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Pulmonary Immune Responses to Aspergillus Fumigatus in Rats

Biomedical and Environmental Sciences 2014年第9期27卷 684-694页

作者： MIRKOV Ivana EL-MUZGHI Amal Atia Mhfuod djokic jelena NINKOV Marina POPOV ALEKSANDROV Aleksandra GLAMOCLIJA Jasmina KATARANOVSKI Milena Department of Ecology Institute for Biological Research ‘Sinisa Stankovic'University of Belgrade Department of Plant Physiology (Mycology Lab) Institute for Biological Research ‘Sinisa Stankovic'University of Belgrade Institute of Physiology and Biochemistry Faculty of BiologyUniversity of Belgrade

Objective To evaluate immunologic mechanisms underlying Aspergillus fumigatus pulmonary infections in immunocompetent Dark Agouti （DA） and Albino Oxford （AO） rats recognized as being susceptible to some inflammatory diseases in different manners. Methods Lung fungal burden （quantitative colony forming units, CFU, assay）, leukocyte infiltration （histology, cell composition） and their function （phagocytosis, oxidative activity, CDllb adhesion molecule expression） and cytokine interferon-y （IFN-y） and interleukin-17 and -4 （IL-17 and IL-4） lung content were evaluated following infection （intratracheally, lxl07 conidia）. Results Slower reduction of fungal burden was observed in AO rats in comparison with that in DA rats, which was coincided with less intense histologically evident lung cell infiltration and leukocyte recovery as well as lower level of most of the their activities including intracellular myeloperoxidase activity, the capacity of nitroblue tetrazolium salt reduction and CDllb adhesion molecule expression （except for phagocytosis of conidia） in these rats. Differential patterns of changes in proinflammatory cytokine levels （unchanged levels of IFN-v and transient increase of IL-17 in AO rats vs continuous increase of both cytokines in DA rats） and unchanged levels of IL-4 were observed. Conclusion Genetically-based differences in the pattern of antifungal lung leukocyte activities and cytokine milieu, associated with differential efficiency of fungal elimination might be useful in the future use of rat models in studies of pulmonary aspergillosis.

关键词： A. fumigatus Rats Lung immune responses

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Pearls and pitfalls in magnetic resonance imaging of hepatocellular carcinoma

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World Journal of Gastroenterology 2020年第17期26卷 2012-2029页

作者： jelena djokic Kovac Tamara Milovanovic Vladimir Dugalic Igor Dumic Departament of Radiology Clinical Center SerbiaBelgrade 11000Serbia School of Medicine Belgrade UniversityBelgrade 11000Serbia Departament of Hepatology Clinical Center SerbiaBelgrade 11000Serbia Departament of Surgery Clinical Center SerbiaBelgrade 11000Serbia Divison of Hospital Medicine Mayo Clinic College of Medicine and SciencesMayo Clinic Health SystemNew YorkNY 10029United States

Hepatocellular carcinoma(HCC)is the most common primary hepatic malignancy,which usually arises in cirrhotic liver.When the typical enhancement pattern,consisting of late arterial hyperenhancement followed by washout,is present in nodules larger than 1 cm,HCC can be confidently diagnosed without the need for tissue biopsy.Nevertheless,HCC can display an atypical enhancement pattern,either as iso or hypovascular lesion,or hypervascular lesion without washout.Not only the enhancement pattern of HCC could be atypical,but also a variety of histological types of HCC,such as steatotic,scirrhous,fibrolamellar,or combined hepatocellular-cholangiocellular carcinoma could raise diagnostic dilemmas.In addition,distinct morphological types of HCC or different growth pattern can occur.Awareness of these atypical and rare HCC presentations on magnetic resonance imaging is important for accurate differentiation from other focal liver lesions and timely diagnosis,which allows optimal treatment of patients.

关键词： Hepatocellular carcinoma Cirrhosis Magnetic resonance imaging Hepatocarcinogenesis

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Low-grade fibromyxoid sarcoma of the liver: A case report

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World Journal of Clinical Cases 2021年第1期9卷 175-182页

作者： Vladimir Dugalic Igor I Ignjatovic jelena djokic Kovac Nikola Ilic jelena Sopta Slavenko R Ostojic Dragan Vasin Marko D Bogdanovic Igor Dumic Tamara Milovanovic Department of Hepatobiliary&Pancreatic Surgery Clinic for Digestive SurgeryClinical Center of SerbiaBelgrade 11000Serbia Department of Radiology Clinical Center of SerbiaBelgrade 11000Serbia Clinic for Vascular and Endovascular Surgery Clinical Center of SerbiaBelgrade 11000Serbia Institute of Pathology University of BelgradeBelgrade 11000Serbia Mayo Clinic Health System Mayo Clinic College of Medicine and ScienceRochesterNY 10029United States Clinic for Gastroenterology and Hepatology Clinical Center of SerbiaSchool of MedicineUniversity of BelgradeBelgrade 11000Serbia

BACKGROUND Low grade fibromyxoid sarcoma(LGFMS)is a rare and benign mesenchymal tumor with indolent course,most commonly found in young or middle-aged men.The majority of the LGFMSs are located in the trunk and deep soft tissue of the lower extremities.They appear as well circumscribed,although not encapsulated,which often leads to incomplete surgical resection.Despite their seemingly benign appearance,these tumors have aggressive behavior with high metastatic and recurrence rates.Accurate histopathologic examination of the specimen and its immunohistochemical analysis are mandatory for a precise diagnosis.CASE SUMMARY We report a case of a 38 year-old-man who presented with jaundice and upper abdominal discomfort.Multi-detector computed tomography and magnetic resonance imaging showed a large left liver tumor mass,extending to the hepatoduodenal ligament.Left hepatectomy was performed with resection and reconstruction of hepatic artery and preservation of middle hepatic vein.Histopathologic examination confirmed the tumor being a low-grade fibromyxoid sarcoma.Three and a half years after surgery,the patient died after being diagnosed with spine metastasis.CONCLUSION Due to poor response to all modalities of adjuvant treatment,we consider that the focus of treatment should be on surgery as the only option for curing the disease.

关键词： Fibromyxoid sarcoma Liver Resection Histopathology Case report

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