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Current status and highlights of the ELI-NP research program

Matter and Radiation at Extremes 2020年第2期5卷 2-25页

作者： K.A.Tanaka K.M.Spohr d.L.Balabanski S.Balascuta L.Capponi M.O.Cernaianu M.Cuciuc A.Cucoanes I.dancus A.dhal B.diaconescu d.doria P.Ghenuche d.G.Ghita S.Kisyov V.Nastasa J.F.Ong F.Rotaru d.sangwan P.-A.Soderstrom d.Stutman G.Suliman O.Tesileanu L.Tudor N.Tsoneva C.A.Ur d.Ursescu N.V.Zamfir Extreme Light Infrastructure(ELI-NP)and Horia Hulubei National Institute for R&din Physics and Nuclear Engineering(IFIN-HH) Str.Reactorului No.30077125 Bucharest–M˘agureleRomania Johns Hopkins University 3400 N.Charles StreetBaltimoreMaryland 21218USA

The emergence of a new era reaching beyond current state-of-the-art ultrashort and ultraintense laser technology has been enabled by the approval of around V 850 million worth of structural funds in 2011–2012 by the European Commission for the installation of Extreme Light Infrastructure(ELI).The ELI project consists of three pillars being built in the Czech Republic,Hungary,and *** challenging proposal is based on recent technical progress allowing ultraintense laser fields in which intensities will soon be reaching as high as I0∼1023Wcm−*** tremendous technological advance has been brought about by the invention of chirped pulse amplification by Mourou and *** is hosting the ELI for Nuclear Physics(ELI-NP)pillar in M˘agurele near *** new facility,currently under construction,is intended to serve the broad national,European,and international scientific *** mission covers scientific research at the frontier of knowledge involving two *** first is laser-driven experiments related to NP,strong-field quantum electrodynamics,and associated vacuum *** second research domain is based on the establishment of a Compton-backscattering-based,high-brilliance,and intenseγbeam with Eγ≲19.5 MeV,which represents a merger between laser and accelerator *** system will allow the investigation of the nuclear structure of selected isotopes and nuclear reactions of relevance,for example,to astrophysics with hitherto unprecedented resolution and *** addition to fundamental themes,a large number of applications with significant societal impact will be *** implementation of the project started in January 2013 and is spearheaded by the ELI-NP/Horia Hulubei National Institute for Physics and Nuclear Engineering(IFIN-HH).Experiments will begin in early 2020.

关键词： intense frontier approval

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Simultaneous bilateral trochanteric fracturesma report of four cases

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Chinese Journal of Traumatology 2012年第6期15卷 360-363页

作者： Vinit Verma Zile Singh Kundu Amit Batra Raj Singh Sukhbir Singh sangwan Pratyush Gupta department of Orthopaedic Surgery Paraplegia &Rehabilitation Pt. B.D. Sharma PGIMS Rohtak 124001Haryana India

Simultaneous bilateral intertrochanteric fractures are very rare. There is a paucity of data in current literature documenting patients with such kind of hip fractures. It is severe and potentially life-threatening, associated with a high morbidity. The major determinants of successful outcome are high vigilance, early single stage stabilization and mobilization as well as management of associated comorbid conditions that may influence the longterm rehabilitation of patients. Here we reported 4 cases of concurrent bilateral trochanteric fractures along with review of the literature. Our study aimed to discover its frequency, identify the injury mechanisms as well as factors present in the pathogenesis of these fractures, and outline the available treatment modalities.

关键词： Hip fractures Bone screws Bone plates

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ACId-Functionalized Porphyrazines Exhibit ANTI-Tumor Behavior in Head and Neck Squamous Cell Carcinomas

ACID-Functionalized Porphyrazines Exhibit ANTI-Tumor Behavio...

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第四届中国肿瘤学术大会暨第五届海峡两岸肿瘤学术会议

作者： Benjamin J. Vesper Neal d. Hammer sangwan Lee Kim Elseth Anthony G. M. Barrett Brian M. Hoffman James A. Radosevich Center for Molecular Biology of Oral diseases College of dentistry University of Illinois at Chicago801 S.Paulina St.ChicagoIL60612USA Center for Molecular Biology of Oral diseases College of dentistry University of Illinois at Chicago801 S.Paulina St.ChicagoIL60612USA department of Chemistry Northwestern University 2145 N.Sheridan Rd.EvanstonIL60208USA Center for Molecular Biology of Oral diseases College of dentistry University of Illinois at Chicago801 S.Paulina St.ChicagoIL60612USA department of Chemistry Imperial College of Science Technology and MedicineExhibition RoadSouth KensingtonLondonSW7 2AZUK department of Chemistry Northwestern University 2145 N.Sheridan Rd.EvanstonIL60208USA Center for Molecular Biology of Oral diseases College of dentistry University of Illinois at Chicago801 S.Paulina St.ChicagoIL60612USA

＜正＞Background/Aims: The porphyrin drug Photofrin is used in photodynamic therapy applications to clinically treat oral and upper aerodigestive tract tumors;however, this drug is limited by its inadequate tumor selectivity and poor optical properties-common problems for members of the porphyrin family. We are currently studying a class of porphyrin derivatives, the porphyrazines （pzs）, which possess superior optical properties and greater synthetic flexibility than the porphyrins and show promise as both PdT agents and traditional anti - tumor agents. Previous work in our laboratory has shown that a subfamily of acid - functionalized pzs exhibit selective anti - tumor activity in A549 human lung adenocarcinoma cells. We here expand this study to test these same pzs in a number of head and neck squamous cell carcinoma （SCC） cell lines. Methods: MTT proliferation/viability assays were used to test the toxicity of three H2[pz（ An;B4-n） ] pzs, where n = 4, 3, or 2 （ in a trans conformation）, A is [S（CH2）3COOH], and B is a fused β,β’ - diisopropyloxybenzo ring. Five SCC cell lines were exposed to the pzs at concentrations of 12.5 - 50 μM, for periods of 24, 48, and 72 hours. Results: As the number of terminal acid groups on the pzs was increased, the amount of toxicity observed in the SCC cell lines upon 72 hour exposure also increased-a trend which was also observed previously in the A549 adenocarcinoma cell line. Additionally, at any given concentration, each compound was found to kill a greater percentage of tumor cells than normal cells. Normal cells were found to be unaffected by the H2A2B2 pz （four acid groups） at concentrations of 25 μM and below, whereas all five SCC cell lines exhibited toxicity in the presence of each of the three pzs at all concentrations studied （12.5 - 50 μM）. Conclusion: The acid - appended pzs were found to exhibit the same structure - function relationship in both adeno-carcinomas and squamous cell carcinomas. The selective tumor toxicity

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Simultaneous bilateral trochanteric fractures——a report of four cases

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中华创伤杂志(英文版) 2012年第6期15卷 360-363页

作者： Vinit Verma Zile Singh Kundu Amit Batra Raj Singh Sukhbir Singh sangwan Pratyush Gupta department of Orthopaedic Surgery Paraplegia & RehabilitationPt.B.D.Sharma PGIMS

Simultaneous bilateral intertrochanteric fractures are very *** is a paucity of data in current literature documenting patients with such kind of hip *** is severe and potentially life-threatening, associated with a high *** major determinants of successful outcome are high vigilance,early single stage stabilization and mobilization as well as management of associated comorbid conditions that may influence the long term rehabilitation of *** we reported 4 cases of concurrent bilateral trochanteric fractures along with review of the *** study aimed to discover its frequency, identify the injury mechanisms as well as factors present in the pathogenesis of these fractures,and outline the available treatment modalities.

关键词： Hip fractures Bone screws Bone plates

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