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TBL联合CBL网络教学模式在神经病学教学中的应用

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科教导刊 2024年第18期 151-155页

作者：丁曼王娟武汉大学人民医院神经内科湖北武汉430060

为探讨线上教学结合以案例为基础的学习(CBL)联合基于团队的学习(TBL)模式在医学本科教学中的应用,本研究选取武汉大学人民医院的145名医学本科生作为研究对象,随机分为对照组74名及实验组71名。对照组采用常规CBL网络教学,实验组采用CB... 详细信息

为探讨线上教学结合以案例为基础的学习(CBL)联合基于团队的学习(TBL)模式在医学本科教学中的应用,本研究选取武汉大学人民医院的145名医学本科生作为研究对象,随机分为对照组74名及实验组71名。对照组采用常规CBL网络教学,实验组采用CBL联合TBL网络教学,统计两组的理论考核成绩、病例分析能力及教学满意度问卷调查结果。结果显示,CBL联合TBL网络教学组对于神经病学病例分析及知识应用能力,以及教学满意度更高。此教学模式能提高医学本科生学习神经病学的积极性及知识巩固能力,是一种有效的临床教学模式,有进一步研究及推广的价值。

关键词： TBL CBL 神经病学医学教学网络互动平台

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基于指纹图谱和一测多评联合化学计量学及熵权TOPSIS法对顶羽菊药材质量评价

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中草药 2024年第16期55卷 5627-5638页

作者：丁曼毛艳赵学佳王新堂阿地娜·阿不都艾尼新疆维吾尔自治区药物研究所新疆维吾尔药重点实验室新疆乌鲁木齐830010 中国医学科学院医药生物技术研究所北京100050 新疆医科大学药学院新疆乌鲁木齐830011

目的建立HPLC指纹图谱与一测多评(quantitative analysis of multi-components with a single-marker,QAMS)结合的方法同时检测顶羽菊Rhaponticum repens药材中新绿原酸、绿原酸、隐绿原酸、1,5-二咖啡酰奎宁酸、异绿原酸C、芹菜素、高... 详细信息

目的建立HPLC指纹图谱与一测多评(quantitative analysis of multi-components with a single-marker,QAMS)结合的方法同时检测顶羽菊Rhaponticum repens药材中新绿原酸、绿原酸、隐绿原酸、1,5-二咖啡酰奎宁酸、异绿原酸C、芹菜素、高车前素的含量,并建立不同产地顶羽菊药材的综合质量评价模型,为顶羽菊药材的整体质量评价提供参考。方法采用HPLC法建立不同产地16批顶羽菊药材的指纹图谱,利用化学计量学模式聚类分析(cluster analysis,CA)和正交偏最小二乘判别分析(orthogonal partial least squares-discrimination analysis,OPLS-DA)对采集的指纹图谱信息进行分析,同时运用加权逼近理想解排序法(technique for order preference by similarity to ideal solution,TOPSIS)、加权秩和比法(rank sum ratio,RSR)及两者模糊联合的方法构建评价模型;以绿原酸为内标,确定新绿原酸、隐绿原酸、1,5-二咖啡酰奎宁酸、异绿原酸C、芹菜素、高车前素的相对校正因子并计算其含量,建立QAMS法。结果建立的顶羽菊药材指纹图谱共标定23个共有峰,指认出其中7个峰。化学计量学模式研究显示不同产地顶羽菊存在明显差异。通过OPLS-DA法筛选出10个主要的差异性成分。构建的熵权TOPSIS法、RSR法以及两者模糊联合的综合质量评价模型,对不同产地顶羽菊药材的质量评价排序结果较为一致。以绿原酸为内标建立的QAMS和外标法含量测定结果无显著性差异(P>0.05)。结论所建立的HPLC指纹图谱结合QAMS法简便可靠,重复性好;建立的综合质量评价模型的分析结果全面客观,可用于顶羽菊药材整体质量的综合评价。

关键词：顶羽菊指纹图谱一测多评法加权逼近理想解排序法加权秩和比法新绿原酸隐绿原酸 1,5-二咖啡酰奎宁酸异绿原酸C 芹菜素高车前素质量评价

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不同干燥方式对双孢菇理化特性影响的研究

农产品加工 2024年第7期 1-4页

作者：朱家明刘咏王雨萱王向东丁曼合肥工业大学食品与生物工程学院安徽合肥230601

研究了不同干燥方式对双孢菇理化特性的影响。结果表明,冷冻真空干燥和热风远红外联合干燥对双孢菇的物理品质特性影响较小,呈现较低的体积收缩率(25.82%和69.02%)、复水率(4.17%和2.69%)与营养成分损失量;氨基酸和挥发性化合物分析表明... 详细信息

研究了不同干燥方式对双孢菇理化特性的影响。结果表明,冷冻真空干燥和热风远红外联合干燥对双孢菇的物理品质特性影响较小,呈现较低的体积收缩率(25.82%和69.02%)、复水率(4.17%和2.69%)与营养成分损失量;氨基酸和挥发性化合物分析表明,热风远红外联合干燥后双孢菇的必需氨基酸含量最高、种类最多,具有特殊香味。

关键词：双孢菇干燥方式理化特性氨基酸含量挥发性化合物

ROUGHNESS COEFFICIENT FOR UNSUBMERGED AND SUBMERGED REED

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Journal of Hydrodynamics 2007年第4期19卷 421-428页

作者： GU Feng-feng NI Han-gen QI ding-man Estuary and Coastal Scientific Research Institute of the Ministry of Communication Shanghai 201201 China School of Civil and Hydraulic Engineering Dalian University of Technology Dalian 116024 China Estuary and Coastal Scientific Research Institute of the Ministry of Communication Shanghai 201201China

The characteristics of the roughness coefficient are very important for practical application. Some experiments are conducted to study the variation of manning＇s n with flow depth, mean velocity, and density of vegetation,. An assumed velocity distribution to describe the vegetative flow of submerged vegetation is confirmed by experimental results. The measured velocities in this study seem to have little effect on the curve of n ~ h, and a new linear relationship between manning＇s n and flow depths is observed clearly. According to the arguments that the flow resistance of densely unsubmerged vegetation is dominated by the resistance exerted on vegetations, the influence of the density of vegetation on manning＇s n is estimated. On the basis of the velocity distribution, the n - h curve under submerged condition is theoretically obtained from the n - h curve under unsubmerged condition. These results are also well confirmed by experimental results and very significant for practical applications.

关键词： hydraulic resistance manning's n vegetation

Aging Characteristics of XLPE Insulation of 110 kV Cables in the Initial Stage of Operation

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Energy Engineering 2021年第5期118卷 1537-1548页

作者： Jie Chen Wei Zhang man ding Libin Hu Jinpeng Wang Chenying Li Jingying Cao State Grid Jiangsu Electric Power Co. Ltd.Research InstituteNanjing211103China Hohai University Nanjing211100China

The aging characteristics of the XLPE insulation of 110 kV power cables in the initial stage of operation are studied in this *** XLPE insulation from cables with different running time was tested by using electrical and physicochemical methods,from which the degradation state of XLPE under multiple stresses during operation was *** broadband dielectric spectrum test taken from 10–1 to 10^(6) Hz showed that the dielectric constant and dielectric loss of the XLPE insulation first decrease and then increase with the increase of cable running time,which show obvious variation until 10 years of *** AC breakdown strengths of the XLPE insulation of operated cables with the service year no longer than 10 years were higher than that of new *** mechanical properties of the XLPE insulation showed no dependence with the cable running *** crystallinity and perfection of the crystallization area were found to be enhanced during operation and the polar functional groups inside the XLPE insulation were found to be determined not only by the cross-linking by-products but also by the oxidation process during cable *** experimental results in this paper are important for improving the operation reliability and reducing the maintenance costs of the cables.

关键词： XLPE power cable aging dielectric property aggregation structure

Ankfy1 is dispensable for neural stem/precursor cell development

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Neural Regeneration Research 2016年第11期11卷 1804-1809页

作者： Chao Weng man ding Lian-sheng Chang Ming-xin Ren Hong-feng Zhang Zu-neng Lu Hui Fu Department of Neurology Renmin Hospital of Wuhan University Department of Anatomy and Embryology School of Basic Medical SciencesWuhan University Department of Pathology Central Hospital of Wuhan Hubei-MOST KLOS & KLOBME

There are few studies on the membrane protein Ankfyl. We have found Ankfyl is specifically expressed in neural stem/precursor cells during early development in mice （murine）. To further explore Ankfyl function in neural development, we developed a gene knockout mouse with a mixed Balb/C and C57/BL6 genetic background. Using immunofluorescence and in situ hybridization, neural defects were absent in mixed genetic Ankfyl null mice during development and in adults up to 2 months old. However, Ankfyl gene knockout mice with a pure genetic background were found to be lethal in the C57/BL6 inbred mice embryos, even after seven generations of backcrossing. Polymerase chain reaction confirmed homozygotes were unattainable as early as embryonic day 11.5. We conclude that Ankfyl protein is dispensable in neural stem/precursor ceils, but could be critical for early embryonic murine development, depending on the genetic background.

关键词： nerve regeneration Ankfyl neural development genetic background protein function gene knockout neural stem/precursor cells embryo neural regeneration

Effects of proton pump inhibitors on inflammatory bowel disease:An updated review

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World Journal of Gastroenterology 2024年第21期30卷 2751-2762页

作者： Yu Liang Zhen Meng Xue-Li ding man Jiang Department of Pharmacy The Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina Department of Intervention The Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina Department of Gastroenterology The Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina

Inflammatory bowel disease(IBD)is believed to be caused by various factors,including abnormalities in disease susceptibility genes,environmental factors,immune factors,and intestinal *** pump inhibitors(PPIs)are the primary drugs used to treat acid-related *** are also commonly prescribed to patients with *** studies have suggested a potential association between the use of certain medications,such as PPIs,and the occurrence and progression of *** this review,we summarize the potential impact of PPIs on IBD and analyze the underlying *** findings may provide insights for conducting further investigations into the effects of PPIs on IBD and serve as an important reminder for physicians to exercise caution when prescribing PPIs to patients with IBD.

关键词： Drug safety Proton pump inhibitor Inflammatory bowel disease Ulcerative colitis Crohn’s disease

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双孢菇粉对面团流变特性及馒头品质的影响

农产品加工 2024年第5期 12-17页

作者：张慧王军辉丁曼刘咏许嘉麒陈晓燕高莉合肥工业大学农产品生物化工教育部工程研究中心安徽合肥230601 合肥工业大学食品与生物工程学院安徽合肥230601

主要研究双孢菇粉不同添加量(5%,10%,15%,20%,25%)对面团流变特性和馒头品质的影响。结果表明,添加量逐渐增大的双孢菇粉于面团中,其吸水率、形成时间、稳定时间和粉质质量指数也呈现增长趋势,面团拉伸特性的各项参数均发生变化。储能模... 详细信息

主要研究双孢菇粉不同添加量(5%,10%,15%,20%,25%)对面团流变特性和馒头品质的影响。结果表明,添加量逐渐增大的双孢菇粉于面团中,其吸水率、形成时间、稳定时间和粉质质量指数也呈现增长趋势,面团拉伸特性的各项参数均发生变化。储能模量(G’)和损耗模量(G’’)的数值均有明显的下降趋势,而且G’大于G’’,面团表现出较大的弹性。馒头的比容和L*值均随着菇粉添加量的增加而下降。物性分析结果显示,添加双孢菇粉的馒头硬度较大,黏着性和咀嚼性较强,而弹性、黏聚性、回复性差于未添加的馒头。感官评价表明,双孢菇粉添加量为5%时评分较高。因此,用5%的双孢菇粉代替小麦粉可生产出具有良好感官品质和质量的双孢菇馒头。

关键词：双孢菇面团特性馒头

团体心理治疗在广泛性焦虑障碍患者中的应用研究

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川北医学院学报 2024年第4期39卷 573-576页

作者：丁曼丽张玉芹陈娟熊雯雯赵金荣阜阳市第三人民医院重症医学科安徽阜阳236000

目的:探讨团体心理治疗在广泛性焦虑障碍(GAD)患者中的应用效果。方法:选取50例GAD患者为对照组,给予药物治疗联合心理辅导;选取55例GAD患者为观察组,给予药物治疗+团体心理治疗。两组患者均干预8周。调查两组患者的治疗依从性,并比较... 详细信息

目的:探讨团体心理治疗在广泛性焦虑障碍(GAD)患者中的应用效果。方法:选取50例GAD患者为对照组,给予药物治疗联合心理辅导;选取55例GAD患者为观察组,给予药物治疗+团体心理治疗。两组患者均干预8周。调查两组患者的治疗依从性,并比较两组患者干预前后焦虑症状。结果:观察组的治疗依从性为89.09%,高于对照组的74.00%,差异有统计学意义(P<0.05)。观察组干预后的广泛性焦虑障碍量表(GAD-7)评分、汉密尔顿焦虑量表(HAMA-14)评分分别为(7.13±1.28)分、(10.32±3.47)分,高于对照组的(10.05±2.17)分、(13.64±3.45)分,差异均有统计学意义(P<0.05)。观察组改善焦虑症状的临床疗效为87.27%,高于对照组的70.00%,差异有统计学意义(P<0.05)。结论:团体心理治疗能够提高GAD患者的治疗依从性,改善患者的焦虑症状。

关键词：团体心理治疗 GAD 焦虑症状