Evaluation of Chito-Oligosaccharide(COS)in Vitro and in Vivo:Permeability Characterization in Caco-2 Cells Monolayer and Pharmacokinetics Properties in Rats

作     者：ZHANG Pengpeng ZHANG Miaomiao DONG Kaiyu ZHANG Yicong YANG Shuang WANG Yuanhong JIANG Tingfu YU Mingming LV Zhihua ZHANG Pengpeng;ZHANG Miaomiao;DONG Kaiyu;ZHANG Yicong;YANG Shuang;WANG Yuanhong;JIANG Tingfu;YU Mingming;LV Zhihua

作者机构：School of Medicine and PharmacyOcean University of ChinaQingdao266003China Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and TechnologyQingdao266003China Key Laboratory of Glycoscience&Glycotechnology of Shandong ProvinceQingdao266003China Key Laboratory of Marine DrugsMinistry of Education of ChinaQingdao266003China 

出 版 物：《Journal of Ocean University of China》 (中国海洋大学学报（英文版）)

年 卷 期：2022年第21卷第3期

页      面：782-788页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 0707[理学-海洋科学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：the Shandong Provincial Natural Science Foundation,China(No.ZR2019BC025) the Fundamental Research Funds for the Central Universities(Nos.201912008,201964019) 

主　　题：chito-oligosaccharide(COS) Caco-2 transport pharmacokinetics bioavailability 

摘      要：Chito-oligosaccharide(COS)had shown a variety of biological activities and potential biomedical *** present study investigated the pharmacokinetics,bioavailability,and in vitro absorption of COS with degrees of polymerization(DPs)2-7 and explored the influence of DPs on *** Caco-2 cell permeation studies,COS were low permeability compounds with no directional effects,suggesting a low in vivo absorption mediated by facilitation diffusion and paracellular *** an intragastrical administration to rats,COS2 showed the highest systemic exposure in six *** bioavailability of COS2-7 was 7.33%,6.11%,4.67%,4.13%,4.02%,0.99%,*** in bioavailability for each COS correlated to structural variations,with high DPs contributing to a decrease in *** conclusion,COS could be absorbed by the intestinal tract both in vitro and in *** very low oral bioavailability of COS could be due to low *** can affect absorption and bioavailability of *** study provided evidence for the absorption characteristics of COS2-7 to help us better understanding the pharmacological actions.