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Misdiagnosis of synovial sarcoma-cellular myofibroma with SRFRELA gene fusion:A case report

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World Journal of Clinical Cases 2024年第7期12卷 1326-1332页

作者： Ying Zhou Yi-Wen Sun Xiao-Yang Liu dan-Hua shen Department of Pathology Peking University People’s HospitalBeijing 100044China

BACKGROUND Cellular myofibroma is a rare subtype of myofibroma that was first described in *** diagnosis is often challenging because of its relative rarity,lack of known genetic abnormalities,and expression of muscle markers that can be confused with sarcomas that have myogenic ***,scholars have limited knowledge of this disease,and published cases are *** accumulation of diagnostic and treatment experiences is *** SUMMARY A 16-year-old girl experienced left upper limb swelling for 3 *** sought medical attention at a local hospital 10 months ago,where magnetic resonance imaging revealed a 5-cm soft tissue *** biopsy performed at a local hospital resulted in the diagnosis of a spindle cell soft tissue *** patient was referred to our hospital for limb salvage surgery with endoprosthetic *** was initially diagnosed with a synovial ***,clinical management with chemotherapy was continued for the malignant *** pathology department also performed fluorescence in situ hybridization for result validation,which returned negative for SS18 gene breaks,indicating that it was not a synovial ***-generation sequencing was used to identify the SRF-RELA *** final pathological diagnosis was a cellular/myofibroblastic neoplasm with an SRF-RELA gene *** patient had initially received two courses of chemotherapy;however,chemotherapy was discontinued after the final *** This case was misdiagnosed because of its rare occurrence,benign biological behavior,and pathological similarity to soft tissue sarcoma.

关键词： Cellular myofibroma SRF RELA Fusion Pathology Case report

Research on Pulsar Time Steered Atomic Time Algorithm Based on DPLL

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Research in Astronomy and Astrophysics 2024年第3期24卷 237-248页

作者： Ze-Hao Zheng Yang Liu dan shen Fan Feng Jiu-Long Liu Yue-Xin Ma Xiang-Wei Zhu School of Electronic and Communication Engineering Sun Yat-sen UniversityShenzhen 518107China School of Aeronautics and Astronautics Sun Yat-sen UniversityShenzhen 518107China School of Systems Science and Engineering Sun Yat-sen UniversityGuangzhou 510275China

In today’s society,there is a wide demand for high-precision and high-stability time service in the fields of electric power,communication,transportation and *** present,the time standard in various countries is mainly based on atomic clocks,but the frequency drift of atomic clocks will affect the long-term stability *** with atomic clocks,millisecond pulsars have better long-term stability and can complement with the excellent short-term stability of atomic *** order to improve the long-term stability of the atomic timescale,and then improve the timing accuracy,this paper proposes an algorithm for steering the atomic clock ensemble(ACE)by ensemble pulsar time(EPT)based on digital phase locked loop(DPLL).First,the ACE and EPT are generated by the ALGOS algorithm,then the ACE is steered by EPT based on DPLL to calibrate the long-term frequency drift of the atomic clock,so that the generated steered atomic time follows both the short-term stability characteristics of ACE and the long-term stability characteristics of EPT,and finally,the steered atomic time is used to calibrate the local cesium *** experimental results show that the long-term stability of atomic time after steering is improved by 2 orders of magnitude compared with that before steering,and the daily drift of a local cesium clock after calibration is less than 9.47 ns in 3 yr,3 orders of magnitude higher than that before calibration on accuracy.

关键词： (stars) pulsars general-time-methods data analysis-instabilities

Berberine Enhances Intestinal Mucosal Barrier Function by Promoting Vitamin D Receptor Activity

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Chinese Journal of Integrative Medicine 2024年第2期30卷 143-151页

作者： HUANG Yong-quan LIU Jia-lin CHEN Geng-xin shen dan-ting ZHU Wang CHEN Xin-lin LIU Feng-bin HOU Qiu-ke Graduate School Guangzhou University of Chinese MedicineGuangzhou(510405)China Department of Orthopedics the Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou(510006)China Department of Preventive Medicine and Health Statistics Guangzhou University of Chinese MedicineGuangzhou(510006)China Department of Gastroenterology the First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou(510405)China

Objective:To evaluate if berberine can act on vitamin D receptors(VDR)and thereby regulate the expression of tight junction proteins(TJPs)in irritable bowel syndrome-diarrhea-predominant(IBS-D)***:The newborn rats were induced into IBS-D rat model via neonatal maternal separation combined with acetic acid chemical *** modeling,the model was evaluated and rats were divided into the control group and berberine treatment groups(0.85,1.7 and 3.4 mg/kg,once a day for 2 weeks).The distal colon was obtained and colonic epithelial cells(CECs)were isolated and cultured after IBS-D model *** vitamin D receptor response element(VDRE)reporter gene was determined in the CECs of IBS-D rats to analyze the effect of berberine on the VDRE *** overexpression or silencing technology was used to analyze whether VDR plays a role in promoting intestinal barrier repair,and to determine which region of VDR plays a role in berberine-regulated intestinal ***:The IBS-D rat model was successfully constructed and the symptoms were improved by berberine in a dose-dependent manner(P<0.05).The activity of VDRE promoter was also effectively promoted by berberine(P<0.05).Berberine increased the expression of TJPs in IBS-D CECs(P<0.05).VDR expression was significantly increased after transfection of different domains of VDR when compared to normal control and basic plasmid groups(all P<0.05).RT-qPCR and Western blot results showed that compared with the blank group,expressions of occludin and zonula occludens-1 were significantly higher in VDR containing groups(all P<0.05).Berberine plus pCMV-Myc-VDR-N group exerted the highest expression levels of occludin and zonula occludens-1(P<0.05).Conclusion:Berberine enhances intestinal mucosal barrier function of IBS-D rats by promoting VDR activity,and the main site of action is the N-terminal region of VDR.

关键词： berberine Chinese medicine irritable bowel syndrome-diarrhea-predominant vitamin D receptors intestinal mucosal barrier tight junction proteins

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水下地形匹配导航研究综述

科学技术与工程 2024年第14期24卷 5690-5706页

作者：丁鹏杨申申王磊沈丹中国船舶科学研究中心无锡214082 深海载人装备国家重点实验室无锡214082 深海技术科学太湖实验室无锡214082

地形辅助导航系统以地形高程特征为定位信息源,可为水下航行器提供有界的定位误差,并能显著地抑制捷联惯性导航系统的误差漂移。而地形匹配算法是地形辅助导航系统的关键技术,其输出的匹配位置可作为组合导航滤波器的观测值以修正导航参... 详细信息

地形辅助导航系统以地形高程特征为定位信息源,可为水下航行器提供有界的定位误差,并能显著地抑制捷联惯性导航系统的误差漂移。而地形匹配算法是地形辅助导航系统的关键技术,其输出的匹配位置可作为组合导航滤波器的观测值以修正导航参数,地形匹配精度直接决定了整个导航系统性能。首先概述了现有水下导航定位技术,然后阐述了地形辅助导航基本原理与组成,最后详细总结了中外地形辅助导航系统和地形匹配算法的研究进展,为中国地形辅助导航系统的开发和研制提供有益参考和支撑。

关键词：水下航行器惯性导航地形辅助导航地形匹配组合导航

Early screening to identify and diagnose primary nasal tuberculosis in patients with tumor necrosis factor inhibitors

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World Journal of Clinical Cases 2024年第33期12卷 6604-6607页

作者： dan-Xiang shen Yu-Wei Wang Zhi-Min Lin Di Jin Zhen-Hua Ying Chen Li Department of Internal Medicine Changxing Third People's HospitalHuzhou 313000Zhejiang ProvinceChina Department of Rheumatology and Immunology Jinzhou Medical University Graduate Training Base Zhejiang Provincial People's HospitalCenter for General Practice MedicineZhejiang Provincial People's HospitalHangzhou 310000Zhejiang ProvinceChina Department of Rheumatology Zhejiang Provincial Key Laboratory of Traditional Chinese Medicine Cultivation for Arthritis Diagnosis and TreatmentHangzhou 310000Zhejiang ProvinceChina Department of Cardiology Yidu Central Hospital of WeifangWeifang 261000Shandong ProvinceChina Third Affiliated Hospital Beijing University of Chinese MedicineBeijing 100020China Department of Rheumatology Weifang People's HospitalWeifang 261000Shandong ProvinceChina Department of Rheumatology Fangshan HospitalBeijing University of Chinese MedicineBeijing 102400China

In this editorial,we comment on the article by Liu et *** on our analysis of a case report,we consider that early screening and recognition of primary nasal tuberculosis are crucial for patients undergoing treatment with tumor necrosis factor inhibitor(TNFi).While TNFi therapy increases the risk of reactivating latent tuberculosis,primary nasal tuberculosis remains rare due to the protective mechanisms of the nasal *** factors for primary nasal tuberculosis include minimally invasive nasal surgery,diabetes,and human immunodefi ciency *** with early symptoms such as nasal congestion,rhinorrhea,altered olfaction,epistaxis,or ulceration,and unresponsive to conventional antibiotics and antihistamines should undergo early rhinoscopy,possibly followed by repeated tissue biopsies and acid-fast bacilli culture when *** diagnosis is challenging,it is essential to consider local tuberculosis epidemiology and the efficacy of diagnostic antituberculosis *** preferred method for tuberculosis screening is the Interferon Gamma Release Assay,with a general recommendation for screening at 3 and 6 months after initial treatment and then every six ***,the optimal frequency is not yet consensus-driven and may be increased in economically viable settings.

关键词： Tumor necrosis factor inhibitor Interferon-gamma release assay Primary nasal tuberculosis Rhinoscopy Diabetes mellitus

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赋的双重叙事进程英译研究

外国语文 2024年第2期40卷 76-85页

作者：阮诗芸申丹福州大学外国语学院福建福州350108 北京大学外国语学院北京100871

赋的修辞交流在很大程度上依靠叙事方法进行,目前对赋的翻译现象尚未有从叙事学角度进行的考察,遑论对赋及其英译中的双重叙事进程加以分析。本文揭示扬雄《羽猎赋》和潘岳《射雉赋》中存在的双重叙事进程,以早期苏格兰传教士湛约翰、... 详细信息

赋的修辞交流在很大程度上依靠叙事方法进行,目前对赋的翻译现象尚未有从叙事学角度进行的考察,遑论对赋及其英译中的双重叙事进程加以分析。本文揭示扬雄《羽猎赋》和潘岳《射雉赋》中存在的双重叙事进程,以早期苏格兰传教士湛约翰、美国汉学家康达维和美国学者窦瑞格的译本为例,分析美颂和讽刺这两种进程在英译过程中的传递和改变,以及译者受到的双重进程之影响。三位译者都倾向于认同讽喻进程,而避免成为美颂进程的理想读者。本文挖掘出其深层原因:译者的不同诗学观、翻译目的以及特定时空会影响和限制译者对文本的理解。双重叙事进程理论与相关叙事学视角可为赋及其他相关文类的翻译研究提供崭新的维度。

关键词：赋的英译双重叙事进程美颂和讽喻不同诗学观蒐狩赋

系统思维视域下高校课程思政与思政课程同向同行机制探究

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系统科学学报 2024年第3期32卷 94-98页

作者：刘广明申丹丹河南工业大学马克思主义学院河南郑州450001

科学构建高校课程思政与思政课程同向同行机制是一项复杂的系统工程。当前高校课程思政与思政课程同向同行机制建设工作因缺乏系统设计,出现了组织管理机制缺乏整体规划、课程建设机制缺乏关联性、教师育人机制不协同、评估评价机制多... 详细信息

科学构建高校课程思政与思政课程同向同行机制是一项复杂的系统工程。当前高校课程思政与思政课程同向同行机制建设工作因缺乏系统设计,出现了组织管理机制缺乏整体规划、课程建设机制缺乏关联性、教师育人机制不协同、评估评价机制多元性不足等问题。系统思维具有整体性、关联性、协同性、多元性等系统性特征,在系统思维指导下,通过构建上下联动的多层级管理机制、左右联动的课程互动机制、专业教师与思政教师协同育人机制、多维度的评估评价机制,可以有效促进高校课程思政与思政课程同向同行,增强课程立德树人效能。

关键词：课程思政思政课程同向同行机制系统思维

肺部菌群干预对PM_(2.5)诱导肉鸡肺部炎症损伤的影响

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南京农业大学学报 2024年第2期47卷 323-333页

作者：周子琳李盛沈丹李春梅南京农业大学动物科技学院家畜环境控制与智慧生产研究中心江苏南京210095

[目的]本试验旨在研究肺部菌群对PM_(2.5)诱导肉鸡肺部炎症损伤的影响,并利用盲肠肠球菌处理肺泡上皮细胞,探究肺部盲肠肠球菌在PM_(2.5)诱发肺部炎症损伤中的作用。[方法]选取45只19日龄雄性AA肉鸡随机分为3组:对照组、PM_(2.5)组(PM)... 详细信息

[目的]本试验旨在研究肺部菌群对PM_(2.5)诱导肉鸡肺部炎症损伤的影响,并利用盲肠肠球菌处理肺泡上皮细胞,探究肺部盲肠肠球菌在PM_(2.5)诱发肺部炎症损伤中的作用。[方法]选取45只19日龄雄性AA肉鸡随机分为3组:对照组、PM_(2.5)组(PM)和肺部菌群干预组(ABX-PM)。从21日龄开始,ABX-PM组肉鸡气管滴注抗生素消减肺部菌群,每天滴注1次,连续滴注3 d,其他2组肉鸡气管滴注无菌生理盐水。在24和26日龄时,分别向PM组和ABX-PM组肉鸡气管滴注PM_(2.5)悬浮液诱导肺部炎症损伤,对照组肉鸡气管滴注无菌生理盐水。在最后一次气管滴注PM_(2.5)24 h后对肉鸡进行称重,并采集肺组织、支气管肺泡灌洗液(bronchoalveolar lavage fluid,BALF)和血清样品。检测BALF和血清内炎症因子水平、肺组织内紧密连接(tight junctions,TJ)蛋白基因表达水平以及肠球菌属和盲肠肠球菌相对含量,并进行盲肠肠球菌相对含量与炎症因子水平的相关性分析。另外,体外培养A549细胞并分为2组,对照组加入不含盲肠肠球菌的DMEM/F12培养基,处理组加入含有1×10^(4) CFU·mL^(-1)盲肠肠球菌的DMEM/F12培养基。处理6 h后,检测2组细胞炎症因子、TJ及细胞凋亡相关基因表达水平。[结果]与对照组相比,PM组肉鸡BALF和血清IL-8水平显著升高,而ABX-PM组差异不显著;与对照组相比,PM组肉鸡肺组织occludin及claudin-1 mRNA表达水平显著降低,claudin-5 mRNA表达水平显著升高,而ABX-PM组差异不显著;PM组肉鸡肺部肠球菌属和盲肠肠球菌的相对含量显著高于对照组和ABX-PM组;肺部盲肠肠球菌相对含量与BALF内IL-1β、IL-6、IL-8水平和血清内IL-1β水平呈显著正相关关系。体外细胞试验结果显示,与对照组相比,处理组A549细胞tnf-α、il-1β、il-6及il-8 mRNA表达水平显著升高,il-10 mRNA表达水平显著降低;处理组A549细胞zo-1及claudin-1 mRNA表达水平显著降低;处理组A549细胞bax/bcl-2 mRNA表达水平的比值及caspase-3 mRNA表达水平显著升高,bcl-2 mRNA表达水平显著降低。[结论]肺部菌群干预降低了PM_(2.5)诱导的盲肠肠球菌增殖,减轻了肉鸡肺部炎症损伤程度,表明肺部菌群参与PM_(2.5)诱导肉鸡肺部炎症损伤的过程;另外,盲肠肠球菌能够诱导体外肺泡上皮细胞炎症反应,提示肺部菌群失衡加剧肺部炎症损伤。

关键词：肺部菌群肺部炎症肉鸡盲肠肠球菌肺泡上皮细胞

基于UPLC指纹图谱和多成分测定的天王补心丸质量控制研究

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中国中药杂志 2024年第5期49卷 1240-1248页

作者：沈丹萍姜鹏詹常森上海和黄药业有限公司上海201401 上海中药固体制剂创新工程技术研究中心上海201401

天王补心丸临床上已有一定疗效,但严重缺少较全面的质量控制,以期保证临床用药安全性和有效性。研究采用超高效液相色谱(UPLC)建立天王补心丸指纹图谱和7个成分含量同时测定的方法,并结合化学计量学等方法寻找天王补心丸质量稳定的关键... 详细信息

天王补心丸临床上已有一定疗效,但严重缺少较全面的质量控制,以期保证临床用药安全性和有效性。研究采用超高效液相色谱(UPLC)建立天王补心丸指纹图谱和7个成分含量同时测定的方法,并结合化学计量学等方法寻找天王补心丸质量稳定的关键因素,为其科学全面的质量控制和评价提供参考。建立了15批天王补心丸指纹图谱,相似度均大于0.96,共标定了25个共有峰,指认出13个成分,对其中7个药效成分(α-亚麻酸、丹酚酸B、甘草酸、五味子醇甲、β-细辛醚、3,6′-二芥子酰基蔗糖和藁本内酯)建立含量测定方法,进一步采用主成分分析(principal component analysis,PCA)和偏最小二乘法-判别分析(partial least square discriminate analysis,PLS-DA)得到控制天王补心丸质量稳定性的关键药效物质为3,6′-二芥子酰基蔗糖、α-亚麻酸和β-细辛醚。结果表明建立的指纹图谱及多成分含量测定方法专属性强,稳定,可靠,提示3,6′-二芥子酰基蔗糖、α-亚麻酸和β-细辛醚是保障天王补心丸批次间质量稳定性的关键药效物质,可较为全面地对天王补心丸进行质量控制,为其质量评价和标准建立提供科学依据。

关键词：天王补心丸指纹图谱多成分含量测定统计学质量评价