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Journal of Ocean University of China 2022年第3期21卷 782-788页

作者： ZHANG Pengpeng ZHANG Miaomiao dong kaiyu ZHANG Yicong YANG Shuang WANG Yuanhong JIANG Tingfu YU Mingming LV Zhihua School of Medicine and Pharmacy Ocean University of ChinaQingdao266003China Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology Qingdao266003China Key Laboratory of Glycoscience&Glycotechnology of Shandong Province Qingdao266003China Key Laboratory of Marine Drugs Ministry of Education of ChinaQingdao266003China

Chito-oligosaccharide(COS)had shown a variety of biological activities and potential biomedical *** present study investigated the pharmacokinetics,bioavailability,and in vitro absorption of COS with degrees of polymerization(DPs)2-7 and explored the influence of DPs on *** Caco-2 cell permeation studies,COS were low permeability compounds with no directional effects,suggesting a low in vivo absorption mediated by facilitation diffusion and paracellular *** an intragastrical administration to rats,COS2 showed the highest systemic exposure in six *** bioavailability of COS2-7 was 7.33%,6.11%,4.67%,4.13%,4.02%,0.99%,*** in bioavailability for each COS correlated to structural variations,with high DPs contributing to a decrease in *** conclusion,COS could be absorbed by the intestinal tract both in vitro and in *** very low oral bioavailability of COS could be due to low *** can affect absorption and bioavailability of *** study provided evidence for the absorption characteristics of COS2-7 to help us better understanding the pharmacological actions.

关键词： chito-oligosaccharide(COS) Caco-2 transport pharmacokinetics bioavailability

Overexpression of the transcription factor MdWRKY115 improves drought and osmotic stress tolerance by directly binding to the MdRD22 promoter in apple

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Horticultural Plant Journal 2024年第3期10卷 629-640页

作者： Qinglong dong Yi Tian Xuemei Zhang Dingyue Duan He Zhang kaiyu Yang Peng Jia Haoan Luan Suping Guo Guohui Qi Ke Mao Fengwang Ma College of Forestry Hebei Agricultural UniversityBaodingHebei 071001China National Engineering Research Center for Agriculture in Northern Mountainous Areas Agricultural Technology Innovation Center in Mountainous Areas of Hebei ProvinceHebei Agricultural UniversityBaodingHebei 071001China State Key Laboratory of Crop Stress Biology for Arid Areas Shaanxi Key Laboratory of AppleCollege of HorticultureNorthwest A&F UniversityYanglingShaanxi 712100China College of Horticulture Hebei Agricultural UniversityBaodingHebei 071001China

Abiotic stress reduces plant yield and *** transcription factors play key roles in abiotic stress responses in plants,but the molecular mechanisms by which WRKY transcription factors mediate responses to drought and osmotic stresses in apple(Malus×domestica Borkh.)remain ***,we functionally characterized the apple GroupⅢWRKY gene ***-PCR analysis showed that MdWRKY115 expression was up-regulated by drought and osmotic *** activity analysis revealed that the promoter activity of MdWRKY115 was enhanced under osmotic *** localization and transactivation assays indicated that MdWRKY115 was localized to the nucleus and had a transcriptional activity domain at the N-terminal *** analysis revealed that the overexpression of MdWRKY115 in Arabidopsis plants and in apple callus markedly enhanced their tolerance to drought and osmotic *** affinity purification sequencing showed that MdWRKY115 binds to the promoter of the stress-related gene *** binding was further verified by an electrophoretic mobility shift ***,these findings suggest that MdWRKY115 is an important regulator of osmotic and drought stress tolerance in apple.

关键词： Apple MdWRKY115 Osmotic stress Drought stress Function analysis

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热像仪的光轴热稳定性仿真及拓扑优化研究

红外与激光工程 2024年第1期53卷 94-100页

作者：李晶董树林金宁杨开宇杨丹徐曼普龙昆明物理研究所云南昆明650223

热成像仪由于工作环境较为恶劣,且自身发热量较大,容易导致热像仪光轴发生热偏移,严重影响其瞄准性能。为了提高红外热像仪的光轴热稳定性,以某型热像仪光轴敏感部件——折转镜为主要研究对象,研究其在不同环境温度条件下的光轴变化情况... 详细信息

热成像仪由于工作环境较为恶劣,且自身发热量较大,容易导致热像仪光轴发生热偏移,严重影响其瞄准性能。为了提高红外热像仪的光轴热稳定性,以某型热像仪光轴敏感部件——折转镜为主要研究对象,研究其在不同环境温度条件下的光轴变化情况,并通过构建折转镜的有限元仿真模型以及试验测试系统,获得与试验数据一致性较好的有限元模型;以此为基础,采用基于变密度法的拓扑优化仿真技术,以刚度最大化为设计目标,以体积分数为约束,对折转镜座进行了拓扑优化设计。通过试验测试得出,优化设计的折转镜座的光轴高温偏移量由46.1″减小到25.5″,减小了44.7%,折转镜座的光轴低温偏移量由92.9″减小到51.0″,减小了45.1%,极大地提高了折转镜的光轴热稳定性。最后,将优化后的折转镜安装到某型热像仪中进行整机试验测试,热像仪整机的高温光轴偏移量由0.461 mrad减小到0.340 mrad,下降了26.2%,低温光轴偏移量由0.485 mrad减小到0.296 mrad,下降了39.0%,证明了仿真与拓扑优化模型的可行性与有效性,为后续红外热像仪整机的轻量化设计与性能提升奠定了基础。

关键词：结构设计拓扑优化红外热像仪折转镜光轴热稳定性

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纳微尺度溶液体系的精确计算

中国科学：化学 2024年第1期54卷 93-111页

作者：霍军张一健张开宇刘沛洪本坤董昊黎书华南京大学匡亚明学院南京210023 南京大学化学化工学院介观化学教育部重点实验室南京大学理论与计算化学研究所南京210023 南京大学生命分析化学国家重点实验室南京大学化学和生物医药创新研究院南京大学脑科学研究院南京210023

在纳微尺度上,分子性质、传质过程、化学反应等均与在宏观尺度表现不同.因此,近年来在生命科学、材料科学等领域对于纳微尺度下的液滴和溶液体系的研究蓬勃发展.采用计算模拟手段对相关体系的准确表征有助于揭示其在微观层面的分子机制... 详细信息

在纳微尺度上,分子性质、传质过程、化学反应等均与在宏观尺度表现不同.因此,近年来在生命科学、材料科学等领域对于纳微尺度下的液滴和溶液体系的研究蓬勃发展.采用计算模拟手段对相关体系的准确表征有助于揭示其在微观层面的分子机制,并为解开生命的奥秘、促进新材料的研发提供新的见解.本综述回顾了使用模拟方法,包括分子力场、量子化学方法以及结合机器学习等,研究此类体系的最新进展,重点关注纳微尺度下气液界面(包括空气/水、空气/溶液,以及大气/水)的溶液体系.此外,我们还对适用于纳微尺度溶液化学的计算模拟手段未来的发展进行了展望.

关键词：纳微尺度气液界面液滴多尺度模拟量子化学机器学习

On the calibration and verification of Voronoi-based discontinuous deformation analysis for modeling rock fracture

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第8期15卷 2025-2038页

作者： kaiyu Zhang Feng Liu Kaiwen Xia Ying Xu Peng dong Changyi Yu College of Water Resources Science and Engineering Taiyuan University of TechnologyTaiyuan030024China State Key Laboratory of Hydraulic Engineering Simulation and Safety School of Civil EngineeringTianjin UniversityTianjin300072China Department of Civil and Mineral Engineering University of TorontoTorontoM5S 1A4Canada CCCC Tianjin Port Engineering Institute Co.Ltd.Tianjin300222China CCCC First Harbor Engineering Company Co.Ltd.Tianjin300461China

Since its introduction,discontinuous deformation analysis(DDA)has been widely used in different areas of rock *** dividing large blocks into subblocks and introducing artificial joints,DDA can be applied to rock fracture ***,parameter calibration,a fundamental issue in discontinuum methods,has not received enough attention in *** this study,the parameter calibration of DDA for intact rock is carefully *** this end,a subblock DDA with Voronoi tessellation is presented ***,a modified contact constitutive law is introduced,in which the tensile and shear meso-strengths are modified to be independent of the bond *** improvement can prevent the unjustified preferential failure of short edges.A method for imposing confining pressure is also ***,sensitivity analysis is performed to investigate the influence of the calculated parameters and meso-parameters on the mechanical properties of modeled *** on the sensitivity analysis,a unified calibration procedure is suggested for both cases with and without confining ***,the calibration procedure is applied to two examples,including a biaxial compression *** results show that the proposed Voronoi-based DDA can simulate rock fracture with and without confining pressure very well after careful parameter calibration.

关键词： Discontinuous deformation analysis(DDA) Voronoi tessellation Parameter calibration Confining pressure Rock fracture

基于CT检查的集成深度学习模型对肝门静脉定性与定量分型研究

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中华消化外科杂志 2024年第7期23卷 976-983页

作者：徐卓凡靳琪奥王开宇张新静张刘彤张然然廖洪恩项灿宏董家鸿清华大学附属北京清华长庚医院肝胆胰外科北京102218 清华大学医学院北京100084

目的基于CT检查的集成深度学习模型对肝门静脉定性与定量分型研究。方法采用回顾性研究方法。收集2017年10月至2019年1月清华大学附属北京清华长庚医院收集291例行上腹部增强CT检查患者的影像学数据;男195例,女96例;年龄为(51±12)岁。... 详细信息

目的基于CT检查的集成深度学习模型对肝门静脉定性与定量分型研究。方法采用回顾性研究方法。收集2017年10月至2019年1月清华大学附属北京清华长庚医院收集291例行上腹部增强CT检查患者的影像学数据;男195例,女96例;年龄为(51±12)岁。采用三维重建系统对增强CT检查肝门静脉系统进行重建,并将三维点云输入至编码器模型后,得到三维重建的向量化表示。该向量化表示可以用于预测定性分型和定量表示分型。正态分布的计量资料以x±s表示,组间比较采用配对t检验。计数资料以百分数或绝对数表示,组间比较采用配对X^(2)检验。结果(1)门静脉三维重建结果及解剖分型。291例患者重建肝门静脉的三维结构,肝门静脉主干分型:Akgul A型211例,Akgul B型29例,Akgul C型16例,Akgul D型10例,无Akgul E型患者,无法分型25例。(2)门静脉主干定性分型的预测。291例患者样本中,排除25例因成像质量差或无法进行Akgul分型的样本,266例样本用于机器模型肝门静脉主干的自动定性分型(肝门静脉分类器),其中Akgul A型211例,Akgul B型29例,Akgul C&D型26例。266例患者Macro‑F1为61.93%±40.50%,准确率为84.99%,Random分类器的Macro‑F1为32.38%±19.81%,准确率为61.65%,两者上述指标比较,差异均有统计学意义(t=7.85,X^(2)=62.89,P<0.05)。(3)定量表示门静脉分型。定量分型相似样本的Akgul定性分型的概率P@1为73%±45%、P@3为70%±37%、P@5为69%±35%、P@10为67%±32%、MRR为80%±34%;基线模型P@1为57%±50%、P@3为58%±35%、P@5为58%±32%、P@10为58%±30%、MRR为70%±37%;两种模型上述指标比较,差异均有统计学意义(t=5.22,5.11,5.00,4.99,3.47,P<0.05)。结论基于CT检查使用三维重建和深度学习技术建立肝门静脉结构的自动分型模型,可实现自动定性分型并定量描述肝门静脉结构。

关键词：三维重建深度学习肝门静脉分型相似患者检索 CT检查

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武威汉代医简所载“甘逐”本草考证

甘肃中医药大学学报 2024年第3期41卷 84-87页

作者：石开玉丁莹叶青赵丽董业宏安徽中医药高等专科学校思政部安徽芜湖241002

通过查阅古今文献,对武威汉代医简所载“甘逐”进行名称、原植物、产地、采收与炮制等方面的考证。“甘逐”即中药甘遂,以产地得名,作为药品正名始载于《神农本草经》,直至今日;甘遂的原植物来源是大戟科大戟属植物甘遂Euphorbia kansui... 详细信息

通过查阅古今文献,对武威汉代医简所载“甘逐”进行名称、原植物、产地、采收与炮制等方面的考证。“甘逐”即中药甘遂,以产地得名,作为药品正名始载于《神农本草经》,直至今日;甘遂的原植物来源是大戟科大戟属植物甘遂Euphorbia kansui *** ex ***.;隋唐以前,甘遂主产于陕西、河南、山西,唐宋后扩展至江苏、浙江、安徽、湖北,现广泛分布于全国温带半湿润气候区;甘遂在春、秋两季采挖其根,干燥后药用,其炮制方法在古代多种多样,今天主要沿用了宋时的醋制法;甘遂药用价值较大,药用史近两千年。

关键词：武威汉代医简甘遂药用本草考证

利用DFIG无功能力的分散式风电并网有功最大控制策略研究

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中国电机工程学报 2017年第7期37卷 2001-2008页

作者：张晓朝段建东石祥宇王开宇董宇鹏慕腾闫富平陈鲁鹏华能定边新能源发电有限公司陕西省榆林市718600 西安理工大学自动化与信息工程学院陕西省西安市710048

分散式风电高渗透并网运行中节点过电压问题非常突出,影响到风电的高效消纳甚至并网安全。该文首先从风电出力的波动和配电网负荷的变化两个因素出发,分析风电分散接入配电网后过电压机理。然后,充分利用双馈型风电机组自身的无功能力,... 详细信息

分散式风电高渗透并网运行中节点过电压问题非常突出,影响到风电的高效消纳甚至并网安全。该文首先从风电出力的波动和配电网负荷的变化两个因素出发,分析风电分散接入配电网后过电压机理。然后,充分利用双馈型风电机组自身的无功能力,在满足风电场可连续运行的约束下,提出尽可能消纳风电功率的并网有功最大的本地控制策略。在电力仿真软件DIgSILEN进行了不同条件下算例的大量测试,结果表明风电并网有功最大控制策略可以实现风机安全并网,并且最大可能避免风电场弃风限电。该控制策略在某风电场分散式并入10k V地方电网的示范性工程上通过了现场试验与一年的运行检验。

关键词：双馈型风场过电压并网有功最大 DIgSILENT

Evaluation of Chito-Oligosaccharide (COS) in Vitro and in Vivo: Permeability Characterization in Caco-2 Cells Monolayer and Pharmacokinetics Properties in Rats

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Remote interfacing between superconducting qubits and Rydberg-atom qubits via thermal coupled cavities

中国海洋大学学报（自然科学英文版） 2022年第3期

作者： ZHANG Pengpeng ZHANG Miaomiao dong kaiyu ZHANG Yicong YANG Shuang WANG Yuanhong JIANG Tingfu YU Mingming LV Zhihua

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Science China(Physics,Mechanics & Astronomy) 2022年第4期65卷 3-9页

作者： Zhen-Tao Liang Guo-Qing Zhang Jianhao Yuan Qinzhou Ye kaiyu Liao Zheng-Yuan Xue Hui Yan Shi-Liang Zhu Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials School of Physics and Telecommunication EngineeringSouth China Normal UniversityGuangzhou 510006China Guangdong-Hong Kong Joint Laboratory of Quantum Matter Frontier Research Institute for PhysicsSouth China Normal UniversityGuangzhou 510006China GPETR Center for Quantum Precision Measurement South China Normal UniversityGuangzhou 510006China

We propose a built-in fault-tolerant geometric operation to realize fast remote entanglement between superconducting qubits anchored to a 15 m K plate and Rydberg-atom qubits trapped near a 1 K plate via thermal coupled cavities. We show that this operation is robust against the detrimental effects of the thermal mode states and fluctuations in the control parameters. The operation can generate a high-fidelity entanglement between superconducting and atomic qubits under realistic experimental parameters, comparable to the results of the existing methods using auxiliary cooling systems. The scheme proposed here will promote the development of quantum network and distributed superconducting quantum computation.

关键词： interfacing thermal-photon resistance geometric operation hybrid quantum network