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Microbiome and metabolome dysbiosis analysis in impaired glucose tolerance for the prediction of progression to diabetes mellitus

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Journal of Genetics and Genomics 2024年第1期51卷 75-86页

作者： Boxun Zhang Xuan Zhang Zhen Luo Jixiang Ren Xiaotong Yu Haiyan Zhao Yitian Wang Wenhui Zhang Weiwei Tian Xiuxiu Wei Qiyou ding Haoyu Yang Zishan jin Xiaolin Tong Jun Wang Linhua Zhao institute of Metabolic Diseases Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Faculty of Biological Science and technology Baotou Teacher's CollegeBaotouInner Mongolia 014030China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Infinitus(china)Company Ltd GuangzhouGuangdong 510405China Affiliated Hospital of Changchun University of chinese Medicine ChangchunJilin 130021China Department of Endocrinology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Xinjiekou Community Health Service Center in Xicheng District Beijing 100035China Department of Spleen and Stomach Shenzhen Traditional Chinese Medicine HospitalShenzhenGuangdong 518033China University of chinese academy of sciences Beijing 100049China beijing University of chinese Medicine Beijing 100105China Northeast Asia institute of Traditional chinese Medicine Changchun University of Chinese MedicineChangchunJilin 130117China

Gut microbiota and circulating metabolite dysbiosis predate important pathological changes in glucose metabolic disorders;however,comprehensive studies on impaired glucose tolerance(IGT),a diabetes mellitus(DM)precursor,are ***,we perform metagenomic sequencing and metabolomics on 47 pairs of individuals with IGT and newly diagnosed DM and 46 controls with normal glucose tolerance(NGT);patients with IGT are followed up after 4 years for progression to *** of baseline data reveals significant differences in gut microbiota and serum metabolites among the IGT,DM,and NGT *** addition,13 types of gut microbiota and 17 types of circulating metabolites showed significant differences at baseline before IGT progressed to DM,including higher levels of Eggerthella unclassified,Coprobacillus unclassified,Clostridium ramosum,L-valine,L-norleucine,and L-isoleucine,and lower levels of Eubacterium eligens,Bacteroides faecis,Lachnospiraceae bacterium 3_1_46FAA,Alistipes senegalensis,Megaspaera elsdenii,Clostridium perfringens,α-linolenic acid,10E,12.-octadecadienoic acid,and dodecanoic acid.A random forest model based on differential intestinal microbiota and circulating metabolites can predict the progression from IGT to DM(AUC=0.87).These results suggest that microbiome and metabolome dysbiosis occur in individuals with IGT and have important predictive values and potential for intervention in preventing IGT from progressing to DM.

关键词： Impaired glucose tolerance Diabetes mellitus Gut microbiota Metabolomics

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Content Filtering Based Dynamic Summarization

Content Filtering Based Dynamic Summarization

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第四届全国信息检索与内容安全学术会议

作者： jin Zhang~1 Xiaolei Wang Hongbo Xu~(1+) ~1 institute of {2. technology,chinese academy of sciences,beijing,P.R.china

This paper addresses the issue of summarizing changes of the dynamic information in the web with time *** deal with the problem,we propose a novel dynamic summarization method to generate summary for the dramatically increasing ***,we propose content filtering models to identify the novel information from the document ***,a novel topic signature is presented to represent topic structures with time going, followed by a topic signature based re-ranking criterion for importance *** experimental results indicate that significant improvements can be achieved through our proposed approaches as compared to the top performing systems in DUC tasks.

关键词： Dynamic Summarization Content Filtering Topic Signature

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Research and Development of Attribute Reduction Algorithm Based on Rough Set

Research and Development of Attribute Reduction Algorithm Ba...

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2.10 chinese Control and Decision Conference

作者： Shifei ding~(1,2.,Hao ding~1 1.School of Computer Science and {2.,china University of Mining and {2.,Xuzhou,2.1116 2.Key Laboratory of Intelligent Information Processing,institute of computing {2.,chinese academy of sciences,beijing 100080

＜正＞Attribute reduction is a form of the data reduction,usually as a preprocessing step in data *** job is to maintain the knowledge base under the premise of the same classification ability to remove irrelevant and redundant attributes properties,thereby reducing the search space and improve *** recent years,attribute reduction has become the focus and hot spot of research in the field of Rough *** paper reviews the current domestic and foreign attribute reduction algorithm on a number of the latest research advances,focusing on the mainstream of attribute reduction methods and cutting-edge progress summary and *** it concludes with a brief discussion of the future direction of research and development.

关键词： Rough Set Attribute Reduction Discernibility Matrix Granular computing

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Distribution of δ18O in surface snow along a transect from Zhongshan Station to Dome A,East Antarctica

Distribution of δ18O in surface snow along a transect from ...

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中国科学院地质与地球物理研究所第十届(2.10年度)学术年会

作者： ding MingHu~(1,2.3*),XIAO CunDe~2.jin Bo~4,REN JiaWen~2.QIN DaHe~2.& SUN WeiZhen~{2. Division of Cenozoic Geology and Environment,institute of Geology and Geophysics,chinese academy of sciences,beijing 10002.,china 2.State Key Laboratory of Cryospheric sciences,Cold and Arid Regions Environmental and Engineering Research institute,chinese academy of sciences,Lanzhou 730000,china 3 Graduate University of chinese academy of sciences,beijing 100049,china 4 chinese Arctic and Antarctic Administration,beijing 100860,china

Surface snow samples were collected during the 14th(1997/1998)and 2.th(2.07/2.08)chinese National Antarctica Research Expeditions along a transect from Zhongshan Station to Dome *** stable oxygen isotope ratios of these samples were measured to investigate their relationships with temperature and geographical parameters(latitude,longitude,altitude and distance to the coast).The results reveal a strong positive correlation(R=0.945)betweenδO and mean annual temperature,with a gradient of 0.84‰℃,which is a little higher than that in Terre Adelie *** analyses also show that theδO of surface snow is strongly correlated with distance to the coast(R=0.942.,latitude(R=0.942.,and altitude(R=0.941).But no significant correlation was found betweenδO and longitude in study *** should be the most important factor influencing theδO distribution because of distinctive ***δO-altitude and T-altitude gradients along this transect are determined to be-1.1‰/100 m and 1.31℃/100 m,respectively.

关键词： Antarctica ITASE isotope Dome A δ18O chinaRE

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Embryonic stem cells generated by nuclear transfer of human somatic nuclei into rabbit oocytes

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Cell Research 2003年第4期13卷 251-263页

作者： YING CHEN, zhi Xu HE, AILIAN LIU, KAI WANG, WEN WEI MAO, JIAN XIN CHU, YONG LU, ZHENG Fu FANG, YING TANG SHI, QING ZHANG YANG, DA YUAN CHEN, MIN RANG WANG, jin SONG LI, SHAO LIANG HUANG, XIANG YIN KONG, YAO ZHOU SHI, Zm QIANG WANG, JIA HuI XIA, zhi GAO LONG, zhi GANG XUE, WEN XIANG ding, HuI ZHEN SHENG Center for Developmental Biology, Shanghai Second Medical University, Shanghai 2.0092. china Laboratory of Stem Cell Biology, institute of Biochemistry and Cell Biology, Shanghai institutes for Biological sciences, chinese academy of sciences, 1665 Kong Jiang Road, Shanghai 2.0092. china Center for Stem Cell Research, the Second Affiliated Hospital, Sun Yat-Sen University, Guangzhou 51012.,china State Key Laboratory of Reproductive Biology, institute of Zoology, chinese academy of sciences, 19 Zhong-guan Cun Road, Haidian District, beijing 100080, china Health Science Center, Shanghai institutes of Biological sciences, chinese academy of sciences and Shanghai Second Medical University, Shanghai 2.002., china National Laboratory of Medical Genetics, Central South University, 88 Xiangya Road, Changsha 410078, china Xinhua Hospital, Shanghai Second Medical University, 1665 Kong Jiang Road, Shanghai 2.0092. china Center for Developmental Biology Shanghai Second Medical University Shanghai 200092 China Laboratory of Stem Cell Biology Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences 1665 Kong Jiang Road Shanghai 200092 China Center for Stem Cell Research the Second Affiliated Hospital Sun Yat-Sen University Guangzhou 510120 China State Key Laboratory of Reproductive Biology Institute of Zoology Chinese Academy of Sciences 19 Zhong-guan Cun Road Haidian District Beijing 100080 China Health Science Center Shanghai Institutes of Biological Sciences Chinese Academy of Sciences and Shanghai Second Medical University Shanghai 200025 China National Laboratory of Medical Genetics Central South University 88 Xiangya Road Changsha 410078 China Xinhua Hospital Shanghai Second Medical University 1665 Kong Jiang Road Shanghai 200092 China

To solve the problem of immune incompatibility, nuclear transplantation has been envisaged as a means to produce cells or tissues for human autologous transplantation. Here we have derived embryonic stem cells by the transfer of human somatic nuclei into rabbit oocytes. The number of blastocysts that developed from the fused nuclear transfer was comparable among nuclear donors at ages of 5, 42. 52.and 60 years, and nuclear transfer (NT) embryonic stem cells (ntES cells) were subsequently derived from each of the four age groups. These results suggest that human somatic nuclei can form ntES cells independent of the age of the donor. The derived ntES cells are human based on karyotype, isogenicity, in situ hybridization, PCR and immunocytochemistry with probes that distinguish between the various species. The ntES cells maintain the capability of sustained growth in an undifferentiated state, and form embryoid bodies, which, on further induction, give rise to cell types such as neuron and muscle, as well

关键词： nuclear transfer (NT) somatic cell nuclear transfer (SCNT) embryonic stem cells (ES cell) therapeutic cloning rabbit oocyte.

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Optimized Chebyshev Fourier migration:A wide-angle dual-domain method for media with strong velocity contrasts

Optimized Chebyshev Fourier migration:A wide-angle dual-doma...

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中国科学院地质与地球物理研究所第十届(2.10年度)学术年会

作者： jin-Hai Zhang,Wei-Min Wang,Shu-Qin Wang,and Zhen-Xing Yao 1 chinese academy of sciences,{2. of Geology and Geophysics,beijing,china. 2.chinese academy of sciences,{2. of Tibetan Plateau Research,Key Laboratory of Continental Collision and Plateau Uplift,beijing,china. 3 Minzu University of china,{2. of Information Engineering,beijing,china.

A wide-angle propagator is essential when imaging complex media with strong lateral velocity contrasts in one-way wave-equation *** have developed a dual-domain one-way propagator using truncated Chebyshev polynomials and a globally optimized *** method increases the accuracy of the expanded square-root operator by adding two high-order terms to the traditional split-step Fourier ***,we approximate the square-root operator using Taylor expansion around the reference background ***,we apply the first-kind Chebyshev polynomials to economize the results of the Taylor ***,we optimize the constant coefficients using the globally optimized scheme,which are fixed and feasible for arbitrary velocity *** analysis and numerical experiments have demonstrated that the method has very high accuracy and exceeds the unoptimized Fourier finite-difference propagator for the entire range of practical velocity contrasts. The accurate propagation angle of the method is always about 60°under the relative error of 1%for complex media with weak,moderate,and even strong lateral velocity *** method allows us to handle wide-angle propagations and strong lateral velocity contrast simultaneously by using Fourier transform *** four 2. Fourier transforms are required for each step of 3D wavefield extrapolation,and the computing cost is similar to that of the Fourier finite-difference *** with the finite-difference method,our method has no two-way splitting error(i.e.,azimuthal-anisotropy error)for 3D cases and almost no numerical dispersion for coarse *** addition, it has strong potential to be accelerated when an enhanced fast Fourier transform algorithm emerges.

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成年和老年小鼠脑蛋白质组双向电泳图谱比较

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生物化学与生物物理进展 2001年第5期28卷 683-687页

作者：丁勤学阙海萍郭尧君景书谦刘少君军事医学科学院基础医学研究所北京100850 中国科学院生物物理研究所北京100101 美国Amgen公司分子遗传学实验室

使用双向电泳 (2. DE)比较成年和老年小鼠脑蛋白质差异 ,从分子水平初步探索老年脑蛋白整体变化规律 .以固相 pH梯度等电聚焦为第一向 ,SDS 聚丙烯酰胺凝胶水平电泳 (PAGE)为第二向进行 2. DE .图象分析软件Imagemaster 2.Elite分析电... 详细信息

使用双向电泳 (2. DE)比较成年和老年小鼠脑蛋白质差异 ,从分子水平初步探索老年脑蛋白整体变化规律 .以固相 pH梯度等电聚焦为第一向 ,SDS 聚丙烯酰胺凝胶水平电泳 (PAGE)为第二向进行 2. DE .图象分析软件Imagemaster 2.Elite分析电泳图谱 .重复性实验结果显示 ,同组样品在三次不同实验中所得蛋白质斑点数目的相对标准差 (变异系数 )为 4 43%± 0 2.5 % ;同一蛋白质斑点在三次实验中等电点、分子质量和蛋白质量的相对标准差分别为 8 76 %± 5 14% ,13 0 0 %± 4 2.2.%和 10 84%± 9 16 % .成年和老年小鼠脑组织 2. DE图谱分别获得 996和 12.5 6个蛋白质斑点 ,其中 8个蛋白质在老年脑组织中含量降低 ,2.0个蛋白质斑点含量增加 .另至少有 4个蛋白质斑点在老年脑组织中缺失 ,14个蛋白质点为老年脑特有 .

关键词：老年脑蛋白固相pH梯度双向电泳图谱蛋白质组成年小鼠脑老化功能退变

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Research on Ranking Support Vector Machine and Prospects

Research on Ranking Support Vector Machine and Prospects

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第二十九届中国控制会议

作者： ding Shi-Fei 1,2.LIU Xiao-Liang 1,ZHANG Li-Wen 1 1.School of Computer Science and technology,{2. University of Mining and technology,Xuzhou 2.1008,P.R.{2. 2.Key Laboratory of Intelligent Information Processing,institute of computing technology,chinese academy of sciences,beijing 100080,P.R.{2.

Learning to rank is designed to determine a ranking for the target objects according to some ***,the problem about learning to rank is to learn a ranking function from a training set whose data has been *** is most applied to the social sciences and information *** to rank is a hot issue in the field of information retrieval and machine learning at *** paper analyses the process of Ranking Support Vector machine（RSVM）from a theoretical point of view from the classification and regression respectively,and sets up the two basic mathematical models about *** general introduction about RSVM in the application,training speed and generalization ability is also *** the end,we come to a conclusion.

关键词： Support Ector Machine(SVM) Ranking SVM(RSVM) Learning to Rank Ordinal Regression

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Reconciled estimation of Antarctic ice sheet mass balance and contribution to global sea level change from 1996 to 2.2.

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Science china Earth sciences 2024年第11期67卷 3562-3578页

作者： Rongxing LI Guojun LI Gang HAI Huan XIE Yuan CHENG Wei CHEN Xiangbin CUI Minghu ding Chunchun GAO Tong HAO Changqing KE Chuanjin LI jin LI Yan LIU Jiangjun RAN Jiawen REN Qiang SHEN Yunzhong SHEN Hongling SHI Songyun WANG Zemin WANG jingang ZHAN Baojun ZHANG Min ZHONG Chunxia ZHOU Center for Spatial Information Science and Sustainable Development Applications Tongji University College of Surveying and Geo-informatics Tongji University institute for the Conservation of Cultural Heritage School of Cultural Heritage and Information Management Shanghai University College of Resource Environment and Tourism Hubei University of Arts and Science Polar Research institute of china State Key Laboratory of Severe Weather Chinese Academy of Meteorological Sciences College of Geodesy and Geomatics Shandong University of Science and Technology School of Geography and Ocean Science Nanjing University Shanghai Astronomical Observatory Chinese Academy of Sciences State Key Laboratory of Remote Sensing Science Faculty of Geographical Science Beijing Normal University Department of Earth and Space sciences Southern University of Science and Technology State Key Laboratory of Cryospheric Science Northwest Institute of Eco-Environment and Resources Chinese Academy of Sciences State Key Laboratory of Geodesy and Earth's Dynamics Innovation Academy for Precision Measurement Science and TechnologyChinese Academy of Sciences Center for Space Research University of Texas at Austin chinese Antarctic Center of Surveying and Mapping Wuhan University School of Geospatial Engineering and Science Sun Yat-sen University

The Antarctic Ice Sheet（AIS） has been losing ice mass and contributing to global sea level rise（GSLR）. Given its mass that is enough to cause ～58 m of GSLR, accurate estimation of mass balance trend is critical for AIS mass loss monitoring and sea level rise forecasting. Here, we present an improved approach to reconciled solutions of mass balance in AIS and its regions from multiple contributing solutions using the input-out, altimetric, and gravimetric methods. In comparison to previous methods, such as IMBIE 2.18, this approach utilizes an adaptive data aggregation window to handle the heterogeneity of the contributing solutions, including the number of solutions, temporal distributions, uncertainties, and estimation techniques. We improved the regression-based method by using a two-step procedure that establishes ensembled solutions within each method（input-output, altimetry, or gravimetry） and then estimates the method-independent reconciled solutions. For the first time, 16contributing solutions from 8 {2. institutions are used to estimate the reconciled mass balance of AIS and its regions from1996 to 2.2.. Our results show that AIS has lost a total ice mass of ～32.3±2.3 Gt during the period, an equivalent of～8.9±0.7 mm of GSLR. There is a sustained mass loss acceleration since 2.06, from 88.1±3.6 Gt yr-1during 1996–2.05 to 130.7 ±8.4 Gt yr-1during 2.06–2.13 and further to 157.0±9.0 Gt yr-1during 2.14–2.2.. The mass loss signal in the West Antarctica and Antarctic Peninsula is dominant and clearly presented in the reconciled estimation and contributing solutions, regardless of estimation methods used and fluctuation of surface mass balance. Uncertainty and challenges remain in mass balance estimation in East Antarctica. This reconciled estimation approach can be extended and applied for improved mass balance estimation in the Greenland Ice Sheet and mountain glacier regions.

关键词： Antarctic Ice Sheet Ice mass loss acceleration Sea level rise Reconciled estimation

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从《碧血剑》内外看满汉间的族群互动

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天津师范大学学报(社会科学版) 2003年第1期 28-33页

作者：定宜庄胡鸿保中国社会科学院历史研究所中国人民大学社会学系北京100732 北京100872

袁崇焕是明末清初之际最重要的历史人物之一 ,三百多年来 ,前贤学者有关他的传记和论著已经为数不少 ;金庸的《碧血剑》和《袁崇焕评传》,又给我们提供了武侠小说及其作者的审视视角 ;而为袁大将军守墓的佘家后人口耳相传的故事 ,则是... 详细信息

袁崇焕是明末清初之际最重要的历史人物之一 ,三百多年来 ,前贤学者有关他的传记和论著已经为数不少 ;金庸的《碧血剑》和《袁崇焕评传》,又给我们提供了武侠小说及其作者的审视视角 ;而为袁大将军守墓的佘家后人口耳相传的故事 ,则是民间流传文本 ,三种类型的文本对于这一真实的历史人物与事件的解释和表述方式有同有异 ,展示了不同的文化心态 ,反映出满汉族群互动关系的复杂性

关键词：小说口述史族群互动

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