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Epidural electrical stimulation for spinal cord injury

Neural Regeneration Research 2021年第12期16卷 2367-2375页

作者： Elliot H.Choi Sandra Gattas Nolan j.Brown john d.Hong joshua N.Limbo Alvin Y.Chan Michael Y.Oh department of Pharmacology School of MedicineCase Western Reserve UniversityClevelandOHUSA department of Ophthalmology Gavin Herbert Eye InstituteSchool of MedicineUniversity of CaliforniaIrvineCAUSA department of Neurosurgery University of CaliforniaIrvineCAUSA

A long-standing goal of spinal cord injury research is to develop effective repair strategies,which can restore motor and sensory functions to near-normal *** advances in clinical management of spinal cord injury have significantly improved the prognosis,survival rate and quality of life in patients with spinal cord *** addition,a significant progress in basic science research has unraveled the underlying cellular and molecular events of spinal cord *** efforts enabled the development of pharmacologic agents,biomaterials and stem-cell based *** these efforts,there is still no standard care to regenerate axons or restore function of silent axons in the injured spinal *** challenges led to an increased focus on another therapeutic approach,namely *** multiple animal models of spinal cord injury,epidural electrical stimulation of the spinal cord has demonstrated a recovery of motor *** evidence regarding the efficacy of epidural electrical stimulation has further expanded the potential of epidural electrical stimulation for treating patients with spinal cord ***,most clinical studies were conducted on a very small number of patients with a wide range of spinal cord ***,subsequent studies are essential to evaluate the therapeutic potential of epidural electrical stimulation for spinal cord injury and to optimize stimulation ***,we discuss cellular and molecular events that continue to damage the injured spinal cord and impede neurological recovery following spinal cord *** also discuss and summarize the animal and human studies that evaluated epidural electrical stimulation in spinal cord injury.

关键词： central nervous system chondroitin sulfate proteoglycans epidural electrical stimulation glial scar gliosis neural activity neuromodulation oligodendrocyte spinal cord injury

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Optimal Supplement dosage of double-Low Rapeseed Meal in Concentrated Feed of Fattening Lambs

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Animal Husbandry and Feed Science 2010年第10期2卷 7-10页

作者： WANG Zhi-you hou Sheng-zhen WANG Xing-fu Agriculture and Animal Husbandry College Qinghai University Xining 810016 China

[ Objective] To determine the optimal supplement dosage of double-low rapeseed meal in concentrated feed of fattening lambs. [ Method] A total of 120 Tibetan lambs at the age of 50 d were selected and divided randomly into four groups. The lambs in these four groups were fed with diets respectively supplemented the double-low rapeseed meal of 50,100,150 and 200 g/kg. Their diets had the same nutritional levels of energy and protein. The experimental period was 120 d. [ Result] daily gain, feed conservation ratio and economic benefits were largely increased in the lambs fed with the diets supplemented the double-low rapeseed meal of 150 g/kg （daily gain, P 〈 0.01 ）. However, the daily gain and feed conservation ratio were largely decreased in the lambs fed with the diets supplemented the double-low rapeseed meal of 200 g/kg. Moreover, serum levels of transaminase and thyroxine were not significantly different between the four groups. [ Conclusion] The optimal supplement dosage of the double-low rapeseed meal is 150 g/kg in fattening lambs.

关键词： Lamb double-low rapeseed daily gain Feed conservation ratio

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Estimating ancestral distributions of lineages with uncertain sister groups:a statistical approach to dispersal-Vicariance Analysis and a case using Aesculus L.(Sapindaceae) including fossils

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journal of Systematics and Evolution 2009年第5期47卷 349-368页

作者： A.j.HARRIS North Carolina State University Department of Plant Biology

We propose a simple statistical approach for using dispersal-Vicariance Analysis(dIVA) software to infer biogeographic histories without fully bifurcating *** this approach,ancestral ranges are first optimized for a sample of Bayesian *** probability P of an ancestral range r at a node is then calculated as P(rY) = n t=1 F(rY)t Pt where Y is a node,and F(rY) is the frequency of range r among all the optimal solutions resulting from dIVA optimization at node Y,t is one of n topologies optimized,and Pt is the probability of topology *** Y is a hypothesized ancestor shared by a specific crown lineage and the sister of that lineage "x",where x may vary due to phylogenetic uncertainty(polytomies and nodes with posterior probability d,the ancestral distribution at Y can be estimated to provide inference of the geographic origins of the specific crown group of *** approach takes into account phylogenetic uncertainty as well as uncertainty from dIVA *** is an extension of the previously described method called Bayes-dIVA,which pairs Bayesian phylogenetic analysis with biogeographic analysis using ***,we show that the probability P of an ancestral range at Y calculated using this method does not equate to pp*F(rY) on the Bayesian consensus tree when both variables are d F(rY) is the frequency of range r for the node containing the specific crown *** tested our dIVA-Bayes approach using Aesculus L.,which has major lineages unresolved as a *** inferred the most probable geographic origins of the five traditional sections of Aesculus and of Aesculus californica *** examined range subdivisions at parental nodes of these ***,we used the dIVA-Bayes data from Aesculus to quantify the effects on biogeographic inference of including two wildcard fossil taxa in phylogenetic *** analysis resolved the geographic ranges of the pare

关键词： Aesculus biogeography dIVA fossil wildcards MrBayes phylogenetic uncertainty.

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3d kinematicmandiblemodel to designmandibular advancement devices for the treatment of obstructive sleep apnea

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Bio-design and Manufacturing 2021年第1期4卷 22-32页

作者： M.García j.A.Cabrera A.Bataller S.Postigo j.j.Castillo department of Mechanical Engineering University of MálagaC/Doctor Ortiz Ramos s/nAmpliación Campus Teatinos29071 MálagaSpain

Mandibular advancement devices(MAds)are one of the treatments used for Obstructive sleep apnea(OSA).MAds try to maintain the mandible in an advanced position to keep the upper airways open when *** achieve this goal,most current MAds limit the mouth opening to a few *** study of the kinematic behaviour of the patient’s jaw is essential in order to design devices that allow greater aperture *** this purpose,a 3d multibody model that reproduces jaw movement has been developed in this *** this end,the movement of the lower incisor has been determined by means of a vision system and reflective *** addition,the kinematics of the temporomandibular joint has been ***,the device is designed and printed using a cam-follower *** way,the cam profiles and the followers are optimally designed and positioned for each patient depending on the physiognomy of the jaw and the opening and advancing movement prescribed by the specialist.

关键词： Mandibular advancement device 3d mandible kinematics Cam-follower mechanism 3d printed devices

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基于全局上下文注意力的点云语义分割

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现代电子技术 2023年第9期46卷 120-125页

作者：侯伟鹏王蕾东华理工大学信息工程学院江西南昌330013

点云语义分割是三维环境感知的基础,直接基于点的语义分割方法避免了因点云结构化处理所造成的信息损失,但大多数深度学习模型的研究主要集中在提取局部几何特征,没有考虑点云不同局部结构之间的上下文关系,并且忽略了低级与高级特征之... 详细信息

点云语义分割是三维环境感知的基础,直接基于点的语义分割方法避免了因点云结构化处理所造成的信息损失,但大多数深度学习模型的研究主要集中在提取局部几何特征,没有考虑点云不同局部结构之间的上下文关系,并且忽略了低级与高级特征之间的语义差距,限制了特征表示的能力,影响了点云语义分割的精度。因此,文中提出一种基于全局上下文注意力的点云语义分割方法,该方法主要由基于外部注意力的全局上下文特征聚合和基于后向竞争性注意力的邻近尺度特征融合两部分组成。通过外部注意力学习不同局部结构之间的长距离依赖关系,从而获得丰富的全局上下文信息。为了进一步增强模型的上下文感知能力,设计基于后向竞争性注意力的邻近尺度特征融合模块,学习低级与高级语义特征之间的相似度,重新为中间特征通道分配权重。在S3dIS大规模室内点云数据集上对所提方法进行评估,结果表明,所提方法的平均交并比在Area5上达到了65.2%,相比于RandLA-Net提高了2.5%,在6折交叉验证上的平均交并比达到了71.4%,相比于RandLA-Net提高了1.4%。证明了所提方法能够有效提取全局上下文特征,提高了语义分割的精度。

关键词：点云语义分割全局上下文特征邻近尺度外部注意力后向竞争性注意力平均交并比

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dietary N-carbamylglutamate or L-arginine improves fetal intestinal amino acid profiles during intrauterine growth restriction in undernourished ewes

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Animal Nutrition 2022年第1期8卷 341-349页

作者： Hao Zhang Xiaoyun Liu Yi Zheng Ying Zhang juan j.Loor Hongrong Wang Mengzhi Wang State Key Laboratory of Sheep Genetic Improvement and Healthy Production Xinjiang Academy of Agricultural and Reclamation ScienceShihezi 832000China Laboratory of Metabolic Manipulation of Herbivorous Animal Nutrition College of Animal Science and TechnologyYangzhou UniversityYangzhou 225009China joint International Research Laboratory of Agriculture and Agri-Product Safety The Ministry of Education of ChinaYangzhou UniversityYangzhou 225009China department of Animal Sciences and division of Nutritional Sciences University of IllinoisUrbanaIL 61801USA

Our previous studies demonstrated that prenatal in utero growth restriction impairs postnatal intestinal ***,improving postpartal intestinal absorption capacity and growth by manipulating the maternal diet prepartum is of *** work was conducted to determine whether supplementation of N-carbamylglutamate(NCG)or rumen-protected L-arginine(RP-Arg)increased fetal intestinal amino acid(AA)profiles in intrauterine growth retardation(IUGR)*** d 35 of gestation,Hu ewes(n=32)carrying twin fetuses were randomized into 4 groups(8 ewes and 16 fetuses in each group),where diets were as follows:100%of nutrient requirements recommended by National Research Council(NRC,2007)(CON);50%of nutrient requirements recommended by NRC(2007)(RES);RES+RPArg(20 g/d),(RES+ARG);and RES+NCG(5 g/d),(RES+NCG).On d 110 of gestation,both fetal and maternal tissues were collected and *** with RES,solute carrier family 1,member 5(SLC1A5)was upregulated(Pjejunum,duodenum and ileum when supplementing NCG and *** to RES,RP-Arg or NCG supplementation to RES resulted in upregulation(Pde transporter 1 protein abundance within the fetal *** or RP-Arg supplementation to RES also upregulated phosphorylated mechanistic target of rapamycin(pmTOR)-to-mTOR ratio in the fetal ileum induced by IUGR(Pduring IUGR,supplementation of Arg or NCG affected intestinal AA profiles in the fetus in part through controlling mTOR signal transduction as well as AA and peptide *** studies should be conducted to understand the role(if any)of the placenta on the improvement of growth and AA profiles independent of the fetal *** would help demonstrate the relative contribution of intestinal uptake in fetal life.

关键词： Intrauterine growth restriction L-arginine Fetal sheep N-carbamylglutamate Intestinal amino acids

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基于证据理论的小波萎缩图像去噪

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光学技术 2005年第5期31卷 713-716页

作者：杨海峰侯朝桢北京理工大学信息科学技术学院自动控制系北京100081

提出了一种基于d-S证据理论的小波萎缩图像去噪方法。对含噪图像进行离散平稳小波变换后,运用Bayes方法分得各层高频子带的小波萎缩系数,根据小波萎缩系数的空间及层间相关性,利用d-S证据理论的合成法则对初始小波萎缩系数进行融合修正... 详细信息

提出了一种基于d-S证据理论的小波萎缩图像去噪方法。对含噪图像进行离散平稳小波变换后,运用Bayes方法分得各层高频子带的小波萎缩系数,根据小波萎缩系数的空间及层间相关性,利用d-S证据理论的合成法则对初始小波萎缩系数进行融合修正。实验结果表明,该方法在有效地去除图像中的噪声的同时,还能较好地保留图像的边缘信息。算法在性能指标和视觉质量上均优于donoho的小波软阈值去噪方法、传统的中值滤波法和Winner滤波法。

关键词： d-S证据理论图像去噪平稳小波变换

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Measurements of d^0-~0 mixing and searches for CP violation:HFAG combination of all data

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Chinese Physics C 2008年第6期32卷 477-482页

作者： A.j.Schwartz Physics department University of CincinnatiCincinnatiOhio 45221USA

We present world average values for d^0-d^0 mixing parameters x and y, CP violation parameters ｜q/P｜ and Arg（q/p）, and strong phase differences δ and δKππ. These values are calculated by the Heavy Flavor Averaging Group （HFAG） by performing a global fit to relevant experimental measurements. The results for x and y differ significantly from zero and are inconsistent with no mixing at the level of 6.7a. The results for ｜q/P｜ and Arg（q/p） are consistent with no CP violation. The strong phase difference δ is less than 45° at 95% C.L.

关键词： mixing CP violation

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古建筑性能化防火设计中火灾场景的设置

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重庆大学学报（自然科学版） 2009年第9期32卷 1093-1097页

作者：王厚华刘希臣重庆大学城市建设与环境工程学院重庆400030

针对中国目前尚无古建筑的防火规范,提出了古建筑火灾场景设置中应注意的问题,特别是火灾蔓延问题。结合某古建筑的性能化设计,探讨了场景设置的原则和步骤,提出了火灾场景设计的完整步骤应包括:起火点位置的设定、热释放速率的确定和... 详细信息

针对中国目前尚无古建筑的防火规范,提出了古建筑火灾场景设置中应注意的问题,特别是火灾蔓延问题。结合某古建筑的性能化设计,探讨了场景设置的原则和步骤,提出了火灾场景设计的完整步骤应包括:起火点位置的设定、热释放速率的确定和火灾蔓延特性分析。并着重分析了火灾的蔓延性,提出了古建筑火灾蔓延的2种途径。

关键词：古建筑火灾性能化防火火灾场景热释放速率火焰蔓延

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Methicillin-resistant Staphylococcus aureus in acute otitis externa

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World journal of Otorhinolaryngology-Head and Neck Surgery 2018年第4期4卷 246-252页

作者： Maria j.duarte Elliott d.Kozin Paulo j.M.Bispo Andreas H.Mitchell Michael S.Gilmore Aaron K.Remenschneider department of Otology and Laryngology Harvard Medical SchoolBostonMAUSA department of Otolaryngology Massachusetts Eye and Ear InfirmaryBostonMAUSA department of Ophthalmology Harvard Medical SchoolMassachusetts Eye and Ear InfirmaryBostonMAUSA department of Microbiology Harvard Medical SchoolMassachusetts Eye and Ear InfirmaryBostonMAUSA department of Immunobiology Harvard Medical SchoolMassachusetts Eye and Ear InfirmaryBostonMAUSA University of Massachusetts Medical School WorcesterMAUSA

Objective:Otologic methicillin-resistant Staphylococcus aureus(MRSA)infection has historically been rare,but given the rise in community-acquired MRSA carriage and infection at other body sites,prevalence rates may be *** goal of this study was to determine the prevalence of MRSA in recent otologic cultures from patients with acute otitis externa(AOE).Study design:Retrospective review of an institutional microbiologic ***:A retrospective analysis was performedon serial culture isolates taken fromthe ear at a quaternary care hospital from january 2014 to April *** causative pathogen and antibiotic sensitivity was determined by culture isolation and end point mean inhibitory concentration(MIC)*** records were reviewed to document patient characteristics,chronicity of infection,symptomatology,and previous ***:Over the study period,173 patients were diagnosed with AOE and underwent otologic cultures of the ***-three(30.6%)of cultures grew ***(SA).Of SA infections,15(28.3%)were identified as *** patients were typically older than patients with methicillin-sensitive SA(MSSA)(mean age 46.717.9 vs 2919.4,PZ0.003)and had more medical comorbidities(4 vs 1.7,PZ0.001).Compared to patients with MSSA,patients with MRSAwere significantly more likely to have had prior ototopical antibiotic exposure(37%vs 73%,PZ0.019).Conclusion:Contemporary ear culture isolates at quaternary care center show higher rates of MRSA compared to historical reports in the *** should consider ear cultures to identify MRSA *** of Evidence:IV.

关键词： Acute otitis externa Staphylococcus aureus Methicillin-resistant Staphylococcus aureus,MRSA

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