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MicroRNAs as potential diagnostic biomarkers for bipolar disorder

Neural Regeneration Research 2025年第6期20卷 1681-1695页

作者： Bridget Martinez Philip v.Peplow Department of Pharmacology University of Nevada-RenoRenoNVUSA Department of Medicine University of Nevada-RenoRenoNVUSA Department of Anatomy University of OtagoDunedinNew Zealand

Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of bipolar disorder. We performed a PubMed search for microRNA biomarkers in bipolar disorder and found 18 original research articles on studies performed with human patients and published from January 2011 to June 2023. These studies included microRNA profiling in bloodand brain-based materials. From the studies that had validated the preliminary findings,potential candidate biomarkers for bipolar disorder in adults could be miR-140-3p,-30d-5p,-330-5p,-378a-5p,-21-3p,-330-3p,-345-5p in whole blood, miR-19b-3p,-1180-3p,-125a-5p, let-7e-5p in blood plasma, and miR-7-5p,-23b-5p,-142-3p,-221-5p,-370-3p in the blood serum. Two of the studies had investigated the changes in microRNA expression of patients with bipolar disorder receiving treatment. One showed a significant increase in plasma miR-134 compared to baseline after 4 weeks of treatment which included typical antipsychotics, atypical antipsychotics, and benzodiazepines. The other study had assessed the effects of prescribed medications which included neurotransmitter receptorsite binders(drug class B) and sedatives, hypnotics, anticonvulsants, and analgesics(drug class c) on microRNA results. The combined effects of the two drug classes increased the significance of the results for miR-219 and-29c with miR-30e-3p and-526b* acquiring significance. MicroRNAs were tested to see if they could serve as biomarkers of bipolar disorder at different clinical states of mania, depression, and euthymia. One study showed that upregulation in whole blood of miR-9-5p,-29a-3p,-106a-5p,-106b-5p,-107,-125a-3p,-125b-5p and of miR-107,-125a-3p occurred in manic and euthymic patients compared to controls, respectively, and that upregulation of miR-106a-5p,-107 was found for manic compared to euthymic patients. In two other studies using blood plasma,downregulation of miR-134 was observed i

关键词： biomarker bipolar disorder blood leukocytes blood plasma blood plasma extracellular vesicles/exosomes blood serum brain tissue brain tissue extracellular vesicles/exosomes lymphoblastoid cell lines microRNA neural progenitor cells whole blood

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MicroRNAs as potential biomarkers for diagnosis of post-traumatic stress disorder

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Neural Regeneration Research 2025年第7期20卷 1957-1970页

Post-traumatic stress disorder is a mental disorder caused by exposure to severe traumatic life ***,there are no validated biomarkers or laboratory tests that can distinguish between trauma survivors with and without post-traumatic stress *** addition,the heterogeneity of clinical presentations of post-traumatic stress disorder and the overlap of symptoms with other conditions can lead to misdiagnosis and inappropriate *** suggests that this condition is a multisystem disorder that affects many biological systems,raising the possibility that peripheral markers of disease may be used to diagnose post-traumatic stress *** performed a PubMed search for microRNAs(miRNAs)in post-traumatic stress disorder(PTSD)that could serve as diagnostic biomarkers and found 18 original research articles on studies performed with human patients and published January 2012 to December *** included four studies with whole blood,seven with peripheral blood mononuclear cells,four with plasma extracellular vesicles/exosomes,and one with serum *** of these studies had also used whole *** studies were excluded as they did not involve microRNA *** of the studies had collected samples from adult male veterans who had returned from deployment and been exposed to combat,and only two were from recently traumatized adult *** measuring miRNA expression levels,many of the studies had used microarray miRNA analysis,miRNA Seq analysis,or NanoString *** six studies had used real time polymerase chain reaction assay to determine/validate miRNA expression in PTSD subjects compared to *** miRNAs that were found/validated in these studies may be considered as potential candidate biomarkers for PTSD and include miR-3130-5p in whole blood;miR-193a-5p,-7113-5p,-125a,-181c,and-671-5p in peripheral blood mononuclear cells;miR-10b-5p,-203a-3p,-4488,-502-3p,-874-3p,-5100,and-7641 in plasma extracellular vesicles/

关键词： biomarker diagnosis microRNA peripheral blood mononuclear cells plasma extracellular vesicles/exosomes post-traumatic stress disorder serum exosomes whole blood whole plasma

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Wafer-Scale Ag₂S-Based Memristive crossbar Arrays with Ultra-Low Switching-Energies Reaching Biological Synapses

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NANO-MIcRO LETTERS 2025年第1期17卷 1-12页

作者： Zhu, Yuan Nyberg, Tomas Nyholm, Leif Primetzhofer, daniel Shi, Xun Zhang, Zhen Uppsala Univ Dept Elect Engn Div Solid State Elect S-75121 Uppsala Sweden Uppsala Univ Dept Chem Uppsala Sweden Uppsala Univ Dept Phys & Astron Uppsala Sweden chinese Acad Sci Shanghai Inst Ceram State Key Lab High Performance Ceram & Superfine M Shanghai 200050 Peoples R China

Memristive crossbar arrays (McAs) offer parallel data storage and processing for energy-efficient neuromorphic computing. However, most wafer-scale McAs that are compatible with complementary metal-oxide-semiconductor (cMOS) technology still suffer from substantially larger energy consumption than biological synapses, due to the slow kinetics of forming conductive paths inside the memristive units. Here we report wafer-scale Ag2S-based McAs realized using cMOS-compatible processes at temperatures below 160 degrees c. Ag2S electrolytes supply highly mobile Ag+ ions, and provide the Ag/Ag2S interface with low silver nucleation barrier to form silver filaments at low energy costs. By further enhancing Ag+ migration in Ag2S electrolytes via microstructure modulation, the integrated memristors exhibit a record low threshold of approximately - 0.1 v, and demonstrate ultra-low switching-energies reaching femtojoule values as observed in biological synapses. The low-temperature process also enables McA integration on polyimide substrates for applications in flexible electronics. Moreover, the intrinsic nonidealities of the memristive units for deep learning can be compensated by employing an advanced training algorithm. An impressive accuracy of 92.6% in image recognition simulations is demonstrated with the McAs after the compensation. The demonstrated McAs provide a promising device option for neuromorphic computing with ultra-high energy-efficiency.

关键词： Wafer-scale Ag2S films Reactive sputter Silver nucleation Ag+ migration Energy-efficient neuromorphic computing

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A Hybrid Power System for a Permanent colony on Mars

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Space(Science & Technology) 2021年第1期2021卷 255-270页

作者： daniel vázquez Pombo Technical University of Denmark(DTU) RisøDenmark vattenfall vindkraft KoldingDenmark

Since the dawn of humanity,people have contemplated the sky exploring the ***,it was not until the twentieth century that humans were able to leave Earth and visit other celestial *** fact,nowadays,rovers roam Mars on a daily basis pushing the limits of science in a seemingly routine *** is just a matter of time before humanity sets foot on the red planet with the aim of establishing a permanent *** a complex endeavour demands continuous research,simulation,and ***,this paper is aimed at starting a proper discussion about the configuration and design of a suitable power system for said Martian *** initial literature review leads to the definition of a reference colony and its growing stages,which is followed by a revision of available energy-related technologies leading to a concrete design of a suitable electrical ***,the proposed hybrid power system is evaluated in terms of its reliability during the long-term operation under the extreme environmental conditions of *** reference colony starts as an unmanned mission,as robots will prepare the selected location for the first human ***,it suffers several upgrades in size reaching a permanent population of 100 ***,a holistic approach is needed when designing the power system in order to ensure the continuous supply of the ***,the selected topology of the colony’s power system is presented.

关键词： planet establishing starting

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Efects of solution chemistry on arsenic(v) removal by low-cost adsorbents

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Journal of Environmental Sciences 2013年第11期25卷 2291-2298页

作者： Yuru Wang daniel c.W.Tsang Department of civil and Environmental Engineering Hong Kong Polytechnic University Department of civil and Natural Resources Engineering University of Canterbury

Natural and anthropogenic arsenic （As） contamination of water sources pose serious health concerns, especially for small communities in rural areas. This study assessed the applicability of three industrial byproducts （coal fly ash, lignite, and green waste compost） as the low-cost adsorbents for As（v） removal under various field-relevant conditions （dissolved oxygen, As（v）/Fe ratio, solution pH, and presence of competing species）. The physico-chemical properties of the adsorbents were characterized by XRD, XRF, FT-IR, and NMR analysis. Batch experiments demonstrated that coal fly ash could provide effective As（v） removal （82.1%-95%） because it contained high content of amorphous iron/aluminium hydroxides for As（v） adsorption and dissolvable calcium minerals for calcium arsenate precipitation. However, the addition of lignite and green waste compost was found unfavourable since they hindered the As（v） removal by 10%-42% possibly due to dissolution of organic matter and ternary arsenate-iron-organic matter complexes. On the other hand, higher concentrations of dissolved iron （comparing As（v）/Fe ratios of 1：1 and 1：10） and dissolved oxygen （comparing 0.2 and 6 mg/L） only marginally enhanced the As（v） removal at pH 6 and 8. Thus, addition of dissolved iron, water aeration, or pH adjustment became unnecessary because coal fly ash was able to provide effective As（v） removal under the natural range of geochemical conditions. Moreover, the presence of low levels of background competing （0.8 or 8 mg/L of humic acid, phosphate, and silicate） imposed little influence on As（v） removal, possibly because the high adsorption capacity of coal fly ash was far from exhaustion. These results suggested that coal fly ash was a potentially promising adsorbent that warranted further investigation.

关键词： adsorption arsenic coal fly ash green waste compost lignite

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Thermal properties and high-temperature ablation of high-entropy (Ti_(0.25)v_(0.25)Zr_(0.25)Hf_(0.25))B_(2) coating on graphite substrate

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Journal of Advanced ceramics 2024年第8期13卷 1268-1281页

作者： Ana c.Feltrin daniel Hedman Farid Akhtar Division of Materials Science Lulea University of TechnologyLulea 97187Sweden center for Multidimensional carbon Materials(cMcM) Institute for Basic Science(IBS)Ulsan 44919Republic of Korea

An entropy-stabilized multicomponent ultrahigh-temperature ceramic(UHTc)coating,(Ti_(0.25)v_(0.25)Zr_(0.25)Hf_(0.25))B_(2),on a graphite substrate was in-situ sintered by spark plasma sintering(SPs)from constituent transition metal diboride ***(Ti_(0.25)v_(0.25)Zr_(0.25)Hf_(0.25))B_(2) coating had a hardness of 31.2±2.1 GPa and resisted 36.9 GPa of stress before delamination,as observed at the *** temperature-dependent thermal properties of the multicomponent diboride(Ti_(0.25)v_(0.25)Zr_(0.25)Hf_(0.25))B_(2) were obtained by molecular dynamics(MD)simulations driven by a machine learning force field(MLFF)trained on density functional theory(DFT)*** thermal conductivity,density,heat capacity,and coefficient of thermal expansion obtained by the MD simulations were used in time-dependent thermal stress finite element model(FEM)*** low thermal conductivity(component diboride coupled with its similar coefficient of thermal expansion to that of graphite indicated that stresses of less than 10 GPa were generated at the interface at high temperatures,and therefore,the coating was mechanically resistant to the thermal stress induced during *** experiments at 220℃ showed that the multicomponent diboride coating was resistant to thermal stresses with no visible cracking or *** ablation mechanisms were mechanical denudation and evaporation of B_(2)O_(5) and light v-Ti oxides,which caused a decrease in the mass and thickness of the coating and resulted in mass and linear ablation rates of-0.51 mg·s^(-1) and -1.38μm·s^(-1),respectively,after 60 *** findings demonstrated the thermal and mechanical stability of multicomponent entropy-stabilized diborides as coatings for carbon materials in engineering components under extreme environments.

关键词： entropy-stabilized diborides ultrahigh temperature ceramics molecular dynamics(MD)simulations density functional theory(DFT) ablation properties

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Respiratory plasticity following spinal cord injury:perspectives from mouse to man

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Neural Regeneration Research 2022年第10期17卷 2141-2148页

作者： Katherine c.Locke Margo L.Randelman daniel J.Hoh Lyandysha v.Zholudeva Michael A.Lane Department of Neurobiology&Anatomy Drexel UniversityPhiladelphiaPAUSA Marion Murray Spinal cord Research center PhiladelphiaPAUSA Lillian S.Wells Department of Neurosurgery University of FloridaGainesvilleFLUSA cardiovascular Disease Gladstone InstitutesSan FranciscoCAUSA

The study of respiratory plasticity in animal models spans *** the bench,researchers use an array of techniques aimed at harnessing the power of plasticity within the central nervous system to restore respiration following spinal cord *** field of research is highly clinically *** living with cervical spinal cord injury at or above the level of the phrenic motoneuron pool at spinal levels c3-c5 typically have significant impairments in breathing which may require assisted *** who are ventilator dependent are at an increased risk of ventilator-associated co-morbidities and have a drastically reduced life ***-clinical research examining respiratory plasticity in animal models has laid the groundwork for clinical *** how widely researched this injury is in animal models,relatively few treatments have broken through the preclinical *** three goals of this present review are to define plasticity as it pertains to respiratory function post-spinal cord injury,discuss plasticity models of spinal cord injury used in research,and explore the shift from preclinical to clinical *** investigating current targets of respiratory plasticity research,we hope to illuminate preclinical work that can influence future clinical investigations and the advancement of treatments for spinal cord injury.

关键词： breathing phrenic plasticity rehabilitation respiration spinal cord injury translation

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A comprehensive investigation on nonlinear vibration and bending characteristics of bio-inspired helicoidal laminated composite structures

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： S.SAURABH R.KIRAN D.SINGH R.vAISH v.S.cHAUHAN School of Mechanical and Materials Engineering Indian Institute of Technology Mandi

Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHSDT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the c0finite element method(FEM), and an in-house code is developed in the MATLAB environment to solve it numerically. various helicoidal layup configurations including helicoidal recursive(HR), helicoidal exponential(HE), helicoidal semi-circular(HS), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. Moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

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Screening large numbers of recombinant plasmids:modifications and additions to alkaline lysis for greater efficiency

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Progress in Natural Science:Materials International 2006年第11期16卷 1231-1232页

作者： N.v.cHANDRASEKHARAN daniel L.SIMMONS Department of chemistry and Biochemistry Brigham Young UniversityProvoUtah 84602USA

Selecting bacteria transformed with recombinant plasmid is a laborious step in gene cloning experiments. This selection process is even more tedious when large numbers of clones need to be screened. We describe here modifications to the ultra fast plasmid preparation method described previously by Law and crickmore. The modified method is coupled to an efficient PcR step to rapidly determine orientation of the inserts. compared to traditional methods of analysis requiring growth of overnight cultures, plasmid isolation and restriction enzyme digestion to determine orientation this procedure allows for the analysis and storage of a large number of recombinants within a few hours.

关键词： plasmid preparation polymerized chain reaction

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Influence of cobalt on performance of cu-ceO2 catalysts for preferential oxidation of cO

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Journal of Rare Earths 2020年第9期38卷 941-950,I0001页

作者： Sachin Malwadkar Parthasarathi Bera c.v.v.Satyanarayana catalysis Division CSIR-National Chemical LaboratoryPune 411008India Surface Engineering Division CSIR-National Aerospace LaboratoriesBengaluru 560017India

copper and cobalt oxides supported on ceO2 were investigated for preferential oxidation of carbon monoxide(cO-PROX)in the presence of excess hydrogen and cO2.(cuo)1-x(co3 O4)x/3-(ceO2)2.5(x=0,0.25,0.50,0.75,0.85 and 1)catalysts were prepared by coprecipitation *** mixed oxide catalysts were characterized by several physicochemical techniques,such as BET surface area(SBET),X-ray diffraction(XRD),high resolution transmission electron microscopy(HRTEM),temperature programmed reduction(TPR)and X-ray photoelectron spectroscopy(XPS).XRD studies show the peaks related to cuO and co3 O4 phases in copper and cobalt containing ceO2 *** average particle size of the ceO2 crystallites is in the range of 8-10 nm as evaluated from HRTEM *** studies demonstrate that cu,co and ce in(cuO)1-x(co3O4)x/3-(ceO2)2.5 catalysts are presented in+2 and+1,+3 and+2 and+4 and+3 oxidation states,*** catalyst with x=0.75 shows better activity and selectivity towards *** the catalyst with only copper(cuO-ceO2,x=0)shows good activity but reverse water gas shift(RWGS)reaction is noticed at high *** the other hand,RWGS reaction is suppressed on the cobalt containing cuO-ceO2 *** on ceO2 with x=1 shows hardly any activity for PRoX reaction at low *** methanation activity is observed on cuO-ceO2 or co3O4-ceO2 *** contrast,combination of copper and cobalt on ceO2 shows methanation of cO where enhanced activity is observed with increasing in cobalt content.

关键词： cO-PROX cu-ceO2 XRD XPS Methanation H2O addition

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