检索结果-南通市图书馆

Epidemiologic differences in esophageal cancer between Asian and Western populations

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer 2012年第6期31卷 281-286页

作者： han-ze Zhang Guang-Fu Jin Hong-Bing Shen Affiliation:Department of Epidemiology and Biostatistics Schoolof Public HealthNanjing Medical UniversityNanjingJiangsu 210029P.R.China

Esophageal cancer is a common cancer worldwide and has a poor prognosis. The incidence of esophageal squamous cell cancer has been decreasing, whereas the incidence of esophageal adenocarcinoma has been increasing rapidly, particularly in Western men. Squamous cell cancer continues to be the major type of esophageal cancer in Asia, and the main risk factors include tobacco smoking, alcohol consumption, hot beverage drinking, and poor nutrition. In contrast, esophageal adenocarcinoma predominately affects the whites, and the risk factors include smoking, obesity, and gastroesophageal reflux disease. In addition, Asians and Caucasians may have different susceptibilities to esophageal cancer due to different heritage backgrounds. However, comparison studies between these two populations are limited and need to be addressed in the near future. Ethnic differences should be taken into account in preventive and clinical practices.

关键词：食管癌亚洲人流行病学西方鳞状细胞癌人群危险因素全球范围

Differences in clinical and genetic characteristics between early-and late-onset narcolepsy in a han Chinese cohort

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2020年第10期15卷 1887-1893页

作者： Hui Ouyang Fang han ze-Chen Zhou Jun Zhang Department of Clinical Neurology Peking University People’s HospitalBeijingChina Department of Clinical Pulmonology Peking University People’s HospitalBeijingChina Department of Epidemiology and Biostatistics School of Public HealthPeking University Health Science CenterBeijingChina

Early-and late-onset narcolepsy constitutes two distinct diagnostic ***,it is not clear whether symptomology and genetic risk factors differ between early-and late-onset *** study compared clinical data and single-nucleotide polymorphisms(SNPs)between early-and late-onset patients in a large cohort of 899 han Chinese narcolepsy ***,cerebrospinal fluid,and clinical data were prospectively collected from patients,and patients were genotyped for 40 previously reported narcolepsy risk-conferring *** risk scores(GRSs),associations of five different sets of SNPs(GRS1–GRS5)with early-and late-onset narcolepsy,were evaluated using logistic regression and receiver operating characteristic *** sleep latency was significantly shorter in early-onset cases than in late-onset *** severity was greater among late-onset patients,with higher rates of sleep paralysis,hypnagogic hallucinations,health-related quality of life impairment,and concurrent presentation with four or more *** levels did not differ significantly between early-and late-onset *** rs3181077(CCR1/CCR3)and rs9274477(HLA-DQB1)were more prevalent among early-onset *** GRS1(26 SNPs;OR=1.513,95%CI:0.893–2.585;P<0.05)and GRS5(6 SNPs;OR=1.893,95%CI:1.204–2.993;P<0.05)were associated with early-onset narcolepsy,with areas under the receiver operating characteristic curves of 0.731 and 0.732,*** GRS1 nor GRS5 included SNPs in HLA *** results indicate that symptomology and genetic risk factors differ between early-and late-onset *** protocol was approved by the Institutional Review Board(IRB)Panels on Medical Human Subjects at Peking University People’s Hospital,China(approval *** 86)in October 2011.

关键词： case-control studies clinical features genetic association studies genetic load genetic loci genetic phenomena hypothalamic diseases precision medicine risk assessment single nucleotide polymorphism

盘钻法上颌窦内提升牙种植术的10年临床效果回顾分析

在线全文

学校读者我要写书评

暂无评论

上海口腔医学 2024年第1期33卷 64-70页

作者：张凯悦韩泽禹姜帅徐昊李凡赵保东青岛大学附属医院口腔种植科山东青岛266000 青岛大学口腔医学院山东青岛266000

目的:分析盘钻法上颌窦内提升牙种植术术后10年种植体周围骨改建情况,并探讨不同因素对种植体存留率的影响。方法:收集青岛大学附属医院口腔种植科2008年1月—2011年12月间,应用盘钻法行上颌窦内提升同期牙种植术患者的临床及影像学资... 详细信息

目的:分析盘钻法上颌窦内提升牙种植术术后10年种植体周围骨改建情况,并探讨不同因素对种植体存留率的影响。方法:收集青岛大学附属医院口腔种植科2008年1月—2011年12月间,应用盘钻法行上颌窦内提升同期牙种植术患者的临床及影像学资料。应用全景片和CBCT测量不同时期种植体周围的骨量变化,利用SPSS 26.0软件包中的Kaplan-Meier法和Log-rank检验法分析不同因素对种植体存留率的影响。结果:共纳入98例患者,合计128颗种植体。随访0~168个月,随访过程中,7颗种植体失败,其余均形成良好的骨结合并行使功能,10年累积存留率达94.53%。获得完整影像学数据的75个种植位点中,术后10年种植体尖端成骨高度(0.29±0.15) mm,窦内成骨高度为(2.74±0.66) mm。Kaplan-Meier法和Log-rank检验法分析表明,初始骨高度、提升骨高度、黏膜穿孔、种植体长度、植入扭力、吸烟、糖尿病、牙周炎等8个因素对种植体存留率有显著影响。结论:盘钻法上颌窦内提升牙种植术是解决上颌后牙区垂直骨缺损的一种可靠、稳定的骨增量手术,10年累计存留率不低于94%。初始骨高度、提升骨高度、黏膜穿孔、种植体长度、植入扭力、吸烟、糖尿病、牙周炎等是影响种植体长期存留率的重要因素。

关键词：牙种植盘钻法上颌窦内提升术存留率

在线全文

学校读者我要写书评

暂无评论

二苯乙烯型荧光增白剂光降解及检测研究进展

理化检验（化学分册） 2024年第9期60卷 947-964页

作者：李扬动赵鹏程王千羽张泽恩韩祺瑞中国刑事警察学院刑事科学技术学院沈阳110854

二苯乙烯型荧光增白剂因荧光效率高和稳定性强等优点,在造纸、纺织、化妆品和洗涤剂等方面应用广泛。近年来,国内外关于荧光增白剂的污染和检验方法的报道逐渐增多,引起社会的高度关注。总结了目前对二苯乙烯型荧光增白剂光降解机理研... 详细信息

二苯乙烯型荧光增白剂因荧光效率高和稳定性强等优点,在造纸、纺织、化妆品和洗涤剂等方面应用广泛。近年来,国内外关于荧光增白剂的污染和检验方法的报道逐渐增多,引起社会的高度关注。总结了目前对二苯乙烯型荧光增白剂光降解机理研究和利用光降解解决污染的方法。简要概述了加速溶剂萃取、凝胶色谱、固相萃取法和QuEChERS等前处理技术,汇总了我国目前关于荧光增白剂的标准检测方法,重点综述了紫外光谱法、荧光光谱法、液相色谱法、液相色谱-串联质谱法和便携式检测等检测技术在二苯乙烯型荧光增白剂中的应用,并对二苯乙烯型荧光增白剂在法庭科学的应用做出展望,同时为治理其污染提出了一些建议,为我国建立二苯乙烯型荧光增白剂现实可行的法规提供了一些思路(引用文献122篇)。

关键词：二苯乙烯型荧光增白剂光降解前处理检测技术

在线全文

学校读者我要写书评

暂无评论

武汉市交通运输高质量发展若干思考

交通企业管理 2024年第2期39卷 10-12页

作者：温汉辉余泽慧刘娅欣中交第二公路勘察设计研究院有限公司

武汉市地处长江与汉水交汇处,历来被称为“九省通衢”之地,是全国重要的工业基地、科教基地和综合交通枢纽。得天独厚的区位优势赋予了武汉市承东启西、沟通南北、维系四方的枢纽定位。随着国民经济和社会持续稳定快速发展,省际间经济... 详细信息

武汉市地处长江与汉水交汇处,历来被称为“九省通衢”之地,是全国重要的工业基地、科教基地和综合交通枢纽。得天独厚的区位优势赋予了武汉市承东启西、沟通南北、维系四方的枢纽定位。随着国民经济和社会持续稳定快速发展,省际间经济交流和互动日趋频繁,武汉市国际性综合交通枢纽城市的地位进一步得到巩固。《交通强国建设纲要》《国家综合立体交通网规划纲要》印发实施.

关键词：运输通道交通出现路网结构客货分离 “两轴三联” 武汉市

维普期刊数据库博看期刊

Paleoglacial and paleoclimate reconstructions during the global Last Glacial Maximum in the Longriba area, eastern Tibetan Plateau

在线全文

学校读者我要写书评

暂无评论

Journal of Mountain Science 2021年第2期18卷 307-322页

作者： YANG Wei-lin han Ye-song PENG Xu RAN ze-ze LIU Qing LIU Geng-nian College of Urban and Environmental Sciences Peking UniversityBeijing 100871China

Owing to the remoteness of the Longriba area and the lack of dating records,it is extremely challenging to reconstruct the chronology and extent of the paleoglaciers in this *** this paper,we combined limited observational data with automated modelling for paleoglacial *** first identified a broadly distributed paleoglacier from satellite imagery and field investigation based on the sediment-landform assemblage principle and dated it to 23.1±1.4~19.5±1.2 ka by ^(10)Be exposure dating,corresponding to the global Last Glacial Maximum(gLGM).Then,we reconstructed the extent and ice surface of 171 paleoglaciers formed during the similar period based on geomorphological evidence and‘ice surface profile’*** results showed that the paleoglacial coverage was 426.5 km2,with an ice volume of 38.1 km^(3),in the Longriba *** reconstructed equilibrium line altitudes(ELAs)based on modelled ice surfaces yielded an average of 4245±66 m above sea level(asl),~725±73 m lower than the present ELA(4970±29 m asl).The temperature was~5.51-6.68℃lower,and the precipitation was~30-34%less in Longriba,during the gLGM compared to the present *** glacial advance was mainly driven by colder climate that was synchronous with Northern Hemisphere cooling events.

关键词： Ice surface profile ^(10)Be surface exposure dating Paleoglacial reconstruction Paleoclimate reconstruction Global Last Glacial Maximum Eastern Tibetan Plateau

Risk factors associated with retinal neovascularization of diabetic retinopathy in type 2 diabetes mellitus

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2011年第2期4卷 182-185页

作者： ze-Long Zhong Mei han and Song Chen Clinical College of Ophthalmology Tianjin Medical University Tianjin Eye Hospital Tianjin 300020 China

AIM: To evaluate the risk factors associated with retinal neovascularization of diabetic retinopathy in northern Chinese han patients with type 2 diabetes mellitus (T2DM). METHODS: The clinical characteristics of 200 patients with proliferative diabetic retinopathy (PDR) and 100 age-matched healthy individuals were compared. The univariate and multivariate logistic regression analysis were performed in the patients with PDR. RESULTS: Fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), blood urea nitrogen (BUN), uric acid (UA), white blood cell count (WBC), absolute neutrophil count, hematocrit (HCT) and mean platelet volume (MPV) and mean platelet volume (MPV) were all significantly higher in patients with PDR than in the control group (Phand, panretinal photocoagulation was associated with reduced risk of retinal neovascularization (OR=0.983; P=0.000). CONCLUSION: Preventing and controlling T2DM in terms of risk factors, including duration of diabetes, BUN, smoking and MPV, might offer novel approaches to prevent or delay the onset of retinal neovascularization in patients with PDR.

关键词： diabetic retinopathy diabetes mellitus type 2 retinal neovascularization risk factors

Kinematic Control of Free Rigid Bodies Using Dual Quaternions

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Automation and computing 2008年第3期5卷 319-324页

作者： Da-Peng han Qing Wei ze-Xiang Li College of Mechatronic Engineering and Automation~ National University of Defense Technology Changsha 410073 PRC Department of Electrical and Electronic Engineering Hong Kong University of Science and Technology Hongkong PRC

This paper proposes a new type of control laws for free rigid bodies. The start point is the dual quaternion and its characteristics. The logarithm of a dual quaternion is defined, based on which kinematic control laws can be developed. Global exponential convergence is achieved using logarithmic feedback via a generalized proportional control law, and an appropriate Lyapunov function is constructed to prove the stability. Both the regulation and tracking problems are tackled. Omnidirectional control is discussed as a case study. As the control laws can handle the interconnection between the rotation and translation of a rigid body, they are shown to be more applicable than the conventional method.

关键词： Kinematic control dual quaternion omnidirectional control proportional control

Myricetin reduces cytotoxicity by suppressing hepcidin expression in MES23.5 cells

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2021年第6期16卷 1105-1110页

作者： han Deng Shang Liu Dong Pan Yi Jia ze-Gang Ma Department of Physiology School of Basic MedicineQingdao UniversityQingdaoShandong ProvinceChina Institute of Brain Science and Disorders Qingdao UniversityQingdaoShandong ProvinceChina

Multiple studies implicate iron accumulation in the substantia nigra in the degeneration of dopaminergic neurons in Parkinson’s ***,slowing of iron accumulation in cells has been identified as the key point for delaying and treating Parkinson’s *** reportedly plays an important role in anti-oxidation,anti-apoptosis,anti-inflammation,and iron ***,the mechanism underlying its neuroprotection remains *** the present study,MES23.5 cells were treated with 1×10^-6 M myricetin for 1 hour,followed by co-treatment with 400 nM rotenone for 24 hours to establish an in vitro cell model of Parkinson’s *** results revealed that myricetin alleviated rotenone-induced decreases in cell viability,suppressed the production of intracellular reactive oxygen species,and restored mitochondrial transmembrane *** addition,myricetin significantly suppressed rotenone-induced hepcidin gene transcription and partly relieved rotenone-induced inhibition of ferroportin 1 mRNA and protein ***,myricetin inhibited rotenone-induced phosphorylation of STAT3 and SMAD1 in MES23.5 *** findings suggest that myricetin protected rotenone-treated MES23.5 cells by potently inhibiting hepcidin expression to prevent iron accumulation,and this effect was mediated by alteration of STAT3 and SMAD1 signaling pathways.

关键词： factor flavonoid hepcidin in vitro iron Parkinson’s disease pathways rotenone