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Journal of Environmental Sciences 2024年第3期137卷 604-614页

作者： Di Wu Xing Lu Li-Xue Dong Juan Tian Jin deng Lei Wei hua Wen Shan Zhong Ming Jiang School of Basic Medical Sciences Wuhan UniversityWuhan 430071China Key Laboratory of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural AffairsYangtze River Fisheries Research InstituteChinese Academy of Fishery SciencesWuhan 430223China Hubei Province Key Laboratory of Allergy and Immunology Wuhan 430071China

Microplastics(MPs)have become a significant concern for their potential ***,the correlation between the size of plastic particles and their toxicity remains ***,we investigate the toxic effects of different sizes(80 nm,800 nm,8μm and 80μm)polystyrene MPs(PS-MPs)on the model organism Nile tilapia(Oreochromis niloticus).The results of bioluminescent imaging indicate that the 80 nm PS-MPs are more likely to invade the body.H&E staining shows severe damage on the intestinal villi and distinct hepatic steatosis in the 80 nm *** U labeling shows that the proliferation activity of intestinal and liver cells reduces significantly in the 80 nm *** gut microbiome analysis shows a severe imbalance of gut microbiota homeostasis in the 80 nm *** analysis of liver transcriptomics and metabolomics shows that the liver lipid metabolism is disordered in the 80 nm *** conclusion,this study confirms that the 80 nm PS-MPs are more likely to induce intestinal and liver *** the above lay the foundation for further study on the pathological damage of MPs to other organisms.

关键词： Microplastics(MPs) Intestinal toxicity Liver toxicity Gut microbiome Lipid metabolism

Study on chromatographic fingerprint of sarcandra glabra (Thunb.) by microwave-assisted extraction coupled to HPLC/DAD

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Journal of Pharmaceutical Analysis 2010年第4期22卷 211-217页

作者： Zhuo-Min Zhang1,Zong-Ning Guo1,Gui-hua Ruan1,2,Jian-Chao deng1,xiao-hua xiao1,Gong-Ke Li11.School of Chemistry and Chemical Engineering,Sun Yat-sen University,Guangzhou 510275 2.Department of Material and Chemistry,Guilin University of Technology,Guilin 541004,China School of Chemistry and Chemical Engineering Sun Yat-sen University Guangzhou 510275 China Department of Material and Chemistry Guilin University of Technology Guilin 541004 China

Microwave-assisted extraction(MAE)was used for extraction of effective components of sarcandra glabra(Thunb.),and then chromatographic fingerprint of sarcandra glabra(Thunb.)was studied by high performance liquid chromatography/diode array detector(HPLC/DAD).The conditions of MAE were optimized by an orthogonal experiment,and then the authentication and validation of the chromatographic fingerprint were *** peaks were identified as common peaks in the fingerprint chromatograms,and isofraxidin was considered as a reference compound and *** standard deviations of retention time and peak area of each component were less than 3% and 8%,*** and difference analysis were conducted by use of PCA and relation *** batches of sarcandra glabra(Thunb.)samples from two different producing areas could be classified into two different groups in the PCA *** results showed that MAE-HPLC/DAD method was simple,efficient and stable for the study of complex chromatographic fingerprint of sarcandra glabra(Thunb.),which could provide more reliable and precise information for quality evaluation.

关键词： chromatographic fingerprint sarcandra glabra(thunb.) microwave-assisted extraction high performance liquid chromatography/diode array detector

Mex-3 RNA binding family member A(MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2091-2103页

作者： Ri-Xin Chen Shui-Dan Xu Min-hua deng Shi-Hui Hao Jie-Wei Chen xiao-Dan Ma Wei-Tao Zhuang Jing-hua Cao Yong-Rui Lv Jin-Long Lin Si-Yu Li Gui-Bin Qiao Dan Xie Feng-Wei Wang Department of Thoracic Surgery Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China Medical Research Institute Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China Department of Pathology Sun Yat-sen University Cancer CenterGuangzhou 510060China

RNA-binding proteins(RBPs)-RNA networks have contributed to cancer *** RNAs(circRNAs)are considered as protein recruiters;nevertheless,the patterns of circRNA-protein interactions in colorectal cancer(CRC)are still *** bodies(PBs)formed through liquid-liquid phase separation(LLPS)are membrane-less organelles(MLOs)consisting of RBPs and *** evidence suggests a connection between PBs dynamics and cancer *** the increasingly acknowledged crucial role of RBPs and RNA in the accumulation and maintenance of MLOs,there remains a lack of specific research on the interactions between PBs-related RBPs and circRNAs in ***,we identify that MEX-3 RNA binding family member A(MEX3A),frequently upregulated in CRC tissues,predicts poorer patient *** MEX3A accelerates malignance and inhibits autophagy of CRC ***,MEX3A undergoes intrinsically disordered regions(IDRs)-dependent LLPS in the ***,circMPP6 acts as a scaffold to facilitate the interaction between MEX3A and PBs *** MEX3A/circMPP6 complex modulates PBs dynamic and promotes UPF-mediated phosphodiesterase 5A(PDE5A)mRNA degradation,consequently leading to the aggressive properties of CRC ***,CRC patients exhibiting high MEX3A expression and low PDE5A expression have the poorest overall *** findings reveal a collaboration between MEX3A and circMPP6 in the regulation of mRNA decay through triggering the PBs aggregation,which provides prognostic markers and/or therapeutic targets for CRC.

关键词： colorectal inhibiting MPP

Chiral Lewis Base/Achiral Acid Co-Catalyzed Atroposelective Sulfenylation of Pyrrole Derivatives: Construction of C-N Axially Chiral Sulfides

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Chinese Journal of Chemistry 2024年第17期42卷 2005-2009页

作者： Qin Yang Hui-Yun Luo deng Zhu Xin-Yu Zhang hua Ke Zhi-Min Chen School of Chemistry and Chemical Engineering Shanghai Key Laboratory for Molecular Engineering of Chiral DrugsShanghai Jiao Tong UniversityShanghai 200240China Engineering Technooy Rearch Centeror Enviromental Proction Materas Pingxng Universty PingangJiangx355China State Key Laboratory of Applied Organic Chemistry Lanzhou UniversityLanzhouGansu 730000China

Chiral BINAM-derived selenide/achiral acid co-catalyzed atroposelective electrophilic sulfenylation of pyrrole derivatives has been realized for the first time.A variety of C-N axially chiral sulfur-containing pyrrole derivatives were readily obtained in moderate to good yields with moderate to excellent *** catalytic system involves sequential desymmetrization and kinetic resolution.

关键词： Electrophilic substitution Desymmetrization Kinetic resolution Atropisomerism Asymmetric catalysis Heterocycles

Using an improved lightweight YOLOv8 model for real-time detection of multi-stage apple fruit in complex orchard environments

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Artificial Intelligence in Agriculture 2024年第1期11卷 70-82页

作者： Baoling Ma Zhixin hua Yuchen Wen Hongxing deng Yongjie Zhao Liuru Pu huaibo Song College of Mechanical and Electronic Engineering Northwest A&F UniversityYanglingShaanxi 712100China Key Laboratory of Agricultural Internet of Things Ministry of Agricultureand Rural AffairsYanglingShaanxi 712100China Shaanxi Key Laboratory of Agricultural Information Perception and Intelligent Services YanglingShaanxi 712100China

For the purpose of monitoring apple fruits effectively throughout the entire growth period in smart orchards.A lightweight model named YOLOv8n-ShuffleNetv2-Ghost-SE was *** ShuffleNetv2 basic modules and down-sampling modules were alternately connected,replacing the Backbone of YOLOv8n *** Ghost modules replaced the Conv modules and the C2fGhost modules replaced the C2f modules in the Neck part of the ***2 reduced the memory access cost through channel splitting *** Ghost module combined linear and non-linear convolutions to reduce the network computation *** Wise-IoU(WIoU)replaced the CIoU for calculating the bounding box regression loss,which dynamically adjusted the anchor box quality threshold and gradient gain allocation strategy,optimizing the size and position of predicted bounding *** Squeeze-and-Excitation(SE)was embedded in the Backbone and Neck part of YOLOv8n to enhance the representation ability of feature *** algorithm ensured high precision while having small model size and fast detection speed,which facilitated model migration and *** 9652 images validated the effectiveness of the *** YOLOv8n-ShuffleNetv2-Ghost-SE model achieved Precision of 94.1%,Recall of 82.6%,mean Average Precision of 91.4%,model size of 2.6 MB,parameters of 1.18 M,FLOPs of 3.9 G,and detection speed of 39.37 *** detection speeds on the Jetson Xavier NX development board were 3.17 *** with advanced models including Faster R-CNN,SSD,YOLOv5s,YOLOv7‑tiny,YOLOv8s,YOLOv8n,MobileNetv3_small-Faster,MobileNetv3_small-Ghost,ShuflleNetv2-Faster,ShuflleNetv2-Ghost,ShuflleNetv2-Ghost-CBAM,ShuflleNetv2-Ghost-ECA,and ShuflleNetv2-Ghost-CA demonstrated that the method achieved smaller model and faster detection *** research can provide reference for the development of smart devices in apple orchards.

关键词： Multi-stage apple fruit Deep learning Real-time detection Lightweight model

Strain engineering in electrocatalysis:Strategies,characterization,and insights

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Nano Research 2024年第5期17卷 3603-3621页

作者： Qibo deng Peng Xu Hassanien Gomaa Mohamed A.Shenashen Sherif A.El-Safty Cuihua An Li-hua Shao Ning Hu School of Mechanical Engineering Hebei University of TechnologyTianjin 300401China Department of Chemistry Faculty of ScienceAl-Azhar University71524AssiutEgypt Department of Petrochemical Egyptian Petroleum Research Institute(EPRI)Nasr City11727CairoEgypt Center for Functional Materials National Institute for Materials Science(NIMS)1-2-1 SengenTsukubaIbaraki-ken305-0047Japan State Key Laboratory of Reliability and Intelligence Electrical Equipment Key Laboratory of Advanced Intelligent Protective Equipment TechnologyMinistry of Educationand School of Mechanical EngineeringHebei University of TechnologyTianjin 300401China National Key Laboratory of Strength and Structural Integrity Institute of Solid MechanicsSchool of Aeronautic Science and EngineeringBeihang UniversityBeijing100191China Advanced Equipment Research Institute Co. Ltd.of HEBUTTianjin 300401China

Strain engineering,as a cutting-edge method for modulating the electronic structure of catalysts,plays a crucial role in regulating the interaction between the catalytic surface and the adsorbed *** electrocatalytic performance is influenced by the electronic structure,which can be achieved by introducing the external forces or stresses to adjust interatomic spacing between surface *** challenges in strain engineering research lie in accurately understanding the mechanical impact of strain on *** paper first introduces the basic strategy for generating the strain,summarizes the different strain generation forms and their advantages and *** progress in researching the characterization means for the lattice strains and their applications in the field of electrocatalysis is also ***,the challenges of strain engineering are introduced,and an outlook on the future research directions is provided.

关键词： strain electrocatalysis characterization chemical reaction kinetics lattice mismatch

Quantitative characterizations of anisotropic dynamic properties in organic-rich shale with different kerogen content

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Petroleum Science 2024年第2期21卷 855-865页

作者： Jian-Yong Xie Yan-Ping Fang Xing-hua Wu Jian'er Zhao Jun-Cheng Dai Jun-Xing Cao Ji-Xin deng State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu University of TechnologyChengdu610059SichuanChina Key Lab of Earth Exploration&Information Techniques of Ministry of Education Geophysical InstituteChengdu University of TechnologyChengdu610059SichuanChina PetroChina Southwest Oil&Gasfield Company Chengdu610017SichuanChina

Understanding the quantitative responses of anisotropic dynamic properties in organic-rich shale with different kerogen content(KC)is of great significance in hydrocarbon exploration and *** controlled experiments with a single variable is challenging for natural shales due to their high variations in components,diagenesis conditions,or pore *** employed the hot-pressing technique to construct 11 well-controlled artificial shale with varying *** artificial shale samples were successive machined into prismatic shape for ultrasonic measurements along different *** revealed bedding perpendicular P-wave velocities are more sensitive to the increasing KC than bedding paralleling velocities due to the preferential alignments of *** elastic stiffnesses except C_(13)are generally decreasing with the increasing KC,the variation of C_(1) and C_(33)on kerogen content are more sensitive than those of C_(44)and C_(66).Apparent dynamic mechanical parameters(v and E)were found to have linear correlation with the true ones from complete anisotropic equations independent of KC,which hold value towards the interpretation of well logs consistently across formations,Anisotropic mechanical parameters(ΔE and brittlenessΔB)tend to decrease with the reducing KC,withΔB showing great sensitivity to KC *** the range of low KC(10%)shale,compilation of data from natural organic rich-shales globally verified the similar systematic relationships that can be empirically used to predict the fraction of KC in shales.

关键词： Elastic properties Organic shale Anisotropy Kerogen content Physical modeling

Microstructure and mechanical properties of Co-28Cr-6Mo-0.22C investment castings by current solution treatment

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China Foundry 2024年第4期21卷 369-378页

作者： Ze-yu Dan Jun Liu Jian-lei Zhang Yan-hua Li Yuan-xin deng Yun-hu Zhang Chang-jiang Song Center for Advanced Solidification Technology School of Materials Science and EngineeringShanghai UniversityShanghai 200444China Wuxi CastPro Precision Co. Ltd.Wuxi 214105JiangsuChina

This study examined the impact of current solution treatment on the microstructure and mechanical properties of the Co-28Cr-6Mo-0.22C alloy investment *** findings reveal that the current solution treatment significantly promotes the dissolution of carbides at a lower *** optimal conditions for solution treatment are determined as a solution temperature of 1,125°C and a holding time of 5.0 *** these parameters,the size and volume fraction of precipitated phases in the investment castings are measured as6.2μm and 1.1vol.%.The yield strength,ultimate tensile strength,and total elongation of the Co-28Cr-6Mo-0.22C investment castings are 535 MPa,760 MPa,and 12.6%,*** values exceed those obtained with the conventional solution treatment at 1,200°C for 4.0 *** findings suggest a phase transformation of M_(23)C_(6)→σ+C following the current solution treatment at 1,125°C for 5.0 *** comparison,the traditional solution treatment at 1,200°C for 4.0 h leads to the formation of M_(23)C_(6)and M_(6)C *** is noteworthy that the non-thermal effect of the current during the solution treatment modifies the free energy of both the matrix and precipitation *** modification lowers the phase transition temperature of the M_(23)C_(6)→σ+C reaction,thereby facilitating the dissolution of *** a result,the current solution treatment approach achieves carbide dissolution at a lower temperature and within a significantly shorter time when compared to the traditional solution treatment methods.

关键词： CoCrMo alloy investment castings current solution treatment microstructure mechanical property carbide

Irisin-loaded electrospun core-shell nanofibers as calvarial periosteum accelerate vascularized bone regeneration by activating the mitochondrial SIRT3 pathway

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Regenerative Biomaterials 2024年第1期3卷 44-57页

作者： Xi hua Mingzhuang Hou Lei deng Nanning Lv Yong Xu Xuesong Zhu Huilin Yang Qin Shi Hao Liu Fan He Department of Orthopaedics The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Orthopaedic Institute Suzhou Medical CollegeSoochow UniversitySuzhou 215000China Department of Orthopedics Suzhou Wuzhong People’s HospitalSuzhouJiangsu Province 215128China Department of Orthopedic Surgery Lianyungang Clinical College of Xuzhou Medical UniversityLianyungang 222003China

The scarcity of native periosteum poses a significant clinical barrier in the repair of critical-sized bone *** challenge of enhancing regenerative potential in bone healing is further compounded by oxidative stress at the fracture ***,the introduction of artificial periosteum has demonstrated its ability to promote bone regeneration through the provision of appropriate mechanical support and controlled release of proosteogenic *** this study,a poly(L-lactic acid)(PLLA)/hyaluronic acid(HA)-based nanofibrous membrane was fabricated using the coaxial electrospinning *** incorporation of irisin into the core-shell structure of PLLA/HA nanofibers(PLLA/HA@Irisin)achieved its sustained *** vitro experiments demonstrated that the PLLA/HA@Irisin membranes exhibited favorable *** osteogenic differentiation of bone marrow mesenchymal stem cells(BMMSCs)was improved by PLLA/HA@Irisin,as evidenced by a significant increase in alkaline phosphatase activity and matrix ***,PLLA/HA@Irisin significantly enhanced the mitochondrial function of BMMSCs via the activation of the sirtuin 3 antioxidant *** assess the therapeutic effectiveness,PLLA/HA@Irisin membranes were implanted in situ into critical-sized calvarial defects in *** results at 4 and 8 weeks post-surgery indicated that the implantation of PLLA/HA@Irisin exhibited superior efficacy in promoting vascularized bone formation,as demonstrated by the enhancement of bone matrix synthesis and the development of new blood *** results of our study indicate that the electrospun PLLA/HA@Irisin nanofibers possess characteristics of a biomimetic periosteum,showing potential for effectively treating critical-sized bone defects by improving the mitochondrial function and maintaining redox homeostasis of BMMSCs.

关键词： periosteum irisin mitochondrial function critical-sized bone defect redox homeostasis

ESW在磁尾磁场重联耗散区分形线附近的观测特性及其作用

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地球物理学报 2009年第4期52卷 902-910页

作者：李世友邓晓华王敬芳武汉大学电子信息学院武汉430079

磁场重联是空间能量释放和转换的重要机制.静电孤立波(ESW)虽然在空间中有广泛观测,但在磁场重联附近少有直接观测,对它在磁场重联附近的特性了解甚少.通过Geotail卫星对一个磁场重联事件的观测,仔细分析了其边界层上观测到的静电孤立... 详细信息

磁场重联是空间能量释放和转换的重要机制.静电孤立波(ESW)虽然在空间中有广泛观测,但在磁场重联附近少有直接观测,对它在磁场重联附近的特性了解甚少.通过Geotail卫星对一个磁场重联事件的观测,仔细分析了其边界层上观测到的静电孤立波的特性,并讨论了它对磁场重联的影响.研究表明,亚暴期间在磁尾发生磁场重联,重联区域的分形线附近观测到了大量的静电孤立波,其特性与在其他地方观测到的并没有显著差别,但具有更明显的非线性和孤立性的特征.它们对电子加速和能量耗散有促进作用,加速磁场重联的进程.

关键词：磁场重联静电孤立波离子耗散区电子加速