检索结果-南通市图书馆

Post-operative protein supplementation following orthopaedic surgery: A systematic review

在线全文

学校读者我要写书评

暂无评论

Sports Medicine and Health Science 2024年第1期6卷 16-24页

作者： Andrew George Brendan M.Holderread Bradley S.Lambert Joshua D.harris Patrick c.Mcculloch Houston Methodist Orthopedics and Sports Medicine 6445 Main Street Suite 2300HoustonTX77030USA Houston Methodist Orthopedic Biomechanics Research Laboratory 6670 Bertner AveHoustonTX77030USA

Decreased mechanical loading after orthopaedic surgery predisposes patients to develop muscle *** purpose of this review was to assess whether the evidence supports oral protein supplementation can help decrease postoperative muscle atrophy and/or improve patient outcomes following orthopaedic surgery.A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and MetaAnalysis(PRISMA).PubMed(MEDLINE),Embase,Scopus,and Web of Science were searched for randomized controlled trials that assessed protein or amino acid supplementation in patients undergoing orthopaedic *** investigators independently conducted the search using relevant Boolean *** outcomes included functional or physiologic measures of muscle atrophy or *** studies including 611 patients(224 males,387 females)were *** studies evaluated protein supplementation after AcL reconstruction(AcLR),3 after total hip arthroplasty(THA),5 after total knee arthroplasty(TKA),and 3 after surgical treatment of hip *** supplementation showed beneficial effects across all types of *** primary benefit was a decrease in muscle atrophy compared to placebo as measured by muscle cross sectional *** authors also demonstrated improved functional measures and quicker achievement of rehabilitation *** supplementation has beneficial effects on mitigating muscle atrophy in the postoperative period following AcLR,THA,TKA,and surgical treatment of hip *** effects often correlate with improved functional measures and quicker achievement of rehabilitation *** research is needed to evaluate long-term effects of protein supplementation and to establish standardized population-specific regimens that maximize treatment efficacy in the postoperative period.

关键词： Orthopaedic surgery Protein supplementation Systematic review Muscle atrophy

Lecanemab Unveiled:Exploring Alzheimer’s Treatment Advancements,Assessing Strengths,Limitations,and Its Therapeutic Landscape Position

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2024年第4期37卷 428-431页

作者： VIcTOR Abiola Adepoju OKEcHUKWU Innocent Onyezue SAFAYET Jamil OLALEKAN John Okesanya don Eliseo Lucero-Prisno Ⅲ Department of HIV and Infectious Diseases Jhpiegoan affiliate of John Hopkins UniversityAbujaNigeria Department of Prevention and community Directorate APIN Public Health InitiativesAbujaNigeria Department of Public Health Daffodil International UniversityDhaka-1216Bangladesh Department of Public Health and Maritime Transport University of ThessalyVolosGreece Department of Global Health and Development London School of Hygiene and Tropical MedicineLondonUnited Kingdom

In the ever-evolving landscape of Alzheimer’s treatment,lecanemab(Leqembi)has emerged as a promising *** conventional therapies that merely alleviate symptoms,lecanemab is a humanized monoclonal antibody with a distinct *** targets protofibrils,insoluble fibrils,amyloid oligomers,and soluble amyloid-beta protofibrils,which are known to be especially damaging to neurons,with high accuracy.

关键词： Alzheimer amyloid Therapeutic

Quasi-Static, Poiseuille Flow of Analgesics from an Elastomeric Pump: Theoretical Determination of Infusion Times and Toxicity conditions

在线全文

学校读者我要写书评

暂无评论

Journal of Biosciences and Medicines 2024年第9期12卷 251-265页

作者： clare B. Lipscombe Trevor c. Lipscombe don S. Lemons Division of General Surgery Vanderbilt University Medical Center Nashville TN USA catholic University of America Press Washington DC USA Department of Physics Bethel College North Newton KS USA

Background: Elastomeric pumps (elastic balls into which analgesics or antibiotics can be inserted) push medicines through a catheter to a nerve or blood vessel. Since elastomeric pumps are small and need no power source, they fit easily into a pocket during infusion, allowing patient mobility. Elastomeric pumps are widely used and widely studied experimentally, but they have well-known problems, such as maintaining reliable flow rates and avoiding toxicity or other peak-and-trough effects. Objectives: Our research objective is to develop a realistic theoretical model of an elastomeric pump, analyze its flow rates, determine its toxicity conditions, and otherwise improve its operation. We believe this is the first such theoretical model of an elastomeric pump consisting of an elastic, medicine-filled ball attached to a horizontal catheter. Method: Our method is to model the system as a quasi-Poiseuille flow driven by the pressure drop generated by the elastic sphere. We construct an engineering model of the pressure exerted by an elastic sphere and match it to a solution of the one-dimensional radial Navier-Stokes equation that describes flow through a horizontal, cylindrical tube. Results: Our results are that the model accurately reproduces flow rates obtained in clinical studies. We also discover that the flow rate has an unavoidable maximum, which we call the “toxicity bump”, when the radius of the sphere approaches its terminal, unstretched value—an effect that has been observed experimentally. conclusions: We conclude that by choosing the properties of an elastomeric pump, the toxicity bump can be restricted to less than 10% of the earlier, relatively constant flow rate. Our model also produces a relation between the length of time that the analgesic fluid infuses and the physical properties of the fluid, of the elastomeric sphere and the tube, and of the blood vessel into which the analgesic infuses. From these, we conclude that elastomeric pumps can be design

关键词： Elastomeric Pump Infusion Therapy Bio-Fluids Medical Devices Antibiotic Delivery Analgesic Delivery

Antisense oligonucleotides provide optimism to the therapeutic landscape for tauopathies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 803-804页

作者： Glenn A.harris Lauren R.Hirschfeld Rainwater charitable Foundation Fort WorthTXUSA

Tauopathies are a group of neurodegenerative diseases characterized by abnormal metabolism of the misfolded tau protein. Tau is encoded by the microtubule-associated protein tau gene(MAPT) and can be classified as either 3-repeat(3R) or 4-repeat(4R) based on the number of repeat domains from alternative splicing of exon 10 of the MAPT gene.

关键词： tau metabolism diseases

Robotic-assisted retroperitoneal lymph node dissection for stage II testicular cancer

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Urology 2024年第1期11卷 121-127页

作者： George Mcclintock Ahmed S.Goolam don Perera Ryan Downey Scott Leslie Peter Grimison Henry Woo Peter Ferguson Nariman Ahmadi Department of Urology Chris O'Brien LifehouseSydneyNSWAustralia Department of Anaesthesia Chris O'Brien LifehouseSydneyNSWAustralia The University of Sydney SydneyNSW2006Australia Department of Medical Oncology Chris O'Brien LifehouseSydneyNSWAustralia

Objective:To evaluate the perioperative as well as early oncological outcomes of patients undergoing robotic retroperitoneal lymph node dissection for treatment of testicular ***:We conducted a prospective consecutive case series of patients undergoing robotic assisted retroperitoneal lymph node dissection for metastatic testicular cancer between May 2018 and July 2021 at our *** were collected on patient and tumour characteristics,intraoperative and postoperative parameters,and functional and oncological *** statistics are ***:Nineteen patients were identified;18(94.7%)completed the procedure robotically and one was converted to open surgery;78.9%of patients had stage≥IIB and 12(63.2%)patients had undergone prior *** median operative time was 300(interquartile range[IQR]240-315)*** blood loss was 100(IQR 50-175)*** length of stay was 2(range 1-11)*** robotically completed patients commenced diet and passed flatus on Day 1 and were discharged by Day *** median lymph node yield was 40.5(IQR 38-51)*** patients undergoing nerve-sparing procedures recovered antegrade ejaculatory *** patient had a clavien-Dindo III complication(chylous ascites requiring drainage).At a median follow-up of 22.3(IQR 16.3-24.9)months,one patient developed retroperitoneal recurrence,which was successfully treated with second-line chemotherapy;no other patients have had ***:Robotic retroperitoneal lymph node dissection is a safe and feasible alternative to open surgery in appropriately selected patients,offering low *** oncological outcomes are *** cohorts and longer follow-ups are required to validate our institution's findings.

关键词： Retroperitoneal lymph node dissection Robotic surgery Testicular cancer Retroperitoneal node dissection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

藏族英雄史诗格萨尔王传形式基础(续)

中国藏学 2024年第1期 106-114,215页

作者：丹珠昂奔中央民族大学北京100081

形式基础是格萨尔研究的基本理论问题,涉及史诗产生、发展、传播的特定时代的社会文化基础,渊源深长。格萨尔的形式集中于“两‘仲’、三要素、一模式”。仲与德乌、苯都是青藏高原古老的文化形式,当格萨尔作为史诗萌芽时,艺人们借用了... 详细信息

形式基础是格萨尔研究的基本理论问题,涉及史诗产生、发展、传播的特定时代的社会文化基础,渊源深长。格萨尔的形式集中于“两‘仲’、三要素、一模式”。仲与德乌、苯都是青藏高原古老的文化形式,当格萨尔作为史诗萌芽时,艺人们借用了他们最熟悉的“仲”的形式,形成了格萨尔王传的形式基础。深刻认识把握这一形式基础,既是认识格萨尔光辉存在的一把钥匙,也是传承、弘扬格萨尔史诗,汲取其精神精华的桥梁,有利于我们传承、研究、弘扬、开发、利用格萨尔的既有成果,确立文化自信,构建各民族共有精神家园。

关键词：格萨尔形式仲仲肯音乐

斯里兰卡初级汉语学习者语音偏误分析及教学对策 ——以凯拉尼亚大学为例

在线全文

学校读者我要写书评

暂无评论

斯里兰卡初级汉语学习者语音偏误分析及教学对策 ——以凯拉尼亚...

作者： JAYASINGHE don UMESHIKA SANU（吴美佳）贵州大学

学位级别：硕士

五株昆虫病原真菌对草地贪夜蛾（Spodoptera frugiperda）生防潜力的评估及其培养基的优化

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

五株昆虫病原真菌对草地贪夜蛾（Spodoptera frugiperda）生防潜...

作者： Wellabada Hewage don Piumalee Isurika Damithri 西北农林科技大学

学位级别：硕士

From source to emplacement:The origin of leucogranites from the Sikkim-Darjeeling Himalayas,India

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

Geoscience Frontiers 2024年第1期15卷 384-401页

作者： Tanya Srivastava Nigel harris catherine Mottram Kumar Batuk Joshi Nishchal Wanjari Department of Geology Sikkim UniversityGangtokIndia School of Environment Earth&Ecosystem SciencesOpen UniversityMiltonKeynesUK School of the Environment Geography and GeosciencesUniversity of PortsmouthUK National centre for Earth Science Studies ThiruvananthapuramKeralaIndia

Himalayan leucogranites are important for understanding the tectonic evolution of collision zones in general and the causes of crustal melting in the Himalayan orogen in *** paper aims to understand the melt source and emplacement age of the leucogranites from Sikkim in order to decipher the deep geodynamic processes of the eastern *** U-Pb analysis of the Higher Himalayan Sequence(HHS)metamorphic core reveals a prolonged period of crustal melting between>33 Ma and ca.14 *** and trace element abundances are presented for 27 leucogranites from North Sikkim that are classified into two-mica and tourmaline leucogranite *** are peraluminous in composition,characterized by high SiO2(70.91-74.9 wt.%),Al2O3(13.69-15.82 wt.%),and low MgO(0.13-0.74 wt.%).Elemental abundances suggest that Sikkim Himalayan leucogranites are derived from crustal *** two-mica leucogranites are derived from a metagreywacke source,whereas the tourmaline leucogranites are sourced from metapelitic sources,with inherited zircons indicating an HHS origin for both types.U-Pb zircon geochronology of the two mica leucogranites indicates ages of ca.19-15 Ma,consistent with crustal melting recorded in HHS gneisses from *** from both the two-mica and tourmaline leucogranites yield a crystallization age of ca.15-14 Ma,coeval with movement on the Main central Thrust and South Tibetan Detachment System which further provides constraints on the timing and mechanism of petrogenesis of leucogranites in the Sikkim Himalayas.

关键词： Leucogranites Gneiss U-Pb geochronology Zircon Monazite Sikkim-Darjeeling Himalayas