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Antisense oligonucleotides provide optimism to the therapeutic landscape for tauopathies

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Neural Regeneration Research 2025年第3期20卷 803-804页

作者： Glenn A.harris Lauren R.Hirschfeld Rainwater charitable Foundation Fort WorthTXUSA

Tauopathies are a group of neurodegenerative diseases characterized by abnormal metabolism of the misfolded tau protein. Tau is encoded by the microtubule-associated protein tau gene(MAPT) and can be classified as either 3-repeat(3R) or 4-repeat(4R) based on the number of repeat domains from alternative splicing of exon 10 of the MAPT gene.

关键词： tau metabolism diseases

Status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Process development for the direct solvent extraction of nickel and cobalt from nitrate solution:aluminum,cobalt,and nickel separation using cyanex 272

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International Journal of Minerals,Metallurgy and Materials 2017年第1期24卷 37-46页

作者： Zela T.Ichlas don c.lbana Leaching and Separation Technologies Group Department of Mining Engineering and Metallurgical EngineeringWA School of MinesCurtin UniversityKalgoorlieWA 6430Australia

A direct solvent extraction（DSX） process for purifying nickel and cobalt from the nitric acid leach solution of nickel laterite ores was conceived and experimentally probed. The proposed process consists of two solvent extraction（SX） steps but with only one extractant - bis（2,4,4-trimethylpentyl）phosphinic acid（cyanex？ 272） - used in both steps. The first extraction step involved the removal of aluminum and zinc, whereas the second extraction step involved the separation of cobalt along with manganese from nickel. The experimental results showed essentially quantitative removal of aluminum（〉97%） and zinc（〉99%） in a single extraction stage using 20vol% cyanex 272 at pH 2.1. Some cobalt（32%） and manganese（55%） were co-extracted but were easily scrubbed out completely from the loaded organic phase using dilute sulfuric acid at pH ≤ 1.38. cobalt and manganese in the first extraction raffinate were extracted completely in four extraction stages at staggered pH values of 4.0, 4.4, 4.5, and 4.0 in the first, second, third, and fourth stages, respectively, using also 20vol% cyanex 272. A small amount of nickel（up to 6.6%） was co-extracted but was easily scrubbed out completely with dilute sulfuric acid at pH 2.0. A flow diagram showing the input and output conditions and the metals separated under the deduced optimum conditions is presented.

关键词： solvent extraction aluminum cobalt nickel nickel laterite ores

The cellular microenvironment and cytoskeletal actin dynamics in liver fibrogenesis

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BIOcELL 2022年第9期46卷 2003-2007页

作者： NOUR HIJAZI don c.ROcKEY ZENGDUN SHI Medical University of South carolina Charleston29425USA

Hepatic stellate cells(HScs)are the primary effector cells in liver *** the normal liver,HScs serve as the primary vitamin A storage cells in the body and retain a“quiescent”***,after liver injury,they transdifferentiate to an“activated”myofibroblast-like phenotype,which is associated with dramatic upregulation of smooth muscle specific actin and extracellular matrix *** result is a fibrotic,stiff,and dysfunctional ***,understanding the molecular mechanisms that govern HSc function is essential for the development of anti-fibrotic *** actin cytoskeleton has emerged as a key component of the fibrogenic response in wound *** data indicate that the cytoskeleton receives signals from the cellular microenvironment and translates them to cellular function—in particular,increased type I collagen *** in nature,the actin cytoskeleton continuously polymerizes and depolymerizes in response to changes in the cellular *** this viewpoint,we discuss the recent developments underlying cytoskeletal actin dynamics in liver fibrosis,including how the cellular microenvironment affects HSc function and the molecular mechanisms that regulate the actininduced increase in collagen expression typical of activated HScs.

关键词： Extracellular matrix Actin dynamics Transcriptional regulation Signaling

One step at a time:new insights into double-stranded ribonucleic acid virus assembly

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Signal Transduction and Targeted Therapy 2024年第10期9卷 4160-4161页

作者： Virgile Rat Alexander Borodavka don c.Lamb Department of chemistry LMU MünchenMünchen GermanyButenandtstrasse 5-1381377MunichGermany Department of chemical Engineering and Biotechnology University of CambridgePhilippa Fawcett DriveCB30ASCambridgeUK

In a recent paper published in cell,Xia et al.1 carried out 3D reconstructions of Blue Tongue Virus(BTV)particles and their assembly intermediates using a combination of cellular cryo-electron tomography(cryo-ET)and single-particle cryo-electron microscopy(cryo-EM).They were able to identify 11 structures,allowing them to refine our understanding of how double-stranded ribonucleic acid(dsRNA)viruses replicate in cells.

关键词： double assembly insight

Predisposing factors’effects on mortality of oak (Quercus) and hickory (carya) species in mature forests undergoing mesophication in Appalachian Ohio

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Forest Ecosystems 2021年第1期8卷 81-94页

作者： don c.Radcliffe David M.Hix Stephen N.Matthews School of Environment and Natural Resources The Ohio State University2021 Coffey RoadColumbus OH 43210USA School of Environmental and Forest Sciences University of WashingtonBox 352100Seattle WA 98195-2100USA

Background:Mature oak(Quercus spp.)and hickory(carya spp.)trees are gradually being replaced by more shadetolerant tree species across the eastern U.S.,likely due to fire suppression and increased *** and hickories are highly valuable to wildlife;therefore,studying their mortality patterns can provide information on the longevity of habitat quality for many animal *** mortality has most often been studied following large oak decline events,but background mortality rates in forests with aging oak and hickory canopies warrant equal attention,especially in the context of widespread oak and hickory regeneration ***:We studied background mortality rates of five oak and one hickory species over a 23–25 year time period(1993–1995 to 2018),using 821/20th hectare permanent plots on the Marietta Unit of the Wayne National Forest in southeastern *** calculated mortality rates based on remeasurement of individual trees for white oak(Quercus alba),chestnut oak(Quercus montana),northern red oak(Quercus rubra),black oak(Quercus velutina),scarlet oak(Quercus coccinea),and pignut hickory(carya glabra).For each of these species other than scarlet oak,we also modeled the relationships of mortality probability with a priori topographic,soil,stand structural,and individual tree covariates,using a mixed-effects logistic regression ***:The species with the highest mortality rate was scarlet oak(61.3%),followed by northern red oak(41.4%),black oak(26.7%),pignut hickory(23.9%),white oak(23.4%),and chestnut oak(19.1%).In our models,northern red oak mortality was associated with more mesic slope positions,shallower solums,more acidic soils,and older stand *** hickory and chestnut oak mortality rates were associated with higher basal areas on the plot,while white oak mortality showed the opposite ***:Our data suggest that red oak subgenus trees in mature forests of our area will become increasingly uncommon relative t

关键词： Mortality Quercus carya Mesophication Wildlife habitat

Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram D.dongale Atul c.Khot chenjie Yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory