Methicillin-resistant Staphylococcus aureus in acute otitis externa

作     者：Maria J.Duarte Elliott D.Kozin Paulo J.M.Bispo Andreas H.Mitchell Michael S.Gilmore Aaron K.Remenschneider Duarte Maria J.;Kozin Elliott D.;Bispo Paulo J.M.;Mitchell Andreas H.;Gilmore Michael S.;Remenschneider Aaron K.

作者机构：Department of Otology and LaryngologyHarvard Medical SchoolBostonMAUSA Department of OtolaryngologyMassachusetts Eye and Ear InfirmaryBostonMAUSA Department of OphthalmologyHarvard Medical SchoolMassachusetts Eye and Ear InfirmaryBostonMAUSA Department of MicrobiologyHarvard Medical SchoolMassachusetts Eye and Ear InfirmaryBostonMAUSA Department of ImmunobiologyHarvard Medical SchoolMassachusetts Eye and Ear InfirmaryBostonMAUSA University of Massachusetts Medical SchoolWorcesterMAUSA 

出 版 物：《World Journal of Otorhinolaryngology-Head and Neck Surgery》 (世界耳鼻咽喉头颈外科杂志（英文）)

年 卷 期：2018年第4卷第4期

页      面：246-252页

学科分类：100208[医学-临床检验诊断学] 1002[医学-临床医学] 10[医学] 

主　　题：Acute otitis externa Staphylococcus aureus Methicillin-resistant Staphylococcus aureus,MRSA 

摘      要：Objective:Otologic methicillin-resistant Staphylococcus aureus(MRSA)infection has historically been rare,but given the rise in community-acquired MRSA carriage and infection at other body sites,prevalence rates may be *** goal of this study was to determine the prevalence of MRSA in recent otologic cultures from patients with acute otitis externa(AOE).Study design:Retrospective review of an institutional microbiologic ***:A retrospective analysis was performedon serial culture isolates taken fromthe ear at a quaternary care hospital from January 2014 to April *** causative pathogen and antibiotic sensitivity was determined by culture isolation and end point mean inhibitory concentration(MIC)*** records were reviewed to document patient characteristics,chronicity of infection,symptomatology,and previous ***:Over the study period,173 patients were diagnosed with AOE and underwent otologic cultures of the ***-three(30.6%)of cultures grew ***(SA).Of SA infections,15(28.3%)were identified as *** patients were typically older than patients with methicillin-sensitive SA(MSSA)(mean age 46.7
17.9 vs 29
19.4,PZ0.003)and had more medical comorbidities(4 vs 1.7,PZ0.001).Compared to patients with MSSA,patients with MRSAwere significantly more likely to have had prior ototopical antibiotic exposure(37%vs 73%,PZ0.019).Conclusion:Contemporary ear culture isolates at quaternary care center show higher rates of MRSA compared to historical reports in the *** should consider ear cultures to identify MRSA *** of Evidence:IV.