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大麦若叶对溃疡性肠炎相关癌变的预防作用及机制初探

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食品与发酵工业 2024年第6期50卷 7-16页

作者：尹子豪戴宇峰李海涛江南大学食品学院江苏无锡214122

大麦若叶(barley leaf,BL)对肠道健康具有潜在益处,但对结直肠癌的预防作用及机制尚未明确。为探究BL对结直肠癌的影响并阐述作用机制,研究分别建立了氧化偶氮甲烷/葡聚糖硫酸钠(azoxymethane/dextran sodium sulfate,AOM/DSS)诱导的结... 详细信息

大麦若叶(barley leaf,BL)对肠道健康具有潜在益处,但对结直肠癌的预防作用及机制尚未明确。为探究BL对结直肠癌的影响并阐述作用机制,研究分别建立了氧化偶氮甲烷/葡聚糖硫酸钠(azoxymethane/dextran sodium sulfate,AOM/DSS)诱导的结直肠癌小鼠模型和CT26移植瘤小鼠模型,研究发现BL明显减少了AOM/DSS诱导模型小鼠肿瘤结节数量但并不影响移植瘤小鼠肿瘤的生长。同时,通过蛋白印迹法,发现BL降低了结肠组织中重要结直肠癌致癌基因环氧合酶-2与表皮生长因子受体的蛋白表达水平;通过16S测序分析以及GC-MS分析,发现5%(质量分数)BL干预能够改善肠道菌群失调,使乙酸含量提升了2.53倍、丙酸3.63倍、丁酸3.81倍;通过细胞实验,发现乙酸钠、丙酸钠及丁酸钠可以抑制由表皮生长因子介导细胞恶性转化过程相关信号通路中p-AKT和p-ERK蛋白表达水平,从而明显抑制小鼠表皮细胞JB 6P+的恶性转化。综上所述,大麦若叶通过改善小鼠肠道菌群失调,提高部分短链脂肪酸的含量,下调肿瘤相关信号通路中关键蛋白的表达,抑制肿瘤细胞的增殖,进而缓解结直肠癌的发生和发展。

关键词：大麦若叶结直肠癌肠道菌群短链脂肪酸恶性转化

Overflow of Siling Co on the central Tibetan Plateau and its environmental impacts

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Science Bulletin 2024年第18期69卷 2829-2832页

作者： Yanbin Lei Jing Zhou Tandong Yao Broxton W.Bird Yifan Yu Shujin Wang Kun Yang Yinsheng Zhang Jianqing Zhai yufeng dai State Key Laboratory of Tibetan Plateau Earth System Environment and ResourcesInstitute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China Department of Earth Sciences Indiana University-Purdue University Indianapolis(IUPUI)Indianapolis IN 46202USA College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China Ministry of Education Key Laboratory for Earth System Modeling Department of Earth System ScienceTsinghua UniversityBeijing 100084China National Climate Center China Meteorological AdministrationBeijing 100081China

The Tibetan Plateau(TP)and its surroundings are also referred to as“Asian Water Tower”,which is the headwater of ten major rivers in Asia and provides ecosystem service for nearly two billion people[1].The interior TP boasts the greatest concentration of high-latitude inland lakes in the world,providing essential water resources,regulating regional climate and maintaining ecological *** the past 50 years,the TP has experienced rapid climate warming and overall wetting,which has led to glacier mass loss,thawing of permafrost,reduction in snow cover,and shortening of lake ice duration[1].Changes in lake water storage provide a means of assessing the regional hydrological response to recent climate change in this sparsely populated region.

关键词： Tibetan glacier inland

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重频速射电磁发射用混合储能系统控制策略

海军工程大学学报 2024年第3期36卷 26-32页

作者：张晓王志翔戴宇峰马涛海军工程大学电磁能技术全国重点实验室武汉430033

面向重频快速电磁发射的应用需求,针对其对混合储能系统初级储能向次级储能超高频率充电的难题,提出了一种基于“超级电容-脉冲电容”的新型混合储能系统,与现有“蓄电池-脉冲电容”混合储能相比,该系统具有快速充电和长寿命的优势。首... 详细信息

面向重频快速电磁发射的应用需求,针对其对混合储能系统初级储能向次级储能超高频率充电的难题,提出了一种基于“超级电容-脉冲电容”的新型混合储能系统,与现有“蓄电池-脉冲电容”混合储能相比,该系统具有快速充电和长寿命的优势。首先,在介绍该储能系统基本电路结构和原理的基础上,结合时序串联充电方式推导了其内部能量转移过程的理论模型;然后,基于Matlab仿真平台搭建系统仿真模型,给出了时序串联充电控制策略,以及充电电压和电流波形,并定量分析了回路阻抗对充电波形的影响。仿真结果表明:所提出的基于“超级电容-脉冲电容”的混合储能系统可实现数十发/分的射速,可为重频速射电磁发射的应用提供有效的能源供给方案,且该混合储能系统基于时序串联控制可实现对电磁发射脉冲电源电压的精准控制。

关键词：混合储能超级电容脉冲电源恒流充电

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基于径向基函数插值的极移参数预报研究

大地测量与地球动力学 2024年第7期44卷 690-692页

作者：吴飞王乐洋曾志庆戴毓锋曹庆晨东华理工大学测绘与空间信息工程学院南昌市330013 东华理工大学自然资源部环鄱阳湖区域矿山环境监测与治理重点实验室南昌市330013 中国矿业大学环境与测绘学院江苏省徐州市221116

极移参数预报的基础数据通常采用国际地球自转和参考系服务组织发布的最终解产品,数据分辨率为1 d。利用径向基函数对极移观测值进行插值,获取6 h分辨率的极移产品,并基于LS+AR模型进行500组预报实验。结果表明,相较于未进行插值的预报... 详细信息

极移参数预报的基础数据通常采用国际地球自转和参考系服务组织发布的最终解产品,数据分辨率为1 d。利用径向基函数对极移观测值进行插值,获取6 h分辨率的极移产品,并基于LS+AR模型进行500组预报实验。结果表明,相较于未进行插值的预报结果,该方法在1~7 d超短期预报中极移X和Y方向预报精度分别平均提升22.4%和38.4%。

关键词：地球自转极移径向基函数 LS+AR

Different n-6/n-3 PUFA diets with fish oil attenuated osteoarthritis in ovariectomized mice via targeting the NLRP3 inflammasome

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Food Bioscience 2022年第1期45卷 313-323页

作者： Tianqi Zhang Xiaolin Bai yufeng dai Ping Dong Jingfeng Wang College of Food Science and Engineering Ocean University of ChinaQingdaoChina

Osteoporosis(OP)and osteoarthritis(OA)co-exist with increased inflammatory cytokines as a common *** diet containing high n-6/n-3 PUFA was suggested contributing to these chronic inflammatory *** fish oil(FO)rich in n-3 PUFAs has been confirmed beneficial for OA and bone loss in previous studies,whether small amounts of FO could alleviate osteoporotic OA under a high n-6/n-3 PUFA condition has not been *** this study,the osteoporotic OA mice were fed with 20:1 or 6:1 n-6/n-3 PUFA diets with or without FO for 12 *** results showed that 20:1 diet with FO ameliorated systemic inflammation and cartilage degradation in model mice,compared to the non-FO 20:1 ***,diets with FO altered the fatty acids composition with elevating n-3/n-6 PUFA in articular cartilage,thus restoring the cartilage homeostasis by inhibiting the catabolic ***,20:1 non-FO diet promoted the expression of NLRP3 via PGE2/EP4/NFκ***,20:1 FO-H diet significantly inhibited the expression of NLRP3 and further exhibited a greater affinity for GPR120 than 20:1 non-FO diet to inactivate caspase-1-dependent NLRP3 *** a consequence,20:1 FO-H diet inhibited chondrocyte pyroptosis and followed by the reduction of the two catabolic cytokines:IL-1β and ***,the 20:1 FO-H diet performed as well as the 6:1 non-FO diet,and 6:1 diet with FO could further improve osteoporotic OA in a dose-dependent *** study demonstrated that FO could attenuate the adverse effect of 20:1 n-6/n-3 PUFA diet on osteoporotic OA,providing skeletal evidence for healthy diet.

关键词： n-3 PUFAs n-6 PUFAs Osteoarthritis Osteoporosis Fish oil NLRP3

Sialoglycoproteins Isolated from the Eggs of Gadus morhua Inhibit Bone Resorption in Ovariectomized Rats by Suppressing the MAPK and NF-κB Pathways

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Journal of Ocean University of China 2019年第5期18卷 1174-1184页

作者： MAO Lei WANG Yiming WANG Meiling dai yufeng WANG Jingfeng XUE Changhu College of Food Science and Engineering Ocean University of China

The present study investigated the anti-osteoporosis function and the mechanism of sialoglycoproteins isolated from the eggs of Gadus morhua(Gm-SGP)on ovariectomized(OVX)*** 3 months of Gm-SGP treatment,OVX-induced bone loss was suppressed and uncoupling bone turnover was balanced,as indicated by systemic biomarkers of bone metabolism;no uterine estrogenicity was ***,rats administered with Gm-SGP exhibited increased bone mineral density and biomechanical strength and significant restoration of the trabecular microarchitecture compared with rats in the control ***-SGP significantly decreased bone resorption-related indicators in *** of the associated mechanisms revealed that Gm-SGP significantly increases the OPG/RANKL ratio at the mRNA and protein *** research suggested that Gm-SGP inhibits the mRNA and protein expressions of important transcription factors of the MAPK and NF-κB signaling *** also attenuates the activation of related transduction signaling pathways by inhibiting phosphorylation of JNK,ERK,p38,and NF-κB,and ultimately suppresses the induction of c-Fos and ***,these results demonstrate that Gm-SGP inhibits bone resorption by suppressing osteoclastogenesis-related MAPK and NF-κB pathways,thereby improving osteoporosis.

关键词： Sialoglycoprotein osteoporosis MAPKs NF-κB bone resorption

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全球变暖加剧青藏高原湖泊效应

Science Bulletin 2024年第7期69卷 968-977页

作者：戴玉凤汪涛盛永伟王磊陈宏斌张潇文李香钰王伟财邬俊飞陈文锋姚檀栋 State Key Laboratory of Tibetan Plateau Earth System Environment and Resources(TPESER)Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China Department of Geography University of CaliforniaLos Angeles CA 90095USA College of Information Science and Engineering Huaqiao UniversityXiamen 361021China Department of Resource Management Tangshan Normal UniversityTangshan 063000China Department of Atmospheric Science School of Environmental StudiesChina University of GeosciencesWuhan 430074China Center for Pan-third Pole Environment Lanzhou UniversityLanzhou 730000China

Lake-effect snowfall(LES)occurs when cold air moves across open *** is expected to occur more frequently over the TP,due to the intensified lake expansion caused by intensified global ***,there is an urgent need to comprehensively assess the LES over the ***,we revealed that the LES is triggered by westerly southward shift leading to the drop in air temperature and is positively correlated with lake area,wind speed and longitude across 12 large lakes(>300 km^(2))based on satellite observations and reanalysis *** a sensitivity model simulation,we determined that large lakes in the southern TP contributed to more than 50%of the snowfall in the downwind area in *** indicate that the westerly-triggered LES will increase under the future RCP4.5 climate warming scenario,highlighting the importance of developing adaptive policies to address the growing risks associated with future LES.

关键词： Lake-effect snowfall Westerly Tibetan Plateau Climate warming

冷冻砂型对铸铁合金凝固行为及组织性能影响规律研究

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金属加工（热加工） 2024年第9期 112-118页

作者：戴宇峰单忠德杨浩秦罗磊梁校南京航空航天大学材料科学与技术学院江苏南京210006 南京航空航天大学机电学院江苏南京210006 航空航天机械结构力学与控制全国重点实验室江苏南京210006

采用冷冻砂型铸造铸铁合金,界面换热系数是反映冷冻砂型与铸铁合金换热程度的重要参数,对于分析铸铁合金组织性能具有重要意义。研究测定了合金的界面接触温度随时间的变化规律,在此基础上分析了界面换热特征,获得了界面换热系数随初始... 详细信息

采用冷冻砂型铸造铸铁合金,界面换热系数是反映冷冻砂型与铸铁合金换热程度的重要参数,对于分析铸铁合金组织性能具有重要意义。研究测定了合金的界面接触温度随时间的变化规律,在此基础上分析了界面换热特征,获得了界面换热系数随初始界面温度变化的函数式,同时分析了冷冻砂型中铸件凝固的铸态微观组织及力学性能。结果表明:界面换热系数随着冷冻砂型初始温度的增加而降低,随含水率的减少而升高。当含水率为6%(质量分数,下同)时,在-35℃、-30℃、-25℃初始冷冻温度条件下,铸型铸件界面换热系数峰值分别是195663W/(m^(2)·K)、147933W/(m^(2)·K)、120836W/(m^(2)·K);当含水率为5%时,在-35℃、-30℃、-25℃初始冷冻温度条件下,铸型铸件界面换热系数峰值分别是209257W/(m^(2)·K)、176878W/(m^(2)·K)、134472W/(m^(2)·K)。相同含水率下初始冷冻温度越低,珠光体晶粒越细,石墨化程度越高,抗拉强度也越高。

关键词：冷冻砂型铸铁合金界面换热系数初始温度含水率

基于盲道病房联合Teach-back的健康教育在眼科术后患者中的实践

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护理实践与研究 2024年第1期21卷 132-137页

作者：戴玉凤谢凯旋王笑华徐文璇胡扬涛廖浩联勤保障部队第九〇八医院五官科江西省南昌市330002

目的探讨盲道病房联合Teach-back的健康教育在眼科术后患者中的应用实践。方法选取2021年1—12月医院收治的122例眼科手术患者为研究对象,按照组间基线资料均衡可比的原则分为对照组和观察组,每组61例。对照组采取常规护理流程;观察组... 详细信息

目的探讨盲道病房联合Teach-back的健康教育在眼科术后患者中的应用实践。方法选取2021年1—12月医院收治的122例眼科手术患者为研究对象,按照组间基线资料均衡可比的原则分为对照组和观察组,每组61例。对照组采取常规护理流程;观察组在对照组基础上采用Teach-back的健康教育方案。比较两组患者干预前后术后视障碍期间意外事件发生率、焦虑评分、术后生活自理能力以及体验的满意程度。结果观察组患者术后视障碍期间意外事件发生率低于对照组,差异具有统计学意义(P<0.05)。观察组患者术后焦虑评分低于对照组,差异具有统计学意义(P<0.05)。观察组患者术后进餐、梳洗、穿衣、如厕、活动等日常生活自理能力评分高于对照组,观察组患者对病房设置体验的满意程度高于对照组,差异均具有统计学意义(P<0.05)。结论盲道病房联合Teach-back的健康教育有利于降低眼科术后患者意外事件发生率,缓解患者术后心理焦虑问题,提高患者术后身心状态及生活自理能力,从而提高眼科护理安全管理和服务能力,也为我国眼科防盲事业发展起了推动作用。

关键词：眼科术后患者盲道病房 Teach-back健康教育焦虑生活自理能力满意度

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