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护肝布祖热颗粒通过EGFR/Ras/PI3K/AKT信号通路改善免疫性肝损伤:一项网络药理学研究和实验验证

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Journal of Chinese Pharmaceutical Sciences 2024年第2期33卷 123-141页

作者：韩正茹宋婉慈罗旸肖敏王梦恒郑吴殷晓但汉雄尹强尹海龙尤朋涛湖北中医药大学湖北省中医药资源与化学重点实验室湖北武汉430065 新疆维吾尔制药有限公司新疆乌鲁木齐830001

护肝布祖热颗粒是维吾尔族传统的护肝方。作者在先前的一项研究中通过调节免疫平衡和抑制IRF1/JNK信号诱导的细胞凋亡,探讨了HBG抗免疫性肝损伤(ILI)的机制。但不是所有的机制都得到了探讨。本研究通过体内实验及网络药理学进一步研究了... 详细信息

护肝布祖热颗粒是维吾尔族传统的护肝方。作者在先前的一项研究中通过调节免疫平衡和抑制IRF1/JNK信号诱导的细胞凋亡,探讨了HBG抗免疫性肝损伤(ILI)的机制。但不是所有的机制都得到了探讨。本研究通过体内实验及网络药理学进一步研究了HBG降低小鼠刀豆球蛋白A(ConA)诱导的ILI的机制。首先,TCMSP、PharmMapper和GeneCards数据库确定了HBG治疗ILI的活性化合物和关键靶点。通过网络药理学和分子对接对确定的关键靶点和相关信号通路进行筛选。ConA诱导的小鼠ILI模型探讨了HBG对抗ILI的疗效和机制;蛋白质印迹分析检测关键蛋白的表达水平;网络药理学鉴定了16个化合物和53个靶标。成分-靶向通路(C-T-P)网络和分子对接表明,EGFR、HRAS、AKT1和PIK3R1是HBG对抗ILI的关键靶点。此外,分子对接显示,前八种活性化合物的对接得分高于阈值。与ConA组相比,HBG显著上调p-EGFR、Ras、p-AKT、p-PI3K、p-BAD和Bcl-2的表达,并下调Bax、裂解caspase 9和3的蛋白水平。HBG通过EGFR/Ras/PI3K/AKT信号通路抑制细胞凋亡,从而减轻ILI。

关键词：护肝布祖热颗粒免疫性肝损伤分子对接细胞凋亡通路

Compound Gaoziban tablet(复方高滋斑片) alleviates depression via toll-like receptor 4/myeloid differentiation factor 88/nuclear factor-kappa B pathway

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Journal of Traditional Chinese Medicine 2022年第6期42卷 956-964页

作者： ZOU Xinshuang SHI Lei YIN Hailong LI Haiping WANG Mengheng SONG Wanci LUO Laichun WU Hezhen YANG Yanfang ZAN Junfeng LIU Yanwen dan hanxiong YIN Qiang YOU Pengtao Hubei Key Laboratory of Resources and Chemistry of Chinese Medicine Hubei University of Chinese MedicineHubei 430065China Xinjiang Uygur Pharmaceutical Co. Ltd.Urumqi 830001China

OBJECTIVE: To evaluate the effect of compound Gaoziban tablet(复方高滋斑片, CGZBT) on depression, and to investigate the underlying mechanism. METHODS: The components of CGZBT were analysed by high-performance liquid chromatography. Then, we assessed the effects of varying doses of CGZBT on an established chronic unpredictable mild stress(CUMS) model in rats. Whether animals were depressed was evaluated by sucrose preference test, open field test and forced swimming test. Neurotransmitters of hippocampus were detected by liquid chromatography-mass spectrometry. Serum levels of tumor necrosis factor-alpha(TNF-α), interleukin(IL)-1β, IL-6, IL-4, and IL-10 were measured by enzyme-linked immunosorbent assay. Expressions of toll-like receptor 4(TLR4), myeloid differentiation factor 88(My D88), phospho-nuclear factorkappa B(p-NF-κB), cyclooxygenase-2(COX-2), ionized calcium binding adapter molecule-1(IBA-1) were assessed by immunohistochemical staining and western blotting. RESULTS: Eight compounds were identified from CGZBT, moreover, our results showed that CGZBT effectively reversed the CUMS-induced decrease in sucrose preference, shortened the movement distance and prolonged immobility time. CGZBT significantly increased levels of 5-hydroxytryptamine, dopamine, norepinephrine, 5-hydroxyindoleacetic acid levels, and reduced the expression of TNF-α, IL-1β, IL-6, yet increased IL-4 and IL-10. Furthermore, the expressions of TLR4, My D88, COX-2, p-NF-κB and IBA-1 in hippocampus were effectively reversed after treatment with CGZBT. CONCLUSIONS: These results indicated that CGZBT could, at least in part, alleviate depression induced by CUMS via the TLR4/My D88/NF-κB pathway, suggesting its potential as an antidepressant drug.

关键词： depression toll-like receptor 4 myeloid differentiation factor 88 NF-kappa B chronic unpredictable mild stress compound Gaoziban tablet

Non-Deterministic Liveness-Enforcing Supervisor Tolerant to Sensor-Reading Modification Attacks

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IEEE/CAA Journal of Automatica Sinica 2024年第1期11卷 240-248页

作者： dan You Shouguang Wang IEEE the School of Information and Electronic Engineering Sussex Artificial Intelligence InstituteZhejiang Gongshang UniversityHangzhou 310018China

In this paper, we study the supervisory control problem of discrete event systems assuming that cyber-attacks might occur. In particular, we focus on the problem of liveness enforcement and consider a sensor-reading modification attack(SM-attack) that may disguise the occurrence of an event as that of another event by intruding sensor communication channels. To solve the problem, we introduce non-deterministic supervisors in the paper, which associate to every observed sequence a set of possible control actions offline and choose a control action from the set randomly online to control the system. Specifically, given a bounded Petri net(PN) as the reference formalism and an SMattack, an algorithm that synthesizes a liveness-enforcing nondeterministic supervisor tolerant to the SM-attack is proposed for the first time.

关键词： Cyber-attacks cyber-physical system(CPS) liveness non-deterministic supervisors Petri net(PN)

氨基柱HPLC法测定盐酸氨基葡萄糖及其制剂的含量

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中国药师 2016年第2期19卷 387-389页

作者：罗立但汉雄华中科技大学同济医学院附属协和医院武汉430022 湖北中医药大学

目的:建立盐酸氨基葡萄糖及其制剂的HPLC含量测定方法。方法:采用Phenomenex Luna NH_2柱(150 mm×4.6 mm,5’m);流动相:磷酸盐缓冲液(取磷酸氢二钾3.5 g,加水1 000 ml使溶解,加入0.25 ml氨水,用磷酸调节p H至7.5)-乙腈(25∶75);流速:1.... 详细信息

目的:建立盐酸氨基葡萄糖及其制剂的HPLC含量测定方法。方法:采用Phenomenex Luna NH_2柱(150 mm×4.6 mm,5’m);流动相:磷酸盐缓冲液(取磷酸氢二钾3.5 g,加水1 000 ml使溶解,加入0.25 ml氨水,用磷酸调节p H至7.5)-乙腈(25∶75);流速:1.5 ml·min^(-1);检测波长:195 nm;柱温:35℃;进样量20μl。结果:盐酸氨基葡萄糖在1.6~16.0 mg·ml^(-1)浓度范围线性关系良好(r=0.999 9),片剂及胶囊的平均回收率分别为99.3%和99.5%,RSD均为0.3%(n=9)。结论:该方法简便、准确,专属性强,适合于盐酸氨基葡萄糖及其制剂的质量控制。

关键词：高效液相色谱法盐酸氨基葡萄糖制剂含量测定

On the Factors Influencing the High Stretch-Flangeability of a Low-Density 1180 MPa Fe-Mn-Al-C-Nbδ-QP Steel

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Acta Metallurgica Sinica(English Letters) 2024年第8期37卷 1291-1300页

作者： dan‑dan Cui Peng Chen Peng‑Fei Wang Xiao‑Wu Li Department of Materials Physics and Chemistry School of Materials Science and Engineeringand Key Laboratory for Anisotropy and Texture of Materials(Ministry of Education)Northeastern UniversityShenyang 110819China State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China

Low-densityδ-quenching and partitioning(δ-QP)steels with excellent strength and ductility have been recently ***,there are still rare reports on the formability of δ-QP steels,which are critical for satisfying the manufacture of structural parts during the application in automotive *** the present work,an 1180 MPa Fe–Mn–Al–C–Nbδ-QP steel with a high ductility was adopted for the stretch–flangeability ***δ-QP steel was developed by separated quenching and partitioning processes.A good hole expansion ratio(HER)of 34.9±0.9%was obtained in the quenched steel,but it has been further increased to 52.2%by the tempering *** improved stretch–flangeability was attributed to the enhanced austenite stability and deformation *** the one hand,the stability of austenite was increased by carbon partitioning during tempering,which reduced crack possibility via the suppression of the fresh martensite *** the other hand,the tempering treatment released the internal stress caused by martensitic transformation and reduced the difference in strength among different phases,resulting in an increase in the resistance to crack initiation and propagation.

关键词： Hole expansion ratio Low-densityδ-quenching and partitioning(δ-QP)steel Stretch-flangeability Austenite stability Deformation uniformity

Variational quantum algorithms for scanning the complex spectrum of non-Hermitian systems

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Frontiers of physics 2024年第4期19卷 275-285页

作者： Xu-dan Xie Zheng-Yuan Xue dan-Bo Zhang Key Laboratory of Atomic and Subatomic Structure and Quantum Control(Ministry of Education) Guangdong Basic Research Center of Excellence for Structure and Fundamental Interactions of Matterand School of PhysicsSouth China Normal UniversityGuangzhou 510006China Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials Guangdong–Hong Kong Joint Laboratory of Quantum Matterand Frontier Research Institute for PhysicsSouth China Normal UniversityGuangzhou 510006China

Solving non-Hermitian quantum many-body systems on a quantum computer by minimizing the variational energy is challenging as the energy can be ***,we propose a variational quantum algorithm for solving the non-Hermitian Hamiltonian by minimizing a type of energy variance,where zero variance can naturally determine the eigenvalues and the associated left and right ***,the energy is set as a parameter in the cost function and can be tuned to scan the whole spectrum efficiently by using a two-step optimization *** numerical simulations,we demonstrate the algorithm for preparing the left and right eigenstates,verifying the biorthogonal relations,as well as evaluating the *** also investigate the impact of quantum noise on our algorithm and show that its performance can be largely improved using error mitigation ***,our work suggests an avenue for solving non-Hermitian quantum many-body systems with variational quantum algorithms on near-term noisy quantum computers.

关键词： quantum algorithm non-Hermitian physics quantum manybody systems

Challenges and Opportunities in Preserving Key Structural Features of 3D-Printed Metal/Covalent Organic Framework

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Nano-Micro Letters 2024年第8期16卷 362-381页

作者： Ximeng Liu dan Zhao John Wang Department of Materials Science and Engineering National University of SingaporeSingapore 117574Singapore Department of Chemical and Biomolecular Engineering National University of SingaporeSingapore 117585Singapore National University of Singapore(Chongqing)Research Institute Chongqing 401123People’s Republic of China

Metal-organic framework(MOF)and covalent organic framework(COF)are a huge group of advanced porous materials exhibiting attractive and tunable microstructural features,such as large surface area,tunable pore size,and functional surfaces,which have significant values in various application *** emerging 3D printing technology further provides MOF and COFs(M/COFs)with higher designability of their macrostructure and demonstrates large achievements in their performance by shaping them into advanced 3D ***,the currently available 3D printing M/COFs strategy faces a major challenge of severe destruction of M/COFs’microstructural features,both during and after 3D *** is envisioned that preserving the microstructure of M/COFs in the 3D-printed monolith will bring a great improvement to the related *** this overview,the 3D-printed M/COFs are categorized into M/COF-mixed monoliths and M/COF-covered *** differences in the properties,applications,and current research states are *** up-to-date advancements in paste/scaffold composition and printing/covering methods to preserve the superior M/COF microstructure during 3D printing are further discussed for the two types of 3D-printed M/*** the analysis of the current states of 3D-printed M/COFs,the expected future research direction to achieve a highly preserved microstructure in the 3D monolith is proposed.

关键词： Metal-organic frameworks Covalent organic frameworks 3D printing Microstructure Monolith

A credible traffic prediction method based on self-supervised causal discovery

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Science China(Information Sciences) 2024年第5期67卷 244-258页

作者： dan WANG Yingjie LIU Bin SONG State Key Laboratory of Integrated Services Networks Xidian University

Next-generation wireless network aims to support low-latency, high-speed data transmission services by incorporating artificial intelligence(AI) technologies. To fulfill this promise, AI-based network traffic prediction is essential for pre-allocating resources, such as bandwidth and computing power. This can help reduce network congestion and improve the quality of service(QoS) for users. Most studies achieve future traffic prediction by exploiting deep learning and reinforcement learning, to mine spatio-temporal correlated variables. Nevertheless, the prediction results obtained only by the spatio-temporal correlated variables cannot reflect real traffic changes. This phenomenon prevents the true prediction variables from being inferred, making the prediction algorithm perform poorly. Inspired by causal science, we propose a novel network traffic prediction method based on self-supervised spatio-temporal causal discovery(SSTCD). We first introduce the Granger causal discovery algorithm to build a causal graph among prediction variables and obtain spatio-temporal causality in the observed data, which reflects the real reasons affecting traffic ***, a graph neural network(GNN) is adopted to incorporate causality for traffic prediction. Furthermore,we propose a self-supervised method to implement causal discovery to to address the challenge of lacking ground-truth causal graphs in the observed data. Experimental results demonstrate the effectiveness of the SSTCD method.

关键词： wireless network traffic prediction causal discovery self-supervised

Recent Advance in Synaptic Plasticity Modulation Techniques for Neuromorphic Applications

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Nano-Micro Letters 2024年第10期16卷 403-434页

作者： Yilin Sun Huaipeng Wang dan Xie School of Integrated Circuits and Electronics Beijing Institute of TechnologyBeijing 100081People's Republic of China School of Integrated Circuits Beijing National Research Center for Information Science and Technology(BNRist)Tsinghua UniversityBeijing 100084People's Republic of China

Manipulating the expression of synaptic plasticity of neuromorphic devices provides fascinating opportunities to develop hardware platforms for artifi-cial ***,great efforts have been devoted to exploring biomimetic mechanisms of plasticity simulation in the last few *** progress in various plasticity modulation techniques has pushed the research of synaptic electronics from static plasticity simulation to dynamic plasticity modulation,improving the accuracy of neuromorphic computing and providing strategies for implementing neuromorphic sensing ***,several fascinating strategies for synap-tic plasticity modulation through chemical techniques,device structure design,and physical signal sensing are *** chemical techniques,the underly-ing mechanisms for the modification of functional materials were clarified and its effect on the expression of synaptic plasticity was also *** on device structure design,the reconfigurable operation of neuromorphic devices was well demonstrated to achieve programmable neuromorphic ***,integrating the sensory units with neuromorphic processing circuits paved a new way to achieve human-like intelligent perception under the modulation of physical signals such as light,strain,and ***,considering that the relevant technology is still in the basic exploration stage,some prospects or development suggestions are put forward to promote the development of neuromorphic devices.

关键词： Plasticity modulation Dynamic plasticity Chemical techniques Programmable operation Neuromorphic sensing