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Functional analysis of the novel mitochondrial tRNA^(Trp)and tRNA^(ser(AgY))variants associated with type 2 diabetes mellitus

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World Journal of Diabetes 2024年第8期15卷 1753-1763页

作者： Yu ding Xue-Jiao Yu Qin-Xian guo Jian-Hang Leng Central Laboratory Hangzhou First People’s HospitalHangzhou 310006Zhejiang ProvinceChina Clinical Laboratory Quzhou People’s HospitalQuzhou 324000Zhejiang ProvinceChina

BACKgROUND Mutations in mitochondrial tRNA(mt-tRNA)genes that result in mitochondrial dysfunction play important roles in type 2 diabetes mellitus(T2DM).We previously reported a large Chinese pedigree with maternally inherited T2DM that harbors novel mt-tRNA^(Trp)A5514g and tRNA^(ser(AgY))C12237T variants,however,the effects of these mt-tRNA variants on T2DM progression are largely *** To assess the potential pathogenicity of T2DM-associated m.A5514g and m.C12237T variants at genetic,molecular,and biochemical *** Cytoplasmic hybrid(cybrid)cells carrying both m.A5514g and m.C12237T variants,and healthy control cells without these mitochondrial DNA(mtDNA)variants were generated using trans-mitochondrial *** features,including mt-tRNA steady-state level,levels of adenosine triphosphate(ATp),mitochondrial membrane potential(MMp),reactive oxygen species(ROs),mtDNA copy number,nicotinamide adenine dinucleotide(NAD+)/NADH ratio,enzymatic activities of respiratory chain complexes(RCCs),8-hydroxy-deoxyguanine(8-Ohdg),malondialdehyde(MDA),and superoxide dismutase(sOD)were examined in cell lines with and without these mt-tRNA *** Compared with control cells,the m.A5514g variant caused an approximately 35%reduction in the steady-state level of mt-tRNA^(Trp)(pser(AgY))steady-state level(p=0.5849).Biochemical analysis revealed that cells with both m.A5514g and m.C12237T variants exhibited more severe mitochondrial dysfunctions and elevated oxidative stress than control cells:ATp,MMp,NAD+/NADH ratio,enzyme activities of RCCs and sOD levels were markedly decreased in mutant cells(psures).By contrast,the levels of ROs,8-Ohdg and MDA were significantly increased(psures),but mtDNA copy number was not affected by m.A5514g and m.C12237T variants(p=0.5942).CONCLUsION The m.A5514g variant impaired mt-tRNA^(Trp)metabolism,which subsequent

关键词： Type 2 diabetes mellitus Mitochondrial tRNA genes Novel variants Oxidative stress Mitochondrial dysfunctions

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Chiral multiple-resonance thermally activated delayed fluorescence materials based on chiral spiro-axis skeleton for efficient circularly polarized electroluminescence

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science China Chemistry 2024年第7期67卷 2257-2264页

作者： shi-Quan song Xiao Han Zhong-Zhong Huo Ching-Fai Yip Xian-Fang Hong Meng-Ning ding You-Xuan Zheng state Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China Key Laboratory of Mesoscopic Chemistry of Ministry of Education School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China

Chiral luminescence materials have potential applications in the field of three-dimensional displays due to their circularly polarized luminescence(CpL)***,the further development of circularly polarized organic light-emitting diodes(Cp-OLEDs)needs to meet the requirements of high efficiency,high color purity,low cost,and high dissymmetry factor(gpLor gEL),chiral multiple resonance thermally activated delayed fluorescence(MR-TADF)materials are considered as candidates in these ***,based on a pair of chiral spirofluorene precursors,two pairs of high-performance chiral MR-TADF emitters((R/s)-p-spiro-DtBuCzB and(R/s)-m-spiro-DtBuCzB)are developed,which exhibit strong emissions peaking at 491 and 502 nm in toluene with full-width at half-maximum values of 25 and 33 nm,*** addition,small singlet–triplet energy gaps of 0.15 and 0.10 eV with high absolute photoluminescence efficiencies of 95.0%and 96.7%are observed for p-spiro-DtBuCzB and m-spiro-DtBuCzB molecules,*** based on p-spiro-DtBuCzB and m-spiro-DtBuCzB display high maximum external quantum efficiencies of 29.6%and 33.8%,*** importantly,Cp-OLEDs present symmetric circularly polarized electroluminescence spectra with|gEL|factors of 3.36×10^(-4)and 7.66×10^(-4)for devices based on(R/s)-p-spiro-DtBuCzB and(R/s)-m-spiro-DtBuCzB enantiomers,respectively.

关键词： chiral spiro-axis skeleton-based material multiple resonance thermally activated delayed fluorescence circularly polarized electroluminescence dissymmetry factor external quantum efficiency

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Ethanol steam reforming over Ni/ZsM-5 nanosheet for hydrogen production

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Chinese Journal of Chemical Engineering 2024年第3期67卷 247-256页

作者： porapak suriya shanshan Xu shengzhe ding sarayute Chansai Yilai Jiao Joseph Hurd Daniel Lee Yuxin zhang Christopher Hardacre prasert Reubroycharoen Xiaolei Fan Department of Chemical Engineering School of EngineeringThe University of ManchesterManchester M139PLUnited Kingdom program of petrochemistry and polymer science Faculty of ScienceChulalongkorn UniversityBangkok10330Thailand shenyang National Laboratory for Materials science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China Liaoning Academy of Materials Shenyang 110167China Center of Excellence in Catalysis for Bioenergy and Renewable Chemicals(CBRC) andDepartment of Chemical TechnologyFaculty of ScienceChulalongkorn UniversityBangkok 10330Thailand Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute University of Nottingham Ningbo ChinaNingbo315100China

Compared to reforming reactions using hydrocarbons,ethanol steam reforming(EsR)is a sustainable alternative for hydrogen(H_(2))production since ethanol can be produced sustainably using *** work explores the catalyst design strategies for preparing the Ni supported on ZsM-5 zeolite catalysts to promote ***,two-dimensional ZsM-5 nanosheet and conventional ZsM-5 crystal were used as the catalyst carriers and two synthesis strategies,i.e.,in situ encapsulation and wet impregnation method,were employed to prepare the *** on the comparative characterization of the catalysts and comparative catalytic assessments,it was found that the combination of the in situ encapsulation synthesis and the ZsM-5 nanosheet carrier was the effective strategy to develop catalysts for promoting H_(2) production via EsR due to the improved mass transfer(through the 2-D structure of ZsM-5 nanosheet)and formation of confined small Ni nanoparticles(resulted via the in situ encapsulation synthesis).In addition,the resulting ZsM-5 nanosheet supported Ni catalyst also showed high Ni dispersion and high accessibility to Ni sites by the reactants,being able to improve the activity and stability of catalysts and suppress metal sintering and coking during EsR at high reaction ***,the Ni supported on ZsM-5 nanosheet catalyst prepared by encapsulation showed the stable performance with~88% ethanol conversion and~65% H_(2) yield achieved during a 48-h longevity test at 550-C.

关键词： ZsM-5 nanosheet In situ encapsulation Ni catalyst Ethanol steam reforming Hydrogen production

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Effects of serum proteins on corrosion rates and product bioabsorbability of biodegradable metals

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Regenerative Biomaterials 2024年第1期3卷 132-148页

作者： Hongjie zhang Xin Li Zehua Qu Wanqian zhang Qunsong Wang dinglingge Cao Yaoben Wang Xin Wang Yang Wang Lin Yu Jiandong ding state Key Laboratory of Molecular Engineering of polymers Department of Macromolecular ScienceFudan UniversityShanghai 200438China

Corrodible metals are the newest kind of biodegradable materials and raise a new problem of the corrosion ***,the removal of the precipitated products has been unclear and even largely ignored in ***,we find that albumin,an abundant macromolecule in serum,enhances the solubility of corrosion products of iron in blood mimetic Hank’s solution *** is universal for other main biodegradable metals such as magnesium,zinc and polyester-coated *** also influences corrosion rates in diverse trends in Hank’s solution and normal *** on quantitative study theoretically and experimentally,both the effects on corrosion rates and soluble fractions are interpreted by a unified mechanism,and the key factor leading to different corrosion behaviors in corrosion media is the interference of albumin to the Ca/p passivation layer on the metal *** work has illustrated that the interactions between metals and media macromolecules should be taken into consideration in the design of the next-generation metal-based biodegradable medical devices in the formulism of precision *** improved Hank’s solution in the presence of albumin and with a higher content of initial calcium salt is suggested to access biodegradable metals potentially for cardiovascular medical devices,where the content of calcium salt is calculated after consideration of chelating of calcium ions by albumin,resulting in the physiological concentration of free calcium ions.

关键词： biodegradable metal macromolecule albumin corrosion bioabsorbability iron polylactide magnesium zinc

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simultaneous Degradation, Dehalogenation, and Detoxification of Halogenated Antibiotics by Carbon Dioxide Radical Anions

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Engineering 2024年第6期37卷 78-86页

作者： Yanzhou ding Xia Yu shuguang Lyu Huajun Zhen Wentao zhao Cheng peng Jiaxi Wang Yiwen Zhu Chengfei Zhu Lei Zhou Qian sui state Environmental protection Key Laboratory of Environmental Risk Assessment and Control on Chemical process School of Resources and Environmental EngineeringEast China University of Science and TechnologyShanghai 200237China shanghai Institute of pollution Control and Ecological security Shanghai 200092China state Key Laboratory of pollution Control and Resource Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China shanghai Academy of Environmental sciences Shanghai 200233China

Despite the extensive application of advanced oxidation processes(AOps)in water treatment,the efficiency of AOps in eliminating various emerging contaminants such as halogenated antibiotics is constrained by a number of *** moieties exhibit strong resistance to oxidative radicals,affecting the dehalogenation and detoxification *** address these limitations of AOps,advanced reduction processes(ARps)have been ***,a novel nucleophilic reductant—namely,the carbon dioxide radical anion(CO_(2)^(·-))—is introduced for the simultaneous degradation,dehalogenation,and detoxification of florfenicol(FF),a typical halogenated *** results demonstrate that FF is completely eliminated by CO_(2)^(·-),with approximately 100%of Cland 46%of Freleased after 120 min of *** detoxification is observed,which exhibits a linear response to the release of free inorganic halogen ions(R^(2)=0.97,pgen-free products is the primary reason for the superior detoxification performance of this method,in comparison with conventional hydroxyl-radical-based *** identification and density functional theory(DFT)calculations reveal the underlying dehalogenation mechanism,in which the chlorine moiety of FF is more susceptible than other moieties to nucleophilic attack by CO_(2)^(·-).Moreover,CO_(2)^(·-)-based ARps exhibit superior dehalogenation efficiencies(>75%)in degrading a series of halogenated antibiotics,including chloramphenicol(CAp),thiamphenicol(THA),diclofenac(DLF),triclosan(TCs),and ciprofloxacin(CIp).The system shows high tolerance to the pH of the solution and the presence of natural water constituents,and demonstrates an excellent degradation performance in actual groundwater,indicating the strong application potential of CO_(2)^(·-)-based ARps in real ***,this study elucidates the feasibility of CO_(2)^(·-)for the simultaneous degradation,dehalogenation,and detoxification of halog

关键词： Carbon dioxide radical anions Advanced reduction processes Halogenated antibiotics Dehalogenation Detoxification

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Association between glucose-lowering drugs and circulating insulin antibodies induced by insulin therapy in patients with type 2 diabetes

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World Journal of Diabetes 2024年第7期15卷 1489-1498页

作者： peng zhang Qing Jiang Bo ding Reng-Na Yan Yun Hu Jian-Hua Ma Department of Endocrinology Nanjing First HospitalNanjing Medical UniversityNanjing 210000Jiangsu ProvinceChina Department of Endocrinology The Affiliated Wuxi People's Hospital of Nanjing Medical UniversityWuxi Medical CenterWuxi 214000Jiangsu ProvinceChina

BACKgROUND Insulin antibodies(IAs)affect blood glucose control in patients receiving insulin *** To investigate the relationship between different hypoglycemic treatments and IAs in patients with type 2 diabetes mellitus(T2DM).METHODs This cross-sectional,retrospective study included 1863 patients with T2DM who were receiving exogenous insulin *** patients received stable antidiabetic therapy in the last 3 months and IA levels were measured using an iodine-125 *** A total of 1863 patients were *** were 902(48.4%)patients who had positive IAs(IA level>5%),with a mean IA level of 11.06%(10.39%-11.72%).IA levels were positively correlated with high fasting blood glucose(odds ratio=1.069,pproportion of positive IAs was lowest in patients using glargine only(31.9%)and highest in patients using human insulin only(70.3%),ps in patients using sulfonylureas/glinides(8.3%),metformin(9.6%),and dipeptidyl peptidase-4 inhibitors(8.2%)were all lower than in patients without these drugs(all psION Nearly half of patients on insulin therapy have positive IA antibodies,and IA antibody levels are associated with blood glucose *** glargine and a combination of oral glucose-lowering drugs were correlated with lower IA levels.

关键词： Insulin antibodies Insulin therapy glucose-lowering drugs glargine Type 2 diabetes

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sleep promotion by 3-Hydroxy-4-Iminobutyric Acid in Walnut Diaphragma juglandis Fructus

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Research 2024年第2期6卷 613-627页

作者： Jian Ji Yongli Ye Lina sheng Jiadi sun Qianqian Hong Chang Liu Jun ding shuxiang geng Deping Xu Yinzhi zhang Xiulan sun state Key Laboratory of Food science and Technology School of Food Science and TechnologyNational Engineering Research Center for Functional FoodSynergetic Innovation Center of Food Safety and Quality ControlJiangnan UniversityLihu Avenue 1800WuxiJiangsu 214100P.R.China College of Food science and pharmacy Xinjang Agricultural UniversityNo.311 Nongda Dong RoadUrumqiXinjangUygur Autonomous Region 830052P.R.China Department of Chemistry Wuhan UniversityWuhanHubei 430072P.R.China Yunnan Academy of Forestry and grassland KunmingYunnan 650201P.R.China

Insufficient sleep can produce a multitude of deleterious repercussions on various domains of human ***,the walnut(Juglans mandshurica)confers numerous salutary biological activities pertaining to ***,the sedative and hypnotic capacities of walnut's functional constituents remain *** this investigation,we analyzed the sedative and hypnotic components of the walnut Diaphragma juglandis fructus and innovatively discovered a compound,defined as 3-hydroxy-4-iminobutyric acid(HIBA),which disrupts motor activity and enhances sleep duration by regulating the neurotransmitters(gABA,DA,etc.)within the brain and serum of ***,a metabolomics approach of the serum,basal ganglia,hypothalamus,and hippocampus as well as the gut microbiota was undertaken to unravel the underlying molecular mechanisms of sleep *** data reveal that HIBA can regulate the metabolism of basal ganglia(sphingolipids,acylcarnitines,etc.),possibly in relation to HIBA's influence on the gut microbiome(Muribaculum,Bacteroides,Lactobacillus,etc.).Therefore,we introduce a novel natural product,HIBA,and explicate the modulation of sleep promotion in mice based on the microbiota-gut-brain *** study contributes fresh insights toward natural product-based sleep research.

关键词： metabolism promotion insight

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Mechanism of Qili Qiangxin Capsule for Heart Failure Based on miR133a-Endoplasmic Reticulum stress

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Chinese Journal of Integrative Medicine 2024年第5期30卷 398-407页

作者： JI Xiao-di YANg ding CUI Xi-yuan LOU Li-xia NIE Bo zhaO Jiu-li zhaO Ming-jing WU Ai-ming Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine Key Laboratory of Chinese Internal Medicine of Ministry of Education and BeijingBeijing 100700China Department of Traditional Chinese Medicine Fuwai HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100037China

Objective:To investigate the pharmacological mechanism of Qili Qiangxin Capsule(QLQX)improvement of heart failure(HF)based on miR133a-endoplasmic reticulum stress(ERs)***:A left coronary artery ligation-induced HF after myocardial infarction model was used in this *** were randomly assigned to the sham group,the model group,the QLQX group[0.32 g/(kg·d)],and the captopril group[2.25 mg/(kg·d)],15 rats per group,followed by 4 weeks of *** function such as left ventricular ejection fraction(EF),fractional shortening(Fs),left ventricular systolic pressure(LVsp),left ventricular end diastolic pressure(LVEDp),the maximal rate of increase of left ventricular pressure(+dp/dt max),and the maximal rate of decrease of left ventricular pressure(–dp/dt max)were monitored by echocardiography and *** and eosin(HE)and Masson stainings were used to visualize pathological changes in myocardial *** m RNA expression of mi R133a,glucose-regulated protein78(gRp78),inositol-requiring enzyme 1(IRE1),activating transcription factor 6(ATF6),X-box binding protein1(XBp1),C/EBp homologous protein(CHOp)and Caspase 12 were detected by *** protein expression of gRp78,p-IRE1/IRE1ratio,cleaved-ATF6,XBp1-s(the spliced form of XBp1),CHOp and Caspase 12 were detected by Western *** T-mediated d UTp nick-end labeling(TUNEL)staining was used to detect the rate of ***:QLQX significantly improved cardiac function as evidenced by increased EF,Fs,LVsp,+dp/dt max,-dp/dt max,and decreased LVEDp(ppstaining showed that QLQX ameliorated cardiac pathologic damage to some *** staining indicated that QLQX significantly reduced collagen volume fraction in myocardial tissue(psults from RT-pCR and Western blot showed that QLQX significantly increased the expression of mi R133a and inhibited the m RNA expressions of gRp78,IRE1,ATF6 and XBp1,as well as decreased the protein expressions of gRp78,cleave

关键词： heart failure Qili Qiangxin Capsule miR133a endoplasmic reticulum stress apoptosis

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structures and ion transport mechanisms of plant high-affinity potassium transporters

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Molecular plant 2024年第3期17卷 409-422页

作者： Jiangqin Wang Yanping Luo Fan Ye Zhong Jie ding shao Jian Zheng shuai Qiao Yong Wang Jiangtao guo Wei Yang Nannan su international Institutes of Medicine the Fourth Affiliated HospitalZhejang University School of MedicineYiwuZhejiang 322000China Department of Biophysics and Department of Neurology of the Fourth Affiliated Hospital Zhejiang University School of MedicineHangzhouZhejang 310058China state Key Laboratory of plant Environmental Resilience College of Life SciencesZhejang UniversityHangzhouZhejang 310058China College of Life sciences Zhejiang UniversityHangzhouZhejiang 310058China NHC and CAMs Key Laboratory of Medical Neurobiology MOE Frontier Science Center for Brain Science and Brain-machine IntegrationSchool of Brain Science and Brain MedicineZhejiang UniversityHangzhouZhejiang 310058China Nanhu Brain-computer Interface Institute Hangzhou.Zheiang 311100.China

plant high-affinity K^(+) transporters(HKTs)mediate Na^(+) and K^(+) uptake,maintain Na^(+)/K^(+) homeostasis,and therefore play crucial roles in plant salt *** this study,we present cryoelectron microscopy structures of HKTs from two classes,classI HKT1;1 from Arabidopsis thaliana(AtHKT1;1)and class II HKT2;1 from Triticum aestivum(TaHKT2;1),in both Na^(+) -and K^(+) -bound states at 2.6-to 3.0-A ***1;1and TaHKT2;1function *** HKT subunit consists of four tan-dem domain units(D1-D4)with a repeated K^(+) -channel-like M-p-M *** each subunit,D1-D4 assemble into an ion conduction pore with a pseudo-four-fold *** both TaHKT2;1and AtHKT1;1 have only one putative Na^(+) ion bound in the selectivity filter with a similar coordination pattern,the two HKTs display different K^(+) binding modes in the ***2;1 has three K^(+) ions bound in the selec-tivity filter,but AtHKT1;1 has only two K^(+) ions bound in the filter,which has a narrowed external entrance due to the presence of a ser residue in the first filter *** structures,along with compu-tational,mutational,and electrophysiological analyses,enable us to pinpoint key residues that are critical for the ion selectivity of *** findings provide new insights into the ion selectivity and ion transport mechanisms of plant HKTs and improve our understanding about how HKTs mediate plant salt tolerance and enhance crop growth.

关键词： HKTs structure ion selectivity mechanism salt tolerance

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Mitochondrial sensitive probe with aggregation-induced emission characteristics for early brain diagnosis of parkinson’s disease

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Aggregate 2024年第1期5卷 216-227页

作者： Liwen Huang Yutong Zhou Di Jiao Jing Ren Yilin Qi Heping Wang Yang shi Dan ding Xue Xue state Key Laboratory of Medicinal Chemical Biology College of PharmacyNankai UniversityTianjinP.R.China state Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive MaterialsMinistry of Educationand College of Life SciencesNankai UniversityTianjinP.R.China

The early diagnosis of parkinson’s disease(pD)provides opportunities for early intervention to slow the progression of neurological degeneration in patients,particularly as the aging population increases in our *** a series of pathological features of pD,mitochondria abnormalities have been identified as central event that occurs at the early stage of ***,the method for detecting mitochondrial abnormalities-associated early pD has not been fully *** herein report a specifically mitochondrial targeting probe(named TpA-BT-sCp)that is able to characterize mitochondria abnormalities for early diagnosis of pD and monitor pD neurodegenerative *** probe is an aggregation-induced emission(AIE)probe with a strong positive charge,a 3D distorted molecular structure,and a separated HOMO-LUMO distribution,designed with unique molecular design *** research demonstrated that TpA-BT-sCp could emit stable and strong fluorescence,and rapidly accumulate in mitochondria due to the negative *** intranasal administration of 1-methy-4-phenyl-1,2,3,6-tetrahydropyridine(MpTp)-induced pD mice,TpA-BT-sCp successfully bypassed the blood−brain barrier to light up the brain,allowing the grading of pD severity based on its high *** together,this work develops a novel AIE probe that exhibits dramatically high sensitivity to mitochondrial changes and enables noninvasive diagnosis of early pD in the brain.

关键词： aggregation-induced emission early diagnosis parkinson’s disease

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