The effect of pmpR on the type Ⅲ secretion system in Pseudomonas aeruginosa

作     者：LIANG HaiHua KONG WeiNa SHEN Tuo DUAN JiaLi DUAN KangMin 

作者机构：Key Laboratory of Resources Biology and Biotechnology in Western ChinaMinistry of EducationFaculty of Life SciencesNorthwest UniversityXi'anShaanxi 710069China 

出 版 物：《Chinese Science Bulletin》 (Chinese Science Bulletin)

年 卷 期：2012年第57卷第19期

页      面：2413-2418页

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China (30870097 and 31000049) Shaanxi Province (2010JQ3008 and2010JK851) the Northwest University (Doctorate Dissertation of Excellence Fund (08YYB05 and 09NW17)) 

主　　题：分泌系统 绿脓杆菌 类型 缺失突变体 传感系统 感应系统 假单胞菌 数据表 

摘      要：The type III secretion system(T3SS) plays important roles in Pseudomonas aeruginosa ***,we reported that the uncharacterized protein PmpR could regulate pqsR,an important regulator in the quorum-sensing system,by directly binding to its promoter *** the T3SS is controlled by the quorum-sensing system,here,we investigated the relationship between PmpR and the *** data showed that expression of the T3SS genes exoS,exoY,exoT,and exsD was dramatically increased in a pmpR-deletion mutant compared with that in the wild-type *** strain *** from DNA mobility assays indicated that PmpR affects the T3SS *** is unlikely that PmpR controls the T3SS via the Pseudomonas quinolone signal(PQS) because the PQS negatively regulates the T3SS,while pmpR negatively regulates the *** effect of PmpR on the T3SS seems to be independent of the PQS;further investigation is required to uncover the underlying regulatory pathways.