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Full-parameter omnidirectional transformation optical devices

National Science Review 2024年第3期11卷 92-99页

作者： Yuan Gao Yu Luo Jingjing Zhang Zhengjie Huang Bin Zheng Hongsheng Chen dexin Ye Interdisciplinary Center for Quantum Information State Key Laboratory of Extreme Photonics and InstrumentationZJU-Hangzhou Global Scientific and Technological Innovation CenterZhejiang University School of Electrical and Electronic Engineering Nanyang Technological University CNRS-InternationalNTU-Thales Research Alliance Nanyang Technological University Institute of Electromagnetic Space Southeast University State Key Laboratory of Millimeter Waves Southeast University International Joint Innovation Center The Electromagnetics Academy at Zhejiang University Zhejiang University Key Laboratory of Advanced Micro/Nano Electronic Devices&Smart Systems of Zhejiang Jinhua Institute of Zhejiang UniversityZhejiang University Shaoxing Institute of Zhejiang University Zhejiang University

Transformation optics(TO) provides an unprecedented technique to control electromagnetic(EM) waves by engineering the constitutive parameters of the surrounding medium through a proper spatial transformation. In general, ideal transformation optical devices require simultaneous electric and magnetic responses along all three dimensions. To ease the practical implementation, previous studies usually made use of reduced parameters or other simplified approaches, which inevitably introduce extra reflection or unwanted phase shift. Up to today, experimental realizations of full-parameter transformation optical devices in free space are still quite limited. Here, a general design strategy is proposed to solve this problem.As a specific example, a full-parameter spatial-compression TO medium with constitutive parameters taking the diagonal form diag(a, a, 1/a) for the TM wave incidence was designed and realized experimentally. Such spatial-compression TO media were then applied to the implementation of an ideal omnidirectional invisibility cloak capable of concealing a large-scale object over a wide range of illumination angles. Both the simulation and experiment confirm that the cloak allows for nearly unity transmission of EM waves in the forward direction without introducing extra scattering or phase shift. This work constitutes an important stepping stone for future practical implementation of arbitrary full-parameter omnidirectional transformation optical devices.

关键词： transformation optical devices omnidirectional impedance matching full-parameter invisibility cloak

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Class I phosphatidylinositol 3-kinase inhibitors for cancer therapy

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Acta Pharmaceutica Sinica B 2017年第1期7卷 27-37页

作者： Wennan Zhao Yuling Qiu dexin kong Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics School of Pharmaceutical Sciences and Research Center of Basic Medical SciencesTianjin Medical UniversityTianjin 300070China

The phosphatidylinositol 3-kinase(PI3K) pathway is frequently activated in human cancers.Class I PI3 Ks are lipid kinases that phosphorylate phosphatidylinositol 4,5-bisphosphate(PIP2) at the 3-OH of the inositol ring to generate phosphatidylinositol 3,4,5-trisphosphate(PIP3), which in turn activates Akt and the downstream effectors like mammalian target of rapamycin(m TOR) to play key roles in carcinogenesis. Therefore, PI3 K has become an important anticancer drug target, and currently there is very high interest in the pharmaceutical development of PI3 K inhibitors. Idelalisib has been approved in USA and Europe as the first-in-class PI3 K inhibitor for cancer therapy. Dozens of other PI3 K inhibitors including BKM120 and ZSTK474 are being evaluated in clinical trials. Multifaceted studies on these PI3 K inhibitors are being performed, such as single and combinational efficacy, resistance, biomarkers,etc. This review provides an introduction to PI3 K and summarizes key advances in the development of PI3 K inhibitors.

关键词： Phosphatidylinositol 3-kinase PI3K inhibitor Drug candidate Cancer therapy PI3K/m TOR selectivity Anticancer

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Fuzzy-Inverse-Model-Based Networked Tracking Control Frameworks of Time-Varying Signals

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IEEE/CAA Journal of Automatica Sinica 2024年第7期11卷 1708-1710页

作者： Shiwen Tong Dianwei Qian Keya Yuan dexin Liu Yuan Li Jiancheng Zhang the College of Robotics Beijing Union UniversityBeijing 100101China the School of Control and Computer Engineering North China Electric Power UniversityBeijing 102206China

Dear Editor,Tracking control in networked environment is a very challenging problem due to the contradiction of rapid response to the time-varying signal and the inevitable delay introduced by networks. This letter has proposed several fuzzy-inverse-model-based network tracking control frameworks which are helpful in handling the system with nonlinear dynamics and uncertainties.

关键词： contradiction letter inverse

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UPA2 and ZmRAVL1:Promising targets of genetic improvement of maize plant architecture^∞

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Journal of Integrative Plant Biology 2020年第4期62卷 394-397页

作者： dexin kong Baobao Wang Haiyang Wang State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources South China Agricultural UniversityGuangzhou 510642China Biotechnology Research Institute Chinese Academy of Agricultural SciencesBeijng 100081China

Maize(Zea mays ssp.mays)is a major staple crop,with the highest tonnage among cereal crops worldwide(FAO 2014).Over the past century,maize yields have increased about 8-fold in the US central Corm Belt(from 1,287 kg/ha in the 19305 to 11,084 kg/ha in 2017,http://***,Duvick 2005b)due to a combination of genetic gain resulting from breeding efforts and im-proved management practices(such as application of synthetic nitrogen fertilizers,weed,and pest control,increased efficiency of harvest equipment,etC.).A major management practice that contributed to the continuous yield increase is continual increases in planting density(from 30,000 plants per hectare or less in the 1930s to 80,000 plants per hectare or higher in the 1980s,Duvick 2005a,2005b).A series of retro-spective studies have suggested that newer hybrids yield more than older hybrids because of improved plant architecture better adapted to high density planting and increased ability to withstand various biotic and abiotic stresses associated with high density planting(ollenaar and Wu 1999;Duvick 2005a,2005b).Although lagging behind the United States,increasing planting density has been a popular practice in other countries as well for increasing grain yield per unit land area in the last few decades(Li et al.2011).

关键词： planting breeding crops

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Light Regulation of Stomatal Development and Patterning: Shifting the Paradigm from Arabidopsis to Grasses

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Plant Communications 2020年第2期1卷 25-33页

作者： Hongbin Wei dexin kong Juan Yang Haiyang Wang State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources South China Agricultural UniversityGuangzhou 510642China Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou 510642China

The stomatal pores of plant leaves control gas exchange with the environment.Stomatal development is prevised regulated by both internal genetic programs and environmental cues.Among various environmental factors,light regulation of stomata formation has been extensively studied in Arabidopsis.In this review,we summarize recent advances in the genetic control of stomata development and its regulation by light.We also present a comparative analysis of the conserved and diverged stomatal regulatory networks between Arabidopsis and cereal grasses.Lastly,we provide our perspectives on manipulation of the stomata density on plant leaves for the purpose of breeding crops that are better adapted to the adverse environment and high-density planting conditions.

关键词： stomatal development spacing patterns light signaling Arabidopsis cereal crops

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Stellettin B renders glioblastoma vulnerable to poly (ADPribose) polymerase inhibitors via suppressing homologydirected repair

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Signal Transduction and Targeted Therapy 2023年第4期8卷 1388-1391页

作者： Xin Peng Yingying Wang Shaolu Zhang Zhennan Tao Yuxiang Dai Francois X.Claret Moshe Elkabets Hou-Wen Lin Zhe-Sheng Chen dexin kong Tianjin Key Laboratory of Technologies Enabling Development of Clinical Therapeutics and Diagnostics School of PharmacyTianjin Medical UniversityTianjin 300070China Key Laboratory of Immune Microenvironment and Diseases(Ministry of Education) Tianjin Medical UniversityTianjin 300070China Department of Systems Biology The University of Texas MD Anderson Cancer CenterHoustonTX 77030USA Department of Neurosurgery the Affiliated Drum Tower HospitalSchool of MedicineNanjing UniversityNanjing 210008China The Shraga Segal Department of Microbiology Immunology and GeneticsFaculty of Health SciencesBen-Gurion University of the NegevBeer-Sheva 84105Israel Research Center for Marine Drugs State Key Laboratory of Oncogenes and Related GenesDepartment of PharmacyRenji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200127China Department of Pharmaceutical Sciences College of Pharmacy and Health SciencesSt.John’s UniversityQueensNY 11439USA

Dear Editor,Glioblastoma(GBM)is one of the most fatal brain tumors.Current first-line post-surgery regimens for GBM including radiotherapy and temozolomide(TMZ)chemotherapy show very limited efficacy.1,2 Novel therapeutic approaches for GBM patients are urgently needed.Natural products are important sources for drug discovery,especially in the field of cancer treatment.3 We previously isolated stellettin B(STELB)(Fig.1a)from marine sponge(Jaspis stellifera)and reported the remarkable and specific anticancer activities.Recently,a series of stellettins has been totally synthesized and the core chemical structure has been indicated.4 However,the specific mechanism and its role in regulating tumor biology remain largely unknown.

关键词： chemotherapy surgery render

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Design Principles and Mechanistic Understandings of Non-Noble-Metal Bifunctional Electrocatalysts for Zinc-Air Batteries

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Nano-Micro Letters 2024年第9期16卷 13-48页

作者： Yunnan Gao Ling Liu Yi Jiang dexin Yu Xiaomei Zheng Jiayi Wang Jingwei Liu Dan Luo Yongguang Zhang Zhenjia Shi Xin Wang Ya‑Ping Deng Zhongwei Chen Power Battery and Systems Research Center State Key Laboratory of CatalysisDalian Institute of Chemical PhysicsDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023People’s Republic of China Department of Chemical Engineering University of WaterlooWaterlooON N2L 3G1Canada Institute of Carbon Neutrality Zhejiang Wanli UniversityNingbo 315100People’s Republic of China College of Materials and Chemistry China Jiliang UniversityHangzhou 310018People’s Republic of China

Zinc-air batteries(ZABs)are promising energy storage systems because of high theoretical energy density,safety,low cost,and abundance of zinc.However,the slow multi-step reaction of oxygen and heavy reliance on noble-metal catalysts hinder the practical applications of ZABs.Therefore,feasible and advanced non-noble-metal elec-trocatalysts for air cathodes need to be identified to promote the oxygen catalytic reaction.In this review,we initially introduced the advancement of ZABs in the past two decades and provided an overview of key developments in this field.Then,we discussed the work-ing mechanism and the design of bifunctional electrocatalysts from the perspective of morphology design,crystal structure tuning,interface strategy,and atomic engineering.We also included theoretical studies,machine learning,and advanced characterization technologies to provide a comprehensive understanding of the structure-performance relationship of electrocatalysts and the reaction pathways of the oxygen redox reactions.Finally,we discussed the challenges and prospects related to designing advanced non-noble-metal bifunctional electrocatalysts for ZABs.

关键词： Zinc-air batteries Bifunctional electrocatalysts Design principles Mechanistic understandings

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A Secure Device Management Scheme with Audio-Based Location Distinction in IoT

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工程与科学中的计算机建模(英文) 2024年第1期138卷 939-956页

作者： Haifeng Lin Xiangfeng Liu Chen Chen Zhibo Liu dexin Zhao Yiwen Zhang Weizhuang Li Mingsheng Cao College of Economics and Management Nanjing University of Aeronautics and AstronauticsNanjing211106China Chengdu Aircraft Industrial(Group)Co. Ltd.Chengdu610073China Academy of Military Sciences of PLA Beijing100091China School of Information and Software Engineering University of Electronic Science and Technology of ChinaChengdu610054China Ningbo Web King Technology Joint Stock Co. Ltd.Ningbo315000China The Network and Data Security Key Laboratory of Sichuan Province University of Electronic Science and Technology of ChinaChengdu610054China

Identifying a device and detecting a change in its position is critical for secure devices management in the Internet of Things(IoT).In this paper,a device management system is proposed to track the devices by using audio-based location distinction techniques.In the proposed scheme,traditional cryptographic techniques,such as symmetric encryption algorithm,RSA-based signcryption scheme,and audio-based secure transmission,are utilized to provide authentication,non-repudiation,and confidentiality in the information interaction of the management system.Moreover,an audio-based location distinction method is designed to detect the position change of the devices.Specifically,the audio frequency response(AFR)of several frequency points is utilized as a device signature.The device signature has the features as follows.(1)Hardware Signature:different pairs of speaker and microphone have different signatures;(2)Distance Signature:in the same direction,the signatures are different at different distances;and(3)Direction Signature:at the same distance,the signatures are different in different directions.Based on the features above,amovement detection algorithmfor device identification and location distinction is designed.Moreover,a secure communication protocol is also proposed by using traditional cryptographic techniques to provide integrity,authentication,and non-repudiation in the process of information interaction between devices,Access Points(APs),and Severs.Extensive experiments are conducted to evaluate the performance of the proposed method.The experimental results show that the proposedmethod has a good performance in accuracy and energy consumption.

关键词： Acoustic hardware fingerprinting device management IoT location distinction

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黄微孢属真菌改善盐碱胁迫下绿豆生长作用分析

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植物研究 2024年第2期44卷 239-247页

作者：马晨曦张瑜孔德馨高颖徐利剑孟威东北盐碱植被恢复与重建教育部重点实验室(东北林业大学) 哈尔滨150040 黑龙江大学现代农业与生态环境学院哈尔滨150080

为探究来自中国东北森林凋落物的新发现黄微孢属(Parametarhizium)真菌改善盐碱胁迫下植物生长的作用,利用该属兴安黄微孢菌(P. hingganense)和长白黄微孢菌(P. changbaiense)处理绿豆(Vigna radiata)种子,并对处理后植株分别进行盐、... 详细信息

为探究来自中国东北森林凋落物的新发现黄微孢属(Parametarhizium)真菌改善盐碱胁迫下植物生长的作用,利用该属兴安黄微孢菌(P. hingganense)和长白黄微孢菌(P. changbaiense)处理绿豆(Vigna radiata)种子,并对处理后植株分别进行盐、碱胁迫,检测生长表型、光合作用、叶绿素荧光参数、渗透物质含量、活性氧水平、脂质过氧化程度及抗氧化酶活性变化。结果表明:与未处理植株相比,2种真菌处理后绿豆植株在无胁迫和盐、碱胁迫条件下均具有较高生物量。盐、碱胁迫下2种真菌处理植株能够维持较高光合活性,脯氨酸含量增加,丙二醛含量降低,抗氧化酶(POD、SOD、CAT)活性不同程度地升高。综上,黄微孢属的2种真菌通过维护光合系统功能、增加渗透调节物质和增强抗氧化能力来不同程度地改善盐碱胁迫下绿豆植株的生长,其中,兴安黄微孢菌处理能够较显著地减缓盐胁迫损伤,而长白黄微孢菌处理较显著地改善碱胁迫下绿豆生长。

关键词：绿豆盐碱胁迫黄微孢属兴安黄微孢菌长白黄微孢菌

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去氢毛钩藤碱抗突变型p53(R273H)结直肠癌的体外作用机制研究

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中草药 2024年第10期55卷 3354-3362页

作者：任泽昊张彦刘东辉孔德新邱玉玲天津医科大学药学院天津300070

目的从抑制结直肠癌细胞HT29增殖角度研究去氢毛钩藤碱(hirsuteine,HST)对突变型p53(R273H)结直肠癌的体外抗癌作用机制。方法采用MTT和平板克隆形成实验评价HST对HT29细胞增殖的影响;流式细胞术和丹酰尸胺(dansylcadaverine,MDC)染色... 详细信息

目的从抑制结直肠癌细胞HT29增殖角度研究去氢毛钩藤碱(hirsuteine,HST)对突变型p53(R273H)结直肠癌的体外抗癌作用机制。方法采用MTT和平板克隆形成实验评价HST对HT29细胞增殖的影响;流式细胞术和丹酰尸胺(dansylcadaverine,MDC)染色法检测细胞周期分布和自噬情况;Western blotting、qRT-PCR分析细胞中p53蛋白、mRNA表达水平和p53下游效应子的表达情况;放线菌酮(actidione,CHX)-chase实验检测p53蛋白半衰期;染色质免疫共沉淀(chromatin immunoprecipitation,ChIP)实验检测p53与其下游靶基因p21启动子区的结合情况。结果HST显著抑制突变型p53(R273H)结直肠癌HT29细胞增殖,引起细胞周期阻滞,诱导杀伤性细胞自噬,缩短突变型p53(R273H)蛋白半衰期,诱导其发生MDM2介导的泛素-蛋白酶体降解,增强其与p21启动子的结合,并上调p21的mRNA表达。结论HST能够促进HT29细胞中突变型p53(R273H)降解并恢复p53野生型转录激活功能,其体外抗结直肠癌活性可能与p53通路密切相关。

关键词：结直肠癌去氢毛钩藤碱突变型p53(R273H) 蛋白酶体降解 p53野生型转录特性恢复

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