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The effect of pmpR on the type Ⅲ secretion system in Pseudomonas aeruginosa

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Chinese Science Bulletin 2012年第19期57卷 2413-2418页

作者： LIANG HaiHua KONG WeiNa SHEN Tuo duan jiali duan KangMin Key Laboratory of Resources Biology and Biotechnology in Western China Ministry of EducationFaculty of Life SciencesNorthwest UniversityXi'anShaanxi 710069China

The type III secretion system(T3SS) plays important roles in Pseudomonas aeruginosa ***,we reported that the uncharacterized protein PmpR could regulate pqsR,an important regulator in the quorum-sensing system,by directly binding to its promoter *** the T3SS is controlled by the quorum-sensing system,here,we investigated the relationship between PmpR and the *** data showed that expression of the T3SS genes exoS,exoY,exoT,and exsD was dramatically increased in a pmpR-deletion mutant compared with that in the wild-type *** strain *** from DNA mobility assays indicated that PmpR affects the T3SS *** is unlikely that PmpR controls the T3SS via the Pseudomonas quinolone signal(PQS) because the PQS negatively regulates the T3SS,while pmpR negatively regulates the *** effect of PmpR on the T3SS seems to be independent of the PQS;further investigation is required to uncover the underlying regulatory pathways.

关键词：分泌系统绿脓杆菌类型缺失突变体传感系统感应系统假单胞菌数据表

Mitochondria-targeted nanoparticles overcome chemoresistance via downregulating BACH1/CD47 axis in ovarian carcinoma

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Chinese Chemical Letters 2024年第5期35卷 344-350页

作者： Ke Gong Jinghan Liao Jiangtao Lin Quan Wang Zhihua Wu Liting Wang jiali Zhang Yi Dong Yourong duan Jianhua Chen State Key Laboratory of Systems Medicine for Cancer Shanghai Cancer InstituteRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200032China Department of Ultrasound Xinhua HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200092China Department of Oncology Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China

The platinum-based chemotherapy is a routine strategy for the treatment of ovarian cancer,while it is prone to chemoresistance in clinical,which hinders the ***,it is urgently needed to elucidate the underlying mechanism of drug resistance and form the appropriate *** sequencing results showed that cisplatin(DDP)resistant ovarian cancer overexpressed BTB and CNC homology 1(BACH1),and up-regulated the“don’t eat me”signal *** identified that hemin,a BACH1 inhibitor,could effectively down-regulate BACH1 and simultaneously inhibit ***,hemin has a synergistic effect with *** designed a pH-responsive nanoparticle(H/D@FA-CaP-NPs)in which folic acid(FA)ensured targeting of ovarian cancer cells,while hemin inhibited BACH1 as well as down-regulated CD47,achieving the promotion of apoptosis of tumor cells and inducing phagocytosis of tumors by ***,hemin has a synergistic effect with DDP to promote apoptosis of tumor ***,hemin and DDP was encapsulated within hydrophobic 1,2-distearoyl-sn-glycero-3-phosphoethanolamine(DSPE)to form a tight core,and hydrophilic polyethylene glycol 2000(PEG2000)and calcium phosphate(CaP)formed the outside shell,and FA was modified on the surface of *** terms of function,(a)FA enhanced the active targeting of nanoparticles to tumors;(b)NPs targeted mitochondria to induce reactive oxygen species(ROS)production;(c)hemin encapsulated in nanoparticles could specifically target BACH1,thereby down regulating CD47;(d)hemin had a synergistic effect with DDP,thus augmenting the ***,mitochondria-targeted nanoparticles H/D@FA-CaP-NPs promoted tumor apoptosis and mobilized phagocytosis to treat tumor,providing a novel scheme for clinical treatment of cisplatin-resistant ovarian carcinoma.

关键词： Cisplatin-resistant Hemin BACH1 CD47 Phagocytosis ROS Synergistic effect

A Soft Tissue Acupuncture Model Based on Mass-Spring Force Ne

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Computers, Materials & Continua 2021年第10期 727-745页

作者： Xiaorui Zhang Tong Xu Wei Sun jiali duan Sunil Kumar Jha Jiangsu Engineering Center of Network Monitoring Engineering Research Center of Digital ForensicsMinistry of EducationSchool of Computer and SoftwareNanjing University of Information Science&TechnologyNanjing210044China Jiangsu Collaborative Innovation Center of Atmospheric Environment and Equipment Technology(CICAEET) Nanjing University of Information Science&TechnologyNanjing210044China Faculty of Information Technology University of Information Technology and ManagementRzeszow35-225Poland

In the simulation of acupuncture manipulation,it is necessary to accurately capture the information of acupuncture points and particles around ***,a soft tissue modeling method that can accurately track model particles is *** this paper,a soft tissue acupuncture model based on the mass-spring force net is *** is used as the auxiliary model and the SHF model is *** is used to establish a three-layer soft tissue model of skin,fat,and muscle,and a layer of the MSM based force network is covered on the surface of soft tissue to realize the complementary advantages and disadvantages of spherical harmonic function and *** addition,a springback algorithm is designed to simulate the springback phenomenon of soft tissue skin during *** evaluation results show that the soft tissue acupuncture modeling method based on mass-spring force net can effectively simulate the springback phenomenon of soft tissue surface during acupuncture surgery,and has good comprehensive performance in the application of virtual acupuncture surgery simulation.

关键词： Mass-spring model puncture simulation virtual surgery soft tissue simulation

Accuracy and capability of tri-ponderal mass index in assessing cardio-metabolic risk factors in Chinese children and adolescents aged 3 to 17 years,compared with body mass index

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Chinese Medical Journal 2023年第11期136卷 1339-1348页

作者： Rui Chen Lang Ji Lijuan Ma Yitong Chen jiali duan Mingjing Ma Ying Sun Jun Tai Linghui Meng Center for Evidence-Based Medicine Capital Institute of PediatricsBeijing 100020China Central Laboratory Beijing Luhe HospitalCapital Medical UniversityBeijing 101149China Department of Clinical Laboratory Children’s Hospital Affiliated to Capital Institute of PediatricsBeijing 100020China Infectious Diseases Control and Prevention Division Daxing Center for Disease Prevention and ControlBeijing 102699China Health Promotion Office Beijing Center for Disease Prevention and ControlBeijing 100013China Department of Health Care Tuanjiehu Community Health Service CenterChaoyang DistrictBeijing 100026China Department of Otorhinolaryngology Head and Neck SurgeryChildren’s Hospital Affiliated to Capital Institute of PediatricsBeijing 100020China Beijing Key Laboratory of Mental Disorders National Clinical Research Center for Mental Disorders&National Center for Mental DisordersBeijing Anding HospitalCapital Medical UniversityBeijing 100088China

Background:Tri-ponderal mass index(TMI)has been reported to be a more accurate estimate of body fat than body mass index(BMI).This study aims to compare the effectiveness of TMI and BMI in identifying hypertension,dyslipidemia,impaired fasting glucose(IFG),abdominal obesity,and clustered cardio-metabolic risk factors(CMRFs)in 3-to 17-year-old ***:A total of 1587 children aged 3 to 17 years were *** regression was used to evaluate correlations between BMI and *** under the curves(AUCs)were used to compare discriminative capability among *** was converted to BMI-z scores,and accuracy was compared by false-positive rate,false-negative rate,and total misclassification ***:Among children aged 3 to 17 years,the mean TMI was 13.57±2.50 kg/m 3 for boys and 13.3±2.33 kg/m 3 for *** ratios(ORs)of TMI for hypertension,dyslipidemia,abdominal obesity,and clustered CMRFs ranged from 1.13 to 3.15,higher than BMI,whose ORs ranged from 1.08 to *** showed similar ability of TMI(AUC:0.83)and BMI(AUC:0.85)in identifying clustered *** abdominal obesity and hypertension,the AUC of TMI was 0.92 and 0.64,respectively,which was significantly better than that of BMI,0.85 and *** of TMI for dyslipidemia and IFG were 0.58 and *** 85th and 95th of TMI were set as thresholds,total misclassification rates of TMI for clustered CMRFs ranged from 6.5%to 16.4%,which was not significantly different from that of BMI-z scores standardized according to World Health Organization ***:TMI was found to have equal or even better effectiveness in comparison with BMI in identifying hypertension,abdominal obesity,and clustered CMRFs TMI was more stable than BMI in 3-to 17-year-old children,while it failed to identify dyslipidemia and *** is worth considering the use of TMI for screening CMRFs in children and adolescents.

关键词： Tri-ponderal mass index Body mass index Cardio-metabolic risk factors Children Adolescents

同源主观数据是否膨胀了变量间的相关性——以战略人力资源管理研究为例

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武汉大学学报（哲学社会科学版） 2015年第6期68卷 83-92页

作者：苏中兴段佳利中国人民大学劳动人事学院北京100872 澳大利亚新南威尔士大学商学院

研究变量之间的相关性是现代管理学实证研究的基本范式。然而,变量之间统计上的相关性极易受到变量的测量方法和数据类型的影响。特别是,基于同源数据的实证研究会夸大变量间的相关程度甚至带来虚假相关,这已经给管理学实证研究带来了... 详细信息

研究变量之间的相关性是现代管理学实证研究的基本范式。然而,变量之间统计上的相关性极易受到变量的测量方法和数据类型的影响。特别是,基于同源数据的实证研究会夸大变量间的相关程度甚至带来虚假相关,这已经给管理学实证研究带来了严峻挑战。不幸的是,目前仍有大量的实证研究都在使用同源主观数据。本文以人力资源管理和企业绩效的关系为例,检验了在同一样本中,对变量的不同测量和数据类型如何导致变量间相关性结论的差异。结果显示,当自变量和因变量是"同源主观数据"时,自变量和因变量之间的相关程度最高;当自变量和因变量是"非同源主观数据"时,相关程度有所下降;当自变量采用主观数据,而因变量采用客观数据时,这种相关没有达到显著性。本文的研究例子表明,在管理学实证研究中一定要谨慎使用同源的主观测量数据。

关键词：人力资源管理企业绩效同源数据虚假相关共同方法偏差

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肺原发恶性黑色素瘤一例并文献回顾

中国医师杂志 2021年第11期23卷 1628-1632页

作者：段甲利邢丽华郑州大学第一附属医院呼吸与危重症医学科 450052

目的探讨并总结肺原发恶性黑色素瘤的临床特点、诊疗及预后。方法报道1例原发于肺的恶性黑色素瘤病例。并以"恶性黑色素瘤、肺脏、原发"为检索词检索中国知网、维普网和万方数据库,以"malignant melanoma、lung、primary"为检索词检索Pu... 详细信息

目的探讨并总结肺原发恶性黑色素瘤的临床特点、诊疗及预后。方法报道1例原发于肺的恶性黑色素瘤病例。并以"恶性黑色素瘤、肺脏、原发"为检索词检索中国知网、维普网和万方数据库,以"malignant melanoma、lung、primary"为检索词检索PubMed数据库中我国的肺原发恶性黑色素瘤患者的文献进行文献回顾。结果本例患者,男,65岁,因"咳嗽伴咯血2月余"入院。胸部CT显示右肺上叶占位,肿物穿刺活检病理结果为恶性黑色素瘤。免疫组化示:S-100(+),SOX-10(+),HMB45(+),MelanA(-),AE1/AE3(-),CK5/6(-),Ki-67(40%)。PET-CT提示多发脏器转移,经对症治疗后症状缓解,由于未接受进一步治疗,病情进展,于3个月后死亡。对36篇文献报道中的41例及本例患者资料进行回顾分析,患者多为中老年人,中位年龄55岁,肿瘤肺叶分布及症状无特异性,影像学绝大部分表现为单发肿物或结节,容易早期转移和复发,31例确诊后生存期范围为27 d至24个月,其中23例(74.2%)患者生存期<12个月。结论肺原发恶性黑色素瘤临床罕见,不易与肺癌等疾病相鉴别,需结合症状、影像学以及组织病理结果等综合诊断,手术、放化疗以及免疫治疗等可以改善患者预后,但由于恶性程度高,极易复发和转移,总体预后不良。

关键词：肺肿瘤恶性黑色素瘤肿瘤,原发性

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榜样教育在高校思想政治教育中的问题及对策

重庆电子工程职业学院学报 2021年第1期30卷 55-58页

作者：段佳丽重庆交通大学马克思主义学院重庆400074

在提升高校思想政治教育的吸引力、说服力与可接受性方面,榜样教育发挥着其独特价值,同时也存在榜样选择的针对性不够、教育深度有限、效果难以持续的主要问题。基于此,本文提出了榜样教育在高校思想政治教育中的优化路径,分别是榜样选... 详细信息

在提升高校思想政治教育的吸引力、说服力与可接受性方面,榜样教育发挥着其独特价值,同时也存在榜样选择的针对性不够、教育深度有限、效果难以持续的主要问题。基于此,本文提出了榜样教育在高校思想政治教育中的优化路径,分别是榜样选择坚持邻近性和真实性、榜样教育内容与形式高度融合、榜样教育过程应注重持续强化。

关键词：榜样教育高校思想政治教育问题分析优化路径

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以学生为本视角下高校教学管理模式探究

长沙大学学报 2017年第5期31卷 143-145页

作者：段佳丽长沙医学院发展规划处湖南长沙410219

教学管理是教学活动的核心,教学管理的水平直接影响到高校教学的质量.以学生为本教育管理理念的核心是教学管理过程中真正做到以学生为教学活动的主体,给予学生自主的发展空间,激发学生的学习兴趣和创新意识,促进学生全面发展.分析了以... 详细信息

教学管理是教学活动的核心,教学管理的水平直接影响到高校教学的质量.以学生为本教育管理理念的核心是教学管理过程中真正做到以学生为教学活动的主体,给予学生自主的发展空间,激发学生的学习兴趣和创新意识,促进学生全面发展.分析了以学生为本教学管理理念的内涵,着重探讨了现阶段高校教学管理中存在的问题,并指出应该从明确高校教学管理目的、完善高校教学管理制度和方法、更新教学管理观念等方面着手,构建以学生为本的教学管理新模式.

关键词：以学生为本教学管理问题模式

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北京地方特色食品原料资源调查研究

中国食品卫生杂志 2023年第7期35卷 1021-1026页

作者：李春雨贾海先段佳丽赵耀北京市疾病预防控制中心北京100013

目的全面了解和掌握北京地方特色食品的种类、原料、产品的详细信息,为北京市地方标准的制定及相关风险监测和评估工作的开展提供基础数据和参考依据。方法通过大数据挖掘软件及实地走访调查的方式,调查北京地区特色食品及食品原料。结... 详细信息

目的全面了解和掌握北京地方特色食品的种类、原料、产品的详细信息,为北京市地方标准的制定及相关风险监测和评估工作的开展提供基础数据和参考依据。方法通过大数据挖掘软件及实地走访调查的方式,调查北京地区特色食品及食品原料。结果北京市常见的食用野菜有86种,排名前5的为黄花菜、香椿、荠菜、蒲公英、栾树芽,但只有黄花菜和香椿在市场上批量流通。北京市1760家农家乐(院)的农家菜中最常用的特色原料有香椿、河虾、花椒芽、虹鳟鱼、榛蘑等。经查询北京发布了88项与食品及原材料相关的地方标准项,其中大部分为食品原材料的生产技术规程/规范,截至目前没有发布北京市食品安全地方标准。结论北京地方独有的特色食品及特色原料较少,主要集中于餐饮及老百姓自制菜肴,也没有相应的食品安全地方标准。今后制定食品安全地方标准的重点可以侧重于传统工艺制作的地方特色食品及生产规范。

关键词：地方特色食品食品原料北京市