检索结果-南通市图书馆

Primary antibiotic resistance of Helicobacter pylori strains isolated from patients with dyspeptic symptoms in Beijing: A prospective serial study

引用

World Journal of Gastroenterology 2015年第9期21卷 2786-2792页

作者： Yue-Xi zhang Li-Ya Zhou Zhi-Qiang Song jian-zhong zhang Li-Hua He Yu ding Department of Gastroenterology Beijing Sixth Hospital Department of Gastroenterology Peking University Third Hospital State Key Laboratory for Infectious Disease Prevention and Control National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and Prevention

AIM:To determine the resistance patterns of Helicobacter pylori(***) strains isolated from patients in Beijing and monitor the change of antibiotic resistance over ***:In this prospective,serial and crosssectional study,*** cultures were successfully obtained from 371 and 950 patients(never receiving eradication) during 2009-2010 and 2013-2014,*** to amoxicillin,clarithromycin,metronidazole,levofloxacin,tetracycline,and rifampicin was determined by Epsilometer ***:The resistance rates of isolates obtained during 2009-2010 were 66.8%,39.9%,34.5%,15.4%,6.7%,and 4.9% to metronidazole,clarithromycin,levofloxacin,rifampicin,amoxicillin and tetracycline,respectively; and the corresponding rates for isolates during 2013-2014 were 63.4%,52.6%,54.8%,18.2%,4.4% and 7.3%,*** resistance rates to clarithromycin and levofloxacin were significantly increased after four *** 2009-2010,14.6% of *** isolates were susceptible to all tested antibiotics,with mono(33.7%),double(28.3%),triple(16.7%),quadruple(6.2%),quintuple(0.3%) and sextuple resistance(0.3%) also being *** 2013-2014,9.4% were susceptible to all tested antibiotics,and mono(27.6%),double(28.4%),triple(24.9%),quadruple(7.3%),quintuple(2.3%) and sextuple resistance(0.1%) was also *** multiple resistant *** isolates were found during ***(to levofloxacin and metronidazole),age(to levofloxacin) and endoscopic findings(to clarithromycin) were independent factors influencing antibiotic ***:*** resistance to commonly used antibiotics in Beijing is high with increased multiple antibiotic resistance.

关键词： Helicobacter pylori Antibiotic resistance Beijing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Association of polymorphisms in C1orf106,IL1RN,and IL10 with post-induction infliximab trough level in Crohn’s disease patients

引用

Gastroenterology Report 2020年第5期8卷 367-373,I0002页

作者： jian Tang Cai-Bin zhang Kun-Sheng Lyu zhong-ming Jin Shao-Xing Guan Na You min Huang Xue-ding Wang Xiang Gao Department of Gastroenterology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China Institute of Clinical Pharmacology School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhouGuangdongP.R.China Southern China Center for Statistical Science School of Mathematics Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background:Trough levels of the post-induction serum infliximab(IFX)are associated with short-term and long-term responses of Crohn’s disease patients to IFX,but the inter-individual differences are *** aimed to elucidate whether single gene polymorphisms(SNPs)within FCGR3A,ATG16L1,C1orf106,OSM,OSMR,NF-jB1,IL1RN,and IL10 partially account for these differences and employed a multivariate regression model to predict patients’post-induction IFX ***:The retrospective study included 189 Crohn’s disease patients undergoing IFX ***-induction IFX levels were measured and 41 tag SNPs within eight genes were *** between SNPs and IFX levels were ***,a multivariate logistic-regression model was developed to predict whether the patients’IFX levels achieved the threshold of therapy(3 lg/mL).Results:Six SNPs(rs7587051,rs143063741,rs442905,rs59457695,rs3213448,and rs3021094)were significantly associated with the post-induction IFX trough level(P=0.015,Pmin(P=0.002),rs442905(P=0.025),rs59457695(P=0.049),rs3213448(P=0.056),and rs3021094(P=0.047).The area under the receiver operating characteristic curve(AUROC)of this prediction model in a representative training dataset was *** result was verified in a representative testing dataset,with an AUROC of ***:Polymorphisms in C1orf106,IL1RN,and IL10 play an important role in the variability of IFX post-induction levels,as indicated in this multivariate prediction model of IFX levels with fair performance.

关键词： infliximab inflammatory bowel disease single nucleotide polymorphism trough level multivariate prediction model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fluorescence polarization immunoassay for salinomycin based on monoclonal antibodies

引用

Science China Chemistry 2010年第3期53卷 552-554页

作者： Wang, Zhan Hui Cheng, Lin Li Shi, Wei min zhang, Su Xia Shen, jian zhong National Reference Laboratories for Veterinary Drug Residue College of Veterinary Medicine China Agricultural University Beijing 100193 China

A fluorescence polarization immunoassay(FPIA) for the determination of salinomycin(SAL) was developed by using anti-SAL monoclonal antibodies(mAb).Fluorescein labeled SAL(tracer) was synthesized by the N-hydroxysuccinimide active ester method and purified using thin layer chromatography(TLC).The developed FPIA for SAL had a dynamic range from 0.60 to 2193 ng/mL with an IC50 value of 33.2 ng/mL and a detection limit(LOD) of 0.08 ng/*** significant cross-reactivities were observed with other drugs but 67.6% with narasin.

关键词： salinomycin tracer fluorescence polarization immunoassay monoclonal antibody

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

学习贯彻习近平总书记在中共中央政治局第十四次集体学习时的重要讲话精神笔谈(兰)

引用

中国大学生就业 2024年第7期 3-20,28页

作者：任友群江涌张金元丁念友李众靳敏山东大学党委江苏省教育厅湖北省教育厅四川省教育厅中国传媒大学党委电子科技大学党委

近日,中共中央政治局就促进高质量充分就业进行第十四次集体学习。习近平总书记在主持学习时强调,促进高质量充分就业,是新时代新征程就业工作的新定位、新使命。要加快建构中国就业理论体系,有效提升我国在就业领域的国际话语权和影响... 详细信息

近日,中共中央政治局就促进高质量充分就业进行第十四次集体学习。习近平总书记在主持学习时强调,促进高质量充分就业,是新时代新征程就业工作的新定位、新使命。要加快建构中国就业理论体系,有效提升我国在就业领域的国际话语权和影响力。为深入学习领会习近平总书记重要讲话精神,本刊特组织“学习贯彻习近平总书记在中共中央政治局第十四次集体学习时的重要讲话精神”笔谈,邀约有关教育行政部门领导、高校领导、专家学者撰文,助力深度研究阐释习近平总书记关于促进高质量充分就业的重要讲话精神,加快推动建构中国大学生就业理论体系。

关键词：高校毕业生高质量充分就业中国就业理论体系

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

噬血细胞性淋巴组织细胞增生症与脓毒症临床特征比较

引用

临床儿科杂志 2024年第6期42卷 547-552页

作者：钟小梅任宏张建李璧如钱娟宁铂涛高怡瑾王莹上海交通大学医学院附属上海儿童医学中心重症医学科上海200127 上海交通大学医学院附属上海儿童医学中心血液肿瘤科上海200127

目的比较噬血细胞性淋巴组织细胞增生症(HLH)与脓毒症的临床特征,寻找帮助鉴别诊断的实验室指标。方法回顾性分析2013年1月—2020年12月无基础疾病HLH以及发热伴外周血二系细胞减少或脾脏肿大的脓毒症患儿的临床资料。结果共106例患... 详细信息

目的比较噬血细胞性淋巴组织细胞增生症(HLH)与脓毒症的临床特征,寻找帮助鉴别诊断的实验室指标。方法回顾性分析2013年1月—2020年12月无基础疾病HLH以及发热伴外周血二系细胞减少或脾脏肿大的脓毒症患儿的临床资料。结果共106例患儿纳入研究。HLH组患儿72例,男46例、女26例,中位年龄26.5(14.3~56.8)个月;脓毒症组患儿34例,男18例、女16例,中位年龄14.0(3.8~89.0)个月。脓毒症组总住院时间和PICU入住时间均长于HLH组,差异有统计学意义(Pmin、中性粒细胞绝对值(ANC)-min、血红蛋白(HB)-min、血小板计数-min、肌酐(CREA)-Max、纤维蛋白原(FIB)-min、C反应蛋白-Max、降钙素原(PCT)-Max较低,三酰甘油-Max、血清铁蛋白(SF)-Max较高,HB减少持续时间较短,ANC减少持续时间较长,组间差异均有统计学意义(均Pmin、FIB-min、CREA-Max和PCT-Max水平的下降有助于诊断HLH(Pmin、FIB-min、CREA-Max和PCT-Max的联合预测因子,其协助判断HLH的AUC为0.95(95%CI:0.89~0.99);联合预测因子的AUC显著大于SF-Max,差异有统计学意义(Pmin、FIB-min、CREA-Max、PCT-Max四项指标拟合可能有助于更好鉴别HLH和脓毒症。

关键词：噬血细胞性淋巴组织细胞增生症脓毒症血清铁蛋白临床特征

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dual human iPSC-derived cardiac lineage cell-seeding extracellular matrix patches promote regeneration and long-term repair of infarcted hearts

引用

Bioactive Materials 2023年第10期28卷 206-226页

作者： Yun jiang Ling-Ling zhang Fan zhang Wei Bi Peng zhang Xiu-jian Yu Sen-Le Rao Shi-Hui Wang Qiang Li Chen ding Ying Jin zhong-min Liu Huang-Tian Yang Translational Medical Center for Stem Cell Therapy&Institute for Heart Failure and Regenerative Medicine Shanghai East HospitalSchool of MedicineTongji UniversityShanghai200092China CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institute of Nutrition and HealthUniversity of Chinese Academy of Sciences(CAS)CASShanghai200031PR China State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development School of Life SciencesInstitute of Biomedical SciencesHuman Phenome InstituteZhongshan HospitalFudan UniversityShanghai200433China Institute for Stem Cell and Regeneration CASBeijing100101PR China

Human pluripotent stem cell-derived cardiovascular progenitor cells (hCVPCs) and cardiomyocytes (hCMs) possess therapeutic potential for infarcted hearts;however, their efficacy needs to be enhanced. Here we tested the hypotheses that the combination of decellularized porcine small intestinal submucosal extracellular matrix (SIS-ECM) with hCVPCs, hCMs, or dual of them (Mix, 1:1) could provide better therapeutic effects than the SIS alone, and dual hCVPCs with hCMs would exert synergic effects in cardiac repair. The data showed that the SIS patch well supported the growth of hCVPCs and hCMs. Epicardially implanted SIS-hCVPC, SIS-hCM, or SIS-Mix patches at 7-day post-myocardial infarction significantly ameliorated functional worsening, ventricular dilation and scar formation at 28- and 90-day post-implantation in C57/B6 mice, whereas the SIS only mildly improved function at 90-day post-implantation. Moreover, the SIS and SIS-cell patches improved vascularization and suppressed MI-induced cardiomyocyte hypertrophy and expression of Col1 and Col3, but only the SIS-hCM and the SIS-Mix patches increased the ratio of collagen III/I fibers in the infarcted hearts. Further, the SIS-cell patches stimulated cardiomyocyte proliferation via paracrine action. Notably, the SIS-Mix had better improvements in cardiac function and structure, engraftments, and cardiomyocyte proliferation. Proteomic analysis showed distinct biological functions of exclusive proteins secreted from hCVPCs and hCMs, and more exclusive proteins secreted from co-cultivated hCVPCs and hCMs than mono-cells involving in various functional processes essential for infarct repair. These findings are the first to demonstrate the efficacy and mechanisms of mono- and dual-hCVPC- and hCM-seeding SIS-ECM for repair of infarcted hearts based on the side-by-side comparison.

关键词： Induced human pluripotent stem cells Cardiac lineage cells Extracellular matrix patch Cardiomyocyte regeneration Infarcted heart repair

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ultrathin nanoporous metal electrodes facilitate high proton conduction for low-Pt PEMFCs

引用

Nano Research 2021年第8期14卷 2681-2688页

作者： Shuai Shi Xianglong Wen Qinqin Sang Shuai Yin Kaili Wang jian zhang min Hu Huiming Yin Jia He Yi ding Tianjin Key Laboratory of Advanced Functional Porous Materials Institute for New Energy Materials&Low-Carbon TechnologiesSchool oj Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China

Design of catalyst layers(CLs)with high proton conductivity in membrane electrode assemblies(MEAs)is an important issue for proton exchange membrane fuel cells(PEMFCs).Herein,an ultrathin catalyst layer was constructed based on Pt-decorated nanoporous gold(NPG-Pt)with sub-Debye-length thickness for proton *** the absence of ionomer incorporation in the CLs,these integrated carbon-free electrodes can deliver maximum mass-specific power density of 198.21 and 25.91 kW·gPt^(-1) when serving individually as the anode and cathode,at a Pt loading of 5.6 and 22.0 pg·cm^(-2),respectively,comparable to the best reported nano-catalysts for ***-depth quantitative experimental measurements and finite-element analyses indicate that improved proton conduction plays a critical role in activation,ohmic and mass transfer polarizations.

关键词： nanoporous metal electrode proton exchange membrane fuel cell(PEMFC) ultrathin catalyst layer proton conduction dealloying

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

HMGB1及血清炎性因子与轻度胃肠炎伴良性惊厥发病机制的关系

引用

实用临床医学（江西） 2024年第3期25卷 42-46页

作者：陈辉陈勇章静静查剑王蕊艳钟建民江西省儿童医院神经内科南昌330038

目的探讨高迁移率族蛋白B1(HMGB1)及白介素(IL)-1β、IL-2R、IL-6、IL-8及肿瘤坏死因子α(TNF-α)与轻度胃肠炎伴良性惊厥(CwG)发病机制的关系。方法选取2022年1月至2023年11月期间在江西省儿童医院就诊的CwG患儿30例(CwG组)和同期轻... 详细信息

目的探讨高迁移率族蛋白B1(HMGB1)及白介素(IL)-1β、IL-2R、IL-6、IL-8及肿瘤坏死因子α(TNF-α)与轻度胃肠炎伴良性惊厥(CwG)发病机制的关系。方法选取2022年1月至2023年11月期间在江西省儿童医院就诊的CwG患儿30例(CwG组)和同期轻度急性胃肠炎(AGE)不伴有惊厥的患儿30例(对照组)。采集2组急性期和恢复期的静脉血,采用酶联免疫吸附法(ELISA)检测血清HMGB1水平;采用化学发光法检测血清IL1β、IL2R、IL6、IL8、TNF-α水平。结果在急性期,CwG组的血清HMGB1、IL-6、IL-8、TNF-α水平均显著高于对照组(P0.05)。CwG组的惊厥发作次数、惊厥发作总时间、病程均与血清HMGB1、IL-6、IL-8、TNF-α水平成正相关(P0.05)。结论 HMGB1介导的免疫炎症网络与CwG的发病过程密切相关,血清HMGB1、IL-6、IL-8、TNF-α水平与CwG急性期的惊厥严重程度及病程转归显著相关。

关键词：高迁移率族蛋白B1 炎症轻度胃肠炎惊厥儿童

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Association of hypomethylation of LINE-1 repetitive element in blood leukocyte DNA with an increased risk of hepatocellular carcinoma

引用

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第10期12卷 805-811页

作者： jian-zhong DI Xiao-dong HAN Wen-ye GU Yu WANG Qi ZHENG Pin zhang Hui-min WU zhong-zheng ZHU Department of General Surgery the Sixth People ＂s Hospital Shanghai Jiao Tong University Shanghai 200233 China Department of Gastroenterology Shanghai Guanghua Hospital Shanghai 200052 China Department of General Surgery Tongji Hospital Tongji University Shanghai 200065 China Department of Oncology No. 113 Hospital of People＇s Liberation Army Ningbo 315040 China

Global DNA hypomethylation has been associated with increased risk for cancers of the colorectum,bladder,breast,head and neck,and testicular germ *** aim of this study was to examine whether global hypomethylation in blood leukocyte DNA is associated with the risk of hepatocellular carcinoma (HCC).A total of 315 HCC cases and 356 age-,sex-and HBsAg status-matched controls were *** methylation in blood leukocyte DNA was estimated by analyzing long interspersed element-1 (LINE-1) repeats using bisulfite-polymerase chain reaction (PCR) and *** observed that the median methylation level in HCC cases (percentage of 5-methylcytosine (5mC)=77.7%) was significantly lower than that in controls (79.5% 5mC) (P=0.004,Wilcoxon rank-sum test).The odds ratios (ORs) of HCC for individuals in the third,second,and first (lowest) quartiles of LINE-1 methylation were 1.1 (95% confidence interval (CI) 0.7-1.8),1.4 (95% CI 0.8-2.2),and 2.6 (95% CI 1.7-4.1) (P for trend median) LINE-1 *** results demonstrate for the first time that individuals with global hypomethylation measured in LINE-1 repeats in blood leukocyte DNA have an increased risk for *** data provide the evidence that global hypomethylation detected in the easily obtainable DNA source of blood leukocytes may help identify individuals at risk of HCC.

关键词： Cancer risk Epigenetics Global hypomethylation Hepatocellular carcinoma LINE-1 repetitive element

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nonsolvent-induced phase separation-derived TiO_(2) nanotube arrays/porous Ti electrode as high-energy-density anode for lithium-ion batteries

引用

Rare Metals 2021年第2期40卷 393-399页

作者： Zhi-Jia zhang Jun Zhao Zhi-Jun Qiao Jia-min Wang Shi-Hao Sun Wen-Xing Fu Xi-Yuan zhang Zhen-Yang Yu Yu-Hai Dou jian-Li Kang ding Yuan Yue-Zhan Feng jian-min Ma State Key Laboratory of Separation Membrane and Membrane Processes Tianjin Municipal Key Laboratory of Advanced Fibers and Energy StorageSchool of Materials Science and EngineeringSchool of Mechanical EngineeringTiangong UniversityTianjin300387China Centre for Clean Environment and Energy Gold Coast CampusGriffith UniversityGold Coast4222Australia Key Laboratory of Materials Processing and Mold Ministry of EducationZhengzhou UniversityZhengzhou450002China Key Laboratory for Micro-/Nano-Optoelectronic Devices Ministry of EducationSchool of Physics and ElectronicsHunan UniversityChangsha410022China

TiO_(2) nanotube arrays,growing on three-dimensional(3 D)porous Ti membrane,were synthesized using a facile nonsolvent-induced phase separation and anodization *** length of those three-dimensional nanotube arrays could be tuned by prolonging the anodizing *** the anodizing time is 8 h,the three-dimensional TiO_(2) nanotube arrays/porous Ti electrode exhibits well cycling stability and ultra-high specific capacity,which is used in lithium-ion batteries,attributed to the high utilization rate of the substrate and the high growth intensity of the active ***-dimensional TiO_(2) nano tube arrays/porous Ti electrode,at 100μA·cm^(-2) with 8 h anodizing time,shows a typical discharge plateau at 1.78 V and exhibits the specific capacity with 2126.7μAh·cm^(-2),The novel nanotube arrays@3 D porous architecture effectively shortens the electron/ion transmission path,which could pave way for optimizing the design of highperformance anode materials for next-generation energy storage system.

关键词： TiO2 nanotube arrays Nonsolvent-induced phase separation Anodization Anode Lithium-ion battery

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：