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Evaluation of SARS-CoV-2.Neutralizing Nanobody Using Virus Receptor Binding Domain-Administered Model Mice

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Research 2022年第2期2022卷 85-98页

作者： Song Liu Guanghui Li Lei ding jin ding Qian Zhang Dan Li Xingguo Hou Xiangxing Kong jing Zou Shiming Zhang Hongbin Han Yakun Wan zhi Yang Hua Zhu Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education beijing)NMPA Key Laboratony for Research and Evaluation of Radiopharmaceuticals Department of Nuclear MedicinePeking University Cancer HospialInstituteBeijing 100142China Instiute of Biomedial Engineering Peking University Shenzhen Graduate SchoolShenzhenGuangdong 518055China Shanghai Novamab Biopharmaceuticals Co.L.td ShanghaiChina Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Bejing).Department of Anesthesiology.Peking University Cancer Hospital 6 Institut Beijing 100142China Instilute of Medical technology Peking Universily Health Science CenterBeijing 100191China Bejig Key Laboratory of Magnetic Resonance Imaging Devices and technology Peking University Third HospitalBeijing 100191China Department of Radiology Peking University Third HospitalPeking UniversilyBejjing 100191China

Due to the rapid spread of coronavirus disease 2.19(COVID-19),there is an urgent requirement for the development of additional diagnostic tools for further analysis of the *** isolated nanobody Nb11-59 binds to the severe acute respiratory syndrome coronavirus 2.SARS-CoV-2.reeptor-binding domain[RBD]with high afinity to neutralize the virus and block the angiotensin-converting enzyme 2.(ACE2.)RBD ***,we introduce a novel nanobody-based radiotracer named^(68)*** radiotracer retained high affinity for the RBD and showed reliable radiochemical characteristics both in vitro and in *** positron emission tomography(PET)studies of Ga-Nb1159 in mice revealed is rapid dearance from circulation and robust uptake into the renal and urinary ***,^(68)Ga-Nb1159 could speifcally reveal the distribution of the RBD in *** sudy also helped to evaluate the pharmacodynamic efects of the neutralizing ***,^(68)Ga-Nb1159 may be a promising l0ol lo explore the distribution of the RBD and improve the understanding of the *** particular,this study identified a novel molecular radioagent and established a reliable evaluation method for speifially investigating the RBD through noninvasive and visual PET technology.

关键词： urinary acute neutral

From knowledge based software engineering to knowware based software engineering

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Science in china(Series F) 2008年第6期51卷 638-660页

作者： LU RuQian jin zhi academy of Mathematics and System sciences & {2. of computing technology Chinese Academy ofSciences Beijing 100190 China

The first part of this paper reviews our efforts on knowledge-based software engineering, namely PROMIS, started from 1990s. The key point of PROMIS is to generate applications automatically based on domain knowledge as well as software knowledge. That is featured by separating the development of domain knowledge from the development of software. But in PROMIS, we did not find an appropriate representation for the domain knowledge. Fortunately, in our recent work, we found such a carrier for knowledge modules, i.e. knowware. Knowware is a commercialized form of domain knowledge. This paper briefly introduces the basic definitions of knowware, knowledge middleware and knowware engineering. Three life circle models of knowware engineering and the design of corresponding knowware implementations are given. Finally we discuss application system automatic generation and domain knowledge modeling on the J2.E platform, which combines the techniques of PROMIS, knowware and J2.E, and the development and deployment framework, i.e. PROMIS/KW＊＊.

关键词： PROMIS knowledge based software engineering knowware J2.E PROMIS/KW** knowware based software engineering

Heterogeneous integration of InP HEMTs on quartz wafer using BCB bonding technology

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Chinese Physics B 2022年第1期31卷 658-663页

作者： Yan-Fu Wang Bo Wang Rui-Ze Feng zhi-Hang Tong Tong Liu Peng ding Yong-Bo Su {2.g-Tao Zhou Feng Yang Wu-Chang ding zhi {2. University of Chinese Academic of sciences Beijing 100029China High-Frequency High-Voltage Device and Integrated Circuits Center Institute of MicroelectronicsChinese Academy of SciencesBeijing 100029China Guangxi Key Laboratory of Precision Navigation technology and Application Guilin University of Electronic TechnologyGuilin 541004China

Heterogeneous integrated InP high electron mobility transistors(HEMTs)on quartz wafers are fabricated successfully by using a reverse-grown InP epitaxial structure and benzocyclobutene(BCB)bonding *** channel of the new device is In_(0.7)Ga_(0.3)As,and the gate length is 100 nm.A maximum extrinsic transconductance gm,max of 855.5 mS/mm and a maximum drain current of 536.5 mA/mm are *** current gain cutoff frequency is as high as 2.2.GHz and the maximum oscillation frequency reaches 2.8 *** addition,a small signal equivalent circuit model of heterogeneous integration of InP HEMTs on quartz wafer is built to characterize device performance.

关键词： heterogeneous integration InP high electron mobility transistor quartz small-signal model

Frontiers in high entropy alloys and high entropy functional materials

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Rare Metals 2024年第10期43卷 4639-4776页

作者： Wen-Tao Zhang Wen Huang Fu-Jie Yu Qi Zhao Xin-Dong Zhu Tao Feng Yao Jiang Xiao-Ming Li Xue-Fei Miao He Zhu Si Lan Xue-Qian Wang Bao-Long Shen Zhe Jia Feng-Qi Zhang Wei Wang Qi Liu Yang Ren Xun-Li Wang Xiao-Ya Cui Xiao-Yang Wang Ya-Nan Chen Bing-Bing Fan Meng-Ru Li Qi-Long Gao Jia-Ming Guo Zeng-Bao Jiao zhi-Min Guo Yu-Ping Zhao Qian Yu Rui Huang Ling-Kun Zhang Yi-Ping Lu Xu-Bo Li Huai-Jun Lin Yan Ma Wei-Ming Yang zhi-Hua Shen Hai-Yan He Yong-Gang Sun Yong-Jiang Huang De-Zhuang Wang Qing-Feng Liu Fei-Yang Wang Hui Liu Hong-Hui Wu Li-Qiang Wang Yang Lu Nan Wang Tian-Li Wang Wei-Bing Liao Yi-Han Wang Yuan Wu Yu-Zhen Yin Jie Pan Yi Zhang Qing Wang Jian-Yang Zhang Tao Yang Yasir Sohail {2.-Yu Zhang Hua Ji Qiang Li Wei-Di Liu zhi-Gang Chen Xiong-Jun Liu Wen Ma Liang Mao Zhen-Duo Wu School of Materials Science and Engineering Nanjing University of Science and Technology Jiangsu Key Laboratory for Advanced Metallic Materials School of Materials Science and Engineering Southeast University Department of Physics City University of Hong Kong School of Materials Science and Engineering Tianjin University School of Physics and Microelectronics Zhengzhou University Department of Mechanical Engineering Research Institute for Advanced Manufacturing The Hong Kong Polytechnic University Center of Electron Microscopy and State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University Key Laboratory of Solidification Control and Digital Preparation technology (Liaoning Province) School of Materials Science and Engineering Dalian University of Technology institute of Advanced Wear & Corrosion Resistance and Functional Materials Jinan University School of Mechanics and Civil Engineering China University of Mining and Technology School of Physical sciences Great Bay University School of Materials Science andEngineering Harbin Institute of Technology State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University beijing Advanced Innovation Center for Materials Genome Engineering Research Institute for Carbon Neutrality University of Science and Technology Beijing Department of Mechanical Engineering The University of Hong Kong School of computing Macquarie University Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic Engineering Shenzhen University State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing State Key Laboratory of Materials Processing and Die & Mould technology School of Materials Science and Engineering Huazhong University of Science and Technology institute of materials Shanghai University Department of Materials Science and Engineering C

Owing to their exceptional properties, high-entropy alloys(HEAs) and high-entropy materials have emerged as promising research areas and shown diverse applications. Here,the recent advances in the field are comprehensively reviewed,organized into five sections. The first section introduces the background of HEAs, covering their definition, significance,application prospects, basic properties, design principles, and microstructure. The subsequent section focuses on cutting-edge high-entropy structural materials, highlighting developments such as nanostructured alloys, grain boundary engineering,eutectic systems, cryogenic alloys, thin films, micro-nano-lattice structures, additive manufacturing, high entropy metallic glasses, nano-precipitate strengthened alloys, composition modulation, alloy fibers, and refractory systems. In the following section, the emphasis shifts to functional materials, exploring HEAs as catalysts, magneto-caloric materials, corrosion-resistant alloys, radiation-resistant alloys, hydrogen storage systems, and materials for biomedicine. Additionally, the review encompasses functional high-entropy materials outside the realm of alloys, including thermoelectric, quantum dots, nanooxide catalysts, energy storage materials, negative thermal expansion ceramics,and high-entropy wave absorption materials. The paper concludes with an outlook, discussing future directions and potential growth areas in the field. Through this comprehensive review,researchers, engineers, and scientists may gain valuable insights into the recent progress and opportunities for further exploration in the exciting domains of high-entropy alloys and functional materials.

关键词： Cutting-edge structural materials Cutting-edgefunctional materials High entropy alloys

Application of comparative genomics in chicken gene mapping

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Application of comparative genomics in chicken gene mapping

Predicting thermal conductivity of liquid suspensions of nanoparticles (nanofluids) based on rheology

The First International Conference on Computers and computing Technologies in Agriculture

作者： YONG TIAN~(1 2. LIzhi LU~(2.*) YAN FU~1 DEQIAN WANG~2.GUOQIN LI~2.AIPING YUAN~2.QINGYAN YUAN~2.jin ZHAO~3 1 Laboratory of Animal Genetics College of Animal {2. Zhejiang University 2.8 Kaixuan Road Hangzhou 31002. PR china 2.institute of Animal Husbandry and Veterinary Science Zhejiang academy of Agricultural {2. 198 Shiqiao Road Hangzhou 31002. PR china 3 College of Life {2. china Jiliang University 2.8 Xueyuan Road Hangzhou 310018 PR china

＜正＞The NDRG4 gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase *** protein encoded by this gene is a cytoplasmic protein that may be involved in the regulation of mitogenic signalling in vascular smooth muscle *** map this gene in the chicken chromosome,a 6000 rads chicken-hamster radiation hybrid panel（ChickRH6） was *** were designed according to the published human sequence for amplification of the chicken NDRG4 gene by comparative *** compared the corresponding human mRNA sequence with the predicted coding sequence of the chicken NDRG4 gene,and found that the assembled contig shared a high percentage of similarity with that of the human *** of samples from the ChickRH6 revealed the locations of the NDRG4 gene to be linked to the marker PARD6G（5 cR away）with a LOD score of *** present results support the idea that the RH technique is indeed a powerful tool for mapping genes due to its rapidity,precision, convenience and reproducibility.

关键词： chicken genetic marker mapping NDRG4 gene RH panel

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Particuology 2009年第2期7卷 151-157页

作者： Haisheng Chen Sanjeeva Witharanaa Yi jin Chongyoup Kim Yulong ding institute of Particle Science andEngineering University of Leeds Leeds LS2 9JT UK institute of Engineering Thermophysics Chinese Academy of Science Beijing 100190 China institute of Environmental Engineering University of Science and Technology Beijing 100083 China Department of Chemical and Biological Engineering Korea University Seoul Republic of Korea

A methodology is proposed for predicting the effective thermal conductivity of dilute suspensions of nanoparticles （nanofluids） based on rheology. The methodology uses the rheological data to infer microstructures of nanoparticles quantitatively, which is then incorporated into the conventional Hamilton-Crosser equation to predict the effective thermal conductivity of nanofluids. The methodology is experimentally validated using four types of nanofluids made of titania nanoparticles and titanate nanotubes dispersed in water and ethylene glycol. And the modified Hamilton-Zrosser equation successfully predicted the effective thermal conductivity of the nanofluids.

关键词： Nanofluids Thermal conductivity Rheology Viscosity Microstructure

Enhancement of radiation hardness of InP-based HEMT with double Si-doped plane

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Chinese Physics B 2020年第3期29卷 455-459页

作者： Ying-Hui Zhong Bo Yang Ming-Ming Chang Peng ding Liu-Hong Ma Meng-Ke Li zhi-Yong Duan Jie Yang zhi jin zhi-Chao Wei School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China institute of Microelectronics Chinese Academy of SciencesBeijing 100029China china academy of Space {2. Beijing 100086China

An anti-radiation structure of In P-based high electron mobility transistor(HEMT) has been proposed and optimized with double Si-doped planes. The additional Si-doped plane under channel layer has made a huge promotion in channel current, transconductance, current gain cut-off frequency, and maximum oscillation frequency of In P-based HEMTs. Moreover, direct current(DC) and radio frequency(RF) characteristic properties and their reduction rates have been compared in detail between single Si-doped and double Si-doped structures after 75-keV proton irradiation with dose of 5× 10^(11) cm^(-2.,1× 10^(12. cm^(-2., and 5× 10^(12. cm^(-2.. DC and RF characteristics for both structures are observed to decrease gradually as irradiation dose rises, which particularly show a drastic drop at dose of 5× 10^(12. cm^(-2.. Besides, characteristic degradation degree of the double Si-doped structure is significantly lower than that of the single Si-doped structure, especially at large proton irradiation dose. The enhancement of proton radiation tolerance by the insertion of another Si-doped plane could be accounted for the tremendously increased native carriers, which are bound to weaken substantially the carrier removal effect by irradiation-induced defects.

关键词： InP-based HEMT anti-radiation proton irradiation Si-doped plane

Fast Unit Commitment Based on Dimension-Reduced Mixed Integer Programming

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Fast Unit Commitment Based on Dimension-Reduced Mixed Intege...

Optimizing radial basis function neural network based on rough sets and affinity propagation clustering algorithm

2.10 The 3rd International Conference on Power Electronics and Intelligent Transportation System (PEITS 2.10)

作者： Xu Dan,ding Qiang,Pan Yi and Zhou jing-yang {2. Electric Power Research institute beijing City,{2.

The unit commitment problem(UCP) is an important optimization problem for power system which can obtain larger economic *** is difficult to obtain the global optimum solution of such large-scale,non-linear,non-differentiable mathematical ***-integer programming(MIP) based techniques area among the most widely applied methods for unit commitment problems(UCP).The calculation scale and computing time are the critical problem to *** of 0-1 variables remarkably affect the performance of *** to this situation,in this paper,we proposed a method which based on load demands tendency analysis and considered continuous time coupled constraints to decrease the 0-1 variables to reduce the *** proposed reduced-dimension IMP is initially tested on the system of 100-1000 generating units along with a 2.-hr time *** numerical tests show the proposed method can effectively improve the performance of MIP especially applicable to large-scale system.

关键词： unit commitment problem,Mixed-integer programming,large-scale system,dimension-reduced,continuous time coupled constraints

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Journal of Zhejiang University-Science C(Computers and Electronics) 2012年第2期13卷 131-138页

作者： Xin-zheng XU Shi-fei ding Zhong-zhi SHI Hong ZHU School of Computer Science and technology China University of Mining and TechnologyXuzhou 221116China Key Laboratory of Intelligent information Processing Institute of Computing TechnologyChinese Academy of SciencesBeijing 100190China

A novel method based on rough sets (RS) and the affinity propagation (AP) clustering algorithm is developed to optimize a radial basis function neural network (RBFNN). First, attribute reduction (AR) based on RS theory, as a preprocessor of RBFNN, is presented to eliminate noise and redundant attributes of datasets while determining the number of neurons in the input layer of RBFNN. Second, an AP clustering algorithm is proposed to search for the centers and their widths without a priori knowledge about the number of clusters. These parameters are transferred to the RBF units of RBFNN as the centers and widths of the RBF function. Then the weights connecting the hidden layer and output layer are evaluated and adjusted using the least square method (LSM) according to the output of the RBF units and desired output. Experimental results show that the proposed method has a more powerful generalization capability than conventional methods for an RBFNN.

关键词： Radial basis function neural network (RBFNN) Rough sets Affinity propagation Clustering