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Multitarget Thiol-Activated Tetrapyridyl Gold(Ⅲ)Complexes for Hypoxic Cancer Therapy

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CCS Chemistry 2024年第3期6卷 783-797页

作者： Xue-Quan Zhou Selda Abyar Imma Carbo-Bague Lan Wang Sebastian Türck Maxime ASiegler Uttara Basu Ingo ott Rongfang Liu Adriaan PIJzerman Sylvestre Bonnet Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate School(SIGS)Tsinghua UniversityShenzhen 518055 Leiden Institute of Chemistry Leiden University2333 CC Leiden department of Chemistry Simon Fraser UniversityBurnabyBritish Columbia V5A 1S6 Institute of Medicinal and Pharmaceutical Chemistry Technische Universität Braunschweig38106 Braunschweig department of Chemistry Johns Hopkins UniversityBaltimoreMaryland 21218 division of drug discovery&Safety Leiden Academic Centre for Drug ResearchLeiden University2333 CC Leiden

Gold complexes have emerged as promising anticancer metallodrugs due to their efficient thioredoxin reductase(TrxR)inhibition,which disturbs the redox balance of cancer ***,in this model,the role of the ligand(s)coordinated to gold is often *** this work,we present a series of tetrapyridyl Au(Ⅲ)complexes that exhibit thiol-induced release of a Au(Ⅰ)ion and a tetrapyridyl *** formation of a free Au(Ⅰ)center is responsible for the expected TrxR ***,the released ligand,which was visible in cells due to its intense blue fluorescence,showed excellent binding properties to the hERG potassium ***,these ligands ended up in the lysosomes,resulting in significant lysosome ***,the Au(Ⅲ)complexes presented in this work showed broad-spectrum anticancer properties,both in hypoxic 2d monolayers and 3d tumor *** suggest that the interaction of the released Au(Ⅰ)center and the tetrapyridyl ligand with two different protein targets may combine into prodrugs that overcome hypoxia-induced drug deactivation.

关键词： anticancer Au(Ⅲ)complexes enzyme inhibtion potassium channel affinity lysosome damage cell imaging prodrug

A Comparative Study of the Local Heat Transfer distributions Around Various Surface Mounted Obstacles

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Journal of Thermal Science 2014年第2期23卷 169-176页

作者： Robert Wyssmann dirk Ullmer Alexandros Terzis Peter ott Group of Thermal Turbomachinery(GTT) cole Polytechnique Fédérale de Lausanne (EPFL)SCI-STI-POCH-1015LausanneSwitzerland

In many engineering applications,heat transfer enhancement techniques are of vital importance in order to ensure reliable thermal designs of convective heat transfer *** study examines experimentally the heat transfer characteristics on the base plate around various surface mounted *** convection coefficients are evaluated in the vicinity of each individual protruding body with great spatial resolution using the transient liquid crystal *** different obstacles of constant height-to-hydraulic diameter ratio(~1.3) are *** include:a cylinder,a square,a triangle,a diamond and a vortex generator of delta wing shape *** experiments were carried out over a range of freestream Reynolds numbers,based on the hydraulic diameter of each obstacle,varying from 4,000 to 13,*** results indicate a negligible effect of the flow speed on the heat transfer topological structure and a considerable effect of the obstacle geometry on the level and distribution of heat transfer enhancement.

关键词： surface obstacles heat transfer enhancement transient liquid crystal technique

Eccentric error and compensation in rotationally symmetric laser triangulation

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仪器仪表学报 2007年第9期28卷 1548-1553页

作者： Wang Lei Gao Jun Wang Xiaojia Johannes Eckstein Peter ott Lab of Image Information Processing School of Computer and Information Hefei University of Technology Hefei 230009 China Optical Engineering Lab. Heilbronn University Heilbronn D-74081 Germany dep. of Mechanical and Electrical Engineering Xiamen University Xiamen 361005 China

Rotationally symmetric triangulation(RST)sensor has more flexibility and less uncertainty limits because of the abaxial rotationally symmetric optical *** if the incident laser is eccentric,the symmetry of the image will descend,and it will result in the eccentric error especially when some part of the imaged ring is *** model of rotationally symmetric triangulation that meets the Schimpflug condition is presented in this *** error from eccentric incident laser is *** is pointed out that the eccentric error is composed of two parts,one is a cosine in circumference and proportional to the eccentric departure factor,and the other is a much smaller quadric factor of the *** the ring is complete,the first error factor is zero because it is integrated in whole ring, but if some part of the ring is blocked,the first factor will be the main *** verifies the result of the a- *** last,a compensation method to the error when some part of the ring is lost is presented based on neural *** results of experiment show that the compensation will make the absolute maximum error descend to half,and the standard deviation of error descends to 1/3.

关键词：补偿作用旋转对称激光三角测量法偏心因子视力测量神经网络

Feasibility of Using Wood Chips to Regulate Relative Humidity Inside a Building: A Numerical Study

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Journal of Renewable Materials 2019年第6期7卷 505-516页

作者： dimitri Bigot Cyril ott Stéphane Guichard Bruno Malet-damour University of La Réunion-40 avenue de Soweto-Terre Sainte-BP 373-97455 Saint-Pierre CedexLa RéunionFrance

The use of bio-based materials in buildings has become more and more significant last *** most of the cases,their health properties and natural provenance have made them a great solution to face global climate warming and the new policies to reduce building energy *** many thermal problems,biobased materials can allow to optimize the building thermal behavior according to its energy consumption and inside comfort *** it is when they are used as an insulation material in the ***,it is not the case in this *** fact,the bio-based matter is rather used as a desiccant wheel to control air conditioning inside the *** aim of this paper is to numerically verify if it is possible to use a bed of wood chips as a hygroscopic material(or a desiccant matter)in order to modify the relative humidity inside the building in Reunion Island and so improve thermal comfort.A simple model of heat and mass transfer between a bed of wood chips and building inside air has been set up and implemented into a validated building simulation code named *** simulations were set up for the four climate zones of the island regulations and a focus has been made on the low altitude one(with high,solar irradiation,temperature and relative humidity).Simulation results give the thermal behavior of the building particularly the temperature and relative humidity of inside air temperature,and temperature and moisture content of wood *** obtained results lead to determine if the wood chips bed is suitable for the reference building and to verify its technical feasibility(wood species,size of the bed,integration to the building,etc.).The results show that the use of a WCB help to decrease the building inside air temperature and water content up to 10°C less and 11.6 ***-1 *** are the ways to improve inside comfort ***,comfort analysis have shown the possibility to significantly increase building users’thermal comfort

关键词： Wood chips bed building inside comfort bio-based material desiccant relative humidity temperature building thermal modelling

A micromechanical model for efective conductivity in granular electrode structures

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Acta Mechanica Sinica 2013年第5期29卷 682-698页

作者： Julia ott Benjamin Vlker Yixiang Gan Robert M.Mc Meeking Marc Kamlah Institute of Applied Materials Karlsruhe Institute of Technology76131 Karlsruhe Germany department of Mechanical Engineering University of CaliforniaSanta BarbaraCA 93106 USA School of Civil Engineering The University of SydneyNSW 2006 Australia Materials department University of CaliforniaSanta BarbaraCA 93106 USA School of Engineering University of AberdeenKing’s CollegeAberdeenAB24 3UE Scotland UK INM-Leibniz Institute for New Materials Campus D22 66123 Saarbrücken Germany

Optimization of composition and microstructure is important to enhance performance of solid oxide fuel cells （SOFC） and lithium-ion batteries （LIB）. For this, the porous electrode structures of both SOFC and LIB are modeled as a binary mixture of electronic and ionic conducting particles to estimate effective transport properties. Particle packings of 10000 spherical, binary sized and randomly positioned particles are created numerically and densified considering the different manufacturing processes in SOFC and LIB： the sintering of SOFC electrodes is approximated geometrically, whereas the calendering process and volume change due to intercalation in LIB are modeled physically by a discrete el- ement approach. A combination of a tracking algorithm and a resistor network approach is developed to predict the con- nectivity and effective conductivity for the various densified structures. For SOFC, a systematic study of the influence of morphology on connectivity and conductivity is performed on a large number of assemblies with different compositions and particle size ratios between 1 and 10. In comparison to percolation theory, an enlarged percolation area is found, es- pecially for large size ratios. It is shown that in contrast to former studies the percolation threshold correlates to varying coordination numbers. The effective conductivity shows not only an increase with volume fraction as expected but also with size ratio. For LIB, a general increase of conductivity during the intercalation process was observed in correlation with increasing contact forces. The positive influence of cal- endering on the percolation threshold and the effective conductivity of carbon black is shown. The anisotropy caused by the calendering process does not influence the carbon black phase.

关键词： Granular electrode structures Effective conductivity - Percolation

Tunable d peak in gated graphene

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Nano Research 2014年第3期7卷 338-344页

作者： Anna ott Ivan A. Verzhbitskiy Joseph Clough Axel Eckmann Thanasis Georgiou Cinzia Casiraghi Physics departmen t Freie Universitat Berlin Berlin 14195 Germany School of Physics andAstronomy University of Manchester ManchesterM 13 9PL UK School of Chemistry University of Manchester Manchester M 13 9PL UK

We report the gate-modulated Raman spectrum of defective graphene. We show that the intensity of the d peak can be reversibly tuned by applying a gate voltage. This effect is attributed to chemical functionalization of the graphene crystal lattice, generated by an electrochemical reaction involving the water layer trapped at the interface between silicon and graphene.

关键词： graphene gating defects doping electrochemistry

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基于单幅灰度图像的快速三维重建方法研究

机械工程学报 2014年第2期50卷 42-47页

作者：高欣健张旭东高亚捷 ott Peter 合肥工业大学计算机与信息学院合肥230009 德国海尔布隆大学光学实验室

对含有阴影的物体表面快速三维重建问题,提出一种融合阴影恢复形状(Shape from shading,SFS)数据与旋转对称激光三角传感器数据的基于单幅灰度图像的快速智能测量方法。针对SFS方法重建过程中出现的二义性问题,利用旋转对称激光三角传... 详细信息

对含有阴影的物体表面快速三维重建问题,提出一种融合阴影恢复形状(Shape from shading,SFS)数据与旋转对称激光三角传感器数据的基于单幅灰度图像的快速智能测量方法。针对SFS方法重建过程中出现的二义性问题,利用旋转对称激光三角传感器的关键数据对其进行修正。同时针对旋转对称激光三角传感器对未知物体表面需要逐点测量,测量速度慢的问题,利用修正后的SFS重建结果对旋转对称激光三角传感器进行智能视觉引导,对含有阴影的物体表面梯度变化较大的点及特征点进行精确测量。在此基础上搭建集成SFS方法的激光三角传感器高精度移动测量平台系统。该系统根据物体表面梯度变化的特点自动选取阈值调节测量精度,从而快速、精确地完成对未知物体表面的三维重建。并通过试验验证了方法的可行性和有效性。

关键词：三维重建数据融合激光三角

用于旋转对称三角传感器的一种鲁棒的处理方法(英文)

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仪器仪表学报 2007年第2期28卷 203-211页

作者：王晓嘉高隽王磊张旭东 Eckstein Johannes ott Peter 合肥工业大学计算机与信息学院海尔布隆大学光学工程实验室海尔布隆d-74081.德国海尔布隆大学光学工程实验室

旋转对称三角传感器由于其光学系统的旋转对称性而比其他的传统激光三角传感器具有更好的柔性,将旋转对称三角传感器应用于工业领域,相应的处理方法的性能是至关重要的。为了使传感器在复杂物体表面情况下仍具有较好的性能,我们设计了... 详细信息

旋转对称三角传感器由于其光学系统的旋转对称性而比其他的传统激光三角传感器具有更好的柔性,将旋转对称三角传感器应用于工业领域,相应的处理方法的性能是至关重要的。为了使传感器在复杂物体表面情况下仍具有较好的性能,我们设计了一种用于旋转对称三角传感器的鲁棒的处理方法。首先,分析旋转对称三角传感器图像的特性,这些特性取决于被测物体的表面特性,而这些图像特性将有助于传感器图像的处理方法的设计。其次,用一种由粗到精检测方法实现对传感器图像的处理。提出在精检测中,一种结合了自适应平滑和峰值法的方法,以实现检测的鲁棒性。在实际传感器图像上的实验结果证明,这种处理方法对于来自复杂表面的传感器图像具有很好的鲁棒性,从而提高了传感器的柔性。

关键词：旋转对称三角传感器由粗到精检测 Hough变换自适应平滑

西班牙东南部东Betic科迪勒拉由扭动断裂作用形成的各种新第三纪晚期的沉积盆地

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国外油气勘探 1999年第6期11卷 677-691页

作者： C.Montenat Ph.ott d'Estevou 刘勇

在本文中我们着重评述了由与新第三纪晚期东Betic剪切带有关的扭断裂作用产生的、并有很好的文献记载的Trans-Alboran剪切带的沉积盆地类型。描述了这种扭动"走廊"的一般特征,其中包括继承性构造的作用。强调了各种盆地类型,正如同时存... 详细信息

在本文中我们着重评述了由与新第三纪晚期东Betic剪切带有关的扭断裂作用产生的、并有很好的文献记载的Trans-Alboran剪切带的沉积盆地类型。描述了这种扭动"走廊"的一般特征,其中包括继承性构造的作用。强调了各种盆地类型,正如同时存在挤压与伸展机制下形成的盆地那样。在东Betic剪切带,拉分盆地看来不是最普遍的盆地类型。相反,平行于主走滑断层展布的挤压"槽状向斜"(与走滑断层走向或运动方向无关)是更有代表性的构造。

关键词：扭断裂类型新第三纪沉积盆地西班牙