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Monoacylglycerol lipase inhibitors: modulators for lipid metabolism in cancer malignancy,neurological and metabolic disorders

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Acta Pharmaceutica Sinica B 2020年第4期10卷 582-602页

作者： hui deng Weimin Li Precision Medicine Key Laboratory of Sichuan Province&Precision Medicine Center West China HospitalSichuan UniversityChengdu 610041China

Monoacylglycerol lipase(MAGL)is a serine hydrolase that plays a crucial role catalysing the hydrolysis of monoglycerides into glycerol and fatty *** links the endocannabinoid and eicosanoid systems together by degradation of the abundant endocannabinoid 2-arachidaoylglycerol into arachidonic acid,the precursor of prostaglandins and other inflammatory *** inhibitors have been considered as important agents in many therapeutic fields,including anti-nociceptive,anxiolytic,antiinflammatory,and even ***,ABX-1431,a first-in-class inhibitor of MAGL,is entering clinical phase 2 studies for neurological disorders and other *** review summarizes the diverse(patho)physiological roles of MAGL and will provide an overview on the development of MAGL *** a large number of MAGL inhibitors have been reported,novel inhibitors are still required,particularly reversible ones.

关键词： Monoacylglycerol lipases 2-Arachidaoylglycerol Arachidonic acid Drug discovery Cancer Neuroinflammation Metabolic syndrome

Durability classification of red beds rocks in central Yunnan based on particle size distribution and slaking procedure

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Journal of Mountain Science 2019年第3期16卷 714-724页

作者： ZHU Jun-jie deng hui State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of Technology

Moisture induced disintegration of soft rock in Red Beds is common all over the world. The slake durability index test is most useful to quantify durability of the soft rocks. Based on a series of slaking test, this article aims to develop a durability classification involving particle size and slaking procedure. To describe the slaking procedure in detail,the Relative Slake Durability Index(Id_i) is proposed. The Id_i is the percentage ratio of the i^(th) weight of oven-dry retained portion to the(i-1)^(th) weight of ovendry retained portion. Results show that the Id_i of samples have a large difference in certain slaking procedure, whereas the traditional Durability Slake Index(Id) is almost constant. Considering this limitation of Id in durability classification, an advanced classification by applying the Id_i and disintegration ratio(DR) is further established in this article. Compared to the durability classification based on Slake Durability Index(Id), the new classification accounts for the particle size of the slaked material and the slaking procedure, so it provides a better measure of the degree of slaking. The classification recommended in this article divide the slake durability into three classes(i.e., low, medium and high class). Furthermore, it divides both the low class and the medium class into 3 subclasses.

关键词： Slaking test Durability classification Relative durability index Durability index Disintegrate rate

Periodic variation and phase analysis of grouped solar flare with sunspot activity

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Research in Astronomy and Astrophysics 2020年第2期20卷 75-84页

作者： hui deng Ying Mei Feng Wang Center For Astrophysics Guangzhou UniversityGuangzhou 510006China CAS Key Laboratory of Solar Activity National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Kunming University of Science and Technology Kunming 650051China

Studies on the periodic variation and the phase relationship between different solar activity indicators are useful for understanding the long-term evolution of solar activity *** we report the statistical analysis of grouped solar flare(GSF) and sunspot number(SN) during the time interval from January 1965 to March *** find that,(1) the significant periodicities of both GSF and SN are related to the differential rotation periodicity,the quasi-biennial oscillation(QBO),and the eleven-year Schwabe cycle(ESC),but the specific values are not absolutely identical;(2) the ESC signal of GSF lags behind that of SN with an average of 7.8 months during the considered time interval,which implies that the systematic phase delays between GSF and SN originate from the inter-solar-cycle *** results may provide evidence about the storage of magnetic energy in the corona.

关键词： Sun:sunspots Sun:flares Sun:activity Sun:magnetic fields

A novel solar cell fabricated with spiral photo-electrode for capturing sunlight 3-dimensionally

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Science China(Technological Sciences) 2006年第6期49卷 663-673页

作者： LIU Yong SHEN hui deng Youjun Institute for Solar Energy Systems State Key Lab of Optoelectronic Materials and Technologies Sun Yat-sen University Guangzhou 510275 China Institute for Solar Energy Systems State Key Lab of Optoelectronic Materials and Technologies Sun Yat-sen University Guangzhou 510275 China Institute for Solar Energy Systems State Key Lab of Optoelectronic Materials and Technologies Sun Yat-sen University Guangzhou 510275 China

A novel solar cell fabricated with spiral photo-electrode for capturing sunlight 3-dimensionally (3D-cell) is proposed in this paper. We studied its performance both in solar simulator and in nature sunlight. Spiral photo-electrode of 3D-cell can receive sunlight from all directions and therefore can track the sun passively. And it is much insensitive to solar azimuth angle and shade. In addition, it increases the area to obtain scattered sunlight and reflected light. Compared with the dye-sensitized solar cells using sandwich structure, it would be more advantageous in the sealing technique.

关键词： solar cell, Titania, dye-sensitized, nanocrystalline, solar to electronic conversion efficiency.

Application of Stochastic Resonance Signal Recovery

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Chinese Journal of Mechanical Engineering 2009年第4期22卷 542-549页

作者： ZHANG Ying WANG Taiyong LENG Yonggang deng hui Tianjin Key Laboratory of Advanced Manufacturing Technologies and Equipments Tianjin University Tianjin 300072 China School of Mechanical Engineering Tianjin University Tianjin 300072 China Textiles School Tianjin Polytechnic University Tianjin 300160 China

Stochastic resonance（SR） enhances the nonlinear system behavior with the assistance of noise, including the sensitivity and selectivity of the response to the exterior stimulus. The energy-transfer mechanism makes the weak information revealed in the output spectrum, while the time-waveform is distorted. The distortion analysis was made both from the particle＇s dynan-fics and signal processing. The factors causing the deviation in the output are presented and the function of the recovery system is proposed. By the investigation of the particle＇s motion track in the bistable system and the suggested recovery system, the influences of noise and system parameters on the recovery course were discussed. Moreover, the pulse distortion appearing the recovery waveform caused by the particle＇s transitions at the bistable potential＇ inflexions was explained. Due to different characteristics, cascaded-bistable SR or mono-stable SR was introduced to process different types of signals. The final recovery signal is just the suggested recovery system＇s response to the SR output. Meanwhile, the recovery system is optional, as parameter-tuned or parameter-fixed. Since the method requires no average processing, it is applicable to a single sample with limited length. The numerical simulations reveal that the SR recovery method can recover the waveform containing weak information submerged ha noise effectively. The engineering application to the vibration analysis of metal cutting chose the combination of mono-stable SR and the parameter-fixed recovery system. Because the optimal SR state is not required strongly, the system parameters are tuned in a wider range than the traditional SR processing methods.

关键词： bistable stochastic resonance signal recovery cascaded-bistable system parameter-tuning noise

Dyes adsorption using a synthetic carboxymethyl cellulose-acrylic acid adsorbent

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Journal of Environmental Sciences 2014年第5期26卷 1203-1211页

作者： Genlin Zhang Lijuan Yi hui deng Ping Sun School of Chemistry and Chemical Engineering Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan Shihezi University

Removal of noxious dyes is gaining public and technological attention. Herein grafting polymerization was employed to produce a novel adsorbent using acrylic acid and carboxymethyl cellulose for dye removal. Scanning electron microscopy and Fourier-transform infrared spectroscopy verified the adsorbent formed under optimized reaction conditions. The removal ratio of adsorbent to Methyl Orange, Disperse Blue 2BLN and malachite green chloride reached to 84.2%, 79.6% and 99.9%, respectively. The greater agreement between the calculated and experimental results suggested that pseudo second-order kinetic model better represents the kinetic adsorption data. Equilibrium adsorptions of dyes were better explained by the Temkin isotherm. The results implied that this new cellulose-based absorbent had the universaiity for removal of dyes through the chemical adsorption mechanism.

关键词： adsorption dye grafting polymerization carboxymethyl cellulose acrylic acid

Isotropic Tuning of Electrochemical Etching forthe Nanometric Finishing of Metals

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Nanomanufacturing and Metrology 2022年第3期5卷 283-296页

作者： Rong Yi Zejin Zhan hui deng Department of Mechanical and Energy Engineering Southern University of Science and TechnologyNo.1088Xueyuan RoadShenzhen 518055GuangdongChina

Isotropic etching polishing(IEP)based on the merging of isotropic etch pits has been proposed as a generic metal finishing *** this work,the tuning of the etching isotropy of various metals,which is the key to realizing the finishing effect of IEP,is studied by theoretical analysis and etching *** isotropic etching of various metals can be realized through mass transfer polarization by adjusting the electrochemical *** addition of sulfuric acid in the electrolyte is the most effective for tuning the isotropy of electrochemical *** can decrease the diffusion coefficient of metal ions,thereby increasing the resistance of mass transfer and transforming the electrochemical dissolution of metal into mass transfer *** this study,the atomic and close-to-atomic scale surface finishing of various metals and alloys has been successfully achieved through isotropic *** etching at a current of 1.5 A for 3 min,the surface Sa roughness of TA2 is drastically reduced from 242 to 3.98 *** etching for 1 min at a current of 3 A,the surface Sa roughness of pure tungsten,NiTi,and CoCrNi decreases from 9.33,76.4,and 37.6 nm,respectively,to 1.16,2.01,and 2.51 nm,respectively.

关键词： ACSM Metal finishing Isotropic etching polishing Electrochemical polishing

Reactivation of a huge ancient landslide by surface water infiltration

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Journal of Mountain Science 2019年第4期16卷 806-820页

作者： TU Guo-xiang HUANG Da deng hui State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of Technology School of Civil and Transportation Engineering Hebei University of Technology

An ancient landslide, situated in Deqin County, Yunnan Province, China, was used to investigate the reactivation by water infiltration. This study considers the infiltration process and landslide stability using finite-element method(FEM)-based models. The results show that the reactivation of old landslide deposit was triggered by the long-term leakage of diversion ditch before October 2012, and the reactivation was triggered again by the intense rainfall on 7-9 October 2012. The old cracks, which formed in the earlier reactivation of landslide, played a key role for the rainfall infiltration. They offered a preferential path for much more rainfall to infiltrate fast into deep soil, and caused wetting front to move down faster in landslide. The old slip zone with lower permeability was another important factor to cause the infiltrated water to accumulate and form a high pore water pressure above slip zone. Then the high pore water pressure decreased the shear strength of slip zone and triggered the reactivation of the old landslide deposit again.

关键词： Landslide Rainfall infiltration Soil stability Finite-element-method Leakage of diversion ditch

Hantavirus Infection during Pregnancy

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Virologica Sinica 2021年第3期36卷 345-353页

作者： deng-hui Lu Hong Jiang Jian-Qi Lian The Center of Diagnosis and Treatment of Infectious Diseases The Second Affiliated HospitalAir Force Medical UniversityXi'an 710038China

Hantavirus infection is a global health challenge,causing widespread public *** recent years,cases of hantavirus infection in pregnant women have been reported in many *** infected pregnant women and their fetuses appear to have more severe clinical symptoms and worse clinical ***,to study the prevalence of hantavirus infection in pregnant women,this study will focus on the epidemiological distribution of the virus,different virus species penetrating the placental barrier,and factors affecting the incidence and clinical outcome of the infection in pregnant women and their *** addition,this review will also discuss the diagnostic tools and treatments for pregnant patients and provide an overview of the relevant future research.

关键词： Hantavirus Pregnancy Hantaan virus(HTNV) HPS HFRS