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铜代谢紊乱介导非酒精性脂肪性肝病合并肌少症的研究进展

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生理科学进展 2024年第2期55卷 163-170页

作者：李畅杨威邓云锋陈宁范晶晶武汉体育学院运动医学院武汉430079 武汉体育学院运动训练监控湖北省重点实验室武汉430079 长沙卫生职业学院公共教学部长沙410100

非酒精性脂肪性肝病(non-alcoholic fatty liver disease)与肌少症(sarcopenia)是与年龄有关的常见慢性病共病,二者存在众多共同的病理生理因素,其潜在相关机制尚未完全阐明。近年来铜死亡作为一种新型细胞死亡方式被发现,铜稳态(copper... 详细信息

非酒精性脂肪性肝病(non-alcoholic fatty liver disease)与肌少症(sarcopenia)是与年龄有关的常见慢性病共病,二者存在众多共同的病理生理因素,其潜在相关机制尚未完全阐明。近年来铜死亡作为一种新型细胞死亡方式被发现,铜稳态(copper homeostasis)在多种慢性疾病中的潜在功能角色成为当前的研究热点。肝脏内铜元素的缺失与早期非酒精性脂肪性肝病的发生密切相关,而骨骼肌内铜过载可能通过多种信号途径促进肌少症的发生,以铜蓝蛋白为代表的血清铜形成的细胞外铜过载在此过程中扮演着潜在性的功能角色。本篇综述从铜代谢角度出发阐述了铜稳态失衡与早期非酒精性脂肪性肝病合并肌少症发病的可能机制,以期为临床早期改善甚至逆转这两种代谢性疾病提供分子靶点和理论基础。

关键词：非酒精性脂肪性肝病肌少症铜铜稳态铜死亡铜代谢铜蓝蛋白氧化应激

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正交试验法优选十三味逐瘀合剂的提取工艺

中国处方药 2024年第3期22卷 66-71页

作者：邓凤云冯丽珍韦贤唐文静吴显兴罗试计姜攀百色市中医医院广西百色533000 广西医科大学南宁530021 右江民族医学院广西百色533000

目的优选十三味逐瘀合剂的水提煎煮工艺,为其后续研究提供参考。方法以煎煮次数(A)、加水量(B)、煎煮时间(C)作为考察因素,羟基红花黄色素A的含量与出膏率的综合评分为指标,确定羟基红花黄色素A含量和出膏率的权重系数分别为70%和30%,通... 详细信息

目的优选十三味逐瘀合剂的水提煎煮工艺,为其后续研究提供参考。方法以煎煮次数(A)、加水量(B)、煎煮时间(C)作为考察因素,羟基红花黄色素A的含量与出膏率的综合评分为指标,确定羟基红花黄色素A含量和出膏率的权重系数分别为70%和30%,通过L_(9)(3^(4))正交试验设计,优选水提的煎煮工艺,并进行验证实验。结果最优选的煎煮工艺为加8倍量水,煎煮2次,每次煎煮90 min。结论优选的工艺条件合理、稳定可行,可用于规范化十三味逐瘀合剂提取。

关键词：十三味逐瘀合剂正交试验法羟基红花黄色素A 提取工艺高效液相色谱法

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海洛因渴求度评估的血清学生物标志物研究

中国药物依赖性杂志 2024年第2期33卷 136-141页

作者：杨博珺苏鹏邓云锋杨旭东杨威武汉体育学院运动医学院武汉430079 池州市精神卫生中心安徽池州247100 长沙卫生职业学院公共教学部长沙410100 襄州戒毒所湖北襄阳441105

目的海洛因成瘾是一种慢性、复发性脑病,具有高度的精神和躯体依赖性,氧化应激、炎症反应、神经因子代谢紊乱被证明参与其成瘾的病理生理机制。开发海洛因成瘾的生物标志物对于其易感性预测、临床干预及治疗效果的评估至关重要,因此,本... 详细信息

目的海洛因成瘾是一种慢性、复发性脑病,具有高度的精神和躯体依赖性,氧化应激、炎症反应、神经因子代谢紊乱被证明参与其成瘾的病理生理机制。开发海洛因成瘾的生物标志物对于其易感性预测、临床干预及治疗效果的评估至关重要,因此,本文力求筛选并探讨潜在性成瘾机制关联因子丙二醛(MDA)、肿瘤坏死因子α(TNF-α)、脑源性神经营养因子(BDNF)及其载体血小板作为海洛因成瘾性血清学生物标志物的可行性和实用性。方法以正常人群52名和海洛因依赖人群51名分别作为对照组和实验组。采用全自动血细胞分析仪测定其血小板数量、酶联免疫吸附法(Enzyme-linked Immunosorbent Assay,ELISA)检测各组别血清MDA、TNF-α及血浆BDNF的含量,采用海洛因渴求评分量表对实验组个体的成瘾性进行评估、Spearman相关性分析评估血清MDA、TNF-α、血浆BDNF和血小板数量与渴求评分的相关性、受试者工作特征曲线(Receiver Operating Characteristic Curve,ROC)评估血浆BDNF和血小板数量对海洛因成瘾性评分的诊断性能及截断值。结果实验组人群血清MDA、TNF-α高于对照组(P<0.05),血浆BDNF和血小板数量低于对照组(P<0.01)。海洛因高成瘾性组血浆BDNF及血小板数量低于海洛因低成瘾性组(P<0.05),实验组血浆BDNF、血小板数量和成瘾性评分呈负相关。血小板数量对海洛因成瘾性的灵敏度和特异度为69%和12%,AUC值为0.76(95%CI:0.66-0.87,P<0.001)。结论研究初步表明,长期海洛因摄入可显著下调血浆BDNF水平和血小板数量,血小板数量可作为评估海洛因成瘾性的新型血清学生物标志物。

关键词：血小板海洛因脑源性神经营养因子成瘾标志物

Treatment of coronavirus disease 2019 in Shandong,China:a cost and affordability analysis

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Infectious Diseases of Poverty 2020年第3期9卷 31-38页

作者： Xue-Zheng Li feng Jin Jian-Guo Zhang yun-feng deng Wei Shu Jing-Min Qin Xin Ma Yu Pang School of Public Health Cheeloo College of MedicineShandong UniversityJinanPeople’s Republic of China Provincial Key Laboratory for Respiratory Infectious Diseases in Shandong Shandong Provincial Chest HospitalCheeloo College of MedicineShandong UniversityJinanPeople’s Republic of China Katharine Hsu International Research Center of Human Infectious Diseases Shandon Provincial Chest HospitalCheeloo College of MedicineShandong UniversityNo.44 Wenhuaxi RoadLixia District250012 JinanPeople’s Republic of China Department of Planning and Finance Shandong Provincial Chest HospitalCheeloo College of MedicineShandong UniversityJinanPeople’s Republic of China National Clinical Laboratory on Tuberculosis Beijing Key laboratory on Drug-resistant Tuberculosis ResearchBeijing Chest HospitalCapital Medical UniversityBeijing Tuberculosis and Thoracic Tumor InstituteNo 9Beiguan StreetTongzhou DistrictBeijing 101149People’s Republic of China

Background:Coronavirus disease 2019(COVID-19)is now a global public *** the pandemic of COVID-19,the economic impact of COVID-19 is essential to add value to the policy-making *** retrospectively conducted a cost and affordability analysis to determine the medical costs of COVID-19 patients in China,and also assess the factors affecting their ***:This analysis was retrospectively conducted in Shandong Provincial Chest Hospital between 24 January and 16 March *** total direct medical expenditures were analyzed by cost *** also assessed affordability by comparing the simulated out-of-pocket expenditure of COVID-19 cases relative to the per capita disposable *** between groups were tested by student t test and Mann-Whitney test when appropriate.A multiple logistic regression model was built to determine the risk factors associated with high ***:A total of 70 COVID-19 patients were included in the *** overall mean cost was USD 6827 per treated *** highest mean cost was observed in drug acquisition,accounting for 45.1%of the overall *** mean cost was significantly higher in patients with pre-existing diseases compared to those without preexisting ***-existing diseases and the advanced disease severity were strongly associated with higher *** USD 0.49 billion were expected for clinical manage of COVID-19 in *** rural households,the proportions of health insurance coverage should be increased to 70%for severe cases,and 80%for critically ill cases to avoid catastrophic health ***:Our data demonstrate that clinical management of COVID-19 patients incurs a great financial burden to national health *** cost for drug acquisition is the major contributor to the medical cost,whereas the risk factors for higher cost are pre-existing diseases and severity of *** of insurance coverage will need to address the barriers of rural

关键词： COVID-19 Cost Treatment Affordability China

Evaluation of the New Automatic Mycob.T Stainer andScanner for Detecting Acid-fast Bacilli in China

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Biomedical and Environmental Sciences 2018年第8期31卷 572-578页

作者： LI Qiang ZHAO Yan Lin WANG Qing deng yun feng BAO Xun Di YANG Hong Guo OU Xi Chao ZHAO Bing ZHANG Jing Bo Beijing Physical Examination Center Beijing 100077China National Center for Tuberculosis Control and Prevention Chinese Center for Disease Control and PreventionBeijing 102206China Anhui Provincial Chest Hospital Hefei 230022AnhuiChina Shandong Provincial Chest Hospital Jinan 250013ShandongChina Linyi People's Hospital Linyi 276003ShandongChina

Objective To validate the performance of Mycob. T Stainer and Scanner(MTSS) for detecting acid-fast bacilli(AFB). Methods A total of 3,816 sputum samples from 1,515 tuberculosis(TB) suspects were tested at the Anhui Provincial Chest Hospital and the Linyi People’s Hospital from April-August, 2016. Each specimen was placed on two smear slides. One slide was stained by the ziehl-neelsen(ZN) method to be read by conventional microscopy(CM). The other slide was stained and scanned by MTSS. All specimens were decontaminated with 4% NaO H, and then inoculated into solid culture. The performance of MTSS was assessed. Results MTSS produced higher average positivity rate(27.96%) as compared with the CM(26.83%). The overall sensitivity and specificity of MTSS were 78.9% and 93.9%, respectively. The sensitivity and specificity of CM was 77.4% and 95.0%, respectively. Conclusion MTSS exhibited a favorable performance in the detection of AFB. It may be an alternative to CM for screening TB.

关键词： Tuberculosis Automatic Stainer Scanner

The synthetic gauge field and exotic vortex phase with spin-orbital-angular-momentum coupling

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Communications in Theoretical Physics 2024年第8期76卷 52-59页

作者： Yingqi Liu yun Chen Yuangang deng Guangdong Provincial Key Laboratory of Quantum Metrology and Sensing&School of Physics and Astronomy Sun Yat-Sen University(Zhuhai Campus)Zhuhai 519082China

Ultracold atoms endowed with tunable spin-orbital-angular-momentum coupling(SOAMC)represent a promising avenue for delving into exotic quantum phenomena. Building on recent experimental advancements, we propose the generation of synthetic gauge fields, and by including exotic vortex phases within spinor Bose-Einstein condensates, employing a combination of a running wave and Laguerre-Gaussian laser fields. We investigate the ground-state characteristics of the SOAMC condensate, revealing the emergence of exotic vortex states with controllable orbital angular momenta. It is shown that the interplay of the SOAMC and conventional spin-linear-momentum coupling induced by the running wave beam leads to the formation of a vortex state exhibiting a phase stripe hosting single multiply quantized singularity. The phase of the ground state will undergo the phase transition corresponding to the breaking of rotational symmetry while preserving the mirror symmetry. Importantly, the observed density distribution of the ground-state wavefunction, exhibiting broken rotational symmetry, can be well characterized by the synthetic magnetic field generated through light interaction with the dressed spin state. Our findings pave the way for further exploration into the rotational properties of stable exotic vortices with higher orbital angular momenta against splitting in the presence of synthetic gauge fields in ultracold quantum gases.

关键词： ultracold atoms synthetic gauge fields vortex phases spin-orbital-angularmomentum coupling

Preparation of tungsten-particle-reinforced Zr-based bulk metallic glass composites by two-step spark plasma sintering:microstructure evolution,densification mechanism and mechanical properties

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Rare Metals 2024年第4期43卷 1793-1808页

作者： yun-Fei Ma Pan Gong Mao Zhang Hui-EHu Zhen Peng Xiao Xu Xin Wang Mehdi Malekan Xue-feng Tang Lei deng Jun-Song Jin Xin-yun Wang State Key Laboratory of Materials Processing and Die and Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan430074China Research Institute of Huazhong University of Science and Technology in Shenzhen Shenzhen518057China Department of Chemistry and Materials Naval University of EngineeringWuhan430032China School of Materials Science and Engineering Jiangsu UniversityZhenjiang212013China College of Machine Shanghai Dianji UniversityShanghai201306China School of Metallurgy and Materials Engineering College of EngineeringUniversity of TehranTehran 11155-4563Iran

A new two-step spark plasma sintering(TSS)process with low-temperature pre-sintering and high-temperature final sintering has been successfully applied to prepare the tungsten-particle(Wp)-reinforced bulk metallic glass composites(Wp/BMGCs).Compared to normal spark plasma sintering(NS),the densification rate and relative density of Wp/BMGCs can be improved by selecting TSS with appropriate sintering pressure in the low temperature pre-sintering ***,the compressive strength and plastic strain of 30%Wp/BMGCs prepared by TSS are both higher than those of the samples prepared by *** TSS process can significantly enhance the compressive strength of 30%Wp/BMGCs by 12%and remarkably increase the plastic strain by 50%,while the trend is completely opposite for 50%Wp/***-in situ experiments and finite element simulations reveal that uneven temperature distribution among particles during low-temperature pre-sintering causes local overheating at contact points between particles,accelerating formation of sintering neck between particles and plastic deformation of *** the volume fraction of Wp is low,TSS can improve the interface bonding between particles by increasing the number of sintering *** makes the fracture mode of Wp/BMGCs being predominantly transgranular ***,as the volume fraction of Wp increases,the adverse effects of Wp plastic deformation are becoming more and more *** aggregated Wp tends to form a solid"cage structure"that hinders the bonding between particles at the interface;correspondingly,the fracture behavior of Wp/BMGCs is mainly dominated by intergranular ***,reducing the sintering pressure during the low-temperature pre-sintering stage of TSS has been shown to effectively decrease plastic deformation in Wp,resulting in a higher degree of densification and better mechanical properties.

关键词： Bulk metallic glass composites Tungsten particle Two-step spark plasma sintering Densification mechanism Mechanical properties

Multi-Axis Attention With Convolution Parallel Block for Organoid Segmentation

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IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1295-1297页

作者： Pengwei Hu Xun deng feng Tan Lun Hu Xinjiang Technical Institute of Physics and Chemistry Chinese Academy of SciencesUrumqi 830011 University of Chinese Academy of Sciences Beijing 100049 Xinjiang Laboratory of Minority Speech and Language Information Processing Urumqi 830011China Merck KGaA Darmstadt 64293Germany

Dear Editor,This letter presents an organoid segmentation model based on multi-axis attention with convolution parallel *** adeptly captures dynamic dependencies within bright-field microscopy images,improving global ... 详细信息

关键词： letter convolution organo

Special issue on electrochemical energy storage and conversion

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Frontiers in Energy 2024年第2期18卷 125-127页

作者： yun ZHENG Gaixia ZHANG Sixu deng Jiujun ZHANG Institute of New Energy Materials and Engineering School of Materials Science and EngineeringFuzhou UniversityFuzhou 350108China Department of Electrical Engineering École de Technologie Supérieure(ÉTS)Universitédu QuébecMontréalH3C 1K3Canada Department of Chemical and Materials Engineering Concordia UniversityMontrealQC H3G 1M8Canada

The escalating global consumption of fossil fuels has significantly elevated the levels of CO_(2)in the atmosphere,leading to an undesirable global energy crisis and environmental *** deployment of renewable energy resources is crucial to mitigate these *** recent years,there has been noteworthy progress in electrochemical energy storage and conversion techniques and devices,including hydrogen energy and fuel cells,advanced energy storage and power batteries,and CO_(2)electrochemical conversion and utilization.

关键词： electrochemical energy elevated