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N-cadherin expression in the midbrain substantia nigra of perinatal rats

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Neural Regeneration Research 2008年第10期3卷 1136-1140页

作者： Junping Cao Yu Sun xia du Dianshuai Gao Department of Neurobiology Xuzhou Medical College Xuzhou 221002 Jiangsu Province China

BACKGROUND： Cellular adhesion molecule mediates the effects of glial cell line-derived neurotrophic factor in dopaminergic neurons during nervous system development. It is assumed that cellular adhesion molecule plays an important role in dopaminergic neuron development. OBJECTIVE： To investigate N-cadherin expression in the midbrain substantia nigra during rat development. DESIGN, TIME AND SETTING： The developmental biology, controlled study was performed at the Laboratory of Research Center of Neurobiology, Xuzhou Medical College, China from April to October 2007. MATERIALS： Sprague Dawley rats （embryonic days 16, 18, and 20, as well as postnatal days 1, 3, 7, 14, and 21） were selected for this study. N-cadherin antibody was purchased from Santa Cruz, USA. METHODS： N-cadherin expression in the midbrain substantia nigra of perinatal rats was detected using reverse transcription polymerase chain reaction, Western blot, and immunohistochemistry methods. N-cadherin-positive cells were counted. MAIN OUTCOME MEASURES： N-cadherin mRNA, protein, and positive cells in the rat midbrain substantia nigra were quantified. RESULTS： The results of reverse transcription polymerase chain reaction and Western blot demonstrated that altered N-cadherin mRNA levels were similar to protein levels in the midbrain substantia nigra. N-cadherin mRNA and protein expression was low in the midbrain substantia nigra of embryonic day 16 rats but gradually increased, and reached a peak at postnatal day 1. N-cadherin mRNA and protein levels were still high at postnatal days 3 and 7, but significantly decreased at postnatal day 14. There was no significant difference in N-cadherin mRNA and protein expression between postnatal days 14 and 21 （P 〉 0.05）. The immunohistochemistry results demonstrated that there was no significant difference in the quantity of N-cadherin-positive cells per area in rats from embryonic day 16 to postnatal day 7 （P 〉 0.05）. The quantity of N-cadherin-positive cells per a

关键词： N-cadherin substantia nigra nervous system development

New Investigation of Potential Acting on an Electron in a Molecule to Draw Molecular Faces

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Chemical Research in Chinese Universities 2015年第6期31卷 982-986页

作者： du xia ZHU Yijing LIU Shuang ZHAO Dongxia Institute of Traditional Chinese Medicine Shaanxi Academy of Traditional Chinese Medicine Xi'an 710003 P. R. China School of Physics and Electronic Technology Liaoning Normal University Dalian 116029 P. R. China School of Chemistry and Chemical Engineering Liaoning Normal University Dalian 116029 P. R. China

A new approach to calculate the potential acting on an electron in a molecule（PAEM） has been established for drawing the molecular face（MF） of a macromolecule, according to the classic point charge model and the atom-bond electronegativity equalization method（ABEEMσπ） for one electron in a molecule. We introduced a dy- namic charge distribution from the view of a local electron movement in a molecule based on the new approach, and as further direct evidence, we calculated some physical quantities using the original ab initio method and the new method to verify the accuracy of the method, such as the boundary distance（BD）, molecular face surface area（MFSA） and molecular reactivities indicated by the MFs for a variety of organic molecules. All the results by the new method are in agreement with the results by ab initio method.

关键词： Potential acting on an electron in a molecule(PAEM) Molecular face(MF) Boundary distance(BD) Molecular face surface area(MFSA)

Synthesis and Crystal Structure of 4-Salicylimine-3, 5-bis(2-hydroxyphenyl)-1, 2, 4-triazole JI Bao-Minga

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Chinese Journal of Structural Chemistry 2002年第3期21卷 252-255页

作者： JI Bao-Ming du Chen-xia ZHU Yu WANG Yang Department of Chemistry Luoyang Teacher's College Luoyang 471022 Department of Chemistry Zhengzhou University Zhengzhou 450052 School of Pharmacy Fudan University 上海 200032

The title compound, 4-salicylimine-3, 5-bis(2-hydroxyphenyl)-1, 2, 4-triazole, was obtained by the condensation reaction of 4-amino-3, 5-bis(2-hydroxyphenyl)-1, 2, 4-triazole with salicylaldehyde in methanol. The crystal structure (C21H16N4O3, Mr = 372.38) belongs to monoclinic system, space group P21/n with a = 10.507(2), b = 16.878(3), c = 11.199(2) ? = 110.86(3), V = 1855.9(6) ?, Z = 4, Dc = 1.333 g/cm3, F(000) = 776, (MoK? = 0.092 mm-1, R = 0.0552 and wR = 0.1095 for 1920 reflections ( I > 2.0(I) ). The analytical results of crystal structure show that there are two different non-covalent interactions in the compound. One is hydrogen bond, and the other p-p stacking interaction. These two types of non-covalent interactions play an important role in the packing of crystal.

关键词： triazole hydrogen bond crystal structure stacking interaction

Single & Two-photon Excited Fluorescence of Two New Compounds with 2-Benzothiazolyl as Electron Acceptor

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Chinese Chemical Letters 2003年第5期14卷 547-550页

作者： du xia CAO Qi FANG Dong WANG Zhi Qiang LIU State Key Laboratory of Crystal Materials Shandong UniversityJi’nan 250100

Two new D--A type compounds, where electron-donor D is tertiary amino group, electron-acceptor A is 2-benzothiazolyl and ?is two conjugated styryl units, have been synthesized. They are named as trans, trans-2-{4-[4-(N, N-diethylamino)styryl]styryl}-1, 3-benzothiazole and trans, trans-2-{4-[4-(N, N-diphenylamino)styryl]styryl}-1, 3-benzothiazole. Both compounds show strong two-photon excited fluorescence in yellow-orange region when excited by a femtosecond laser at 800 nm.

关键词： Benzothiazole derivatives two-photon excited fluorescence nonlinear optical compounds.

Preparation of nano-TiO_2 photocatalysts and their decomposition activity in phenol-contaminated water

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第11期10卷 1651-1659页

作者： xiao-yuan JIANG Feng du Chun-xia GUO Qiong YANG xiao-ming ZHENG Institute of Catalysis Faculty of Science Zhejiang University Hangzhou 310028 China

ZiO2 was prepared by the hydrolyzation method in （NH4）2SO4-modified TiCl4 solution, and TiO2 photocatalysts were obtained by accelerating the precipitation of TiO2 powder in a high-temperature water bath. The photocatalysts were characterized by Brunauer-Emmett-Teller （BET）, X-ray diffraction （XRD）, Raman spectrum and UV-Vis （Ultraviolet-Visible） spectrometry techniques, and the photocatalytic activity in phenol-contaminated water was investigated. The results showed that photocatalysts calcined at 400 ℃ had a specific surface area of 138.2 m^2/g and an average particle size of 9 nm, and a significant increase in thermal stability of anatase phase. At the calcination temperature of 700 ~C, the crystal form of TiO2 started to change into rutile （anatase： 97%, rutile： 3%）. The activity of TiO2 photocatalysts prepared with （NH4）2SO4-modified TIC14 solution was markedly stronger than that without （NH4）2SOg-modified TIC14 solution. Maximal photocatalytic activity was observed at the mole ratio of Ti：（NH4）2SO4= 1：2, the water-bath temperature of 90℃ and the calcination temperature of 700 ℃.

关键词： Ammonium sulfate Titanium dioxide Photocatalysis reaction Phenol-contaminated water

Dispersion behavior of core-shell silica-polymer nanoparticles

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China Particuology 2007年第4期5卷 300-304页

作者： Yi Wang Yangchuan Ke Jingzi Li Shouqin du Yanfeng xia State Key Laboratory of Heavy Oil Processing China University of Petroleum No. 18 Fuxue Road Changping 102249 Beijing PR China

Core-shell silica nanoparticles are superior in modifying surface wetting behavior, enhancing nucleation and growth in crystallization, improving dispersion of naked nanoparticles, and thus upgrading the overall properties of organic polymers. The dispersion behavior and morphology of monodisperse core-shell silica particles in several polymers including polyesters are reviewed and their potential applications are discussed.

关键词： Core-shell SiO2 Nanoparticles Preparation Dispersion Application

Recent developments in electrosynthesis of nitriles and electrocatalytic cyanations

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Journal of Energy Chemistry 2022年第7期31卷 542-575,I0014页

作者： Haiyan Hu Shanxuan Wu Fachao Yan Mohamed Makha Yuxia Sun Chen-xia du Yuehui Li State Key Laboratory for Oxo Synthesis and Selective Oxidation Suzhou Research Institute of LICPCenter for Excellence in Molecular SynthesisLanzhou Institute of Chemical Physics(LICP)Chinese Academy of SciencesLanzhou 730000GansuChina University of Chinese Academy of Sciences Zhengzhou 450001HenanChina College of Chemistry Zhengzhou UniversityBeijing 100049China

Nitrile compounds are a class of high-value chemicals and versatile intermediates which can easily be transformed into a variety of useful products bearing functional groups such as carboxyl, carbamoyl, aminomethyl, ketyl and heterocyclic derivatives. Various thermal catalytic cyanation procedures have been devised and scaled up industrially while developing alternative methods are actively pursued. The access to these classes of molecules electrochemically offers greener alternatives to their preparation. The development of electrochemical synthesis of cyano-containing compounds under mild conditions with low energy consumption will imminently become indispensable approaches for industrial production of nitriles. The electrochemical cyanation presents many challenges from the toxicity of cyanide to the development of catalysts and the design of electrochemical cells. Electrochemical cyanation reaction offers promise to conveniently accessing nitriles but still requires efficient electro-catalysts, safe protocols and scale up considerations. This review discusses recent progress in the field of electrochemical synthesis of nitrile compounds placing emphasis on electro-synthetic and electro-catalytic mechanism aspects while making reference to original works to highlight the progress in this area.

关键词： Cyano compounds Nitriles Cyanation Electrosynthesis Electrocatalysis

Molecularly Imprinted Polymers on Chloromethyl Polystyrene Resin Prepared via RAFT Polymerization

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Chinese Chemical Letters 2006年第4期17卷 549-552页

作者： Zhen xia du Hong LIU Zhi Feng FU Wan Tai YANG Key Laboratory for Controlled Chemical Reactions of Education Ministry Beijing University of Chemical Technology Beijing 100029

Surface molecularly imprinted polymers （SMIP） was prepared via the reversible addition-fragmentation chain transfer （RAFT） polymerization on the chloromethyl polystyrene resin （CPR） in the presence of the template D-phenylalanine. The structure of SMIP was characterized by FTIR and SEM. The adsorption behavior of D-phenylalanine of SMIP was preliminarily investigated.

关键词： Surface molecularly imprinted polymers reversible addition-fragmentation chain transfer.

Screening and analysis of key active constituents in Guanxinshutong capsule using mass spectrum and integrative network pharmacology

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Chinese Journal of Natural Medicines 2018年第4期16卷 302-312页

作者： LIU Feng du xia LIU Pei-Rong SUN Yu-Hong ZHANG Yan-Min School of Pharmacy Health Science CenterXi'an Jiaotong UniversityXi'an 710061China Shaanxi Institute of lnternational Trade&Commence Xianyang 712046China Shaanxi Buchang Pharmaceutical Co.Ltd Xi'an 710075China Shannxi Academy of Traditionnal Chinese Medicine Xi'an 710003China School of Life Sciences Northwest UniversityXi'an 710069China

Guanxinshutong capsule(GXSTC) is an effective and safe traditional Chinese medicine used in the treatment of cardiovascular diseases(CVDs) for many years. However, the targets of this herbal formula and the underlying molecular mechanisms of action involved in the treatment of CVDs are still unclear. In the present study, we used a systems pharmacology approach to identify the active ingredients of GXSTC and their corresponding targets in the calcium signaling pathway with respect to the treatment of CVDs. This method integrated chromatographic techniques, prediction of absorption, distribution, metabolism, and excretion, analysis using Kyoto Encyclopedia of Genes and Genomes, network construction, and pharmacological experiments. 12 active compounds and 33 targets were found to have a role in the treatment of CVDs, and four main active ingredients, including protocatechuic acid, cryptotanshinone, eugenol, and borneol were selected to verify the effect of(GXSTC) on calcium signaling system in cardiomyocyte injury induced by hypoxia and reoxygenation. The results from the present study revealed the active components and targets of GXSTC in the treatment of CVDs, providing a new perspective to enhance the understanding of the role of the calcium signaling pathway in the therapeutic effect of GXSTC.

关键词： Mass spectrum Systems pharmacology Guanxinshutong capsule Cardiovascular diseases Calcium signaling pathway