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Chemical Research in Chinese Universities 2004年第5期20卷 548-550页

作者： YINHan-dong CUIJi-chun DepartmentofChemistry LiaochengUniversityLiaocheng252059P.R.China

Two-dimensional 4,4-bipyridyllead halides, PbI_2(4,4′-bpy)(1) and PbBr_2(4,4′-bpy)(2), were synthesized. The structures were determined by means of X-ray single crystal diffraction. The structure shows a distorted octahedral configuration with six-coordinated central lead atoms. In crystals 1 and 2, the molecules are packed in a two-dimensional network structure through bridging halide atoms and 4,4′-bipyridine ligands between the adjacent lead atoms.

关键词： Bipyridyllead halide Synthesis Crystal structure

Impact of lymph node micrometastasis on gastric carcinoma prognosis:A meta-analysis

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World Journal of Gastroenterology 2015年第5期21卷 1628-1635页

作者： Yong-Ji Zeng chun-dong Zhang dong-Qiu Dai Department of Gastrointestinal Surgery the Fourth Affiliated Hospital of China Medical University

AIM:To investigate the prognostic significance of lymph node micrometastasis(LNMM) in patients with gastric ***:Two reviewers independently searchedelectronic databases including Pub Med,EMBASE,the Cochrane Database of Systematic Reviews,the Cochrane Controlled Studies Register,and the China National Knowledge Infrastructure electronic database between January 1996 and January *** literature retrieval and data extraction were performed to extract relevant *** analysis was conducted using Rev Man 5.2.4 software,and relative risks(RRs) for patient death in five years and recurrence were calculated.A fixed- or random-effects model was selected to pool and a forest plot was used to display ***:Twelve cohort studies containing a total of 1684 patients were *** positivity was worse than LNMM negativity with regards to the number of patients who died in five *** effects of LNMM positivity in patients with gastric cancer of different T-stages remain *** in patients with gastric carcinoma was also associated with a higher recurrence *** regards to the number of patients who died in five years,Asian patients were worse than European and Australian ***:We recommend that LNMM should not be used as a gold standard for prognosis evaluation in patients with gastric cancer in clinical settings until more high quality trials are available.

关键词： Gastric carcinoma Survival Lymph node micrometasta

Thermodynamic analysis and simulation for gas baffle entrance collimator of EAST-NBI system based on thermo-fluid coupled method

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Nuclear Science and Techniques 2018年第1期29卷 90-95页

作者： Ling Tao chun-dong Hu Yuan-Lai Xie Institute of Plasma Physics Chinese Academy of Sciences

The world's first full Experimental Advanced Superconducting Tokamak(EAST) is designed with the auxiliary heating method of neutral beam injection(NBI)system. Beam collimators are arranged on both sides of the beam channel for absorbing the divergence beam during the beam transmission process in the EAST-NBI *** gas baffle entrance collimator(GBEC) is a typical high-heat-flux component located at the entrance of gas baffle. An efficient and accurate analysis of its thermodynamic performance is of great significance to explore the working limit and to ensure safe operation of the system under a high-parameter steady-state condition. Based on the thermo-fluid coupled method, thermodynamic analysis and simulation of GBEC is performed to get the working states and corresponding operating limits at different beam extraction conditions. This study provides a theoretical guidance for the next step to achieve long pulse with highpower experimental operation and has an important reference to ensure the safe operation of the system.

关键词： Neutral beam injection High-heat-flux component Beam collimator Thermo-fluid coupled method Thermodynamic analysis

Characteristics of general distribution of hepatitis B virus genotypes in China

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Hepatobiliary & Pancreatic Diseases International 2009年第4期8卷 397-401页

作者： Zhu, Chang-Tai dong, chun-Lei Suzhou Univ Changzhou Canc Hosp Dept Lab Med Changzhou 213001 Peoples R China

BACKGROUND: Based on differences in the virus nucleotide sequence, hepatitis B virus (HBV) genotypes are presently divided into genotypes A-H. The geographic distributions of HBV genotypes differ in countries and regions. To determine the general characteristics of their distributions in the mainland of China, we reviewed articles on HBV genotypes published in China. METHODS: The Wanfang Database and the CNKI Database were searched for original articles involving HBV in China, and then the data from the articles were classified according to genotype and latitude and analyzed using SPSS 11.0. RESULTS: The main HBV genotypes were C, B and BC, and their rates were 50.99%, 35.58%, 6.07%, respectively; other genotypes were rare. There was a negative correlation between latitude and the rate of genotype B (r=-0.782, P0.05). CONCLUSIONS: In China, HBV genotype C predominates, followed by genotype C and mixed genotype BC; genotypes A, D and others are rare. With an increasing latitude, the distribution of genotype B decreases gradually, while that of genotype C tends to increase. The other genotypes do not show any changes.

关键词： hepatitis B virus genotype chronic hepatitis B

Conditional Stability of Solitary-Wave Solutions for Generalized Compound KdV Equation and Generalized Compound KdV-Burgers Equation

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Communications in Theoretical Physics 2006年第6X期46卷 1091-1100页

作者： ZHANG Wei-Guo dong chun-Yan FAN En-Gui College of Science University of Shanghai for Science and Technology Shanghai 200093 China Institute of Mathematics Fudan University Shanghai 200433 China

In this paper, we discuss conditional stability of solitary-wave solutions in the sense of Liapunov for the generalized compound KdV equation and the generalized compound KdV-Burgers equations. Linear stability of the exact solitary-wave solutions is proved for the above two types of equations when the small disturbance of travelling wave form satisfies some special conditions.

关键词： generalized compound KdV equation generalized compound KdV-Burgers equation

Three-microRNA signature identified by bioinformatics analysis predicts prognosis of gastric cancer patients

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World Journal of Gastroenterology 2018年第11期24卷 1206-1215页

作者： Cheng Zhang chun-dong Zhang Ming-hui Ma dong-qiu dai Department of Gastroenterological Surgery the Fourth Affiliated Hospital of China Medical University

AIM To identify multiple micro RNAs(mi RNAs) for predicting the prognosis of gastric cancer(GC) patients by bioinformatics *** The original microarray dataset GSE93415,which included 20 GC and 20 tumor adjacent normal gastric mucosal tissues,was downloaded from the Gene Expression Omnibus database and used for screening differentially expressed mi RNAs(DEMs).The cutoff criteria were P *** addition,we acquired the mi RNA expression profiles and clinical information of 361 GC patients from The Cancer Genome Atlas database to assess the prognostic role of the *** target genes of mi RNAs were predicted using Target Scan,mi RDB,mi RWalk,and DIANA,and then the common target genes were selected for functional enrichment *** A total of 110 DEMs including 19 up-regulated and 91 down-regulated mi RNAs were identified between 20 pairs of GC and tumor adjacent normal tissues,and the Kaplan-Meier survival analysis found that a threemi RNA signature(mi R-145-3 p,mi R-125 b-5 p,and mi R-99 a-5 p) had an obvious correlation with the survival of GC ***,univariate and multivariate Cox regression analyses indicated that the three-mi RNA signature could be a significant prognostic marker in GC *** common target genes of the three mi RNAs are added up to 108 and used for Gene Functional Enrichment *** Process and Molecular Function analyses showed that the target genes are involved in cell recognition,gene silencing and nucleic acid binding,transcription factor activity,and transmembrane receptor *** Component analysis revealed that the genes are portion of nucleus,chromatin silencing complex,and TORC1/2 *** Pathway analysis indicated that the genes participate in several cancer-related pathways,such as the focal adhesion,PI3 K,and m TOR signaling *** This study justified that a three-mi RNA signature could play a role in predicting the surviv

关键词： Gene functional enrichment Prognosis Bioinformatic analysis Differentially expressed miRNAs Gastric cancer

Clinicopathological significance of B-cell-specific Moloney murine leukemia virus insertion site 1 expression in gastric carcinoma and its precancerous lesion

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World Journal of Gastroenterology 2009年第17期15卷 2145-2150页

作者： Jing Zhao Xiang-dong Luo chun-Li Da Yan Xin The Fourth Laboratory of Cancer Institute Department of Tumor Pathology of General Surgery Institute First Affiliated Hospital of China Medical University Shenyang 110001 Liaoning Province China

AIM： To explore the relation between B-cell-specific Moloney murine leukemia virus insertion site 1 （Bmi-1） expression and the clinicopathological features of gastric carcinoma （GC）.METHODS： Immunohistochemistry was used to detect the expression of Bmi-1 and ki-67. Doublelabeling staining was used to display the distribution of Bcl-2^＋/ki-67 cells in 162 cases of GC and its matched normal mucosa and precancerous ***： The positive rate of Bmi-1 expression in GC（52.5%） was significantly higher than that in normal gastric mucosa （21.6%, X^2 = 33.088, P 〈 0.05）. The Bmi-1 expression in GC was closely related with the Lauren＇s and Borrmann＇s classification and clinicalstage （X^2 = 4.400, 6.122 and 11.190, respectively, P〈 0.05）. The expression of ki-67 was related to the Borrmann＇s classification （X^2 = 13.380, P 〈 0.05）.Bcl-2 expression was correlated with the Lauren＇s classification （Z2 = 4.725, P 〈 0.05）, and the Bmi-1 expression both in GC （rk = 0.157, P 〈 0.05） and inintestinal metaplasia （rk = 0.270, P 〈 0.05）.CONCLUSION： Abnormal Bmi-1 expression in GCmay be involved in cell proliferation, apoptosis andcancerization. This marker can objectively indicate theclinicopathological characteristics of GC.

关键词： B-cell-specific Moloney murine leukemiavirus insertion site 1 Gastric carcinoma Precancerouslesion Cell proliferation Apoptosis

Influencing factors of sediment deposition and their spatial variability in riparian zone of the Three Gorges Reservoir,China

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Journal of Mountain Science 2016年第8期13卷 1387-1396页

作者： WANG Bin-yan YAN dong-chun WEN An-bang CHEN Jia-cun Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu 610041China University of Chinese Academy of Sciences Beijing 100049China

Many factors can affect the sediment deposition and soil erosion process in riparian zone, including terrain, sediment transport and water level fluctuations. Clarifying the factors influencing sediment deposition process in the riparian zone of the Three Gorges Reservoirs is an important problem to determine the key area of sediment deposition and its trend of development in the study area. In order to reveal the influence of these environmental factors on the sediment deposition in riparian zone of the Three Gorges Reservoir, this study investigated 1） the amount of deposited sediment in different environmental conditions, 2） the potential factors affecting sediment deposition in riparian zone of the Three Gorges Reservoir, 3） the relationship between the deposited sediment amount and these factors previously mentioned using correlation analysis, and 4） the influence of human activities considered as an additional factor. This study found that 1） slope gradient, elevation, inundating duration and human activities were the main factors influencing sedimentation in riparian zone of the Three Gorges Reservoir, and 2） the impact of each factor varied with spaces. Specifically, in the upper reach from Jiangjin to Fuling, human activities such as gravel dredging, bank revetment and ports and wharfs constructing disturbed considerable amounts of deposited sediment, as a result, there was no natural law to dictate the distribution. In the middle reach from Fuling to Fengjie, slope gradient and inundating duration were the controlling factors, and the sediment deposition amount was greater in the areas with a gentler slope or lower elevation. Water flow on gentler slopes generally had lower velocity, resulting in more sediment to deposit. Sites with lower elevations would be drowned by sediment-laden flow with a longer duration resulting from hydrologic regime controlled by the operating strategy of the Three Gorges Reservoir, leading to a larger amount of sediment deposit

关键词： Influencing Factors Spatial variability Sediment deposition Riparian zone Three GorgesReservoir

Phenylalanine ammonia-lyase gene families in cucurbit species: Structure, evolution, and expression

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Journal of Integrative Agriculture 2016年第6期15卷 1239-1255页

作者： dong chun-juan CAO Ning ZHANG Zhi-gang SHANG Qing-mao Institute of Vegetables and Flowers Chinese Academy of Agricultural SciencesKey Laboratory of Horticultural Crop Biology and Germplasm Innovation Ministry of Agriculture

Phenylalanine ammonia-lyase （PAL）, the first enzyme of phenylpropanoid pathway, is always encoded by multigene families in plants. In this study, using genome-wide searches, 13 PAL genes in cucumber （CsPAL1-13） and 13 PALs in melon （Cm- PALl-13） were identified. In the corresponding genomes, ten of these PAL genes were located in tandem in two clusters, while the others were widely dispersed in different chromosomes as a single copy. The protein sequences of CsPALs and CmPALs shared an overall high identity to each other. In our previous report, 12 PAL genes were identified in watermelon （CIPAL1-12）. Thereby, a total of 38 cucurbit PAL members were included. Here, a comprehensive comparison of PAL gene families was performed among three cucurbit plants. The phylogenetic and syntenic analyses placed the cucurbit PALs as 11 CsPAL-CmPAL-CIPAL triples, of which ten triples were clustered into the dicot group, and the remaining one, CsPAL1-CmPAL8-CIPAL2, was grouped with gymnosperm PALs and might serve as an ancestor of cucurbit PALs. By comparing the syntenic relationships and gene structure of these PAL genes, the expansion of cucurbit PAL families might arise from a series of segmental and tandem duplications and intron insertion events. Furthermore, the expression profiling in different tissues suggested that different cucurbit PALs displayed divergent but overlapping expression profiles, and the CsPAL-CmPAL-CIPAL orthologs showed correlative expression patterns among three cucurbit plants. Taken together, this study provided an extensive description on the evolution and expression of cucurbit PAL gene families and might facilitate the further studies for elucidating the functions of PALs in cucurbit plants.

关键词： phenylalanine ammonia-lyase (PAL) gene family cucurbit evolution expression

Using ^(137)Cs Tracing Methods to Estimate Soil Redistribution Rates and to Construct a Sediment Budget for a Small Agricultural Catchment in the Three Gorges Reservoir Region,China

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Journal of Mountain Science 2013年第3期10卷 428-436页

作者： JU Li WEN An-bang LONG Yi YAN dong-chun GUO Jin Key Laboratory of Mountain Surface Processes and Ecological Regulation Institute of Mountain Hazards and EnvironmentChinese Academy of Sciences University of Chinese Academy of Sciences

Soil erosion and associated off-site sedimentation are threatening the sustainable use of the Three Gorges Dam. To initiate management intervention to reduce sediment yields, there is an increasing need for reliable information on soil erosion in the Three Gorges Reservoir Region （TGRR）. The purpose of this study is to use 137Cs tracing methods to construct a sediment budget for a small agricultural catchment in the TGRR. Cores were taken from a pond and from paddy fields, for laTCs measurements. The results show that the average sedimentation rate in the pond since 1963 is 1.50 g cm-2 yr-1 and the corresponding amount of sediment deposited is 1,553 t. The surface erosion rate for the sloping cultivated lands and the sedimentation rate in the paddy fields were estimated to be 3,770 t km-2 yr-1 and 2,600 t km-2 yr^1 respectively. Based on the estimated erosion and deposition rates, and the area of each unit, the post 197o sediment budget for the catchment has been constructed. A sediment delivery ratio of 0.5 has been estimated for the past 42 years. The data indicate that the sloping cultivated lands are the primary sediment source areas, and that the paddy fields are deposition zones. The typical land use pattern （with the upper parts characterized by sloping cultivated land and the lower parts by paddy fields） plays an important role in reducing sediment yield from agricultural catchments in the TGRR. A 137Cs profile for the sediment deposited in a pond is shownto provide an effective means of estimating the land surface erosion rate in the upstream catchment.

关键词： Pond deposition Soil erosion rate Sediment budget 137Cs Sediment delivery ratio Three Gorges Reservoir Region