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Qinghua decoction(清化饮)improves chronic nonbacterial prostatitis possibly via regulating the chromogranin A/nerve growth factor/tyrosine kinase A signaling pathway mediated by inflammatory factors

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中医杂志:英文版 2023年第4期43卷 695-703页

作者： HAN Yunpeng YU Wentao ZHANG Ying XU Huazhou deng guoxing FANG Chaoyi School of Basic Medical Sciences Hebei University of Chinese MedicineShijiazhuang 050200China Hebei Key Laboratory of Integrated Chinese and Western Medicine for Lung Disease Research Shijiazhuang 050091China

OBJECTIVE:To explore the mechanism by which Qinghua decoction(清化饮)regulates neuroendocrine inflammation in chronic nonbacterial prostatitis(CNP)model rats and provide an experimental basis for clinical treatment.METHODS:The rats were randomly divided into six groups:normal control,model,Qianlie Tongyu capsule,low-dose Qinghua decoction,medium-dose Qinghua decoction,and high-dose Qinghua decoction group with six rats in each group.Rats in each group were sacrificed on the 29th day of treatment,and blood and prostate tissues were collected.Serum levels of tumor necrosis factor-alpha and interleukins 1-beta,6,8,and 10(TNF-αand IL-1β,-6,-8,and-10,respectively)were measured using enzyme-linked immunosorbent assay.The pathological changes in the rat prostate tissue in each group were observed under a light microscope.The expression levels of chromogranin A(CgA),nerve growth factor(NGF),and tyrosine kinase A(TrkA)were detected using reverse transcription quantitative polymerase chain reaction.Western blotting was used to detect protein expression of CgA,NGF,and TrkA.RESULTS:In the model group,the prostate capsule membrane and stroma were significantly dilated with more inflammatory cells infiltrating the stroma and perivessels.TNF-α,IL-1β,-6,and-8,CgA,NGF,and TrkA levels increased,whereas the content of IL-10 decreased,which was statistically significant compared to that in the normal control group(P<0.05).Prostate tissue cells in the high-dose group were neatly arranged with no obvious inflammatory cell infiltration.When compared with the model group,the high-dose Qinghua decoction group showed a significant improvement in these indices(P<0.05).CONCLUSION:Qinghua decoction led to inhibition of pathological changes in the prostate tissue of rats with CNP,regulation of inflammatory cytokine expression,and inhibition in the expression of CgA,NGF,and TrkA.This mechanism may be primarily related to regulation of the CgA/NGF/TrkA signaling pathway mediated by various inflammatory factors.

关键词： inflammation interleukins chromogranin A nerve growth factor chronic nonbacterial prostatitis Qinghua decoction

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化肥减量配施有机肥对植烟土壤理化特性和微生物群落结构的影响

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华北农学报 2024年第3期39卷 146-158页

作者：孙子隽钟国兴张少搏杨欣彭金良郭维梁耀星李淮源白云峰陈建军邓世媛华南农业大学烟草研究室广东广州510642 湖南省烟草公司衡阳市公司湖南衡阳421000 广东中烟工业有限责任公司广东广州510610 华南农业大学基础实验与实践训练中心广东广州510642

探究化肥减量配施有机肥对植烟土壤理化性质和微生物群落结构的影响,为烟草生产上肥料减量和有机肥的合理施用提供理论参考。以常规施肥不配施有机肥为对照(CK),采用Illumina高通量测序技术,结合生物信息学,分析化肥减量10%(T1)、化肥减... 详细信息

探究化肥减量配施有机肥对植烟土壤理化性质和微生物群落结构的影响,为烟草生产上肥料减量和有机肥的合理施用提供理论参考。以常规施肥不配施有机肥为对照(CK),采用Illumina高通量测序技术,结合生物信息学,分析化肥减量10%(T1)、化肥减量10%+芝麻饼肥(T2)、化肥减量10%+腐殖酸肥(T3)、化肥减量10%+芝麻饼肥+腐殖酸肥(T4)等不同处理下土壤理化性质和微生物群落结构的变化特征。结果表明,与CK相比,T1处理的植烟土壤养分含量和土壤酶活性均下降、土壤物理特性略有改善,配施有机肥使土壤养分和物理特性得到进一步改善,容重降低、含水率和孔隙度增加,T2和T4处理的有效磷、速效钾含量显著高于CK和T1处理,所有配施有机肥处理的土壤酶活性均显著增加。配施有机肥增加了植烟土壤中的细菌和真菌门类,其中优势细菌门类均为变形菌门和放线菌门,其次是厚壁菌门、拟杆菌门、绿弯菌门、酸杆菌门,优势真菌门类为子囊菌门、子囊菌门盘菌亚门、被孢霉门、绿藻门、纤毛虫门、担子菌门。Alpha多样性指数表明,化肥减量降低了微生物群落的丰富度,但配施有机肥处理增加了细菌和真菌群落多样性指数,其中细菌群落丰富度提高更明显。RDA分析表明,影响土壤微生物群落结构与多样性的重要土壤理化因子包括有机质、速效钾、碱解氮、有效磷和土壤物理特性等,相对而言土壤理化因子对细菌群落结构的影响更大。综上,化肥减量配施有机肥对土壤养分、物理特性、土壤酶活性及微生物群结构有显著改善效果,尤其以同时配施芝麻饼肥和腐殖酸肥处理的效果更佳。

关键词：烟草化肥减量有机肥植烟土壤理化特性微生物群落结构

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鲜余甘子干燥过程化学成分变化规律研究

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今日药学 2024年第1期34卷 13-17,39页

作者：邓桂珠卢泳甘国兴朱卫星向燕芬龙国斌臧艳红黄晶清远市中医院广东清远511500 广东省鲜药民族医药工程技术研究中心广东清远511500 惠州市中医医院广东惠州516000

目的研究鲜余甘子干燥过程化学成分的变化规律。方法采用HPLC法测定鲜余甘子干燥过程芦丁、没食子酸、柯里拉京和鞣花酸的含量,并进行比较分析。结果温度≤70℃时,随着干燥时间延长,鲜余甘子中芦丁、柯里拉京和鞣花酸含量缓慢增加;温度... 详细信息

目的研究鲜余甘子干燥过程化学成分的变化规律。方法采用HPLC法测定鲜余甘子干燥过程芦丁、没食子酸、柯里拉京和鞣花酸的含量,并进行比较分析。结果温度≤70℃时,随着干燥时间延长,鲜余甘子中芦丁、柯里拉京和鞣花酸含量缓慢增加;温度≥80℃时,随着干燥时间延长,鲜余甘子中芦丁和鞣花酸含量快速增加。结论在干燥过程中,鲜余甘子芦丁、没食子酸、柯里拉京和鞣花酸含量随干燥时间延长而呈现增加趋势,增加速率和幅度受温度影响,温度越高其增加速率和幅度越大。可为鲜余甘子的干燥工艺提供参考。

关键词：鲜余甘子干燥过程化学成分变化规律

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Malus-metasurface-assisted polarization multiplexing

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Light(Science & Applications) 2020年第1期9卷 1038-1046页

作者： Liangui deng Juan deng Zhiqiang Guan Jin Tao Yang Chen Yan Yang Daxiao Zhang Jibo Tang Zhongyang Li Zile Li Shaohua Yu guoxing Zheng Hongxing Xu Cheng-Wei Qiu Shuang Zhang Electronic Information School Wuhan University430072 WuhanChina NOEIC State Key Laboratory of Optical Communication Technologies and NetworksWuhan Research Institute of Posts&Telecommunications430074 WuhanChina School of Physics and Technology Wuhan University430072 WuhanChina Department of Electrical and Computer Engineering National University of Singapore4 Engineering Drive 3Singapore 117583Singapore Integrated Circuit Advanced Process Center Institute of MicroelectronicsChinese Academy of Sciences100029 BeijingChina School of Physics&Astronomy University of BirminghamBirmingham B152TTUK

Polarization optics plays a pivotal role in diffractive,refractive,and emerging flat optics,and has been widely employed in contemporary optical industries and daily life.Advanced polarization manipulation leads to robust control of the polarization direction of light.Nevertheless,polarization control has been studied largely independent of the phase or intensity of light.Here,we propose and experimentally validate a Malus-metasurface-assisted paradigm to enable simultaneous and independent control of the intensity and phase properties of light simply by polarization modulation.The orientation degeneracy of the classical Malus’s law implies a new degree of freedom and enables us to establish a one-to-many mapping strategy for designing anisotropic plasmonic nanostructures to engineer the Pancharatnam–Berry phase profile,while keeping the continuous intensity modulation unchanged.The proposed Malus metadevice can thus generate a near-field greyscale pattern,and project an independent far-field holographic image using an ultrathin and single-sized metasurface.This concept opens up distinct dimensions for conventional polarization optics,which allows one to merge the functionality of phase manipulation into an amplitudemanipulation-assisted optical component to form a multifunctional nano-optical device without increasing the complexity of the nanostructures.It can empower advanced applications in information multiplexing and encryption,anti-counterfeiting,dual-channel display for virtual/augmented reality,and many other related fields.

关键词： optics enable unchanged

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Spatial effect of environmental regulation measures on industrial structure upgrading from the empirical analysis of Beijing-Tianjin-Hebei region and its surrounding areas

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Chinese Journal of Population,Resources and Environment 2019年第3期17卷 267-277页

作者： guoxing Zhang Peide Zhang Nana deng Haixu Bao Jiexun Li School of Management Lanzhou UniversityLanzhouChina Department of Decision Sciences Western Washington UniversityBellinghamWAUSA

This paper investigates the spatial effect of environmental regulation measures on the upgrading of industrial structure in the integrated development strategy of Beijing-Tianjin-Hebei region and its surrounding areas.In order to reflect the effect of the environmental regulation and different regulation measures more truly,this paper constructs indices of the environmental regulation measures through the results of policy texts quantification.On the basis of the previous research,this paper divides environmental regulation into the following types:personnel and administrative measures of command and control;market-oriented fiscal,taxation,financial and other economic measures;guidance measures.Spatial panel regression results show that administrative measures of command control and market-oriented fiscal measures have a significant role in promoting regional industrial structure upgrading,but not conducive to the advancement of the industrial structure of adjacent areas.Their roles in promoting and inhibition are counteracted,which causes the total effect of industrial structure upgrading of Beijing-Tianjin-Hebei and the surrounding areas are not significant.Personnel measures,financial measures,other economic measures and guidance measures do not have the short-term effect and spatial effect on the upgrading of industrial structure.

关键词： Beijing-Tianjin-Hebei and its surrounding areas policy quantification environmental regulatory measures upgrading of industrial structure

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补阳还五汤对大鼠脑缺血再灌注损伤后脑组织铁转运相关蛋白的影响

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中华中医药杂志 2023年第11期38卷 5231-5236页

作者：陈娟暴军张颖邓国兴河北中医药大学石家庄050200

目的:观察补阳还五汤对大鼠脑缺血再灌注损伤后脑组织铁转运相关蛋白表达及铁死亡的影响。方法:32只雄性SD大鼠随机分为假手术组、模型组、依达拉奉组和补阳还五汤组,每组8只。除假手术组外,其他组均建立大鼠大脑中动脉阻塞(MCAO)模型... 详细信息

目的:观察补阳还五汤对大鼠脑缺血再灌注损伤后脑组织铁转运相关蛋白表达及铁死亡的影响。方法:32只雄性SD大鼠随机分为假手术组、模型组、依达拉奉组和补阳还五汤组,每组8只。除假手术组外,其他组均建立大鼠大脑中动脉阻塞(MCAO)模型。除假手术组外,其余3组均于术前7 d和再灌注后连续3 d分别给予等量0.9%氯化钠溶液、依达拉奉腹腔注射,补阳还五汤颗粒剂灌胃,每日1次。采用TTC染色检测各组大鼠脑梗死面积,HE染色和尼氏染色观察缺血侧海马CA3区病理组织形态变化,免疫组织化学法观察缺血侧海马CA3区Fn、Tf、TfR、FPN1蛋白表达情况,Western Blot法检测铁死亡相关蛋白Nrf2、HO-1、GPX4蛋白表达情况。结果:与模型组比较,补阳还五汤组脑梗死面积显著减小(P<0.01),尼氏小体计数显著增多(P<0.05),病理损伤减轻,Tf、TfR、Fn蛋白表达显著降低(P<0.05),FPN1、Nrf2、HO-1和GPX4蛋白表达显著升高(P<0.05)。结论:补阳还五汤通过调节脑缺血再灌注损伤大鼠缺血侧海马CA3区铁转运蛋白的表达,调控Nrf2/HO-1/GPX4信号通路,减轻脑缺血损伤。

关键词：补阳还五汤脑缺血再灌注损伤铁超载转铁蛋白铁死亡

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Prediction and Optimization of the Thermal Properties of TiO_(2)/Water Nanofluids in the Framework of a Machine Learning Approach

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Fluid Dynamics & Materials Processing 2023年第8期19卷 2181-2200页

作者： Jiachen Li Wenlong deng Shan Qing Yiqin Liu Hao Zhang Min Zheng Sate Key Laboratory of Complex Nonferrous Clean Utilization Kunming University of Science and TechnologyKunming650093China Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming650093China Jiangxi guoxing Intelligent Energy Co. Ganzhou330300China Faculty of Media and Information Engineering Yunnan Open UniversityKunming650500China

In this study,comparing multiple models of machine learning,a multiple linear regression(MLP),multilayer feed-forward artificial neural network(BP)model,and a radial-basis feed-forward artificial neural network(RBF-BP)model are selected for the optimization of the thermal properties of TiO_(2)/water nanofluids.In particular,the least squares support vector machine(LS-SVM)method and radial basis support vector machine(RB-SVM)method are implemented.First,curve fitting is performed by means of multiple linear regression in order to obtain bivariate correlation functions for thermal conductivity and viscosity of the nanofluid.Then the aforementioned models are used for a predictive analysis of the dependence of its thermal conductivity and viscosity on temperature and volume fraction.The results show that the least squares support vector machine(LS-SVM)has a prediction accuracy higher than the other models.The model predicts the thermal conductivity of TiO_(2)/water MSE=1.0853×10^(-6),R2=0.99864,MAE=0.00092,RMSE=0.00104,and the viscosity of TiO_(2)/water MSE=8.1397×10^(-6),R2=0.99995,MAE=0.00074,RMSE=0.0009.

关键词： Nanofluids viscosity thermal conductivity machine learning predictive modeling

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Zero-order-free meta-holograms in a broadband visible range

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Photonics Research 2020年第5期8卷 723-728页

作者： RAO FU LIANGUI deng ZHIQIANG GUAN SHENG CHANG JIN TAO ZILE LI guoxing ZHENG Electronic Information School Wuhan UniversityWuhan 430072China NOEIC State Key Laboratory of Optical Communication Technologies and NetworksWuhan Research Institute of Posts and TelecommunicationsWuhan 430074China School of Physics and Technology Center for Nanoscience and Nanotechnologyand Key Laboratory of Artificial Micro-and Nano-structures of Ministry of EducationWuhan UniversityWuhan 430072China

The unwanted zero-order light accompanied by the birth of diffractive optical elements and caused mainly by fabrication errors and wavelength variations is a key factor that deteriorates the performance of diffraction-related optical devices such as holograms,gratings,beam shapers,beam splitters,optical diffusers,and diffractive microlenses.Here,inspired by the unique characteristic of nano-polarizer-based metasurfaces for both positive and negative amplitude modulation of incident light,we propose a general design paradigm to eliminate zero-order diffraction without burdening the metasurface design and fabrication.The experimentally demonstrated metahologram,which projects a holographic image with a wide angle of 70°×70°in the for field,presents a very low zero-order intensity(only 0.7%of the total energy of the reconstructed image).More importantly,the zero-orderfree meta-hologram has a large tolerance limit for wavelength variations(under a broadband illumination from520 to 660 nm),which brings important technical advances.The strategy proposed could significantly relieve the fabrication difficulty of metasurfaces and be viable for various diffractive-optics-related applications includingholography,laser beam shaping,optical data storage,vortex beam generation,and so on.

关键词： visible illumination holographic

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Apelin与鱼类摄食

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水产学报 2020年第11期44卷 1926-1934页

作者：聂国兴邓大鹏闫潇河南师范大学水产学院

鱼类通过摄食活动获得能量和营养物质,而食欲是影响鱼类摄食的重要因素之一。食欲调控是一个复杂的网络,大脑整合机体能量和摄食信号,通过食欲调节因子(包括促进食欲因子和抑制食欲因子)调控鱼类摄食行为。Apelin作为一种新型内分泌因子... 详细信息

鱼类通过摄食活动获得能量和营养物质,而食欲是影响鱼类摄食的重要因素之一。食欲调控是一个复杂的网络,大脑整合机体能量和摄食信号,通过食欲调节因子(包括促进食欲因子和抑制食欲因子)调控鱼类摄食行为。Apelin作为一种新型内分泌因子,在体内发挥广泛的生物学作用。其中,Apelin在摄食调节方面的作用正在引起学者的关注。本文以哺乳动物为参照,综述了Apelin的组织分布、饥饿和营养物质对Apelin表达的影响、Apelin处理对鱼类摄食的影响及其潜在的机制和信号通路,旨在为促进鱼类摄食和水产养殖提供参考。

关键词： Apelin 鱼类摄食信号通路

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混合式教学在全科医生转岗培训中的应用

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中国卫生产业 2023年第19期20卷 215-218页

作者：邓妍安国兴王莉民甘肃省武威市人民医院科教科甘肃武威733000

目的探究混合式教学在武威市全科医生转岗培训中的应用可行性。方法选择2022年5月—2023年5月甘肃省武威市人民医院60名转岗培训的全科医生为研究对象,随机数表法分为对照组和观察组,每组30名。对照组学生实施常规教学模式,观察组实习... 详细信息

目的探究混合式教学在武威市全科医生转岗培训中的应用可行性。方法选择2022年5月—2023年5月甘肃省武威市人民医院60名转岗培训的全科医生为研究对象,随机数表法分为对照组和观察组,每组30名。对照组学生实施常规教学模式,观察组实习生实施混合式教学模式,对比两个时间段全科医生转岗培训的考试成绩、评判性思维能力以及岗位胜任力。结果观察组转岗医生考试成绩、评判性思维能力评分、胜任力评分均高于对照组,差异有统计学意义(P<0.05)。结论武威市全科医生转岗培训应用常规教学和混合式教学两种模式的对比之下,混合式教学模式在提高其考核成绩、改善评判性思维能力、强化岗位胜任力方面效果更佳。

关键词：混合式教学全科医生转岗培训评判性思维岗位胜任力

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