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Epigallocatechin-3-gallate （EGCG） attenuates nflammation in MRL/Ipr mouse mesangial cells

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Cellular & Molecular Immunology 2010年第2期7卷 123-132页

作者： Abigail Peairs rujuan dai Lu Gan Samuel Shimp M Nichole Rylander Liwu Li Christopher M Reilly Virginia College of Osteopathic Medicine Blacksburg VA USA Department of Biomedical Sciences and Pathobiology Virginia Maryland Regional College of VeterinaryMedicine Virginia Polytechnic Institute and State University Blacksburg VA USA Department of Biological Sciences Virginia Polytechnic Institute and State UniversityBlacksburg VA USA Department of Mechanical Engineering Virginia Polytechnic Institute and State University Blacksburg VA USA

Epigallocatechin-3-gallate （EGCG）, a bioactive component of green tea, has been reported to exert anti-inflammatory effects on immune cells. EGCG is also shown to activate the metabolic regulator, adenosine 5＇-monophosphate-activated protein kinase （AMPK）. Reports have also indicated that EGCG inhibits the immune-stimulated phosphoinositide 3-kinase （PI3K）/Akt/mammalian target of rapamycin （mTOR） pathway. The PI3K/Akt/mTOR pathway has been implicated in mesangial cell activation in lupus. Mesangial cells from MRUIpr lupus-like mice are hyper-responsive to immune stimulation and overproduce nitric oxide （NO） and other inflammatory mediators when stimulated. In our current studies, we sought to determine the mechanism by which EGCG attenuates immune-induced expression of pro-inflammatory mediators. Cultured mesangial cells from MRL/Ipr mice were pre-treated with various concentrations of EGCG and stimulated with lipopolysaccharide （LPS）/interferon （IFN）-γ. EGCG activated AMPK and blocked LPS/ IFN-γ-induced inflammatory mediator production （iNOS expression, supernatant NO and interleukin-6）. Interestingly, EGCG attenuated inflammation during AMPK inhibition indicating that the anti-inflammatory effect of EGCG may be partially independent of AMPK activation. Furthermore, we found that EGCG effectively inhibited the immune-stimulated PI3K/Akt/mTOR pathway independently of AMPK, by decreasing phosphorylation of Akt, suggesting an alternate mechanism for EGCG-mediated anti-inflammatory action in mesangial cells. Taken together, these studies show that EGCG attenuated inflammation in MRL/Ipr mouse mesangial cells via the PI3K/Akt/mTOR pathway. Our findings suggest a potential therapeutic role for the use of EGCG to regulate inflammation and control autoimmune disease.

关键词： AMPK inflammation lupus metabolism MRL/Ipr

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多发性硬化患者白细胞介素6水平及临床意义

中华医学检验杂志 1998年第5期21卷 272-274页

作者：戚其学李玉芬戴茹娟中国医科大学第一临床学院神经内科实验室辽宁省人民医院神经内科

目的探讨白细胞介素６（ＩＬ６）在多发性硬化（ＭＳ）发病中的作用。方法以生物学方法检测３７例ＭＳ患者血清及脑脊液（ＣＳＦ）中ＩＬ６含量。结果ＭＳ患者血清及脑脊液中ＩＬ６含量分别为７２６７±５２４６；１７５０... 详细信息

目的探讨白细胞介素６（ＩＬ６）在多发性硬化（ＭＳ）发病中的作用。方法以生物学方法检测３７例ＭＳ患者血清及脑脊液（ＣＳＦ）中ＩＬ６含量。结果ＭＳ患者血清及脑脊液中ＩＬ６含量分别为７２６７±５２４６；１７５０±５２１Ｕ／ｍｌ而非炎症性神经病（ＮＩＮＤ）组分别为１９７４±１３８１和５５６±２２５Ｕ／ｍｌ，正常对照（ＮＣ）组血清ＩＬ６含量为６３３±１０３９Ｕ／ｍｌ，ＭＳ患者血清及脑脊液ＩＬ６水平均明显高于对照组（Ｐ＜００１），但ＭＳ患者血清与ＣＳＦＩＬ６水平不呈线性相关，血清ＩＬ６水平随病情稳定而下降。

关键词：多发性硬化症白细胞介素6 血清脑脊液

猪肥胖基因(ob)位点的RFLP多态性分析

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农业生物技术学报 2000年第2期8卷 123-124页

作者：昔奋攻戴茹娟李宁曹更生赵要风吴常信中国农业大学农业生物技术国家重点实验室!北京100094 中国农业大学动物科技学院!北京100094 河南大学生物工程系!开封475001

肥胖基因（ob）产物—Leptin是反映体内脂肪含量和调节体重的重要信号因子。本研究从构建的猪脂肪cDNA文库中分离克隆猪ob基因，并以克隆的猪ob基因片段为探针，Bg／Ⅱ酶切基因组DNA对不同品种猪在ob基因位点的多态性进行了分析。结果... 详细信息

肥胖基因（ob）产物—Leptin是反映体内脂肪含量和调节体重的重要信号因子。本研究从构建的猪脂肪cDNA文库中分离克隆猪ob基因，并以克隆的猪ob基因片段为探针，Bg／Ⅱ酶切基因组DNA对不同品种猪在ob基因位点的多态性进行了分析。结果表明脂肪型猪与瘦肉型猪在RFLP带型上存在明显差异，在所有瘦肉型猪中都存在一条4．3kb的带，脂肪型猪存在一条3．5kb的带，在所分析的6个品种，共60个样品中检测到4种基因型的存在。

关键词：猪肥胖基因(ob) RFLPs

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石化剩余污泥理化性能与热动力学特性研究

常州大学学报（自然科学版） 2022年第1期34卷 33-41页

作者：张大山戴如娟毛林强彭明国张文艺常州大学环境与安全工程学院江苏常州213164 无锡马盛环境能源科技有限公司江苏无锡214000

针对石化废水生物处理产生的剩余污泥处置难题,考察利用其中所含油类及生物质热值的可行性,采用XRF,FT-IR,XRD,GC,TG-DSC等分析手段,表征其理化性质及热动力学特性。结果表明:干基石化剩余污泥晶体种类主要为α-石英相,CaO,Fe_(2)O_(3)... 详细信息

针对石化废水生物处理产生的剩余污泥处置难题,考察利用其中所含油类及生物质热值的可行性,采用XRF,FT-IR,XRD,GC,TG-DSC等分析手段,表征其理化性质及热动力学特性。结果表明:干基石化剩余污泥晶体种类主要为α-石英相,CaO,Fe_(2)O_(3)两种助溶剂质量分数较高,分别为39.2%和18.6%,Cl和Cr_(2)O_(3)含量最低;污泥中包含N—H,—CO—NH—,—CO—X—,CO_(2)^(-3),SiO_(2)^(-4),SO_(4)^(2-)等;重金属含量相对较低,其中Zn含量为50.44 mg/kg、Cu含量为2.14 mg/kg、Ni含量为6.44 mg/kg;石油烃含量丰富,m(C10~C14)∶m(C16~C28)∶m(C30~C40)为5∶18∶2,油脂类C16~C28含量最高,达29.77 g/kg;200~500℃时石化剩余污泥失重速率达到最大,800℃以上污泥热失重趋于结束。综合燃烧特性分析表明,随着升温速率的增大,试样的着火温度介于252.17~256.49℃,燃尽温度、最大失重速率、平均失重速率和综合燃烧特性指数(S)随之呈现升高的趋势。在较高的升温速率下污泥S值越大,综合燃烧特性越好。本研究对石化剩余污泥热值焚烧利用及焚烧飞灰的处置有一定应用参考价值。

关键词：石化剩余污泥理化性能热动力学综合燃烧特性指数

A closed-loop process for recycling LiNi_xCo_yMn_((1-x-y))O_2 from mixed cathode materials of lithium-ion batteries

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Green Energy & Environment 2017年第1期2卷 42-50页

作者： rujuan Zheng Wenhui Wang Yunkun dai Quanxin Ma Yuanlong Liu Deying Mu Ruhong Li Jie Rena Changsong dai MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of Technology College of Chemistry and Chemical Engineering Qiqihar University College of Animal Science and Veterinary Medicine Jilin University State Key Laboratory of Advanced Chemical Power Sources

With the rapid development of consumer electronics and electric vehicles(EV), a large number of spent lithium-ion batteries(LIBs) have been generated worldwide. Thus, effective recycling technologies to recapture a significant amount of valuable metals contained in spent LIBs are highly desirable to prevent the environmental pollution and resource depletion. In this work, a novel recycling technology to regenerate a LiNi_(1/3)Co_(1/3)Mn_(1/3)O_2 cathode material from spent LIBs with different cathode chemistries has been developed. By dismantling, crushing,leaching and impurity removing, the LiNi_(1/3)Co_(1/3)Mn_(1/3)O_2(selected as an example of LiNi_xCo_yMn_(1-x-y)O_2) powder can be directly prepared from the purified leaching solution via co-precipitation followed by solid-state synthesis. For comparison purposes, a fresh-synthesized sample with the same composition has also been prepared using the commercial raw materials via the same method. X-ray diffraction(XRD), scanning electron microscopy(SEM) and electrochemical measurements have been carried out to characterize these samples. The electrochemical test result suggests that the re-synthesized sample delivers cycle performance and low rate capability which are comparable to those of the freshsynthesized sample. This novel recycling technique can be of great value to the regeneration of a pure and marketable LiNi_xCo_yMn_(1-x-y)O_2 cathode material with low secondary pollution.

关键词： Spent lithium-ion battery Cathode material recycling Acid leaching Purification Co-precipitation

废旧锂离子电池中Li,Fe和V的回收及xLiFePO_4-yLi_3V_2(PO_4)_3的制备

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稀有金属材料与工程 2018年第1期47卷 344-350页

作者：郑茹娟刘元龙马全新穆德颖李如宏戴长松哈尔滨工业大学黑龙江哈尔滨150001 齐齐哈尔大学黑龙江齐齐哈尔161006

由于LiFePO_4和Li_3V_2(PO_4)_3材料的特征相近,制备方法类似,提供了一种从废旧LiFePO_4和Li_3V_2(PO_4)_3混合电池中回收Li、Fe和V,再制备xLiFePO_4-yLi_3V_2(PO_4)_3的方法。在空气气氛中600℃热处理1h后,去除粘结剂PVDF使活性物质与集流体分离。调节Li、Fe、V和P摩尔比,球磨、锻烧,配制不同比例的xLiFePO_4-yLi_3V_2(PO_4)_3(x:y=5:1,7:1,9:1)复合电极材料。表征了其形貌、结构和电化学性能,结果表明,回收制备的复合材料将同时具备LiFePO_4和Li_3V_2(PO_4)_3两种材料的电化学性能,能显著改善LiFePO_4的倍率性能。

关键词：废旧锂离子电池 LiFePO4 Li3V2(PO4)3 xLiFePO(4-y)Li3V2(PO4)3 回收