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配药机器人批量调配参数的优化

医疗卫生装备 2024年第2期45卷 35-40页

作者：丁海文童彤杜黎黎刘圣中国科学技术大学附属第一医院(安徽省立医院)药学部合肥230001 无锡安之卓医疗机器人有限公司江苏无锡214000

目的:优化配药机器人批量调配参数,保证成品输液的标准化与同质化。方法:以不溶性微粒为考察指标,利用正交试验优化配药机器人批量调配过程中的推拉次数、静置时间、转针速度、溶媒体积、抽拉角度5种调配参数。比较于室温下调配0、2、4... 详细信息

目的:优化配药机器人批量调配参数,保证成品输液的标准化与同质化。方法:以不溶性微粒为考察指标,利用正交试验优化配药机器人批量调配过程中的推拉次数、静置时间、转针速度、溶媒体积、抽拉角度5种调配参数。比较于室温下调配0、2、4、6、8 h时的4种成品输液(泮托拉唑钠溶液、艾司奥美拉唑钠溶液、奥美拉唑钠溶液、艾普拉唑钠溶液)的外观性状、pH值、渗透压和不溶性微粒数;对比采用配药机器人调配和人工调配4种成品输液的空西林瓶内的药液残留量及批量调配效率。结果:优化后,配药机器人批量调配参数为推拉次数2次、静置时间5 s、转针速度慢速、溶媒体积6 mL、抽拉角度90°。室温下调配8 h时,艾普拉唑钠溶液颜色变为淡黄色澄清,不溶性微粒数超出2020年版《中国药典》规定;其他3种成品输液0、2、4、6、8 h时外观性状均为无色澄清,不溶性微粒数均符合2020年版《中国药典》规定。4种成品输液0、2、4、6、8 h时pH值、渗透压均无显著变化。配药机器人调配的药液残留量显著低于人工调配,1人操作2台机器人的批量调配效率高于1人手工及1人操作1台机器人的批量调配效率,差异有统计学意义(P<0.05)。结论:采用正交试验优化配药机器人批量调配参数,保证了成品输液的标准化与同质化,可降低药液残留,提高批量调配效率。

关键词：配药机器人调配参数批量调配不溶性微粒

基于CKF-SLAM改进的无人水下航行器动态目标跟踪算法研究

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云南民族大学学报（自然科学版） 2024年第1期33卷 102-110页

作者：都立立邢传玺万志良李聪颖云南民族大学电气信息工程学院云南昆明650500

针对容积卡尔曼滤波(cubature Kalman filter,CKF)同步定位与建图(simultaneous localization and mapping,SLAM)算法在动态目标跟踪(object tracking,OT)的应用中,存在算法实时性不高、计算复杂以及对动态目标物跟踪精度较低的问题,提... 详细信息

针对容积卡尔曼滤波(cubature Kalman filter,CKF)同步定位与建图(simultaneous localization and mapping,SLAM)算法在动态目标跟踪(object tracking,OT)的应用中,存在算法实时性不高、计算复杂以及对动态目标物跟踪精度较低的问题,提出基于平方根容积卡尔曼滤波SLAM的无人水下航行器(unmanned underwater Vehicle,UUV)目标跟踪算法(SRCKF-SLAM-OT).该算法将CKF-SLAM-OT中复杂的计算部分,利用3阶容积准则选取一组相同权值的容积点来近似计算,再利用数值积分法计算非线性方程模型的后验状态估计平均值和方差,并对协方差矩阵的平方根因子进行更新.仿真结果表明:SRCKF-SLAM-OT算法简化了计算量和改善了数值精度,提高了UUV在未知水下环境中自身定位的精度和动态目标物跟踪的能力.

关键词：动态目标跟踪容积卡尔曼滤波同步定位与建图平方根容积卡尔曼滤波无人水下航行器

Sea-level variation/change and thermal contribution in the Bering Sea

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Acta Oceanologica Sinica 2005年第6期24卷 36-45页

作者： ZUO Juncheng ZHANG Jianli du ling li Peiliang li Lei College of Physical and Environmental Oceanography Ocean University of China Qingdao 266003 China College of Physical and Environmental Oceanography Ocean University of China Qingdao 266003 China College of Physical and Environmental Oceanography Ocean University of China Qingdao 266003 China College of Physical and Environmental Oceanography Ocean University of China Qingdao 266003 China College of Physical and Environmental Oceanography Ocean University of China Qingdao 266003 China

The long-term sea-level trend in the Bering Sea is obtained by the analysisof TOPEX/Poseidon altimeter data, including the data of two tide gauges. The averaged sea-level inthe Bering Sea rises at a rate of 2.47 mm/a from 1992 to 2002. The mean sea-level is falling in themost part of the Bering Sea, especially in its central basin, and it is rising in the northeasternpart of the Bering Sea. during the 1998/99 change, the sea-level anomaly differences exhibit asignificant sea-level anomaly fall in the deep basin of the Bering Sea, which is roughly in the sameposition where a prominent SST fall exists. The maximal fall of sea-level is about 10 cm in thesouthwestern part of the Bering Sea, and the maximal fall of about 2℃ in the SST also appeared inthe same region as the sea level did. The steric sea-level change due to temperature variations isdiscussed. The results are compared with the TOPEX/Poseidon altimeter data at the different spatialscales. It is indicated that the seasonal amplitude of the steric height is about 35% of theobserved TOPEX/Poseidon amplitude, which is much smaller than the 83% in the mid-latitudes area. Thesystematic difference between the TOPEX/Poseidon data with the range of about 7.5 cm and thethermal contribution with the range of about 2.5 cm is about 5 cm. This indicates that the thermaleffect on the sea level is not as important as the case in the mid-latitudes area. In the BeringSea, the phase of the steric height leads the observed sea level by about three months.

关键词： sea-level variation steric bering sea

MicroRNA encoded by the HSV-1 latency-associated transcript anti-apoptotic function in human mesenchymal stem cells

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Chinese Science Bulletin 2008年第11期53卷 1691-1698页

作者： ZHANG Jing li YongMei du WenCai li GuangMing li WeiXia ZHU Ze Department of Medical Microbiolgy Tianjin Key Laboratory of Cellular and Molecular Immunology '13anjin Medical University Tianjin300070 China

Human mesenchymal stem cells (HMSCs) have emerged as a promising cell type for tissue repopulat-ing and for use as ex vivo gene delivery vehicles. Herpes simplex virus-1 (HSV-1) possesses many vector features, which make it especially suitable for HMSC applications. Here we performed real-time RT-PCR to detect the level of mature microRNA encoded by the HSV-1 latency-associated transcript (microRNA-LAT) in HMSCs cytoplasm with a specific stem loop reverse primer. Three small interfering RNAs (siRNAs) were chemically synthesized towards microRNA-LAT, TGF-β1 and SMAD3. The results demonstrate that HSV-1 and microRNA-LAT prevented HMSCs from undergoing cisplatin-induced apoptosis. In comparison with cells only treated with cisplatin, the apoptosis phenomenon with HSV-1 and microRNA-LAT were markedly reduced. The apoptosis rates of these two groups were both lower (Pling pathway components were by these means knocked down. Moreover, the levels of the mature microRNA-LAT were decreased in cis-platin-treated HMSCs. In conclusion, HSV-1 and microRNA-LAT exert their anti-apoptotic effect on HMSCs by down-regulation of the TGF-β signalling pathway. Thus HSV-1, having anti-apoptotic effect naturally encoded in its microRNA-LAT, is a good candidate to be developed for HMSC vector.

关键词：间叶细胞干细胞组织再生单纯疱疹病毒1 基因转录

Development and characterization of formulation of dust-suppressant used for stope road in open-pit mines

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Journal of Coal Science & Engineering(China) 2013年第2期19卷 219-225页

作者： Cui-Feng du li li Civil and Environmental Engineering Institute University of Science and Technology Beijing Beijing 100083 China

The components of dust-suppressant were determined based on the analysis on characteristics and mechanisms of road dust raising in open-pit mines. The components were initially selected from moisture agent, coagulation agent and surfactant. The optimal formulation was determined based on orthogonal test and using the water loss rate as the evaluation index. The performances of moisture releasing and adsorption, wind resistance of optimal formulation in the natural environment were tested. The results show that the formula obtained in experiments provide a good performance of moisture absorption and water retention, and it also had a good dust preventing and controlling performance due to its high surface strength and consolidation under dry conditions. It has good application prospects considering the wide variety of sources for materials and the simple preparation process.

关键词： hygroscopic coagulation agent surfactant open-pit mine road dust suppressant formulation

Synthesis and Temperature-dependent Electrochemical Properties of Boron-doped Diamond Electrodes on Titanium

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Chemical Research in Chinese Universities 2012年第3期28卷 507-510页

作者： du li-li SUN Jian-rui CUI Hang li Hong-dong CUI Tian liN Hai-bo State Key Laboratory of Superhard Materials Jilin UniversityChangchun 130012P.R.China College of Chemistry Jilin UniversityChangchun 130012P.R.China State Key Laboratory of Theoretical and Computational Chemistry Institute of Theoretical ChemistryJilin UniversityChangchun 130021P.R.China

On the sand-blasting-treated titanium（Ti） substrate, the boron-doped diamond（BDD） electrodes with a wide potential window were prepared by microwave plasma chemical vapor deposition（MPCVD）. The electrochemi- cal oxidation ratios of phenol at BDD/Ti electrodes at elevated temperatures（from 20 ℃ to 80 ℃） were examined by the chemical oxygen demand（COD） of phenol electrolyte during electrolysis. The results show that the COD removal was increased at high temperatures and the optimized temperature for enhancing the electrochemical oxidation ratio of phenol is 60 ℃. The mechanism for the temperature-dependent electrochemical oxidation ratios of phenol at the electrodes was investigated. The study would be favorable for further improving the performance of BDD/Ti elec- trodes, especially working at high temperatures.

关键词： BDD/Ti electrode Microwave plasma chemical vapor deposition Phenol Electrochemical degradation

Sequential Propagation of Chaos for Mean-Field BSDE Systems

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Chinese Annals of Mathematics,Series B 2024年第1期45卷 11-40页

作者： Xiaochen li Kai du Shanghai Center for Mathematical Sciences Fudan UniversityShanghai 200433China. Shanghai Artificial Intelligence Laboratory 701 Yunjin RoadShanghai 200433China

A new class of backward particle systems with sequential interaction is proposed to approximate the mean-field backward stochastic differential *** is proven that the weighted empirical measure of this particle system converges to the law of the McKean-Vlasov system as the number of particles *** on the Wasserstein met-ric,quantitative propagation of chaos results are obtained for both linear and quadratic growth ***,numerical experiments are conducted to validate our theoretical results.

关键词： Backward propagation of chaos Particle system Sequential interaction McKean-Vlasov BSDE Convergence rate

Numerical study on the effective thermal conductivity and thermal tortuosity of porous media with different morphologies

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Science China(Technological Sciences) 2024年第6期67卷 1685-1694页

作者： du Shen li Dong li Meng-Jie HE Ya-ling Key Laboratory of Thermo-Fluid Science and Engineering of Ministry of Education School of Energy and Power EngineeringXi’an Jiaotong UniversityXi’an710049China

Effective thermal conductivity and thermal tortuosity are crucial parameters for evaluating the effectiveness of heat conduction within porous *** direct pore-scale numerical simulation method is applied to investigate the heat conduction processes inside porous structures with different *** thermal conduction performances of idealized porous structures are directly compared with real foams across a wide range of *** foam structures are reconstructed using X-ray computed tomography and image processing techniques,while Kelvin and Weaire-Phelan structures are generated through periodic unit cell *** detailed temperature fields inside the porous structures are determined by solving the heat conduction equation at the pore *** results present that the equivalent thermal conductivity of Kelvin and Weaire-Phelan structures is similar to and greater than that of the real foam structure with the same strut *** thermal tortuosity of real foam structure is relatively larger and the heat conduction path becomes straighter by adopting the anisotropic *** thermal tortuosity of the fluid channels for Kelvin,Weaire-Phelan,and real foam structures is close to *** thermal conductivity of porous structures with heat transfer fluid increases as the thermal conductivity ratio of fluid to solid becomes larger.A small porosity of porous media leads to a larger equivalent thermal conductivity due to the dominant contribution of porous skeleton in the heat conduction *** derived from parallel and series models,as well as the Maxwell-Eucken models,provide decent predictions of effective thermal conductivity,with an average error of less than 8%in the entire range of thermal conductivity ratio.

关键词： volumetric solar receiver porous morphology direct pore-scale simulation equivalent thermal conductivity thermal tortuosity empirical correlation

Comparison of Direct Pore-Scale and Volume-Averaging Methods for the Performance Evaluation of Porous Volumetric Solar Receiver

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Journal of Thermal Science 2024年第5期33卷 1607-1617页

作者： du Shen HE Yaling li Dong liU Zhanbin li Mengjie National Innovation Platform(Center)for Industry-Education Integration of Energy Storage Technology Key Laboratory of Thermo-Fluid Science and Engineering of Ministry of EducationXi’an Jiaotong UniversityXi’an710049China

Direct pore-scale and volume-averaging numerical simulations are two methods for investigating the performance of porous volumetric solar *** clarify the difference in the prediction of heat transfer processes,a direct comparison between these two methods was conducted at both steady state and transient *** numerical models were established based on X-ray computed tomography scans and a local thermal non-equilibrium model,*** empirical parameters,which are indispensable to the volume-averaging simulation,were determined by Monte Carlo ray tracing and direct pore-scale numerical *** predicted outlet air temperature of the receiver by the volume-averaging simulation method corresponded satisfactorily to that in the direct pore-scale *** largest discrepancies were observed when the receiver's working temperature was elevated,with differences of 5.5%and 3.68%for the steady state and transient state simulations,***,the volume-averaging method is incapable of capturing the local temperature information of the air and porous *** underestimates the inlet temperature of the receiver,leading to an overestimation of the receiver's thermal efficiency,with the largest difference being 6.51%.The comparison results show that the volume-averaging model is a good approximation to the pore-scale model when the empirical parameters are carefully selected.

关键词： porous media volumetric solar receiver pore-scale method volume-averaging method thermal performance