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Testing of 1TnR RRAM array with sneak path technique

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Science china(Information Sciences) 2017年第2期60卷 208-210页

作者： Xiaole CUI Qiang ZhanG Xiaoxin CUI Xinan WANG Jinfeng KANG xiaoyan liu Key Laboratory of Integrated Microsystems Peking University Shenzhen Graduate School institute of microelectronics Peking University

Dear editor,RRAM is regarded as one of the most promising candidates among emerging nonvolatile memory technologies[1,2].Recently,the 1Tn R RRAM structure,in which n RRAM cells in each row share a common bottom electrode connected to the drain node of a selector transistor,was proposed to improve the integration density[3,4].The area of the 1T4R RRAM test chip is 30%smaller than that of the conventional 1T1R cell[3].However,the complexity of the conventional

关键词： RRAM cell Testing of 1TnR RRAM array with sneak path technique

Plant crop remains from the outer burial pit of the han Yangling Mausoleum and their significance to Early Western han agriculture

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Chinese Science Bulletin 2009年第10期54卷 1738-1743页

作者： YANG xiaoyan liu ChangJiang ZhanG JianPing YANG WuZhan ZhanG XiaoHu LV HouYuan institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Beijing 100101 China institute of Botany Chinese Academy of Sciences Beijing 100091 China institute of Geology and Geophysics Chinese Academy of Sciences Beijing 100029 China Shaanxi Provincial institute of Archaeology Xi'an 710001 China College of Urban and Environmental Science Peking University Beijing 100871 China

A large amount of carbonized plant remains were discovered in one of the outer burial pits of the han Yangling Mausoleum, which was built more than 2000 years ago for the Jing Emperor, liu, Qi (188―141 cal a BC), the fourth emperor of the Western han Dynasty. The remains are identified by phytolith analysis and macrofossil morphological features. Seeds from foxtail millet (Setaria italica), broomcorn millet (Panicum miliaceum), rice (Oryza sativa) and chenopod (possible Chenopodium giganteum) are identified, suggesting that these four crops might have been the staple plant foods in the capital area (Guanzhong area), Shaanxi Province during the Early Western han Dynasty. Chenopods were often considered as weeds since they have only been rarely found as carbonized seeds in prehistoric sites. This is the first time such a large amount of seeds has been found at a site, which provides strong material evidence for chenopod cultivation with a long history in china. Wheat was thought to be promoted and popularized in the Guanzhong area since the Wu Emporor, liu, Che (156―87 cal a BC), the fifth emperor of the Western han Dynasty. No wheat was found at this site, which supports the historical document record that wheat was still secondary in the diet and agrarian economy before the Wu Emperor's reign.

关键词：植物性食品早期农业西汉陵墓作物杨凌汉族关中地区

Correlation between the different chain lengths of free fatty acid oxidation and abili .ty of trophoblastic invasion

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Chinese Medical Journal 2014年第19期127卷 3378-3382页

作者： Yu Huan Yang Zi Ding xiaoyan Wang Yanling han Yiwei Department of Obstetrics and Gynecology Peking University ThirdHospital Beijing 100191 State Key Laboratory of Reproductive Biology Institute of ZoologyChinese Academy of Sciences Beijing 1 00101 China

Background Preeclampsia （PE） is associated with abnormal fatty acid beta-oxidation （FAO）, especially metabolic disorders of long-chain fatty acid oxidation. The role of FAO dysfunction in inadequate invasion is unclear. The aim of this study was to explore the influence of various lengths fatty acids oxidation on invasiveness of trophoblasts. Methods Primary human trophoblast cells and HTR8/SVneo cells were treated with fatty acids of various lengths. Morphological changes, lipid deposition and ultrastructure changes of trophoblast cells were detected. Cells invasiveness was determined by transwell insert. CPT1, CPT2 and long-chain 3-hydroxyacyI-CoA dehydrogenase （LCHAD） protein expression were analyzed. The correlation between intracellular lipid droplets deposition and cells invasiveness was evaluated. Results Cells treated with long-chain fatty acids showed significant increased lipid droplets deposition, severe mitochondrial damage, decreased CPT2 and LCHAD protein expression （P 〈0.05） but no significant difference in CPT1 protein expression （P 〉0.05）. Invasiveness of the trophoblast cells of the LC-FFA group significantly decreased （P 〈0.05）. Intracellular lipid droplets deposition was negatively correlated with invasivenss （R=-0.745, P 〈0.05）. Conclusion Trophoblast cells after stimulation with long chain fatty acids exist fatty acid oxidation disorders, and reduce the ability of trophoblastic invasion.

关键词： fatty acid beta-oxidation long chain fatty acid trophoblasts invasion

铜绿假单胞菌在液滴界面的二维和三维运动特征

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微生物学报 2022年第8期62卷 3124-3136页

作者：朱晓艳韩苗韩天富韩峥王钢郑州大学物理学院河南郑州450001 中国农业大学土地科学与技术学院北京100193 中国农业科学院农业资源与农业区划研究所北京100081

【目的】环境中无处不在的气-液界面能够影响细菌的运动和养分的传输扩散,进而调控微生物的种群互作和群落结构。因此,系统地认知微生物在微观界面的运动特征对于理解和解析微生物多样性的产生、维持机制以及生态功能至关重要。【方法... 详细信息

【目的】环境中无处不在的气-液界面能够影响细菌的运动和养分的传输扩散,进而调控微生物的种群互作和群落结构。因此,系统地认知微生物在微观界面的运动特征对于理解和解析微生物多样性的产生、维持机制以及生态功能至关重要。【方法】本文基于微流体显微系统(超高速荧光显微镜和数字全息显微镜),以具备主动运动能力的模式菌株铜绿假单胞菌(Pseudomonas aeruginosa PAO1)为研究对象,观测并解析了细菌细胞在气-液界面的二维运动特征和气-液-固界面的二维与三维运动特征。【结果】PAO1既能在气-液界面处执行近似直线轨迹的运动,也能在气-液界面下方执行顺时针或逆时针旋转的圆周运动(最小曲率半径Rmin=3μm)。在气-液-固界面处,6.45%的不运动细胞聚集于气-液-固界面边缘处,并在该处完成不可逆附着;同时,游动细胞由于受到液滴内部毛细管流和马兰戈尼(Marangoni)涡流运动的综合作用,直线游动至距界面约40μm内的区域后,其运动轨迹转变为垂直界面方向返回或以近似界面平行方向运动并附着,这些行为显著调节了PAO1的空间分布,促使了其朝向气-液-固界面的迁移,表明个体PAO1的鞭毛在此处的主动游动作用较弱。【结论】PAO1在气-液界面处能够执行与固-液界面类似的运动轨迹,且能够在各种作用力下朝向气-液-固界面运动并附着。

关键词：气-液界面气-液-固界面数字全息显微镜铜绿假单胞菌细菌运动性

A cubic triboelectric generator as a self-powered orientation sensor

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Science china(Technological Sciences) 2015年第5期58卷 842-847页

作者： QIU GuoLin liu Wen han MengDi CHENG XiaoLiang MENG Bo SMITHA Ankanahalli Shankaregowda ZHAO JiangMing ZhanG HaiXia Science and Technology on Micro/Nano Fabrication Laboratory Institute of Microelectronics Peking University School of Mechanical Engineering Zhengzhou University

Recently, triboelectric generator(TEG) has attracted a lot of attention due to its high output voltage and low-cost fabrication process. Here, a novel cubic TEG box is designed, which has separated electrodes on different surfaces. Thanks to the specially designed structure, it can scavenge vibration energy from all directions. Firstly the device is investigated through finite element method(FEM) simulation. Then the device is evaluated by experiments. The measuremental results show that this device can generate an amount of 25 n C charge during once shake by charging a 10 n F capacitor. Besides, an output voltage about 100 V is obtained, which is able to directly light up several light-emitting diodes(LEDs) simultaneously. At last, the device is utilized as a self-powered orientation sensor, which shows explicit directivity. This work extends the applications of TEG for ambient vibration energy harvesting techniques and the self-powered orientation sensor.

关键词： cubic powered generator fabrication utilized outer capacitor directions separated charges

A brain structural connectivity biomarker for autism spectrum disorder diagnosis in early childhood

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Psychoradiology 2023年第1期3卷 171-181页

作者： Xi Jiang Xiao-Jing Shou Zhongbo Zhao Yuzhong Chen Fan-Chao Meng Jiao Le Tian-Jia Song Xin-Jie Xu Weitong Guo xiaoyan Ke Xiao-E Cai Weihua Zhao Juan Kou Ran Huo Ying liu Hui-Shu Yuan Yan Xing Ji-Sheng han Song-Ping han Yun Li Hua Lai Lan Zhang Mei-Xiang Jia Jing liu Xuan liu Keith M.Kendrick Rong Zhang The Clinical Hospital of Chengdu Brain Science institute MOE Key Lab for NeuroinformationSchool of Life Science and TechnologyUniversity of Electronic Science and Technology of ChinaChengdu 611731China Neuroscience Research institute Key Laboratory for NeuroscienceMinistry of Education of ChinaKey Laboratory for NeuroscienceNational Committee of Health and Family Planning of ChinaDepartment of NeurobiologySchool of Basic Medical SciencesPeking UniversityBeijing 100191China State Key Laboratory of Cognitive Neuroscience and Leamning Beijing Key Laboratory of Brain Imaging and Connectomicsand IDG/McGovermn Institute for Brain ResearchBeijing Normal UniversityBeijng 100875China Chengdu Women's and Children's Central Hospital School of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 611731China Child Mental Health Research Center Nanjing Brain Hospital Affliated of Nanjing Medical UniversityNanjing 210029China Radiology Department Peking University Third HospitalBeijing 100191China Department of Pediatrics Peking University Third HospitalBeijing 100191China Wuxi Shenpingxintai Medical Technology Co LtdWuxi 214091China Mental Health institute Peking UniversityKey Laboratory of Ministry of HealthThe Ministry of Public HealthBeijing 100191China Shandong Ke Luo Ni Ke(CLINIC)Medical Technology Co LtdDezhou 253011China Autism Research Center of peking university Health Science Center Beiing 100191China Department of Integration of Chinese and Western Medicine School of Basic Medical SciencesPeking University100191BeijingChina

Background:Autism spectrum disorder(ASD)is associated with altered brain development,but it is unclear which specific structural changes may serve as potential diagnostic markers,particularly in young children at the age when symptoms become fully ***,such brain markers need to meet the requirements of precision medicine and be accurate in aiding diagnosis at an individual rather than only a group ***:This study aimed to identify and model brain-wide differences in structural connectivity using diffusion tensor imaging(DTI)in young ASD and typically developing(TD)***:A discovery cohort including 93 ASD and 26 TD children and two independent validation cohorts including 12 ASD and 9 TD children from three different cities in china were ***-wide(294 regions)structural connectivity was measured using DTI(fractional anisotropy,FA)together with symptom severity and cognitive development.A connection matrix was constructed for each child for comparisons between ASD and TD *** classification was performed on the discovery dataset and the resulting model was tested on the two independent validation ***:Thirty-three structural connections showed increased FA in ASD compared to TD children and associated with both autistic symptom severity and impaired general cognitive *** majority(29/33)involved the frontal lobe and comprised five different networks with functional relevance to default mode,motor control,social recognition,language and ***,clas-sification achieved very high accuracy of 96.77%in the discovery dataset,and 91.67%and 88.89%in the two independent validation ***:Identified structural connectivity differences primarily involving the frontal cortex can very accurately distinguish novel individual ASD from TD children and may therefore represent a robust early brain biomarker which can address the requirements of precision medicine.

关键词： autism spectrum disorder diffusion tensor imaging fractional anisotropy brain structural connectivity individual diag-nosis early childhood

A photomemory by selective-assembling hybrid porphyrin-silicon nanowire field-effect transistor

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Science china(Information Sciences) 2020年第6期63卷 253-255页

作者： Gong CHEN Bocheng YU Xiaokang LI Xiaoqiao DONG xiaoyan XU Zhihong LI Ru HUANG Ming LI Key Laboratory of Microelectronic Devices and Circuits(MOE) Institute of MicroelectronicsPeking University National Key Laboratory of Science and Technology on Micro/Nano Fabrication Peking University Faculty of Information Technology Beijing University of Technology

Dear editor,Recently, the integration of photosensitive material and electronic nanodevice has been the center of attention with Internet of things (IoT)technology development [1–3]. The immobilization of such photoactive molecules on the semiconductor surface was necessarily adopted to employ their photoelectric characteristics which can be observed in the solution. Porphyrin-based hybrid transistors have emerged as promising candidates for photonic sensing application due to the

关键词： A photomemory by selective-assembling hybrid porphyrin-silicon nanowire field-effect transistor

Effective gate length model for asymmetrical gate-all-around silicon nanowire transistors

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Science china(Information Sciences) 2020年第10期63卷 288-290页

作者： Xiaoqiao DONG Ming LI Wanrong ZhanG Yuancheng YANG Gong CHEN Shuang SUN Jianing WANG xiaoyan XU Xia AN Key Laboratory of Microelectronic Devices and Circuits Institute of MicroelectronicsPeking University Faculty of Information Technology Beijing University of Technology

Dear editor,With the development of VLSI technology,gateall-around (GAA) silicon nano wire transistor(SNWT) has emerged as one of the most potential candidates for ultimately scaled CMOS devices at the end of the technology *** pioneering research studies have demonstrated super scalability and high performance with GAA SNWT [1-3].Whereas,in the practical fabrica-

关键词： gate-all-around nanowire effective gate length effective model asymmetrical

2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma

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Cancer Biology & Medicine 2023年第2期20卷 129-146页

作者： Ping Li Yang liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing xiaoyan Ke Jianyong Li Yuhua Li Qifa liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong han Aibin Liang Department of Hematology Shanghai Tongji HospitalTongji University School of MedicineShanghai 200065China Department of Bio-therapeutic Chinese PLA General HospitalBeijing 100853China Department of Hematology The Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310009China Department of Hematology Chinese PLA General HospitalBeijing 100853China Department of Hematology The First Hospital of Jilin UniversityChangchun 130012China Center for Bone Marrow Transplantation The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310058China institute of Hematology Union Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China peking university People’s Hospital&peking university institute of Hematology Beijing Key Laboratory of Hematopoietic Stem Cell TransplantationBeijing 100044China Department of Hematology Lymphoma Research CenterPeking University Third HospitalBeijing 100191China Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjing 210029China Department of Hematology Zhujiang HospitalSouthern Medical UniversityGuangzhou 510280China Department of Hematology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Lu Daopei institute of Hematology Beijing 101102China Department of Hematology West China HospitalSichuan UniversityChengdu 610041China The Affiliated Cancer Hospital of Zhengzhou university Zhengzhou 450008China Department of Lymphoma Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital and InstituteBeijing 100142China Department of Hematology Shanxi Cancer HospitalTaiyuan 030013China State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesDivision of Pediatric Blood Disease CenterInstitute of Hematology&Blood Disease HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianj

Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of ***,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this *** and studying the clinical management of these toxicities are *** contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for ***,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese *** consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS.

关键词： CAR T-cell therapy B-cell non-Hodgkin lymphoma toxicity cytokine-release syndrome clinical management