Chiral Lewis Base/Achiral Acid Co-Catalyzed Atroposelective Sulfenylation of Pyrrole Derivatives: Construction of C-N Axially Chiral Sulfides

作     者：Qin Yang Hui-Yun Luo Deng Zhu Xin-Yu Zhang Hua Ke Zhi-Min Chen Qin Yang;Hui-Yun Luo;Deng Zhu;Xin-Yu Zhang;Hua Ke;Zhi-Min Chen

作者机构：School of Chemistry and Chemical EngineeringShanghai Key Laboratory for Molecular Engineering of Chiral DrugsShanghai Jiao Tong UniversityShanghai 200240China Engineering Technooy Rearch Centeror Enviromental Proction MaterasPingxng Universty PingangJiangx355China State Key Laboratory of Applied Organic ChemistryLanzhou UniversityLanzhouGansu 730000China 

出 版 物：《Chinese Journal of Chemistry》 (中国化学（英文版）)

年 卷 期：2024年第42卷第17期

页      面：2005-2009页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：Z.-M.Chen thanks National Natural Science Foundation of China(22071149,21871178) Natural Science Foundation of Shanghai(23ZR1428200) financial support.H.Ke thanks Natural Science Foundation of Jiangxi Province(20202ACBL213005)for financial support 

主　　题：Electrophilic substitution Desymmetrization Kinetic resolution Atropisomerism Asymmetric catalysis Heterocycles 

摘      要：Chiral BINAM-derived selenide/achiral acid co-catalyzed atroposelective electrophilic sulfenylation of pyrrole derivatives has been realized for the first time.A variety of C-N axially chiral sulfur-containing pyrrole derivatives were readily obtained in moderate to good yields with moderate to excellent *** catalytic system involves sequential desymmetrization and kinetic resolution.