检索结果-南通市图书馆

Antioxidant and Antiapoptotic Polyphenols from Green Tea Extract Ameliorate CCl4-Induced Acute Liver Injury in Mice

Chinese Journal of Integrative Medicine 2020年第10期26卷 736-744页

作者： diao jian-xin OU Jin-ying DAI Huan LI Hai-ye HUANG Wei HUA He-yu XIE Ting WANG Ming YANG Yun-gao School of Traditional Chinese Medicine Southern Medical UniversityGuangzhou(510515)China Department of Internal Medicine Yongxing County People’s HospitalChengzhou(423000)Hunan ProvinceChina Department of Traditional Chinese Medicine Zhujiang Hospital of Southern Medical UniversityGuangzhou(510515)China

Objective To investigate the phenolic composition,antioxidant properties,and hepatoprotective mechanisms of polyphenols from green tea extract(GTP)in carbon tetrachloride(CCl4)-induced acute liver injury mouse *** High-performance liquid chromatography was used to analyze the chemical composition of the *** activity of GTP was assessed by O2∙-,OH∙,DPPH∙,and ferric-reducing antioxidant power(FRAP)assay in *** Kunming mice were divided into 6 groups including control,model,low-,medium-,and high-doses GTP(200,400,800 mg/kg)and vitamin E(250 mg/kg)groups,10 in each *** and vitamin E were administered at a level of abovementioned doses twice per day for 7 days prior to exposure to a single injection of *** effects of GTP were evaluated in a CCl4-induced mouse model of acute liver injury,using commercial enzyme linked immunosorbent assay kits,histopathological observation,terminal deoxynucleotidyl transferase-mediated dUTPNick-end labeling(TUNEL)assay and Western *** GTP contained 98.56µg gallic acid equivalents per milligram extract total polyphenols,including epicatechingallate,epigallocatechin gallate,epicatechin,and *** with the model group,low-,medium-,or high doses GTP significantly decreased serum levels of alanine aminotransferase and aspartate transaminase(P<0.01).Histopathological observation confirmed that pretreatment of GTP prevented swelling and necrosis in CCl4-exposed *** effects of low-,medium-,and high-dose GTP were associated with eliminating free radicals and improving superoxide dismutase,catalase,and glutathione peroxidase activity in the ***,low-,medium-,and high-dose GTP decreased cell apoptosis in the CCl4-exposed liver(P<0.01).Phosphorylated nuclear factor kappa-B(NF-κB),p53,Bcl-2 associated x protein/B-cell lymphoma/leukemia-2 gene,cytochrome C,and cleaved caspase-3 levels were downregulated compared with the model gro

关键词： polyphenol carbon tetrachloride acute liver injury anti-oxidant anti-apoptosis green tea

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mechanism of AsperosaponinⅥRelated to EGFR/MMP9/AKT/PI3K Pathway in Treatment of Rheumtoid Arthritis

引用

Chinese Journal of Integrative Medicine 2025年第2期31卷 131-141页

作者： LUO Jin-fang YU Yang LIU jian-xin School of Basic Medicine Guizhou University of Traditional Chinese MedicineGuiyang(550025)China Sino-Pakistan Center on Traditional Chinese Medicine China-Pakistan International Science and Technology Innovation Cooperation Base for Ethnic Medicine Development in Hunan ProvinceSchool of Pharmaceutical SciencesHunan University of MedicineHuaihua CityHunan Province(418000)China

Objective:To explore the mechanism of action of asperosaponinⅥ(AⅥ)in the treatment of rheumatoid arthritis(RA)and validate it in ex vivo experiments using network pharmacology and molecular docking ***:The predicted targets of AⅥwere obtained from PharmMaper,UniProt and Swiss Target Prediction platforms,the disease targets were collected from Online Mendelian Inheritance in Man,Therapeutic Target Database and Gene Cards databases,the intersection targets of AⅥand RA were obtained from Venny 2.1.0,and the protein-protein interaction(PPI)network was obtained from STRING database,which was analyzed by Cytoscape software and screened to obtain the core *** software was used to analyze PPI network and screen the core *** on the Database for Annotation,Visualization and Integrated Discovery database,Gene Ontology functional and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis were performed,and Cytoscape software was used to construct the"DiseasePathway-Target-Drug"network,which was finally verified by molecular docking and animal ***:Network pharmacological studies showed that AⅥwas able to modulate 289 targets,with 102 targets for the potential treatment of RA,with the core pathway being the AKT/PI3K signaling pathway,and the core targets being the epidermal growth factor receptor(EGFR)and matrix metalloproteinase 9(MMP9).Molecular docking results showed that AⅥcould produce strong binding with both of the 2 core *** vitro cellular experiments showed that AⅥreduced nitric oxide,prostaglandin E_2,tumor necrosis factor-alpha(TNF-α),interleukin-6(IL-6),and IL-1βlevels(P<0.05)and inhibited cyclooxygenase-2,nitric oxide synthase,EGFR,MMP9,phosphorylated phosphoinositide 3-kinase(p-PI3K),and phosphorylated serine-threonine kinase(p-AKT)proteins(P<0.05).The results of in vivo studies showed that AⅥimproved RA score and foot swelling thickness and decreased TNF-α,IL-6,p-PI3K and p-AKT levels in RA rat

关键词： inflammation rheumatoid arthritis network pharmacology asperosaponinⅥ EGFR/MMP9/AKT/PI3K pathway

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

高效液相色谱法检测局部用药后塞来昔布在舌组织中的吸收浓度

引用

南方医科大学学报 2010年第8期30卷 1827-1829页

作者：徐芳李伟忠刁建新南方医科大学南方医院口腔科广东广州510515 南方医科大学中医药学院中医分子生物实验室广东广州510515

目的建立高效液相色谱法(HPLC)检测口腔局部涂抹自制COX-2抑制剂塞来昔布糊剂后舌组织中的药物浓度及吸收率。方法将塞来昔布用混合基质配成糊剂(6%)涂抹于金黄地鼠舌黏膜表面,分别于5、10、15、30、60、90、120min后将舌体组织取下并... 详细信息

目的建立高效液相色谱法(HPLC)检测口腔局部涂抹自制COX-2抑制剂塞来昔布糊剂后舌组织中的药物浓度及吸收率。方法将塞来昔布用混合基质配成糊剂(6%)涂抹于金黄地鼠舌黏膜表面,分别于5、10、15、30、60、90、120min后将舌体组织取下并制成匀浆,采用HPLC检测舌体组织中药物的吸收浓度及吸收率。结果塞来昔布的保留时间是4.4min,塞来昔布的最低检测质量浓度为10μg/L(S/N=3)。舌组织匀浆液中塞来昔布在25~800μg/L范围内线性关系良好,回归方程为Y=24306X+66747,R2=0.9991(n=6);提取回收率为83.75%~90.01%,方法回收率为91.98%~99.07%;日内RSD分别为2.15%、3.16%和3.67%;日间RSD分别为3.40%、4.56%、4.42%,且稳定性良好。局部给药后120min内塞来昔布在金黄地鼠舌组织中的浓度波动于(0.685±0.019)^(3.168±0.143)μg/g之间,在15min时药物吸收达最高浓度。结论舌黏膜局部应用塞来昔布后可迅速通过舌黏膜吸收,在舌组织内达到较高的药物浓度。采用HPLC检测舌组织中药物药物浓度及吸收率,具有方法简便灵敏、干扰小、重复性好等优点,为进一步探索口腔局部应用环氧化酶2抑制剂预防口腔癌及癌前病变提供了依据。

关键词：塞来普布舌高效液相色谱法药代动力学

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gold nanorods as biocompatible nano-agents for the enhanced photothermal therapy in skin disorders

引用

Journal of Biomedical Research 2025年第1期39卷 1-17页

作者： Yamei Gao Shaohu Huo Chao Chen Shiyu Du Ruiyuan Xia jian Liu Dandan Chen Ziyue diao xin Han Zhiqiang Yin Department of Dermatology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Pediatrics the First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China State Key Laboratory on Technologies for Chinese Medicine Pharmaceutical Process Control and Intelligent Manufacture School of MedicineNanjing University of Chinese MedicineNanjingJiangsu 210046China College of Engineering and Applied Sciences State Key Laboratory of Analytical Chemistry for Life ScienceNanjing UniversityNanjingJiangsu 210008China

Rod-shaped gold nanomaterials,known as gold nanorods(GNRs),may undergo specific surface modification,because of their straightforward surface *** feature makes them appropriate for use as functional and biocompatible *** optimizing the absorption of longitudinally localized surface plasmon resonance in the near-infrared region,which corresponds to the near-infrared bio-tissue window,GNRs with appropriate modifications may improve the results of photothermal treatment(PTT).In dermatology,potential noninvasive uses of GNRs to enhance wound healing,manage infections,combat cutaneous malignancies,and remodel skin tissues via PTT have attracted research attention in recent *** review discussed the basic properties of GNRs,such as their shape,size,optical performance,photothermal efficiency,and ***,the disadvantages of using these particles in photodynamic therapy are ***,biological applications of GNRs-based PTT are explored in ***,the limitations and future perspectives of this research are addressed,providing a comprehensive perspective on the potential GNRs with PTT.

关键词： gold nanorods photothermal therapy skin tumors wound healing skin infections inflammatory disease

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

High-throughput screening of CO_(2) cycloaddition MOF catalyst with an explainable machine learning model

引用

Green Energy & Environment 2025年第1期10卷 132-138页

作者： Xuefeng Bai Yi Li Yabo Xie Qiancheng Chen xin Zhang jian-Rong Li Beijing Key Laboratory for Green Catalysis and Separation and Department of Chemical Engineering College of Materials Science&EngineeringBeijing University of TechnologyBeijing100124China

The high porosity and tunable chemical functionality of metal-organic frameworks(MOFs)make it a promising catalyst design ***-throughput screening of catalytic performance is feasible since the large MOF structure database is *** this study,we report a machine learning model for high-throughput screening of MOF catalysts for the CO_(2) cycloaddition *** descriptors for model training were judiciously chosen according to the reaction mechanism,which leads to high accuracy up to 97%for the 75%quantile of the training set as the classification *** feature contribution was further evaluated with SHAP and PDP analysis to provide a certain physical understanding.12,415 hypothetical MOF structures and 100 reported MOFs were evaluated under 100℃ and 1 bar within one day using the model,and 239 potentially efficient catalysts were *** them,MOF-76(Y)achieved the top performance experimentally among reported MOFs,in good agreement with the prediction.

关键词： Metal-organic frameworks High-throughput screening Machine learning Explainable model CO_(2)cycloaddition

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

凉膈散对内毒素致急性肺损伤大鼠信号转导与转录激活子1表达的影响

引用

南方医科大学学报 2010年第1期30卷 43-46页

作者：余林中刘建新胡孔友刁建新王丽南方医科大学中医药学院广东广州510515

目的观察凉膈散对内毒素致急性肺损伤(ALI)大鼠肺组织中的信号转导与转录激活子1(STAT1)的影响及其作用机制。方法静脉注射内毒素脂多糖(LPS)制作大鼠急性肺损伤模型。将实验动物随机分为空白组、LPS组、LPS+凉膈散高、中、低剂量组、L... 详细信息

目的观察凉膈散对内毒素致急性肺损伤(ALI)大鼠肺组织中的信号转导与转录激活子1(STAT1)的影响及其作用机制。方法静脉注射内毒素脂多糖(LPS)制作大鼠急性肺损伤模型。将实验动物随机分为空白组、LPS组、LPS+凉膈散高、中、低剂量组、LPS+地塞米松组,LPS组又分为致伤后1、2、4、8、16h不同时间点组,用蛋白免疫印迹法测定大鼠肺组织STAT1及磷酸化STAT1的表达。结果与空白组比较,LPS组STAT1蛋白在4h、p-STAT1蛋白在2h表达最显著(P<0.01),凉膈散各组及地塞米松组在2、4、8h能显著下调STAT1及p-STAT1蛋白的表达,与LPS组比较,有统计学意义(P<0.05,P<0.01)。结论内毒素致急性肺损伤中存在STAT1异常表达,凉膈散各组通过下调STAT1及p-STAT1的表达,从而减轻LPS所致的急性肺损伤,这可能是凉膈散治疗急性肺损伤的机制之一。

关键词：凉膈散急性肺损伤内毒素信号转导与转录激活子1

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

内毒素致急性肺损伤大鼠肺组织信号转导和转录激活因子1的调控作用

引用

中国危重病急救医学 2009年第7期21卷 387-389页

作者：余林中胡孔友刘建新刁建新王丽南方医科大学中医药学院广东广州510515

目的探讨信号转导和转录激活因子1（STAT1）在内毒素致急性肺损伤（ALI）大鼠肺组织中的表达及其调控作用。方法静脉注射内毒素脂多糖（LPS）制备大鼠ALI模型。将动物随机分为对照组、LPS组、地塞米松（DEX）干预组；DEX干预组灌胃DEX0... 详细信息

目的探讨信号转导和转录激活因子1（STAT1）在内毒素致急性肺损伤（ALI）大鼠肺组织中的表达及其调控作用。方法静脉注射内毒素脂多糖（LPS）制备大鼠ALI模型。将动物随机分为对照组、LPS组、地塞米松（DEX）干预组；DEX干预组灌胃DEX0．135mg／kg，对照组和LPS组分别灌胃等量生理盐水，连用5d后LPS组和DEX干预组经尾静脉注射LPS5mg／kg，对照组以生理盐水1ml替代。于致伤后1、2、4、8、16h各处死6只大鼠，取肺组织，用蛋白质免疫印迹法（Western blotting）测定STAT1表达的动态变化，光镜下观察肺组织病理学改变。结果与对照组比较，LPS组STAT1的活化从1h开始增高，4h达高峰，然后逐渐下降；2、4、8h时STATl表达显著升高（P均d0．01）；DEX干预组STATl表达趋势同LPS组，但2、4、8h时STAT1表达显著低于LPS组（P均〈0．05）。结论内毒素致AL1中存在STAT1异常表达；STAT1参与了肺组织炎症的形成。

关键词：肺损伤,急性内毒素信号转导和转录激活因子1

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

浅谈公路桥面混凝土病害原因及预防措施

引用

山西建筑 2009年第18期35卷 331-332页

作者：刁建新新疆铁道勘察设计院有限公司

对桥面裂缝病害进行了分析,从设计、施工、运营等多方面对桥面的裂缝病害原因进行了论述,并对有效的预防措施进行了研究,提出病害处理方法,以期达到良好的效果,解决公路桥面裂缝病害问题。

关键词：桥面铺装裂缝病害原因预防措施

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Positive effect of Mo on mechanical properties of a Ni-42W-10Co-xMo medium heavy alloy

引用

China Foundry 2025年第1期22卷 108-116页

作者： Guo-xin Cao jian-xin Dong Yong-sheng He He jiang Fang Hao Zhi-hua Nie Teng-fei Ma Bao-quan Fu School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Xi'an Superalloy Technology Co. Ltd.Xi’an 710299China School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China Key Laboratory of Air-driven Equipment Technology of Zhejiang Province Quzhou UniversityQuzhou 324000ZhejiangChina

In this study,a novel Ni-W-Co-Mo medium heavy alloy(MHA)was designed to improve its mechanical strength via Mo *** the Ni-42W-10Co-x Mo alloy series,where x represents the weight percent of Mo and varies between 0,1,2,5,and 10,the microstructure transitions from a dendritic structure to a hypo-eutectic structure as the Mo content increases from 0 to 5wt.%.Moreover,as the Mo content increases from 0 to 10wt.%,the distribution of theμ-phase shifts from being individually dispersed to forming aggregates,and its volume fraction rises from 0.5%to 7.9%.Notably,theμ-phase evolves into an eutectic microstructure,which helps in minimizing the segregation of *** change is accompanied by a substantial enhancement in mechanical properties;specifically,the compressive yield strength at room temperature increases from 350 MPa to 646 MPa,indicating a significant 85%***,the microhardness increases from 230 HV to 304 *** dynamics simulations further reveal that the strengthening mechanism of Ni-42W-10Co-x Mo alloys is Mo-induced solid solution strengthening and precipitation strengthening.

关键词： medium-heavy alloys Ni-based alloy mechanical properties solid solution strengthening precipitation strengthening

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Least Square Estimation for Multiple Functional Linear Model with Autoregressive Errors

引用

Acta Mathematicae Applicatae Sinica 2025年第1期41卷 84-98页

作者： Meng WANG Ming-liang SHU jian-jun ZHOU Si-xin WU Min CHEN School of Management University of Science and Technology of ChinaHefei 230026China Academy of Mathematics and System Science Chinese Academy of SciencesBeijing 100190China Yunnan Key Laboratory of Statistical Modeling and Data Analysis Yunnan UniversityKunming 650091China

As an extension of linear regression in functional data analysis, functional linear regression has been studied by many researchers and applied in various fields. However, in many cases, data is collected sequentially over time, for example the financial series, so it is necessary to consider the autocorrelated structure of errors in functional regression background. To this end, this paper considers a multiple functional linear model with autoregressive errors. Based on the functional principal component analysis, we apply the least square procedure to estimate the functional coefficients and autoregression coefficients. Under some regular conditions, we establish the asymptotic properties of the proposed estimators. A simulation study is conducted to investigate the finite sample performance of our estimators. A real example on China's weather data is applied to illustrate the validity of our model.

关键词： multiple functional linear model autoregressive errors principal component analysis consistency

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：