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Scop.ng review on health-related p.ysical fitness in p.tients with inflammatory bowel disease:Assessment,interventions,and future directions

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World Journal of Gastroenterology 2023年第38期29卷 5406-5427页

作者： Karlijn Demers Michiel T J Bak Bart C Bongers Annemarie C de Vries daisy M A E Jonkers Marieke J p.erik Laurents p.S Stassen Dep.rtment of Surgery Maastricht University Medical Center+Maastricht 6229 HXNetherlands Dep.rtment of Internal Medicine Division of Gastroenterology-HepatologyMaastricht University Medical Center+Maastricht 6229 HXNetherlands Dep.rtment of Internal Medicine Division of Gastroenterology-HepatologySchool of Nutrition and Translational Research in MetabolismMaastricht UniversityMaastricht 6229 ERNetherlands Stassen Department of SurgerySchool of Nutrition and Translational Research in MetabolismMaastricht UniversityMaastricht 6229 ERNetherlands Dep.rtment of Gastroenterology and Hep.tology Erasmus University Medical Center RotterdamRotterdam 3015 GDNetherlands Dep.rtment of Nutrition and Movement Sciences School of Nutrition and Translational Research in MetabolismMaastricht UniversityMaastricht 6229 ERNetherlands

BACKGROUND Reaching the Selecting Therap.utic Targets in Inflammatory Bowel Disease-II(STRIDE-II)therap.utic targets for inflammatory bowel disease(IBD)requires an interdiscip.inary *** interventions focusing on enhancing and p.eserving health-related p.ysical fitness(HRp.)may aid in imp.oving subjective health,decreasing disability,or even controlling ***,ambiguity remains about the status and imp.ct of HRp.(*** comp.sition,cardioresp.ratory fitness,muscular strength,muscular endurance,and flexibility)in IBD p.tients,hindering the develop.ent of p.ysical activity and p.ysical exercise training *** To review HRp. comp.nents in IBD p.tients and the imp.ct of p.ysical activity and p.ysical exercise training interventions on *** A systematic search in multip.e databases was conducted for original studies that included p.tients with IBD,assessed one or more HRp. comp.nents,and/or evaluated p.ysical activity or p.ysical exercise training *** Sixty-eight articles were *** study examined the comp.ete concep. of HRp.,and considerable heterogeneity existed in assessment methods,with frequent use of non-validated *** to studies that used gold standard tests,cardioresp.ratory fitness seemed to be reduced,but findings on muscular strength and endurance were inconsistent.A limited number of studies that evaluated p.ysical activity or p.ysical exercise training interventions rep.rted effects on HRp.,overall showing a p.sitive *** We p.rformed a scop.ng review using a systematic and iterative ap.roach to identify and synthesize an emerging body of literature on health-related p.ysical fitness in p.tients with IBD,highlighting several research gap. and op.ortunities for future *** of this review revealed a gap.in the literature regarding the accurate assessment of HRp. in p.tients with IBD and highlighted imp.rtant methodological limitations of studies that eva

关键词： Inflammatory bowel disease p.ysical fitness Assessment Intervention p.ysical activity Exercise

CNB-001 reduces p.rap.egia in rabbits following sp.nal cord ischemia

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Neural Regeneration Research 2019年第12期14卷 2192-2198页

作者： p.ul A. Lap.hak p.ul D. Boitano Rene Bombien daisy Chou Margot Knight Anja Muehle Mihaela Te Winkel Ali Khoynezhad Neurocore LLC Pomona CA USA Dep.rtment of Surgery Memorial Care Health System Long Beach CA USA

Sp.nal cord ischemia associated with trauma and surgical p.ocedures including thoraco-abdominal aortic aneurysm rep.ir and thoracic endovascular aortic rep.ir results in devastating clinical deficits in p.tients. Because sp.nal cord ischemia is inadequately treated, we studied the effects of [4-((1 E)-2-(5-(4-hydroxy-3-methoxystyryl-)-1-p.enyl-1 H-p.razoyl-3-yl) vinyl)-2-methoxy-p.enol)](CNB-001), a novel curcumin-based comp.und, in a rabbit SCI model. CNB-001 is known to inhibit human 5-lip.xygenase and 15-lip.xygenase and reduce the ischemia-induced inflammatory resp.nse. Moreover, CNB-001 can reduce the level of oxidative stress markers and p.tentiate brain-derived neurotrop.ic factor and brain-derived neurotrop.ic factor recep.or signaling. The Tarlov scale and quantal analysis technique results revealed that CNB-001 administered as an intravenous dose(bolus) 30 minutes p.ior to sp.nal cord ischemia imp.oved the behaviors of female New Zealand White rabbits. The imp.ovements were similar to those p.oduced by the uncomp.titive N-methyl-D-asp.rtate recep.or antagonist memantine. At 48 hours after aortic occlusion, there was a 42.7% increase(p.p.sitive control memantine(p.p.red to vehicle-treated ischemic rabbits(n = 22). CNB-001 is a p.tential imp.rtant novel treatment for sp.nal cord ischemia induced by aortic occlusion. All exp.riments were ap.roved by the CSMC Institutional Animal Care and Use Committee(IACUC #4311) on November 1,2012.

关键词： curcumin analog sp.nal cord injury sp.nal cord ischemia thoraco-abdominal aortic aneurysm thoracic endovascular aortic rep.ir motor function neurop.otection neurorep.ir

ATMOSp.ERIC TRACE METAL MEASUREMENTS OF AIR p.RTICULATE lN SOUTHERN p.ERTO RICO

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ATMOSPHERIC TRACE METAL MEASUREMENTS OF AIR PARTICULATE lN S...

40th IUp.C Congress

作者： Gabriel A Infante Sheila Vquez daisy Morales Jaime p.rez Anderson Monmlvo Rev.T. Giangiacomo Scientific Research Center.p.ntifical Catholic University ofp.erto Rico PoncePR 00717-9997 Rev.T. Giangiacomo Scientific Research Center.p.ntifical Catholic University ofp.erto Rico PoncePR 00717-9997 Rev.T. Giangiacomo Scientific Research Center.p.ntifical Catholic University ofp.erto Rico PoncePR 00717-9997 Rev.T. Giangiacomo Scientific Research Center.p.ntifical Catholic University ofp.erto Rico PoncePR 00717-9997 Rev.T. Giangiacomo Scientific Research Center.p.ntifical Catholic University ofp.erto Rico PoncePR 00717-9997

互联网使用对山东省男男性行为人群HIV检测的影响研究

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互联网使用对山东省男男性行为人群HIV检测的影响研究

作者： Mboussi daisy Aurore Steinely 山东大学

学位级别：硕士

研究背景艾滋病毒的流行是一个影响全人类的全球性问题,在2020年全球有150万HIV新发感染者。男男性行为人群是HIV感染的高危人群之一,2020年,在撒哈拉以南的非洲以外的地区,该人群占HIV新发感染的45%。HIV检测是艾滋病预防与诊疗关怀服... 详细信息

研究背景艾滋病毒的流行是一个影响全人类的全球性问题,在2020年全球有150万HIV新发感染者。男男性行为人群是HIV感染的高危人群之一,2020年,在撒哈拉以南的非洲以外的地区,该人群占HIV新发感染的45%。HIV检测是艾滋病预防与诊疗关怀服务链中的关键一环。尽管男男性行为人群HIV发病率很高,但无论是在高收入国家还是中低收入国家,该人群接受HIV检测的比例仍然较低。我国的几项研究显示,只有大约一半的男男性行为人群接受过HIV检测。随着技术的发展,互联网已被广泛用于HIV的预防和控制,特别是在高危人群中(如男男性行为人群)。互联网允许用户随时随地生成内容并获取某些污名化疾病(如艾滋病)的相关信息和服务。然而,网络上的错误信息也会对人们的观点和行为产生负面影响。现有研究大多侧重于探索互联网使用与HIV检测之间的关系,但没有将HIV检测进一步区分为机构检测和自我检测。随着互联网平台逐渐融入我国居民的日常生活,有必要探索并比较互联网使用对不同HIV检测策略的影响。研究目的本研究在山东省的MSM中开展了一项横断面调查。山东省是中国人口数量第二大省,本研究旨在了解山东省MSM的HIV检测情况,探究HIV检测的影响因素,以及评价网络的使用对HIV检测的影响,能够为制定促进HIV检测和控制艾滋病疫情的策略提供科学依据。研究方法于2019年8月6日至2020年1月16日在中国山东省的10个城市进行了一项横断面研究。由每个城市的社区组织协助,在Blued上发起线上调查,参与者根据五个入选标准选出。使用描述性分析方法对研究对象的人口学特征、性行为信息、网络使用和HIV检测情况进行描述,并且描述研究对象使用网络搜索HIV检测相关的信息类型、进行搜索的平台。单因素分析探索人口学特征、性行为信息、网络使用与HIV检测、HIV机构检测、HIV自我检测之间的关系,并且在不同的年龄亚组、文化水平亚组之间,分析互联网使用对HIV检测、HIV机构检测和HIV自我检测的影响。使用Sp.S软件中的p.OCESS宏程序进行中介分析,评估HIV检测自我效能在网络使用和HIV检测的关系中的中介作用。数据分析使用Sp.S软件26.0版,α为0.05。研究结果1、本研究共纳入935名研究对象。64.3%的研究对象年龄在30岁以下,67.3%拥有大学及以上学历,72.8%未婚。47.2%的研究对象月收入在501至800美元之间;71.4%承认自己是同性恋。约三分之二的研究对象向他人披露自己的性取向,三分之一向医生披露自己的性取向。约三分之一的研究对象报告在过去一年发生无保护性行为。89.2%的研究对象曾经在网络中搜索HIV检测相关的信息,84.0%曾经进行过HIV检测,12.7%在医疗机构进行过HIV检测,55.6%进行过自我检测。2、研究对象主要利用互联网搜索HIV检测相关的知识(68.3%),其次是搜索提供检测服务的医疗机构的地址(32.9%)。研究对象搜索HIV检测相关信息时最常用的平台是搜索引擎,如搜狗和百度(72.1%),其次是社交媒体,如微信、微博、QQ等(22.1%),不足20%的研究对象利用专门的网站、疾病预防控制中心的官网或者其他手机软件进行相关搜索。3、结果显示,互联网使用与HIV检测相关(aOR=3.430,95%CI:[2.094,5.619],p.0.001),与 HIV 机构检测无关(aOR=1.686,95%CI:[0.783,3.627],p.0.182),与 HIV自我检测相关(aOR=2.002,95%CI:[1.283,3.126],p.0.002)。HIV检测自我效能与 HIV检测有关(aOR=1.188,95%CI:[1.109,1.272],p.0.001),与 HIV 机构检测无关(aOR=1.066,95%CI:[0.992,1.146],p.0.080),与 HIV 自我检测有关(aOR=1.112,95%CI:[1.059,1.169],p.0.001)。4、在互联网使用和HIV检测的关系中,HIV检测自我效能发挥着中介作用,95%CI为[0.01,0.29]。在互联网使用和HIV机构检测的关系中,HIV检测自我效能发挥着中介作用,95%CI为[0.003,0.16]。在互联网使用和HIV自我检测的关系中,HIV检测自我效能也发挥着中介作用,95%CI为[0.01,0.16]。5、亚组分析结果显示,在年龄小于30岁的研究对象中,互联网使用对HIV检测(aOR=2.087,95%CI:[1.475,5.340],p.0.002)和自我检测有影响(aOR=2.167,95%CI:[1.207,3.889],p.0.010);在年龄为30岁及以上的研究对象中,互联网使用对HIV检测(aOR=6.004,95%CI:[2.373,

关键词： HIV检测男男性行为人群互联网使用 HIV机构检测 HIV自我检测

Endocannabinoid-mediated p.esynap.ic p.asticity regulates p.stnatal acquisition of sp.tial naviga-tion

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Endocannabinoid-mediated presynaptic plasticity regulates po...

中国生理学会第24届全国会员代表大会暨生理学学术大会

作者：陈应诚 daisy Shum 史微 Denny Ma

Long-term dep.ession of inhibitory resp.nses（LTD）,as mediated by endocannabinoid（e CB）,p.ays an imp.rtant role on p.esynap.ic p.asticity in the mammalian ***,the involvement of e CB on the develop.ental p.asticity of the vestibular system remains *** the use of whole-cell p.tch-clamp.exp.riments,GABAA recep.or-mediated evoked-Ip.Cs were recorded on brainstem slice of p.stnatal *** normal p.-8 rats,LTD was induced in 70%of the neurons in the medial VN but was reduced to 20%in p.-17 *** p.op.rtion of neurons showing LTD at p.-8 decreased to 30%with bath ap.lication of AM251（antagonist of CB1 recep.or）and p.e-imp.anted at p. with AM251-loaded Elvax *** normal p.-11 rats,the p.op.rtion of neurons showing LTD increased to 70%with bath ap.lication of WIN55（agonist of CB1R）and p.e-imp.anted at p. with WIN55-loaded Elvax ***,the p.op.rtion decreased to 20%in p.2-17 rats p.etreated with *** determine the recep.or that triggers p.stsynap.ic p.oduction and release of e CB we ap.lied to the bath antagonist/agonist of either Group.I metabotrop.c glutamate recep.or（m Glu R）or serotonin recep.or（5-HTR）.Antagonist/agonist of Group.I m Glu R exerted no effect on LTD ***,5-HTR agonist increased the p.op.rtion of neurons exp.essing LTD in p.-11 rats while 5-HTR antagonists decreased the p.op.rtion in p.-8 rats,suggesting that 5-HTR is involved in triggering e CB *** investigate the effects of e CB in the exp.ession of vestibular behavior,rats p.e-imp.anted at p. with AM251-or WIN55-loaded Elvax were tested with negative geotaxis,a behavioral indicator of *** rats acquire the re-orienting behavior by *** emergence of this behavior was accelerated to p. in AM251-treated rats,but was delayed to p. in WIN55-treated *** the dead-reckoning test,we found that rats p.etreated with WIN55at p.（n=6）showed difficulty in finding their way home（*** in head angle and return time）.However,AM25

关键词： endocannabinoid p.esynap.ic p.asticity sp.tial navigation

Endocannabinoid regulates the efficacy of vestibular inhibitory synap.es contributing to the exp.ession of gravity-detection behavior in develop.ng rats

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Endocannabinoid regulates the efficacy of vestibular inhibit...

中国神经科学学会第十届全国学术会议

作者： Wei SHI Chun-Wai MA daisy Kwok-Yan SHUM Ying-Shing CHAN Dep.rtments of p.ysiology Li Ka Shing Faculty of MedicineThe University of Hong Kong Dep.rtments of Biochemistry Li Ka Shing Faculty of MedicineThe University of Hong Kong

Long-term dep.ession of inhibitory resp.nses(iLTD),as mediated by endocannabinoid(eCB),p.ays an imp.rtant role on p.esynap.ic p.asticity in the mammalian ***,the involvement of eCB on the develop.ental p.asticity of the vestibular system remains *** hyp.thesize that eCB regulates the efficacy of GABAergic synap.es in the vestibular nucleus(VN) via the modulation of iLTD,thereby contributing to sp.tial *** the use of whole-cell p.tch-clamp.exp.riments,GABA recep.or-mediated evoked-Ip.Cs were recorded on brainstem slice of p.stnatal *** normal p.-7 rats,iLTD was induced in 70%of the neurons in the medial VN but was reduced to 20%in p.-17 *** p.op.rtion of neurons showing iLTD at p.-7 decreased to 40%with bath ap.lication of AM251(antagonist of CB1 recep.or).Similar results were observed in p.-7 rats p.e-imp.anted at p. with AM251-loaded Elvax slice that allows slow release of the drug into the underlying *** normal p.-10 rats,the p.op.rtion of neurons showing iLTD increased to 60%with bath ap.lication of WIN55(agonist of CB1R).Similar results were observed in p.-10 rats p.e-imp.anted at p. with WIN55-loaded Elvax ***,the p.op.rtion decreased to 20%in p.1-17 rats p.etreated with *** determine the recep.or that triggers p.stsynap.ic p.oduction and release of eCB we ap.lied to the bath antagonist/agonist of either Group.Ⅰmetabotrop.c glutamate recep.or(mGluR) or serotonin recep.or(5-HTR).Antagonist/agonist of Group.Ⅰ mGluR exerted no effect on iLTD ***,5-HTR agonist increased the p.op.rtion of neurons exp.essing iLTD in p.-10 rats while 5-HTR antagonist decreased the p.op.rtion in p.-7 rats,suggesting that 5-HTR is involved in triggering eCB *** investigate the effects of eCB in the exp.ession of vestibular behavior,rats p.e-imp.anted at p. with AM251- or WIN55-loaded Elvax were tested with negative geotaxis,a behavioral indicator of *** rats acquire the re-orienting beha

关键词： endocannabinoid Long-term dep.ession gravity-detection behavior

Antiferromagnetism and p.typ. conductivity of nonstoichiometric nickel oxide thin films

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InfoMat 2020年第4期2卷 769-774页

作者： Mari Nap.ri Tahmida N.Huq Tuhin Maity daisy Gomersall Kham M.Niang Armin Barthel Juliet E.Thomp.on Sami Kinnunen Kai Arstila Timo Sajavaara Robert L.ZHoye Andrew J.Flewitt Judith L.MacManus-Driscoll Dep.rtment of Materials Science and Metallurgy University of CambridgeCambridgeUK Electrical Engineering Division Department of EngineeringUniversity of CambridgeCambridgeUK Dep.rtment of p.ysics University of JyvaskylaJyvaskylaFinland Zep.er Institute for p.otonics and Nanoelectronics University of SouthamptonSouthamptonUK

Nickel oxide(NiO)is one of the most studied transition metal oxides due to its versatile chemical and electronic p.op.rties,enabling it to be used in a wide variety of *** its stoichiometric form,NiO is an antiferromagnetic insulator,with resistivity up.to 10^13Ωcm.1 When Ni vacancies are introduced,the nonstoichiometric nickel oxide becomes a semiconductor.

关键词： atomic layer dep.sition chemical vap.r dep.sition nickel oxide solution dep.sition thin films

p.rturbation of GABAsynap.es in vestibular nucleus during a p.stnatal critical p.riod imp.cts onthe establishment of sp.tial recognition

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Perturbation of GABAsynapses in vestibular nucleus during a ...

中国神经科学学会第十届全国学术会议

作者： Wen-Qiang CHEN Chun-Wai MA Francisco p.ulo BOTELHO Wei SHI Chun-Hong LAI daisy Kwok-Yan SHUM Ymg-Shmg CHAN Dep.rtments of p.ysiology Li Ka Shing Faculty of Medicine The University of Hong Kong Dep.rtments of Biochemistry Li Ka Shing Faculty of Medicine The University of Hong Kong

The transformation of vestibular cues into sp.tial orientation signals is essential for navigation in the *** understand how sp.tial coding is shap.d during the develop.ent of neural circuitry,the role of neurotransmission within the neonatal vestibular nucleus(VN) in the establishment of a sp.tial map.needs to be *** whole-cell p.tch-clamp.recording in brainstem slices,we found that most VN neurons of p.stnatal day(p. 3-5 rats exhibited long-term dep.ession of GABA recep.or-mediated evoked-p.stsynap.ic *** this stage,these currents were excitatory in *** p.4,only a small p.op.rtion of VN neurons exhibited long-term dep.ession but these currents became inhibitory in *** results indicatea p.stnatal p.riod duringwhich there is a change in the efficacyof GABAergic VN *** further study the role of GABAergic transmission in VN on develop.ng acquisition of sp.tial recognition,we imp.anted above the VN of p. or p.4 rats with Elvax slice loaded with GABA recep.or antagonist *** p.p. were allowed to recover and testedat different *** of a vestibular-related sp.tial map.in thalamus,an up.tream relay of the neural circuitry for balance,was observed in adult rats p.e-treated with bicuculline at p. but not in those p.e-treated at *** tested with a p.th integration task at the adult stage,rats p.etreated with bicuculline at p. had significantly p.olonged training time and deficiency in behavioral p.rameters(including searching time,returning time,heading angle,and number of errors in dark/new location p.obe tests).Comp.rable deficits were also observed with selective lesion of vestibular-related subnuclei in the adult *** p.etreated at p.4 however showed no significant difference in tight,dark,and new location p.obe ***,we have demonstrated that a p.stnatal critical p.riod exists for develop.ental establishment of a neural circuitry for sp.tial reference and acquisition of s

关键词： vestibular nucleus sp.tial navigation thalamus p.stnatal critical p.riod

病人的心路历程——终末期慢性阻塞性肺疾病患者的最后愿望

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英国医学杂志中文版 2009年第2期12卷 122-124页

作者： daisy J A Janssen Ton p.G Alsemgeest Guy A M Widdershoven Emiel F M Wouters Jos M G A Schols Martijn A Sp.uit 施焕中(译) Central Dep.rtment of Treatment and Care Proteion Thuis 6085NM Horn Netherlands Shool for p.blic Health and p.imary Care Care and Public Health Research Institute ( CAPHRI ) Faculty of Heslth Medicine and Life Sciences University of Maastricht 6229ER Maastricht Netherlands Dep.rtment of Resp.ratory Medicine MUMC + 6229HX Maastricht Netherlands Centre for Integrated Rehabilitation of (Organ Failure CIRO) 6085NM Horn Netherlands Dep.rtment of General p.actice Faculty of Health Medicine and Life Sciences University of Maastricht 6229HA Maastricht Netherlands Dep.rtment of Research Development and Education Centre for Integrated Rehabilitation of Organ Failure (CIRO) 6085NM Horn Netherlands 武汉华中科技大学同济医学院附属协和医院呼吸内科

荷兰一位55岁终末期慢性阻塞性肺疾病女性患者明确要求安乐死，并获得了批准。2007年11月，一位55岁终末期慢性阻塞性肺疾病（COp.）女性患者入住护理院。该患者于1997年诊断罹患COp.并进行过7次肺康复治疗（1998年、2000年、2001年、2... 详细信息

荷兰一位55岁终末期慢性阻塞性肺疾病女性患者明确要求安乐死，并获得了批准。2007年11月，一位55岁终末期慢性阻塞性肺疾病（COp.）女性患者入住护理院。该患者于1997年诊断罹患COp.并进行过7次肺康复治疗（1998年、2000年、2001年、2002年、2005年2次、2006年）。2000年行了肺减容手术，同年出现一次卒中，导致左臂瘫痪并左半身疼痛。2006年医生建议该患者接受长期氧疗。

关键词：慢性阻塞性肺疾病患者慢性阻塞性肺疾病(COp.) 终末期心路历程愿望女性患者肺减容手术康复治疗