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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Human endogenous retrovirus type-W and multiple sclerosis–related smoldering neuroinflammation

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Neural Regeneration Research 2025年第3期20卷 813-814页

作者： Joel Gruchot Laura Reiche Andrew Chan Robert Hoepner Patrick küry department of Neurology Medical Faculty and University Hospital DüsseldorfHeinrich Heine University DüsseldorfDüsseldorfGermany department of Neurology InselspitalBern University Hospital and University of BernBernSwitzerland

Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human dNA.

关键词： endogenous inflammation Human

Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

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Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： krisztián Pajer Tamás Bellák Antal Nógrádi department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(khyeam et al.,2021).

关键词： injured capacity modified

Promising drug targets and associated therapeutic interventions in Parkinson's disease

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Neural Regeneration Research 2021年第9期16卷 1730-1739页

作者： Sachchida Nand Rai Payal Singh Ritu Varshney Vivek k.chaturvedi Emanuel Vamanu M.P.Singh Brijesh kumar Singh Centre of Biotechnology University of AllahabadPrayagrajIndia department of Zoology Institute of ScienceBanaras Hindu UniversityVaranasiIndia department of Bioengineering and Chemistry Indian Institute of Technology GandhinagarPalajGujaratIndia Faculty of Biotechnology University of Agronomic Science and Veterinary MedicineBucharestRomania department of Pathology and Cell Biology Columbia University Medical CenterNew YorkNYUSA

Parkinson's disease(Pd) is one of the most debilitating brain diseases. despite the availability of symptomatic treatments, response towards the health of Pd patients remains scarce. To fulfil the medical needs of the Pd patients, an efficacious and etiological treatment is required. In this review, we have compiled the information covering limitations of current therapeutic options in Pd, novel drug targets for Pd, and finally, the role of some critical beneficial natural products to control the progression of Pd.

关键词： dopamine epigenetics gene therapies glutamate receptor levodopa molecular chaperones monoamine oxidase B mucuna alpha-synuclein Parkinson's disease striatum substantia nigra

3d biofabrication of vascular networks for tissue regeneration:A report on recent advances

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Journal of Pharmaceutical Analysis 2018年第5期8卷 277-296页

作者： M.d.Sarker Saman Naghieh N.k.Sharma Xiongbiao Chen division of Biomedical Engineering College of Engineering University of Saskatchewan department of Mechanical Engineering College of Engineering University of Saskatchewan

Rapid progress in tissue engineering research in past decades has opened up vast possibilities to tackle the challenges of generating tissues or organs that mimic native structures. The success of tissue engineered constructs largely depends on the incorporation of a stable vascular network that eventually anastomoses with the host vasculature to support the various biological functions of embedded cells. In recent years, significant progress has been achieved with respect to extrusion, laser, micro-molding, and electrospinning-based techniques that allow the fabrication of any geometry in a layer-by-layer fashion. Moreover, decellularized matrix, self-assembled structures, and cell sheets have been explored to replace the biopolymers needed for scaffold fabrication. While the techniques have evolved to create specific tissues or organs with outstanding geometric precision, formation of interconnected, functional, and perfused vascular networks remains a challenge. This article briefly reviews recent progress in 3d fabrication approaches used to fabricate vascular networks with incorporated cells, angiogenic factors, proteins, and/or peptides. The influence of the fabricated network on blood vessel formation, and the various features, merits, and shortcomings of the various fabrication techniques are discussed and summarized.

关键词： 3d bioprinting Tissue engineering Vascularization Extrusion Laser-based printing Co-axial printing

Short-Term Load Forecasting Using Soft Computing Techniques

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International Journal of Communications, Network and System Sciences 2010年第3期3卷 273-279页

作者： d. k. chaturvedi Sinha Anand Premdayal Ashish Chandiok 不详

Electric load forecasting is essential for developing a power supply strategy to improve the reliability of the ac power line data network and provide optimal load scheduling for developing countries where the demand is increased with high growth rate. In this paper, a short-term load forecasting realized by a generalized neuron–wavelet method is proposed. The proposed method consists of wavelet transform and soft computing technique. The wavelet transform splits up load time series into coarse and detail components to be the features for soft computing techniques using Generalized Neurons Network (GNN). The soft computing techniques forecast each component separately. The modified GNN performs better than the traditional GNN. At the end all forecasted components is summed up to produce final forecasting load.

关键词： Wavelet Transform Short Term Load Forecasting Soft Computing Techniques

Self-assembled vertically aligned gold nanorod super-lattices for ultra-high sensitive detection of molecules

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Nano Research 2015年第3期8卷 907-919页

作者： Amey Apte Prashant Bhaskar Raja das Smita chaturvedi PankajPoddar Sulabha kulkarni Indian Institute of Science Education and Research (IISER) Homi Bhabha Road Pashan Pune - 411008 India Physical and Materials Chemistry division CSIR-National Chemical Laboratory Pashan Pune - 411008 India Academy of Scientific and Innovative Research (AcSIR) Anusandhan Bhavan 2 Raft Marg New Delhi - 10000 I India

We show that self-assembled vertically aligned gold nanorod （VA-GNRs） superlattices can serve as probes or substrates for ultra-high sensitive detection of various molecules. d-glucose and 2,4,6-trinitrotoluene （TNT） have been chosen as model systems due to their very low Raman cross-sections （5.6× 10-30 ***-1 for d-glucose and 4.9 × 10-31 ***-1 for TNT） to show that the VA-GNR superlattice assembly offers as low as yoctomole sensitivity. Our experiment on mixed samples of bovine serum albumin （BSA） and d-glucose solutions demonstrate sensitivity for the latter, and the possible extension to real samples. Self-assembled superlattices of VA-GNRs were achieved on a silicon wafer by depositing a drop of solvent containing the GNRs and subsequent solvent evaporation in ambient conditions. An additional advantage of the VA-GNR monolayers is their extremely high reproducible morphology accompanied by ultrahigh sensitivity which will be useful in many fields where a very small amount of analyte is available. Moreover the assembly can be reused a number of times after removing the already present molecules. The method of obtaining VA-GNRs is simple, inexpensive and reproducible. With the help of simulations of monolayers and multilayers it has been shown that superlattices can achieve better sensitivity than monolaver assembly of VA-GNRs.

关键词： nanostructures self-assemblies superlattices Raman spectroscopy sensors

Inverse Optimal Control of Evolution Systems and Its Application to Extensible and Shearable Slender Beams

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IEEE/CAA Journal of Automatica Sinica 2019年第2期6卷 395-409页

作者： k.d.do A.d.Lucey the department of Mechanical Engineering Curtin University

An optimal(practical) stabilization problem is formulated in an inverse approach and solved for nonlinear evolution systems in Hilbert spaces. The optimal control design ensures global well-posedness and global practical k∞-exponential stability of the closed-loop system, minimizes a cost functional,which appropriately penalizes both state and control in the sense that it is positive definite(and radially unbounded) in the state and control, without having to solve a Hamilton-Jacobi-Belman equation(HJBE). The Lyapunov functional used in the control design explicitly solves a family of HJBEs. The results are applied to design inverse optimal boundary stabilization control laws for extensible and shearable slender beams governed by fully nonlinear partial differential equations.

关键词： Boundary control evolution system Hilbert space inverse optimal control slender beams

Fabrication of 3d-printed molds for polydimethylsiloxane-based microfluidic devices using a liquid crystal display-based vat photopolymerization process:printing quality,drug response and 3d invasion cell culture assays

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Microsystems & Nanoengineering 2023年第6期9卷 205-219页

作者： Matthew d.Poskus Tuo Wang Yuxuan deng Sydney Borcherding Jake Atkinson Ioannis k.Zervantonakis department of Bioengineering UPMC Hillman Cancer CenterUniversity of PittsburghPittsburghPAUSA McGowan Institute of Regenerative Medicine PittsburghPAUSA

Microfluidic platforms enable more precise control of biological stimuli and environment dimensionality than conventional macroscale cell-based assays;however,long fabrication times and high-cost specialized equipment limit the widespread adoption of microfluidic *** improvements in vat photopolymerization three-dimensional(3d)printing technologies such as liquid crystal display(LCd)printing offer rapid prototyping and a cost-effective solution to microfluidic *** information is available about how 3d printing parameters and resin cytocompatibility impact the performance of 3d-printed molds for the fabrication of polydimethylsiloxane(PdMS)-based microfluidic platforms for cellular *** a low-cost,commercially available LCd-based 3d printer,we assessed the cytocompatibility of several resins,optimized fabrication parameters,and characterized the minimum feature *** evaluated the response to both cytotoxic chemotherapy and targeted kinase therapies in microfluidic devices fabricated using our 3d-printed molds and demonstrated the establishment of flow-based concentration ***,we monitored real-time cancer cell and fibroblast migration in a 3d matrix environment that was dependent on environmental *** results demonstrate how vat photopolymerization LCd-based fabrication can accelerate the prototyping of microfluidic platforms with increased accessibility and resolution for PdMS-based cell culture assays.

关键词： invasion printing culture