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Silencing of Jumonji domain-containing 1C inhibits the osteogenic differentiation of bone marrow mesenchymal stem cells via nuclear factor-κB signaling

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World Journal of Stem Cells 2024年第2期16卷 151-162页

作者： Jing-yi Li Ting-Ting Wang Li Ma Yu Zhang di Zhu Department of Medical Cosmetology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Department of General Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Plastic Surgery China-Japan Friendship HospitalBeijing 100029China Senior Department of Hematology The Fifth Medical CentreGeneral Hospital of Chinese People’s Liberation ArmyBeijing 100071China Department of Orthopaedic Surgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China

BACKGROUND Osteoporosis is a common metabolic bone disorder induced by an imbalance between osteoclastic activity and osteogenic *** osteoporosis,bone mesenchymal stem cells(BMSCs)exhibit an increased ability to differentiate into adipocytes and a decreased ability to differentiate into osteoblasts,resulting in bone *** domain-containing 1C(JMJD1C)has been demonstrated to suppress *** To examine the effect of JMJD1C on the osteogenesis of BMSCs and the potential underlying *** BMSCs were isolated from mouse bone marrow *** Red O staining,Alizarin red staining,alkaline phosphatase staining and the expression of adipo-genic and osteogenic-associated genes were assessed to determine the differen-tiation of *** marrow-derived macrophages(BMMs)were incubated with receptor activator of nuclear factor-kappaΒligand to induce osteoclast differentiation,and osteoclast differen-tiation was confirmed by tartrate-resistant acid phosphatase *** related genes were measured via reverse transcription coupled to the quantitative polymerase chain reaction and western ***-linked immunosorbent assays were used to measure the levels of inflammatory cytokines,including tumor necrosis factor alpha,interleukin-6 and interleukin-1 *** The osteogenic and adipogenic differentiation potential of BMSCs isolated from mouse bone marrow samples was ***1C mRNA and protein expression was upregulated in BMSCs after osteoblast induction,while p-nuclear factor-κB(NF-κB)and inflammatory cytokines were not significantly *** of JMJD1C repressed osteogenic differentiation and enhanced NF-κB activation and inflammatory cytokine release in ***,JMJD1C expression decreased during BMM osteoclast *** The JMJD1C/NF-κB signaling pathway is potentially involved in BMSC osteogenic differentiation and may play vital roles in the pathogenesis of osteoporosis.

关键词： Osteoporosis Mesenchymal stem cells Osteogenesis Jumonji domain-containing 1C Nuclear factor-κB

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Prediction of multiscale laminae structure and reservoir quality in fine-grained sedimentary rocks:The Permian Lucaogou Formation in Jimusar Sag,Junggar Basin

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Petroleum Science 2022年第6期19卷 2549-2571页

作者： Xiao-Jiao Pang Gui-Wen Wang Li-Chun Kuang Jin Lai Yang Gao yi-di Zhao Hong-Bin Li Song Wang Meng Bao Shi-Chen Liu Bing-Chang Liu State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China College of Geosciences China University of Petroleum(Beijing)Beijing102249China Technology Administration Department Petro China Company LimitedBeijing100007China Research Institute of Exploration and Development Xinjiang Oilfield CompanyPetro ChinaKaramayXinjiang834000China

Fine-grained sedimentary rocks have become a research focus as important reservoirs and source rocks for tight and shale oil and *** development determines the accumulation and production of tight and shale oil and gas in fine-grained ***,due to the resolution limit of conventional logs,it is challenging to recognize the features of centimeter-scale *** close this gap,complementary studies,including core observation,thin section,X-ray diffraction(XRD),conventional log analysis,and slabs of image logs,were conducted to unravel the centimeter-scale *** laminae recognition models were built using well *** fine-grained rocks can be divided into laminated rocks(lamina thickness of0.1 m)according to the laminae scale from core *** to the mineral superposition assemblages from thin-section observations,the laminated rocks can be further divided into binary,ternary,and multiple *** typical mineral components,slabs,and T2spectrum distributions of various lamina types are *** core can identify the centimeter-millimeter-scale laminae,and the thin section can identify the millimeter-micrometer-scale ***,they can detect mineral types and their superposition *** logs can identify the meter-scale layers,whereas image logs and related slabs can identify the laminae variations at millimeter-centimeter ***,the slab of image logs combined with thin sections can identify laminae assemblage characteristics,including the thickness and vertical *** identification and classification of lamina structure of various scales on a single well can be predicted using conventional logs,image logs,and slabs combined with thin *** layered rocks have better reservoir quality and oil-bearing potential than the massive and laminated *** laminated rocks’binary lamina is bette

关键词： Fine-grained sedimentary rocks Mineral composition Multiscale laminae structure Reservoir quality Image logs Lucaogou formation

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Amine-functionalized metal organic framework@graphene oxide as filler in PAEK-containing carboxyl group membrane for ultrafiltration with ultra-high permeability and strong fouling resistance

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Chinese Journal of Chemical Engineering 2024年第6期70卷 93-103页

作者： Zhaoli Wang Wenjing Li yi Zhang Yanyin Cheng Junjian Yu Tianming Dong Xiaoyu Chi di Liu Zhe Wang School of Chemistry and Life Science Changchun University of TechnologyChangchun 130012China Advanced Institute of Materials Science Changchun University of TechnologyChangchun 130012China Key Laboratory of Advanced Functional Polymer Membrane Materials of Jilin Province Changchun 130012China

Achieving high fouling resistance and permeability using membrane separation technology in water treatment processes remains a *** this work,a novel mixed-matrix membrane(MMM)(poly(arylene ether ketone)[PAEK]-containing carboxyl groups[PAEK-COOH]/UiO-66-NH_(2)@graphene oxide[GO])with superb fouling resistance and high permeability was prepared by the nonsolvent-induced phase separation method,by in-situ growth of UiO-66-NH_(2) on the GO layer,and by preparing hydrophilic *** the basis of the structure and performance analysis of the MMM,the maximum water flux reached 591.25 L·m^(-2)·h^(-1) for PAEK-COOH/UiO-66-NH_(2)@GO,whereas the retention rate for bovine serum albumin increased from 85.40%to 94.87%.As the loading gradually increased,the hydrophilicity of the MMMs increased,significantly enhancing their fouling *** strongest anti-fouling ability observed was 94.74%,which was 2.02 times greater than that of the pure *** the same time,the MMMs contained internal amide and hydrogen bonds during the preparation process,forming a cross-linked structure,which further enhanced the mechanical strength and chemical *** summary,the MMMs with high retention rate,strong permeability,and anti-fouling ability were successfully prepared.

关键词： Poly(arylene ether ketone)-containing Carboxyl groups(PAEK-COOH) UiO-66-NH_(2)@graphene oxide Hydrophilic modification Ultra-high selectivity Strong anti-fouling

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参数不定的旋转圆盘在有界扰动下混沌振动的滑模变结构控制

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物理学报 2011年第5期60卷 84-91页

作者：陈帝伊申滔马孝义西北农林科技大学水利与建筑工程学院电气系杨凌712100 西北农林科技大学机械与电子工程学院杨凌712100

为了消除具有不确定参数的旋转圆盘横向混沌振动,克服其对整个系统及工作状况的不利影响,假设作用在旋转圆盘上的集中力不确定且有界,并鉴于干扰的普遍存在性,对有界扰动下的旋转圆盘横向振动的四维非线性方程进行了复杂动力学特征分析... 详细信息

为了消除具有不确定参数的旋转圆盘横向混沌振动,克服其对整个系统及工作状况的不利影响,假设作用在旋转圆盘上的集中力不确定且有界,并鉴于干扰的普遍存在性,对有界扰动下的旋转圆盘横向振动的四维非线性方程进行了复杂动力学特征分析,包括相轨迹图、Lyapunov指数和庞加莱映射图,这些特征加深了对其的认识,同时也证明该四维动力系统含有混沌吸引子.为了保证系统控制的鲁棒性,利用滑模变结构法,将旋转圆盘从混沌轨道先后控制到任意固定点和周期轨道,并用MATLAB模拟验证其有效性.结果证明,用滑膜变结构法能够使系统严格地跟踪参考轨道,且具有过渡时间短、过渡平稳,对干扰不敏感等诸多优点,同时也为相关混沌系统的混沌态的有效控制提供了借鉴.

关键词：旋转圆盘混沌滑模变结构控制有界扰动

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Amino-functionalized UiO-66-doped mixed matrix membranes with high permeation performance and fouling resistance

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Chinese Journal of Chemical Engineering 2024年第3期67卷 68-77页

作者： yi Zhang di Liu Zhaoli Wang Junjian Yu Yanyin Cheng Wenjing Li Zhe Wang Hongzhe Ni Yuchao Wang School of Chemical Engineering Changchun University of TechnologyChangchun 130012China Advanced Institute of Materials Science Changchun University of TechnologyChangchun 130012China Key Laboratory of Advanced Functional Polymer Membrane Materials of Jilin Province Changchun 130012China School of Chemistry and Life Science Changchun University of TechnologyChangchun 130012China

For the reduction of bovine serum proteins from wastewater,a novel mixed matrix membrane was prepared by functionalizing the substrate material polyaryletherketone(PAEK),followed by carboxyl groups(C-SPAEKS),and then adding amino-functionalized UiO-66-NH_(2)(Am-UiO-66-NH_(2)).Aminofunctionalization of UiO-66 was accomplished by melamine,followed by an amidation reaction to immobilize Am-UiO-66-NH_(2),which was immobilized on the surface of the membrane as well as in the pore channels,which enhanced the hydrophilicity of the membrane surface while increasing the negative potential of the membrane *** nanoparticle-loaded ultrafiltration membrane has good permeation performance,with a pure water flux of up to 482.3 L·m^(-2)·h^(-1) for C-SPAEKS/AmUiO-66-NH_(2) and a retention rate of up to 98.7%for bovine serum albumin(BSA)-contaminated ***,after several hydrophilic modifications,the flux recovery of BSA contaminants by this series of membranes increased from 56.2%to 80.55%of pure *** results of ultra-filtration flux time tests performed at room temperature showed that the series of ultrafiltration membranes remained relatively stable over a test time of 300 ***,the newly developed mixed matrix membrane showed potential for high efficiency and stability in wastewater treatment containing bovine serum proteins.

关键词： Ultrafiltration Mixed matrix membranes Amino functionalization Hydrophilic modification Negatively charged

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Robust tantalum tuned perovskite oxygen electrode for reversible protonic ceramic electrochemical cells

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Rare Metals 2024年第7期43卷 3055-3065页

作者： Yu-Shi Feng Yu Shen Fang Wang Chuan Tian Qin-yi Hu Qian Duan Jing-Wei Li di Bao School of Materials Science and Engineering Changchun University of Science and TechnologyChangchun 130022China Zhongshan Institute of Changchun University of Science and Technology Zhongshan528437China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of SciencesChangchun 130022China Key Laboratory of Preparation and Applications of Environmental Friendly Materials Ministry of EducationJilin Normal UniversityChangchun 130103China

Perovskite oxides with diverse composition and structure have exhibited grand advances in boosting the oxygen reduction and evolution reaction(ORR/OER),which are essential for the reversible protonic ceramic electrochemical cell(R-PCEC)toward the sustainable hydrogen production and ***,enhancement of their activity and stability remains ***,we develop the Ta-regulated BaCo_(0.7)Fe_(0.3)O_(3-δ)perovskite oxygen electrode(Ba(Co_(0.7)Fe_(0.3))_(1-x)Ta_xO_(3-δ))with abundant oxygen defects and achieve the simultaneous enhancement in the electrocatalytic activity and stability toward ORR and ***-fabricated R-PCEC with(Ba(Co_(0.7)Fe_(0.3))_(0.9)Ta_(0.1)O_(3-δ))(BCFT10)oxygen electrode performs high power density of 1.47 W·cm^(-2)at 650℃in fuel cell mode,and the current density is up to-2.11 A·cm^(-2)at 1.4 V at 650℃in electrolysis mode,as well as the good stability in both the fuel cell and electrolysis ***,the cell also demonstrates a stable cycling operation between fuel cell and electrolysis mode,suggesting a great potential of BCFT10 as oxygen electrode material for R-PCECs.

关键词： Reversible protonic ceramic electrochemical cells Perovskite oxide Oxygen electrode Ta element doping Oxygen defects

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Prognostic value of a nomogram model for postoperative liver metastasis of colon cancer

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1055-1065页

作者： De-Xin Cheng Kang-di Xu Han-Bo Liu yi Liu Department of Interventional Medicine Zhejiang Provincial People’s Hospital(Affiliated People’s HospitalHangzhou Medical College)Hangzhou 310014Zhejiang ProvinceChina General Surgery Cancer CenterDepartment of Vascular SurgeryZhejiang Provincial People’s Hospital(Affiliated People’s HospitalHangzhou Medical College)Hangzhou 310014Zhejiang ProvinceChina

BACKGROUND Colon cancer is one of the most common malignant tumors of the digestive *** metastasis after colon cancer surgery is the primary cause of death in patients with colon *** To construct a novel nomogram model including various factors to predict liver metastasis after colon cancer *** We retrospectively analyzed 242 patients with colon cancer who were admitted and underwent radical resection for colon cancer in Zhejiang Provincial People’s Hospital from December 2019 to December *** were divided into liver metastasis and non-liver metastasis ***,age,and other general and clinicopathological data(preoperative blood routine and biochemical test indexes)were *** risk factors for liver metastasis were analyzed using singlefactor and multifactorial logistic regression.A predictive model was then constructed and evaluated for *** Systemic inflammatory index(SII),C-reactive protein/albumin ratio(CAR),red blood cell distribution width(RDW),alanine aminotransferase,preoperative carcinoembryonic antigen level,and lymphatic metastasis were different between groups(Pdiagram prediction model constructed based on these risk factors to distinguish whether liver metastasis occurred *** actual curve of the column-line diagram predicting the risk of postoperative liver metastasis was close to the ideal curve,with good *** prediction model curves in the decision curve analysis showed higher net benefits for a larger threshold range than those in extreme cases,indicating that the model is *** Liver metastases after colorectal cancer surgery could be well predicted by a nomogram based on the SII,CAR,and RDW.

关键词： Systemic immunoinflammatory index C-reactive protein/albumin ratio Erythrocyte distribution width Colon cancer Liver metastasis Novel nomogram model

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Texture and Se vacancy optimization induces high thermoelectric performance in Bi_(2)Se_(3) flexible thin films

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Rare Metals 2024年第6期43卷 2796-2804页

作者： Dong-Wei Ao Wei-di Liu Yue-Xing Chen Fan Ma yi-Jie Gu Zhuang-Hao Zheng School of Machinery and Automation Weifang UniversityWeifang 261061China Australian Institute for Bioengineering and Nanotechnology The University of QueenslandBrisbane 4072Australia Shenzhen Key Laboratory of Advanced Thin Films and Applications Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong ProvinceCollege of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen518060China School of Materials Science and Engineering Inner Mongolia University of TechnologyHohhot 010051China

Bi_(2)Se_(3)-based flexible thin film with high thermoelectric performance is promising for the waste heat recovery *** this work,a novel post-selenization method is employed to prepare n-type Bi_(2)Se_(3)flexible thin films with highly textured *** strengthened texture and Se vacancy optimization can be simultaneously achieved by optimizing the selenization *** highly oriented texture leads to the increased carrier mobility and results in a high electric conductivity of~290.47 S·cm^(-1)at 623 ***,a high Seebeck coefficient(>110μW·K-1)is obtained due to the reduced carrier concentration,induced by optimizing vacancy ***,a high power factor of 3.49μW·cm^(-1)·K^(-2)at 623 K has been achieved in asprepared highly-bendable Bi_(2)Se_(3)flexible thin films selenized at 783 *** study introduces an effective post-selenization method to tune the texture structure and vacancies of Bi_(2)Se_(3)flexible thin films,and correspondingly achieves high thermoelectric performance.

关键词： Thermoelectric Bi_(2)Se_(3) Flexible thin film Post-selenization

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滑模变结构法实现旋转圆盘混沌振动的控制

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振动与冲击 2011年第9期30卷 248-252页

作者：陈帝伊申滔马孝义西北农林科技大学机械与电子工程学院陕西杨凌712100 西北农林科技大学水利与建筑工程学院陕西杨凌712100

为了消除旋转圆盘横向混沌振动,克服其对整个系统及工作状况的不利影响,对旋转圆盘横向振动的四维非线性方程进行了复杂动力学特征分析,包括相轨迹图、Lyapunov指数和庞加莱映射图。利用比例积分滑模变结构法,将旋转圆盘从其横向混沌振... 详细信息

为了消除旋转圆盘横向混沌振动,克服其对整个系统及工作状况的不利影响,对旋转圆盘横向振动的四维非线性方程进行了复杂动力学特征分析,包括相轨迹图、Lyapunov指数和庞加莱映射图。利用比例积分滑模变结构法,将旋转圆盘从其横向混沌振动的混沌轨道先后控制到任意固定点和周期轨道,并用MATLAB模拟验证其有效性。重点讨论了滑模变结构方法的增益系数对抖振问题、受控系统的过渡过程的时间、峰值和控制器的过渡时间、峰值和稳定后的状态及其上下界的影响。结果为比例积分滑模变结构法的应用和相关机械系统混沌态的有效控制提供了理论依据。

关键词：旋转圆盘混沌奇怪吸引子比例积分滑模变结构固定点周期轨道

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TEUPERNIN A,B AND C,THREE ENT-CLERODANE diTERPENOIDS FROM TEUCRIUM PERNyi FRANCH

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Chinese Chemical Letters 1991年第7期2卷 539-542页

作者： di An SUN Guang yi LI Institute of Materia Medica,Chinese Academy of Medical Sciences,Beijing 100050

Three furanoid ent-clerodane diterpenoids,teupernin A,B and C have been isolated from the acetone extract of Teucrium pernyi *** structures were established by spectroscopic means(UV,IR,MS,~1H NMR,^(13)C NMR,H-H COSY,... 详细信息

关键词： Pro NOE TEUPERNIN A,B AND C,THREE ENT-CLERODANE diTERPENOIDS FROM TEUCRIUM PERNyi FRANCH La

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