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Bronchoalveolar lavage fluid assessment facilitates precision medicine for lung cancer

Cancer Biology & Medicine 2024年第3期21卷 230-251页

作者： Hantao Zhang Dan deng shujun Li Jing Ren Wei Huang Dan Liu Weiya Wang Department of Pathology West China HospitalSichuan UniversityChengdu 610000China West China Biobank West China HospitalSichuan UniversityChengdu 610000China Department of Respiratory and Critical Care Medicine Clinical Research Center for Respiratory DiseaseWest China HospitalSichuan UniversityChengdu 610000China

Lung cancer is the most common and fatal malignant disease worldwide and has the highest mortality rate among tumor-related causes of *** diagnosis and precision medicine can significantly improve the survival rate and prognosis of lung cancer *** present,the clinical diagnosis of lung cancer is challenging due to a lack of effective non-invasive detection methods and biomarkers,and treatment is primarily hindered by drug resistance and high tumor *** biopsy is a method for detecting circulating biomarkers in the blood and other body fluids containing genetic information from primary tumor *** lavage fluid(BALF)is a potential liquid biopsy medium that is rich in a variety of bioactive substances and cell *** contains information on the key characteristics of tumors,including the tumor subtype,gene mutation type,and tumor environment,thus BALF may be used as a diagnostic supplement to lung *** this review,the current research on BALF in the diagnosis,treatment,and prognosis of lung cancer is *** advantages and disadvantages of different components of BALF,including cells,cell-free DNA,extracellular vesicles,and micro RNA are *** particular,the great potential of extracellular vesicles in precision diagnosis and detection of drug-resistant for lung cancer is *** addition,the performance of liquid biopsies with different body fluid sources in lung cancer detection are compared to facilitate more selective studies involving BALF,thereby promoting the application of BALF for precision medicine in lung cancer patients in the future.

关键词： Lung cancer bronchoalveolar lavage fluid extracellular vesicles liquid biopsy precision medicine

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Organic single-crystal light-emitting transistors with external quantum efficiency over 20%

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Aggregate 2023年第4期4卷 122-127页

作者： Jian deng Zejian Zhang Pengpeng Sang shujun Yin Shitong Zhang Yuan Li Bing Yang Cheng Gu Yuguang Ma State Key Laboratory of Luminescent Materials and Devices Institute of Polymer Optoelectronic Materials and DevicesSouth China University of TechnologyGuangzhouP.R.China School of Information Science and Engineering Shandong UniversityQingdaoP.R.China State Key Laboratory of Supramolecular Structure and Materials Institute of Theoretical ChemistryCollege of ChemistryJilin UniversityChangchunP.R.China Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates South China University of TechnologyGuangzhouP.R.China

Organic light-emitting transistors(OLETs)have attracted increasing attention because of their potential applications in next-generation displays and high-energy operating ***,the simultaneous achievement of high luminescent efficiency and carrier mobility in organic semiconductors remains challenging because the localized excitons are advantageous for light emission,whereas the delocalized carriers are beneficial for efficient charge ***,we report an organic single crystal of a cyano-substituted styrene derivative with balanced mobility yielding a record-high external quantum efficiency of 20.5%in ***-dependent I–V curves and electronic structure analyses based on firstprinciples calculations were performed to disclose the underlying mechanism as a band transport,which provides an efficient way to achieve high quantum efficiency in OLETs.

关键词： organic electronics organic light-emitting transistors single crystals styrene

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磁性介孔氧化锆载药体系的制备及其抗肺癌活性研究

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广东药科大学学报 2020年第2期36卷 205-209页

作者：彭延波叶昌邦陶灿邓淑君林洁柔许汇成卢焕俊刘冰赵平广东药科大学医药化工学院广东中山528458 广东药科大学药学院广东广州510006

目的建立安全有效的抗肿瘤药物运载和控释方法。方法采用化学包埋法,以超顺磁性Fe 3O 4纳米粒子为磁核、ZrO 2为壳层制备了MnO 2封堵的磁性氧化锆纳米微球,差量法研究该纳米微球对化疗药物道诺霉素的运载情况,并通过MTT法对其抗肺癌活... 详细信息

目的建立安全有效的抗肿瘤药物运载和控释方法。方法采用化学包埋法,以超顺磁性Fe 3O 4纳米粒子为磁核、ZrO 2为壳层制备了MnO 2封堵的磁性氧化锆纳米微球,差量法研究该纳米微球对化疗药物道诺霉素的运载情况,并通过MTT法对其抗肺癌活性进行评价。结果成功制备了磁性介孔氧化锆纳米微球并实现对道诺霉素的高效运载;载体浓度高达100μg/mL时,对A549细胞无明显生物毒性;载药纳米微球在8 mmmol/L谷胱苷肽中的缓释率较同浓度其他溶质高出8~10倍,显示出灵敏的谷胱苷肽刺激响应性;此外,载药纳米微球(IC 50为0.40 mmol/L)具有比自由道诺霉素(IC 50为0.68 mmol/L)更高的体外抗肺癌活性。结论二氧化锰封堵的磁性介孔氧化锆纳米体系在抗肿瘤药物的运载方面具有较大的应用潜力。

关键词：氧化锆二氧化锰载药体系谷胱苷肽刺激响应性抗肿瘤活性

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Efficacy and safety of chemotherapy combined with bevacizumab in Chinese patients with metastatic colorectal cancer:A prospective,multicenter,observational,non-interventional phaseⅣtrial

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Chinese Journal of Cancer Research 2021年第4期33卷 490-499页

作者： Fenghua Wang Guanghai Dai Yanhong deng Yong Tang Wei Wang Zuoxing Niu Feng Bi Liangjun Zhu Zengqing Guo Jin Yan Bing Hu Min Tao shujun Yang Suzhan Zhang Lu Wen Ruihua Xu Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060China Department of Medical Oncology Chinese PLA General HospitalBeijing 100853China Department of Medical Oncology the Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China Department of Medical Oncology Xinjiang Medical University Cancer HospitalUrumqi 830000China Department of Medical Oncology Foshan First People’s HospitalFoshan 528010China Department of Medical Oncology Shandong Cancer HospitalJinan 250117China Department of Medical Oncology West China Hospital of Sichuan UniversityChengdu 610041China Department of Medical Oncology Jiangsu Cancer HospitalNanjing 210009China Department of Medical Oncology Fujian Cancer HospitalFuzhou 350014China Department of Surgical Oncology Sichuan Cancer HospitalChengdu 610041China Department of Medical Oncology Anhui Provincial HospitalHefei 230001China Department of Medical Oncology the First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Medical Oncology Henan Cancer HospitalZhengzhou 450003China Department of Medical Oncology the Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009China Department of Medical Oncology Shanxi Provincial Cancer HospitalTaiyuan 030009China

Objective:Bevacizumab has an important and evolving role in improving outcomes in patients with metastatic colorectal cancer(mCRC)worldwide and was approved in China in ***,there are limited real-world data on the efficacy and safety of chemotherapy regimens combined with bevacizumab in Chinese patients with *** observational,phase IV trial study aimed to obtain more experience on the efficacy and safety of bevacizumab combined with chemotherapy in Chinese mCRC ***:Between September 2013 and November 2016,patients with histologically confirmed mCRC were enrolled in a prospective,multicenter,observational,non-interventional phase IV trial at 26 centers across *** patients received different chemotherapeutic regimens combined with *** efficacy and safety data in the intention-to-treat study population were ***:A total of 611 patients were included in the efficacy *** median overall survival and median progression-free survival was 18.00 and 10.05 months,*** objective response rate was 21.00%and disease control rate was 89.40%.In subgroup analyses,the survival differences were observed according to metastatic status,duration of treatment and elevation in blood pressure.A total of 613 patients were evaluable for safety *** 569(92.82%)patients reported at least one adverse event(AE),and 151(24.63%)experienced grade 3 or higher *** incidence of bevacizumab-associated AEs of special interest was reported in 31(5.06%)patients with hypertension(n=12),abscesses and fistulae(n=7),bleeding(n=6),proteinuria(n=3),gastrointestinal perforation(n=2)and venous thrombotic events(n=1).Conclusions:This observational phase IV trial broadens our experience and knowledge of bevacizumab in the Chinese population and provides a good indication of its overall efficacy and *** in combination with chemotherapy offers clinical benefits to Chinese patients with mCRC and has an acce

关键词： Metastatic colorectal cancer bevacizumab chemotherapy efficacy safety

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Enhanced protective immunity against SARS-CoV-2 elicited by a VSV vector expressing a chimeric spike protein

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Signal Transduction and Targeted Therapy 2021年第12期6卷 3697-3708页

作者： Hongyue Li Yuhang Zhang Dong Li Yong-Qiang deng Hongde Xu Chaoyue Zhao Jiandong Liu Dan Wen Jianguo Zhao Yongchun Li Yong Wu shujun Liu Jiankai Liu Junfeng Hao Fei Yuan Shuguang Duo Cheng-Feng Qin Aihua Zheng State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of Sciences100101 BeijingChina CAS Center for Excellence in Biotic Interactions University of Chinese Academy of Sciences100101 BeijingChina Shenzhen Kangtai Biotechnology Co.Ltd518106 ShenzhenGuangdongChina State Key Laboratory of Pathogen and Biosecurity Institute of Microbiology and EpidemiologyAcademy of Military Medical Sciences100071 BeijingChina School of Pharmaceutical Sciences Zhengzhou University450001 ZhengzhouHenanChina State Key Laboratory of Stem cell and Reproductive Biology Institute of ZoologyChinese Academy of Sciences100101 BeijingChina Division of Animal Model Research Institute for Laboratory Animal ResourcesNational Institutes for Food and Drug Control102629 BeijingChina Laboratory Animal Center Institute of ZoologyChinese Academy of Sciences100101 BeijingChina Core Facility for Protein Research Institute of BiophysicsChinese Academy of Sciences100101 BeijingChina College of Life Science Henan Normal University453007 XinxiangChina

SARS-CoV-2 and SARS-CoV are genetically related coronavirus and share the same cellular receptor *** replacing the VSV glycoprotein with the spikes(S)of SARS-CoV-2 and SARS-CoV,we generated two replication-competent recombinant viruses,rVSVSARS-CoV-2 and *** wild-type and human ACE2(hACE2)knock-in mouse models,we found a single dose of rVSV-SARS-CoV could elicit strong humoral immune response via both intranasal(i.n.)and intramuscular(i.m.)*** the high genetic similarity between SARS-CoV-2 and SARS-CoV,no obvious cross-neutralizing activity was observed in the immunized mice *** macaques,neutralizing antibody(NAb)titers induced by one *** of rVSV-SARS-CoV-2 were eight-fold higher than those by a single ***,our data indicates that rVSV-SARS-CoV-2 might be suitable for *** instead of the traditional *** in *** rVSV-SARS-CoV elicited significantly stronger NAb responses than rVSV-SARS-CoV2 in a route-independent manner,we generated a chimeric antigen by replacing the receptor binding domain(RBD)of SARS-CoV S with that from the *** expressing the chimera(rVSV-SARS-CoV/2-RBD)induced significantly increased NAbs against SARS-CoV-2 in mice and macaques than rVSV-SARS-CoV-2,with a safe Th1-biased *** immunized with rVSV-SARS-CoV/2-RBD showed no cross-reactivity with ***2 mice receiving a single *** of either rVSV-SARS-CoV-2 or rVSV-SARSCoV/2-RBD were fully protected against SARS-CoV-2 challenge without obvious lesions in the *** results suggest that transplantation of SARS-CoV-2 RBD into the S protein of SARS-CoV might be a promising antigen design for COVID-19 vaccines.

关键词： ACE2 immunity protective

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基于泥石流危险性的拦挡坝减灾效益评价方法

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自然灾害学报 2024年第2期33卷 46-53页

作者：田述军程小松邓志银西南科技大学土木工程与建筑学院四川绵阳621010

实现泥石流拦挡坝减灾效益定量评价对于优化工程设计和保护人民生命财产安全具有重要的理论意义和实践意义。采用数值模拟方法获取不同工况下泥石流泥深、流速和范围,建立了基于高危险等级面积和总危险度的2种危险性评价指标体系,提出... 详细信息

实现泥石流拦挡坝减灾效益定量评价对于优化工程设计和保护人民生命财产安全具有重要的理论意义和实践意义。采用数值模拟方法获取不同工况下泥石流泥深、流速和范围,建立了基于高危险等级面积和总危险度的2种危险性评价指标体系,提出了拦挡坝减灾效益的定量评价方法,并以锄头沟泥石流为例进行了实证研究。根据拦挡坝减灾效益评价方法可以分析拟建工程和现有工程及其组合的减灾效益,判断其是否达到了减灾目标,并可对比和量化不同工程在减灾方面的重要程度,可为泥石流拦挡坝修建及改良提供依据和参考。单位高度减灾效益能够反映拦挡坝增加单位高度所带来的减灾效果,可应用于泥石流拦挡坝设计、改良和最佳工程组合方案的确定。总危险度与高危险等级面积的减灾效益变化规律一致,说明2种危险性评价方式均可体现拦挡坝组合及其变化的减灾效益。

关键词：泥石流拦挡坝数值模拟减灾效益锄头沟

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Crucial control measures to contain China's first Delta variant outbreak

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National Science Review 2022年第4期9卷 41-50页

作者： Lei Luo Zifeng Yang Jingyi Liang Yu Ma Hui Wang Chitin Hon Mei Jiang Zhengshi Lin Wenda Guan Zhitong Mai Yongming Li Kailin Mai Zhiqi Zeng Chuanmeizi Tu Jian Song Bin Liu Yong Liu Jianfeng He Huiyuan Li Bosheng Li Hang Dong Yutian Miao shujun Fan Lirui Fan Xingyi Liang Ke Li Chun Chen Huihong deng Zhicong Yang Nanshan Zhong Institute of Public Health Guangzhou Medical University & Guangzhou Center for Disease Control and Prevention Guangzhou Key Laboratory for Clinical Rapid Diagnosis and Early Warning of Infectious Diseases Department of Urban and Rural Planning Shunde Urban and Rural Planning Information Research Center Guangzhou Laboratory Bio-Island State Key Laboratory of Quality Research in Chinese Medicine Macau Institute for Applied Research in Medicine and HealthMacau University of Science and Technology Kingmed Virology Diagnostic & Translational Center Guangzhou Kingmed Center for Clinical Laboratory Co.Ltd State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical University Guangdong Center for Disease Control and Prevention Macau Institute of Systems Engineering Macau University of Science and Technology

The SARS-C oV-2 B.1.617.2(Delta) variant flared up in late May in Guangzhou,*** characteristics of Delta variant were analysed for 153 confirmed cases and two complete transmission chains with seven generations were fully presented.A rapid transmission occurred in five generations within10 *** basic reproduction number(R) was 3.60(95% confidence interval:2.50-5.30).After redefining the concept of close contact,the proportion of confirmed cases discovered from close contacts increased from 43% to 100%.With the usage of a yellow health code,the potential exposed individuals were self-motivated to take a nucleic acid test and regained public access with a negative testing *** the massive requirement of screening,novel facilities like makeshift inflatable laboratories were promptly set up as a vital supplement and 17 cases were found,with 1 *** dynamic adjustment of these three interventions resulted in the decline of Rt from 5.00 to 1.00 within 9 *** breaking the transmission chain and eliminating the transmission source through extending the scope of the close-contact tracing,health-code usage and mass testing,the Guangzhou D elta epidemic was effectively contained.

关键词： COVID-19 public health control measure close contact mass testing

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列宁新经济政策思想中国化的历史轨迹及当代发展

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理论学刊 2017年第2期 28-33页

作者：靳书君广西师范大学马克思主义学院广西桂林541004

列宁新经济政策理论与实践的核心,是将市场纳入了社会主义范畴,这对中国共产党人产生了深远的影响。经过陈独秀、刘少奇、张闻天、毛泽东,特别是从邓小平到习近平的接续探索,列宁新经济政策在中国的历史定位发生了变化,由新经济政策措... 详细信息

列宁新经济政策理论与实践的核心,是将市场纳入了社会主义范畴,这对中国共产党人产生了深远的影响。经过陈独秀、刘少奇、张闻天、毛泽东,特别是从邓小平到习近平的接续探索,列宁新经济政策在中国的历史定位发生了变化,由新经济政策措施逐步上升为新经济政策战略、新经济政策体制、新经济政策道路,在新时期则系统回答了市场与社会主义的关系,发展为新经济政策理论。几代中国共产党人的艰辛探索,勾画出列宁新经济政策思想中国化的历史轨迹。

关键词：列宁新经济政策中国化中国特色社会主义

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海拉尔盆地复杂岩性储层的产能预测

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大庆石油地质与开发 2014年第2期33卷 158-160页

作者：邓刚刘传平殷树军中国科学院地质与地球物理研究所北京100029 大庆油田有限责任公司开发部黑龙江大庆163453 大庆油田有限责任公司勘探开发研究院黑龙江大庆163712

海拉尔盆地储层岩性复杂,不仅孔隙度、渗透率的相关性差,而且有效厚度与产能匹配差.为了合理规划产能,应用测井资料进行了单井产能预测研究.首先,采用频率累积法对储层物性进行分类,在岩电实验的基础上采用变参数法确定了胶结指数;然后... 详细信息

海拉尔盆地储层岩性复杂,不仅孔隙度、渗透率的相关性差,而且有效厚度与产能匹配差.为了合理规划产能,应用测井资料进行了单井产能预测研究.首先,采用频率累积法对储层物性进行分类,在岩电实验的基础上采用变参数法确定了胶结指数;然后,应用测井资料确定了复杂岩性储层的含油性,再结合储层物性建立了油层分类标准.采用厚度加权法预测的单井产能与实际生产情况比较吻合.

关键词：低渗透胶结指数油层分类产能预测

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天然气水合物生成及分解的工艺流程设计

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天然气工业 2006年第3期26卷 134-137页

作者：付越陈树军陈保东邓子龙辽宁石油化工大学机械工程学院上海交通大学制冷及低温工程研究所

天然气水合物技术可显著降低天然气储运费用,提高天然气储运的经济性和安全性,受到了工业界的普遍重视,而设计研究高效的水合物生产工艺则是其工业化应用的基础。目前的天然气水合物工艺流程普遍存在着投资大、生产效率低、经济性差的... 详细信息

天然气水合物技术可显著降低天然气储运费用,提高天然气储运的经济性和安全性,受到了工业界的普遍重视,而设计研究高效的水合物生产工艺则是其工业化应用的基础。目前的天然气水合物工艺流程普遍存在着投资大、生产效率低、经济性差的缺点。为此,从水合物的基本组成出发,从降低能耗、优化水合物生成及分解的温度与压力、提高生成及分解的反应速率等方面对流程进行了设计:进入水合物反应釜前,水和天然气各自以一条支路流动;水从上支路泵入反应釜,而天然气则从下支路喷入反应釜;反应釜内温度控制为10℃,压力控制为5MPa。综合考虑了各种分解方法的优缺点,选用加注热水法作为水合物分解的激发方式。该流程是专为固态天然气储运技术而开发的,具有成本低廉,可以高效连续制备、分解固体天然气等优点。

关键词：天然气水合物生成分解工艺流程天然气输送

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