation could provide more therapeutic targets for individualized and safe pharmacotherapy during pregnancy. Currently, the roles of epigenetic mechanisms in regulating placental drug transporters are still unclear. This study aimed to investigate the effect of histone deacetylases （HDACs） inhibition on MRP2 expression in the placental trophoblast cell line and to explore whether HDAC 1/2/3 are preliminarily involved in this process. Methods： The human choriocarcinoma-derived trophoblast cell line （Bewo cells） was treated with the HDAC inhibitors-trichostatin A （TSA） at different concentration gradients of 0.5, 1.0, 3.0, and 5.0 μmol/L. Cells were harvested after 24 and 48 h treatment. Small interfering RNA （siRNA） specific for HDACI/HDAC2/HDAC3 or control siRNA was transfected into cells. Total HDAC activity was detected by colorimetric assay kits. HDAC 1/2/3/ABCC2 messenger RNA （mRNA） and protein expressions were determined by real-time quantitative polymerase chain reaction and Western-blot analysis, respectively. Immunofluorescence for MRP2 protein expression was visualized and assessed using an immunofluorescence microscopy and ImageJ software, respectively. Results： TSA could inhibit total HDAC activity and HDAC 1/2/3 expression in company with increase ofM RP2 expression in Bewo cells. Reduction of HDAC 1 protein level was noted after 24 h of TSA incubation at 1.0, 3.0, and 5.0 μmol/L （vs. vehicle group, all P 〈 0.001 ）, accompanied with dose-dependent induction of MRP2 expression （P = 0.045 for 1.0 μmol/L, P = 0.001 for 3.0 μmol/L, and P 〈 0.001 for 5.0 μmol/L）, whereas no significant diferences in MRP2 expression were noted after HDAC2/3 silencing. Fluorescent micrograph images of MRP2 protein were expressed on the cell membrane. The fluorescent inte

关键词： Epigenetic Regulation: Histone Deacetylases: Multidrug Resistance-associated Protein 2 Placenta

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The composite phenotype analysis identifies potential concerted responses of physiological systems to high altitude exposure

引用

National Science Review 2023年第5期10卷 109-111页

作者： yi Li Meng Hao Zixin Hu Yanyun Ma Kun wang Xiaoyu Liu Xianhong yin Menghan Zhang yi wang Meng Liang Yuan Guo Lei Bao Shixuan Zhang Shiguan Le Chenyuan Wu Dayan Sun Yang Wei Fei Wu Rui Zhang Lingxian Zhu Hui Zhang Shuai Jiang Xingdong Chen Xiaofeng wang Yao Zhang Longli Kang Wenyuan duan Bin Qiao Jiucun wang Li Jin State key laboratory of Genetic Engineering Collaborative Innovation Center for Genetics and DevelopmentSchool of Life Sciences and Human Phenome InstituteFudan University institute for Six-sector Economy Fudan University International Human Phenome institutes Ministry of Education key laboratory of Contemporary Anthropology Department of Anthropology and Human GeneticsSchool of Life SciencesFudan University Greater Bay Area institute of Precision Medicine(Guangzhou) School of Life SciencesFudan University Artificial Intelligence Innovation and Incubation institute Fudan University Shanghai Pudong Hospital Fudan University Pudong Medical Center Fudan-Taizhou institute of Health sciences key laboratory of High-Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region School of MedicineXizang Minzu University institute of Cardiovascular Disease Shandong Provincial Western Hospital Research Unit of Dissecting the Population Genetics and Developing New Technologies for Treatment and Prevention of Skin Phenotypes and Dermatological Diseases (2019RU058) Chinese Academy of Medical Sciences

Environmental stresses,such as temperature,disease and altitude could induce systematic changes of biological systems which manifests as concerted responses across multiple systems within a certain period of time[1].High altitude acclimatization (HAA) refers to a series of adaptive physiological responses to hypoxic *** these processes,

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

中国中南部G8P[8]型A组轮状病毒全基因组遗传特征研究

引用

病毒学报 2024年第1期40卷 27-37页

作者：熊光萍田毅范佳欣唐晓苹董梦洁车如意李伟红唐梅荣周珺刘颂王铭月李丹地段招军甘肃中医药大学公共卫生学院兰州730000 沧州医学高等专科学校病原生物学与免疫学教研室沧州061001 传染病溯源预警与智能决策全国重点实验室中国疾病预防控制中心病毒病预防控制所北京102206 北京市疾病预防控制中心北京100013 广西壮族自治区疾病预防控制中心南宁530028 江西省疾病预防控制中心南昌330046 青岛市疾病预防控制中心青岛266033

G8基因型轮状病毒已在我国出现并迅速增加。本研究拟对采集于中国中南部5岁以下急性胃肠炎患儿的7例G8P[8]型RVA毒株进行全基因组分子特征分析。对轮状病毒特异性扩增结合高通量测序方法对中国中南部14株G8P[8]型RVA毒株进行全基因组测... 详细信息

G8基因型轮状病毒已在我国出现并迅速增加。本研究拟对采集于中国中南部5岁以下急性胃肠炎患儿的7例G8P[8]型RVA毒株进行全基因组分子特征分析。对轮状病毒特异性扩增结合高通量测序方法对中国中南部14株G8P[8]型RVA毒株进行全基因组测序。利用MEGA11.0、Geneious Prime、Geneious9.0.2和DNASTAR软件对RVA毒株进行全序列及遗传变异和进化分析。7株G8P[8]型RVA的基因分型为G8-P[8]-I2-R2-C2-M2-A2-N2-T2-E1-H2,显示为DS-1样基因型。系统进化树结果显示,本研究中国中南部7株G8P[8]分为两大谱系G8-I(13株)和谱系G8-Ⅱ(1株),VP7的最大分支可信度(MCC)树表明,G8的平均进化率估计为1.4×10^(-3)替换/位点/年。G8P[8]基因型RVA在我国包括两个谱系,从该病毒在中国的出现到该病毒在中国的流行传播将经过1~2年,持续的全国RVA监测至关重要。

关键词：轮状病毒 G8P基因型分子特征平均进化率

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

白木香茎皮的化学成分及其抗幽门螺旋杆菌活性研究

引用

中国中药杂志 2024年第15期49卷 4100-4110页

作者：陈小宇李俊甫李颖硕杨珺段晓燕罗吉凤赵富伟王跃虎中国科学院昆明植物研究所资源植物与生物技术重点实验室、云南省野生资源植物研发重点实验室云南昆明650201 中国科学院大学生命科学学院北京100049 云南省东南亚生物多样性保护国际联合实验室云南勐仑666303 生态环境部南京环境科学研究所江苏南京210042

瑞香科植物白木香Aquilaria sinensis的茎皮为彝族药,彝族名为“理娃资姓”,用于治疗慢性胃炎等疾病,但其活性成分未见报道。该研究以幽门螺旋杆菌(Helicobacter pylori,Hp)为模型,试图阐明白木香茎皮的活性成分。采用柱色谱、高效液相... 详细信息

瑞香科植物白木香Aquilaria sinensis的茎皮为彝族药,彝族名为“理娃资姓”,用于治疗慢性胃炎等疾病,但其活性成分未见报道。该研究以幽门螺旋杆菌(Helicobacter pylori,Hp)为模型,试图阐明白木香茎皮的活性成分。采用柱色谱、高效液相色谱、重结晶等方法从白木香茎皮中分离得到19个化合物,包括1个新的木脂素:白木香双酯(1),以及18个已知化合物:咖啡酸二十二酯(2)、6-羟基-2-[2-(4-甲氧基苯基)乙基]-4H-1-苯并吡喃-4-酮(3)、qinanone A(4)、6-羟基-2-(2-苯乙基)色酮(5)、6-羟基-2-[2-(3-羟基-4-甲氧基苯基)乙基]-4H-1-苯并吡喃-4-酮(6)、6-羟基-2-[2-(3-甲氧基-4-羟基苯基)乙基]-4H-1-苯并吡喃-4-酮(7)、6-羟基-2-[2-(3,4-二甲氧基苯基)乙基]色酮(8)、6-羟基-2-[(1E)-2-(4-羟基-3-甲氧基苯基)乙基]-4H-1-苯并吡喃-4-酮(9)、芫花素(10)、5-羟基-2-(4-羟基-3,5-二甲氧基苯基)-7-甲氧基-4H-1-苯并吡喃-4-酮(11)、3-羟基-1-(4-羟基-3,5-二甲氧基苯基)-1-丙酮(12)、(+)-丁香脂素(13)、浙贝素(14)、aquilarin A(15)、caruilignan D(16)、(-)-榕醛(17)、pistaciamide(18)、原儿茶酸(19)。抗菌结果显示,化合物2~7、10~11和13对Hp有一定的抑制活性,其中,2-(2-苯乙基)色酮类化合物6-羟基-2-(2-苯乙基)色酮(5)和6-羟基-2-[2-(3-甲氧基-4-羟基苯基)乙基]-4H-1-苯并吡喃-4-酮(7)对Hp抑制作用最强,MIC均为6.25μmol·L^(-1)。2-(2-苯乙基)色酮类化合物是白木香茎皮的主要活性成分。

关键词：沉香属白木香茎皮胃炎幽门螺旋杆菌 2-(2-苯乙基)色酮

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Using Composite Phenotypes to Reveal Hidden Physiological Heterogeneity in High-Altitude Acclimatization in a chinese Han Longitudinal Cohort

引用

Phenomics 2021年第1期1卷 3-14页

作者： yi Li Yanyun Ma Kun wang Menghan Zhang yi wang Xiaoyu Liu Meng Hao Xianhong yin Meng Liang Hui Zhang Xiaofeng wang Xingdong Chen Yao Zhang Wenyuan duan Longli Kang Bin Qiao Jiucun wang Li Jin State key laboratory of Genetic Engineering Collaborative Innovation Center for Genetics and DevelopmentSchool of Life Sciences and Human Phenome InstituteFudan UniversityShanghai 200438China Ministry of Education key laboratory of Contemporary Anthropology Department of Anthropology and Human GeneticsSchool of Life SciencesFudan UniversityShanghai 200438China institute for Six‑Sector Economy Fudan UniversityShanghai 200433China Fudan-Taizhou institute of Health sciences Taizhou 225300China key laboratory of High Altitude Environment and Genes Related To Diseases of Tibet Autonomous Region School of MedicineXizang Minzu UniversityXianyang 712082China institute of Cardiovascular Disease Shandong Provincial Western HospitalJinanShandong 250022China Research Unit of Dissecting the Population Genetics and Developing New Technologies for Treatment and Prevention of Skin Phenotypes and Dermatological Diseases(2019RU058) Chinese Academy of Medical SciencesBeijing 100730China

Altitude acclimatization is a human physiological process of adjusting to the decreased oxygen *** several physiological processes are involved and their correlations are complicated,the analyses of single traits are insufficient in revealing the complex mechanism of high-altitude *** this study,we examined these physiological responses as the composite phenotypes that are represented by a linear combination of physiological *** developed a strategy that combines both spectral clustering and partial least squares path modeling(PLSPM)to define composite phenotypes based on a cohort study of 883 chinese Han *** addition,we captured 14 composite phenotypes from 28 physiological traits of high-altitude *** these composite phenotypes,we applied k-means clustering to reveal hidden population physiological heterogeneity in high-altitude ***,we employed multivariate linear regression to systematically model(Models 1 and 2)oxygen saturation(SpO_(2))changes in high-altitude acclimatization and evaluated model fitness *** phenotypes based on Model 2 fit better than single trait-based Model 1 in all measurement *** new strategy of using composite phenotypes may be potentially employed as a general strategy for complex traits research such as genetic loci discovery and analyses of phenomics.

关键词： Altitude acclimatization Composite phenotypes Hypoxia Complex traits Phenomics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

铁死亡参与急性肾损伤的新机制

引用

中华实验外科杂志 2024年第6期41卷 1341-1347页

作者：孙佳怡王泽洁俞瑾瑶张燕妮段宇鑫柏艺李玲叶啟发武汉大学中南医院武汉大学肝胆疾病研究院武汉大学移植医学中心国家人体捐献器官获取质量控制中心移植医学技术湖北省重点实验室武汉430071 中南大学湘雅三医院卫生部移植医学工程技术研究中心长沙410013

急性肾损伤(AKI)是一种常见而严重的临床肾脏综合征,由多种生理和病理因素引起,以急性短暂肾功能降低为主要病征。其发病率和死亡率较高,且临床有效治疗策略有限。越来越多证据表明,铁死亡作为一种由脂质过氧化引起的铁依赖性、非凋亡... 详细信息

急性肾损伤(AKI)是一种常见而严重的临床肾脏综合征,由多种生理和病理因素引起,以急性短暂肾功能降低为主要病征。其发病率和死亡率较高,且临床有效治疗策略有限。越来越多证据表明,铁死亡作为一种由脂质过氧化引起的铁依赖性、非凋亡形式的调节性细胞死亡方式,以铁过载、活性氧积累和脂质过氧化为典型特征,在横纹肌溶解、脓毒症、缺血再灌注损伤以及使用肾脏毒性药物等多种因素引起的急性肾损伤中扮演重要作用。本文旨在对铁死亡的诱发和防御机制及其参与AKI的作用途径等方面进行归纳和延伸,为后续相关研究提供理论依据。

关键词：急性肾损伤铁死亡脂质过氧化缺血再灌注

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

多菌种固体共发酵生物软化稻壳的研究

引用

微生物学通报 2004年第4期31卷 14-18页

作者：杨艳红郑一敏王伯初段传人重庆工学院生物工程学院重庆400050 重庆大学生物工程学院生物力学及组织工程教育部重点实验室重庆400044

用NaOH对稻壳预处理 ,解除木质素和半纤维素对纤维素的保护作用以及破坏纤维素的晶体结构 ,使其更容易被微生物分解利用。据多种微生物共生及代谢特性 ,建立由瑞氏木霉AS3 371 1、黑曲霉AS3 31 6和啤酒酵母AS2 399组成的复合微生物体... 详细信息

用NaOH对稻壳预处理 ,解除木质素和半纤维素对纤维素的保护作用以及破坏纤维素的晶体结构 ,使其更容易被微生物分解利用。据多种微生物共生及代谢特性 ,建立由瑞氏木霉AS3 371 1、黑曲霉AS3 31 6和啤酒酵母AS2 399组成的复合微生物体系。通过正交实验优化出一组具有实践前景的多菌种固体共发酵的技术路线和工艺方法 ,较好地实现了复合微生物软化稻壳的目的。实验结果显示 ,在发酵温度 30℃ ,pH4 5左右条件下 ,发酵7d后的最高滤纸酶活力为 5 64U/g发酵物 ,1 0d后的纤维素的降解率为 :2 8 0 5 %。

关键词：多菌种固体发酵软化稻壳

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

ALOX15-launched PUFA-phospholipids peroxidation increases the susceptibility of ferroptosis in ischemia-induced myocardial damage

引用

Signal Transduction and Targeted Therapy 2022年第9期7卷 3523-3535页

作者： Xiao-Hui Ma Jiang-Han-Zi Liu Chun-Yu Liu Wan-Yang Sun Wen-Jun duan Guan wang Hiroshi Kuriara Rong-Rong He yi-Fang Li Yang Chen Hongcai Shang Guangdong Engineering Research Center of chinese Medicine&Disease Susceptibilty Jinan UniversityGuangzhou 510632China Guangdong Province key laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research College of PharmacyJinan UniversityGuangzhou 510632China international Cooperative laboratory of Traditional chinese Medicine Modernization and Innovative Drug Development of chinese Ministry of Education(MOE) Jinan UniversityGuangzhou 510632China institute of Traditional chinese Medicine Xinjiang Medical UniversityUrumqi 830054China Sinnovation Center of Nursing Research Nursing Key Laboratory of Sichuan ProvinceState Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan UniversityChengdu 610041China College of Pharmacy Guangzhou University of Chinese Medicine Guangzhou 510405China key laboratory of chinese Internal Medicine of Ministry of Education Dongzhimen HospitalBeijing University of Chinese Medicine100700 BeijingChina

Myocardial ischemia/reperfusion(/R)injury is a classic type of cardiovascular disease characterized by injury to cardiomyocytes leading to various forms of cell *** is believed that irreversible myocardial damage resulted from I/R occurs due to oxidative stress evoked during the reperfusion *** we demonstrate that ischemia triggers a specific redox reaction of polyunsaturated fatty acids(PUFA)-phospholipids in myocardial cells,which acts as a priming signaling that initiates the outbreak of robust oxidative damage in the reperfusion *** animal and in vitro models,the crucial lipid species in I/R injury were identifed to be oxidized PUFAs enriched *** multi-omics,arachidonic acid 15-lipoxygenase-1(ALOx15)was identified as the primary mediator of ischemia-provoked phospholipid peroxidation,which was further confirmed using chemogenetic ***,our results reveal that ALOx15 induction in the ischemia phase acts as a"burning point"to ignite phospholipid oxidization into ferroptotic *** finding characterizes a novel molecular mechanism for myocardial ischemia injury and offers a potential therapeutic target for early intervention of V/R injury.

关键词： peroxidation ischemia damage

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Collagen triple helix repeat containing-1 promotes functional recovery of sweat glands by inducing adjacent microvascular network reconstruction in vivo

引用

Burns & Trauma 2022年第1期10卷 387-400页

作者： Xingyu Yuan Xianlan duan Zhao Li Bin Yao Enhejirigala Wei Song yi Kong Yuzhen wang Fanliang Zhang Liting Liang Shijun Zhu Mengde Zhang Chao Zhang Sha Huang Xiaobing Fu School of Medicine Nankai University94 Wei Jin RoadTianjin 300071PR China Research Center for Tissue Repair and Regeneration affiliated to the Medical Innovation Research Department PLA General Hospital28 Fu Xing RoadBeijing 100853PR China PLA key laboratory of Tissue Repair and Regenerative Medicine and Beijing key Research laboratory of Skin Injury Repair and RegenerationChinese PLA General Hospital and PLA Medical College51 Fu Cheng RoadBeijing 100048PR China Research Unit of Trauma Care Tissue Repair and RegenerationChinese Academy of Medical Sciences2019RU051Beijing 100048PR China academy of Medical Engineering and Translational Medicine Tianjin University92 Weijin RoadTianjin300072PR China College of Graduate Tianjin Medical UniversityTianjin 300070PR China institute of Basic Medical Research Inner Mongolia Medical UniversityHohhot 010110Inner MongoliaPR China Department of Burn and Plastic Surgery Air Force Hospital of Chinese PLA Central Theater CommandDatong 037000ShanxiPR China

Background:Sweat glands(SGs)have low regenerative potential after severe burns or trauma and their regeneration or functional recovery still faces many *** practice,restoring SG function requires not only the structural integrity of the gland itself,but also its neighboring tissues,especially blood *** triple helix repeat containing-1(CTHRC1)was first identified in vascular repair,and increasing reports showed a close correlation between cutaneous appendage specification,patterning and *** purpose of the present study was to clarify the role of CTHRC1 in SGs and their adjacent microvessels and find therapeutic strategies to restore SG ***:The SGs and their adjacent microvascular network of Cthrc^(1−/−)mice were first inves-tigated using sweat test,laser Doppler imaging,tissue clearing technique and transcriptome *** effects of CTHRC1 on dermal microvascular endothelial cells(DMECs)were further explored with cell proliferation,DiI-labeled acetylated low-density lipoprotein uptake,tube for-mation and intercellular junction establishment *** effects of CTHRC1 on SG function restoration were finally confirmed by replenishing the protein into the paws of Cthrc(1−/−)***:CTHRC1 is a key regulator of SG function in *** the tissue level,Cthrc1 deletion resulted in the disorder and reduction of the microvascular network around *** the molecular level,the knockout of Cthrc1 reduced the expression of vascular development genes and functional proteins in the dermal ***,CTHRC1 administration considerably enhanced SG function by inducing adjacent vascular network ***:CTHRC1 promotes the development,morphogenesis and function execution of SGs and their neighboring *** study provides a novel target for the restoration or regeneration of SG function in vivo.

关键词： Collagen triple helix repeat containing-1 Sweat glands Microvascular network Dermalmicrovascular endothelial cells Reconstruction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Disruption of Planar Cell Polarity Pathway Attributable to Valproic Acid-Induced Congenital Heart Disease through Hdac3 Participation in Mice

引用

chinese Medical Journal 2018年第17期131卷 2080-2088页

作者： Hong-Yu Ouan Kai-Yu Zhou Tao wang yi Zhang yi-Fei Li yi-Min Hua Chuan wang Department of Pediatric Cardiology West China Second University Hospital Sichuan University Chengdu Sichuan 610041 China Cardiac Development and Early Intervention Unit West China Institute of Women and Children's Health West China Second University Hospital Sichuan University Chengdu Sichuan 610041 China key laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education Chengdu Sichuan 610041 China key laboratory of Development and Diseases of Women and Children of Sichuan Province West China Second University Hospital Sichuan University Chengdu Sichuan 610041 China

Background： Valproic acid （VPA） exposure during pregnancy has been proven to contribute to congenital heart disease （CHD）. Our previous findings implied that disruption of planar cell polarity （PCP） signaling pathway in cardiomyocytes might be a factor for the cardiac teratogenesis of VPA. In addition, the teratogenic ability of VPA is positively correlated to its histone deacetylase （HDAC） inhibition activity. This study aimed to investigate the effect of the VPA on cardiac morphogenesis, HDAC1/2/3, and PCP key genes （Vangl2/Scrib/Rac 1）, subsequently screening out the specific HDACs regulating PCP pathway. Methods： VPA was administered to pregnant C57BL mice at 700 mg/kg intraperitoneally on embryonic day ! 0.5. Dams were sacrificed on E15.5, and death/absorption rates of embryos were evaluated. Embryonic hearts were observed by hematoxylin-eosin staining to identify cardiac abnormalities. H9C2 cells （undifferentiated rat cardiomyoblasts） were transfected with Hdac1/2/3 specific small interfering RNA （siRNA）. Based on the results of siRNA transfection, cells were transfected with Hdac3 expression plasmid and subsequently mock-treated or treated with 8.0 mmol/L VPA. Hdac1/2/3 as well as Vangl2/Scrib/Racl mRNA and protein levels were determined by real-time quantitative polymerase chain reaction and Western blotting, respectively. Total HDAC activity was detected by colorimetric ***： VPA could induce CHD （P 〈 0.001） and inhibit mRNA or protein expression of Hdac1/2/3 as well as Vangl2/Scrib in fetal hearts, in association with total Hdac activity repression （all P 〈 0.05）. In vitro, Hdac3 inhibition could significantly decrease Vangl2/Scrib expression （P 〈 0.01 ）, while knockdown of Hdac 1/2 had no influence （P 〉 0.05）, VPA exposure dramatically decreased the expression of Vanlg2/Scrib together with Hdac activity （P 〈 0.01 ）, while overexpression of Hdac3 could rescue the VPA-induced inhibition （P 〉 0.05）. Conclusion： VPA could inhibit Hdac1/2/3, Vang12/Sc

关键词： Congenital Heart Disease Hdacs Planar Cell Polarity Valproic Acid

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：