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Shielding AZ91d-1%Ca from corrosion through ultrasound melt treatment:A study for stent design

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Journal of Magnesium and Alloys 2023年第8期11卷 2901-2915页

作者： I.V.Gomes M.Pacheco M.Nienaber S.C.Neves d.Mei A.barros R.L.Reis J.L.Alves H.Puga CMEMS–UMinho University of MinhoGuimarãesPortugal LABBELS–Associate Laboratory BragaGuimarãesPortugal B's Research Group-Research Institute on Biomaterials Biodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAvepark-Parque de Ciência e TecnologiaBarco GuimarãesPortugal ICVS/3B's-PT Government Associate Laboratory BragaGuimarãesPortugal Institute of Material and Process design Helmholtz-Zentrum HereonGeesthacht 21502Germany School of Materials Science and Engineering&Henan Key Laboratory of Advanced Magnesium Alloy Zhengzhou UniversityZhengzhou 450001China

Magnesium-based materials show great potential for producing biodegradable stents,but their high corrosion rates are a *** study investigates whether ultrasound melt treatment can change the corrosion response of an extruded AZ91d-1.0%Ca(wt.%)in Earle's Balanced Salt Solution by tailoring the intermetallics'morphology in the as-extruded *** results showed that the wires from ultrasound-treated ingots corroded faster than non-treated ones in immersion for up to 6 *** trend shifted for longer periods,and ultrasound-treated material showed lower corrosion rates and uniform corrosion,while the non-treated material displayed localized corrosion *** testing of the wires demonstrated that immersion in EBSS lowered the tensile strength and elongation at fracture due to material degradation,regardless of the processing ***,this decline was sharper in the non-treated *** findings suggest that ultrasound melt processing can be a promising method for improving the corrosion resistance of magnesium-based materials,paving the way for their use in manufacturing biodegradable stents.

关键词： Magnesium Ultrasound treatment Stent Corrosion Mechanical properties

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Out of Sight, Out of Mind, Right? Not in COVId-19 Shock or Anaerobic and Exhaustive Shock versus Septic Shock dilemma That Means to Live or die. Emergency Attention and a Necessity of Trials

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Open Journal of Emergency Medicine 2022年第1期10卷 19-47页

作者： Luiz Gonzaga Francisco de Assis barros d’Elia Zanella Infectious diseases department (MI-HSPE) Hospital do Servidor Público do Estado de S&#227 o Paulo S&#227 o Paulo Brazil Phd Program in Allergy and Immunopathology School of Medicine University of S&#227 o Paulo S&#227 o Paulo Brazil Emergency and Urgency department University Hospital of University of S&#227 o Paulo Butant&#227 S&#227 o Paulo Brazil

Background: COVId-19 brought challenges that did not end after a two-year pandemic. From more straightforward changes in habits to studying to understand the enigmatic parasite-host relationship, we can better manage the patient infected with SARS-CoV-2 even with a vaccine full of doubts and antivirals that do not correctly cover the viral period. SARS-CoV-2 brought the chronic inflammation now called “The Long COVId-19 Syndrome” (LCS), something still little talked about, but we already see deaths due to non-identification of this inflammatory syndrome that can lead to shock. Theory: LCS Shock is due to a long period of metabolic stress, reflecting the shift from inflammation to oxidative stress and innate immunity, and does not respond to antimicrobials, as its main component is inflammatory, although there may be conjoined bacterial translocation. Thus, we are losing patients to a new syndrome confused with sepsis and septic shock. While septic shock (SS) responds to antimicrobials, Inflammatory Shock (ISc) does not respond to antimicrobials alone, requiring high doses of corticosteroids. Review: This study shows that we need to differentiate SS and ISC, as the treatment is different. The review shows that Lactate, LdH and the presence of new/recent cardiac changes and bradycardia in the face of a status where there should be tachycardia as the usual response can differ ISC from SS. Maybe the main responsible for high LdH is Warburg Effect. Conclusion: We have a dilemma that requires clinical studies that routinely match high doses of corticosteroids (until there is something better to be done) and bring laboratory and imaging differences to diagnose SS vs ISc better.

关键词： Acute Respiratory distress Syndrome Cardiovascular System Critical Care COVId-19 Lactate

Bone marrow-derived monocyte infusion improves hepatic fibrosis by decreasing osteopontin,TGF-β1,IL-13 and oxidative stress

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World Journal of Gastroenterology 2017年第28期23卷 5146-5157页

作者： Veruska Cintia Alexandrino de Souza Thiago Almeida Pereira Valéria Wanderley Teixeira Helotonio Carvalho Maria Carolina Accioly Brelaz de Castro Carolline Guimaraes d’assuncao Andreia Ferreira de barros Camila Lima Carvalho Virgínia Maria barros de Lorena Vláudia Maria Assis Costa Alvaro Aguiar Coelho Teixeira Regina Celia Bressan Queiroz Figueiredo Sheilla Andrade de Oliveira Centro de Pesquisas Aggeu Magalhaes Fundacao Oswaldo Cruz Immunopathogenesis Section Laboratory of Parasitic DiseasesNational Institute of Allergy and Infectious DiseaseNational Institutes of HealthBethesdaMDUSA and Laboratório de Doencas Parasitárias e infecciosasFaculdade de MedicinaUniversidade Federal de Minas Gerais departamento de Morfologia e Fisiologia Animal Universidade Federal Rural de Pernambuco departamento de Biofísica e Radiobiologia Universidade Federal de Pernambuco Centro Acadêmico de Vitória Universidade Federal de Pernambuco departamento de Medicina Tropical Universidade Federal de Pernambuco

To evaluate the therapeutic effects of bone marrow-derived Cd11b+Cd14+ monocytes in a murine model of chronic liver *** liver damage was induced in C57BL/6 mice by administration of carbon tetrachloride and ethanol for 6 mo. Bone marrow-derived monocytes isolated by immunomagnetic separation were used for therapy. The cell transplantation effects were evaluated by morphometry, biochemical assessment, immunohistochemistry and enzyme-linked immunosorbent ***11b+Cd14+ monocyte therapy significantly reduced liver fibrosis and increased hepatic glutathione levels. Levels of pro-inflammatory cytokines, including tumor necrosis factor-α, interleukin (IL)-6 and IL-1β, in addition to pro-fibrotic factors, such as IL-13, transforming growth factor-β1 and tissue inhibitor of metalloproteinase-1 also decreased, while IL-10 and matrix metalloproteinase-9 increased in the monocyte-treated group. Cd11b+Cd14+ monocyte transplantation caused significant changes in the hepatic expression of α-smooth muscle actin and *** therapy is capable of bringing about improvement of liver fibrosis by reducing oxidative stress and inflammation, as well as increasing anti-fibrogenic factors.

关键词： Monocytes Bone marrow mononuclear cells Cell therapy Macrophages Glutathione Liver fibrosis

Integration of high-rate filtration using waste-derived biochar as a potential sustainable technology for drinking water supply

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Biochar 2023年第1期5卷 1075-1097页

作者： Fernando García-Ávila Andrés Galarza-Guamán Mónica barros-Bermeo Emigdio Antonio Alfaro-Paredes Alex Avilés-Añazco Sergio lglesias-Abad Carrera de Ingeniería Ambiental Facultad de Ciencias QuímicasUniversidad de CuencaCuencaEcuador departamento de Química Aplicada y Sistemas de Producción Grupo de Evaluación de Riesgos Ambientales en Sistemas de Producción y Servicios(RISKEN)CuencaEcuador Professional School of Systems Engineering Research Institute of Science and TechnologyUniversidad César VallejoLimaPeru Carrera de Ingeniería Ambiental Universidad Católica de CuencaCuencaEcuador

This research aimed to evaluate the efficiency of eucalyptus(E)and bamboo(B)residual biomass biochars as filter materials for drinking water *** efficiencies of these two biochars in the rapid filtration process were evaluated using water(raw,flocculated and settled)at the rate of 120 m^(3)/m^(2)/*** that bamboo biochar manufactured under a slow pyrolysis process"b"(Bb)had the best ***,Bb was evaluated with three different granulometries,and it was found that the effective size with the best performance was the finest(0.6-1.18 mm).Subsequently,this biochar was compared with conventional filter materials such as gravel,sand and anthracite,using different types of water(raw,flocculated and settled)and at different filtration rates(120 and 240 m^(3)/m^(2)/d),and it was found that the filter material with the best performance was precisely biochar,with average removal efficiencies of 64.37%turbidity and 45.08%colour for raw water;93.9%turbidity and 90.75%colour for flocculated water,and 80.79%turbidity and 69.03%colour for settled *** efficiency using simple beds of sand,biochar,anthracite and gravel at the rate of 180 m^(3)/m^(2)/d was 75.9%copper,90.72%aluminium,95.7%iron,10.9%nitrates,94.3%total coliforms and 88.9%fecal *** efficiencies achieved by biochar were higher compared to those of conventional filter *** was also found that biochar contributes to improving the performance of sand and anthracite in mixed ***,it was possible to demonstrate that the volume of washing water required for the biochar is lower compared to the other filter ***,it is recommended to carry out more tests for the purification of water with biochars from rural areas affected by the mining and oil exploitation,as well as the purification of seawater with biochars from coastal areas with residues from dry forests and organic residues from municipalities.

关键词： Biochar Filter medium Rapid filtration Pyrolysis Eucalyptus Bamboo

Epigenetic regulation of TP53 is involved in prostate cancer radioresistance and dNA damage response signaling

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5404-5416页

作者： Catarina Macedo-Silva Vera Miranda-Gonçalves Nuno Tiago Tavares daniela barros-Silva Joana Lencart João Lobo Ângelo Oliveira Margareta PCorreia Lucia Altucci Carmen Jerónimo Cancer Biology&Epigenetics Group Research Center of IPO Porto(CI-IPOP)/CI-IPOP@RISE(Health Research Network)Portuguese Oncology Institute of Porto(IPO-Porto)/Porto Comprehensive Cancer Center Raquel Seruca(Porto.CCC)R.Dr.António Bernardino de Almeida4200-072PortoPortugal department of Precision Medicine University of Campania“Luigi Vanvitelli”80138NaplesItaly department of Pathology and Molecular Immunology ICBAS-School of Medicine&Biomedical SciencesUniversity of PortoR.Jorge de Viterbo Ferreira 2284050-313PortoPortugal Medical Physics Radiobiology and Radiation Protection Group-Research Center of IPO Porto(CI-IPOP)/CI-IPOP@RISE(Health Research Network)Portuguese Oncology Institute of Porto(IPO-Porto)/Porto Comprehensive Cancer Center Raquel Seruca(Porto.CCC)R.Dr.António Bernardino de Almeida4200-072PortoPortugal department of Medical Physics Portuguese Oncology Institute of Porto4200-072PortoPortugal department of Pathology Portuguese Oncology Institute of PortoPortoPortugal department of Radiation Oncology Portuguese Oncology Institute of PortoPortoPortugal BIOGEM Molecular Biology and Genetics Research Institute83100AvellinoItaly IEOS Institute of Endocrinology and Oncology80100NaplesItaly

External beam radiotherapy(RT)is a leading first-line therapy for prostate cancer(PCa),and,in recent years,significant advances have been ***,RT resistance can arise and result in long-term recurrence or disease progression in the worst-case ***,making crucial the discovery of new targets for PCa ***,we generated a radioresistant PCa cell line,and found p53 to be highly expressed in radioresistant PCa cells,as well as in PCa patients with recurrent/disease progression submitted to *** dissection revealed that RT could promote p53 expression via epigenetic ***,a decrease of H3K27me3 occupancy at TP53 gene promoter,due to increased KdM6B activity,was observed in radioresistant PCa ***,p53 is essential for efficient dNA damage signaling response and cell recovery upon stress induction by prolonged fractionated ***,KdM6B inhibition by GSK-J4 significantly decreased p53 expression,consequently attenuating the radioresistant phenotype of PCa cells and hampering in vivo 3d tumor ***,this work contributes to improve the understanding of p53 as a mediator of signaling transduction in dNA damage repair,as well as the impact of epigenetic targeting for PCa radiosensitization.

关键词： TP53 damage cancer

Understanding the corrosion of Mg alloys in in vitro urinary tract conditions: A step forward towards a biodegradable metallic ureteral stent

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Journal of Magnesium and Alloys 2023年第11期11卷 4301-4324页

作者： Margarida Pacheco Ivo M.Aroso Joana M.Silva Sviatlana V.Lamaka Jan Bohlen Maria Nienaber dietmar Letzig Estêvão Lima Alexandre A.barros Rui L.Reis 3B’s Research Group-Research Institute on Biomaterials Biodegradables and BiomimeticsUniversity of MinhoGuimarãesPortugal ICVS/3B’s-PT Government Associate Laboratory Braga/GuimarãesPortugal Institute of Surface Science Helmholtz-Zentrum hereon GmbHGermany Institute of Material and Process design Helmholtz-Zentrum hereon GmbHGermany School of Health Sciences Life and Health Sciences Research Institute(ICVS)University of MinhoBragaPortugal

Ureteral stents play a fundamental role in modern time urology. However, following the deployment, stent-related symptoms are frequent and affect patient health and quality of life. Using biodegradable metals as ureteral stent materials have emerged as a promising strategy, mainly due to the improved radial force and slower degradation rate expected. Therefore, this study aimed to characterize different biodegradable metals in urinary tract environment to understand their propensity for future utilization as base materials for ureteral stents. The corrosion of 5 Mg alloys - AZ31, Mg-1Zn, Mg-1Y, pure Mg, and Mg-4Ag - under simulated urinary tract conditions was accessed. The corrosion layer of the different alloys presented common elements, such as Mg(OH)_(2), MgO, and phosphate-containing products, but slight variations in their chemical compositions were detected. The corrosion rate of the different metals varied, which was expected given the differences in the corrosion layers. On top of this, the findings of this study highlighted the significant differences in the samples' corrosion and corrosion layers when in stagnant and flowing conditions. With the results of this study, we concluded that Mg-1Zn and Mg-4Ag presented a higher propensity for localized corrosion, probably due to a less protective corrosion layer;Mg-4Ag corroded faster than all the other four alloys,and Mg-1Y stood out due to its distinct corrosion pattern, that showed to be more homogeneous than all the other four samples, making this one more attractive for the future studies on biodegradable metals.

关键词： Biodegradable metals Magnesium alloys Localized corrosion Biodegradable metallic ureteral stent

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Sediment transport under the presence and absence of emergent vegetation in a natural alluvial channel from Brazil

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International Journal of Sediment Research 2016年第4期31卷 360-367页

作者： Yuri Jacques Agra Bezerra da Silva José Ramon barros Cantalice Vijay P.Singh Cinthia Maria Cordeiro Atanázio Cruz Wagner Luís da Silva Souza Soil Conservation Engineering Laboratory Rural Federal University of Pernambuco(UFRPE) Brazil department of Biological and Agricultural Engineering Texas A & M University College Station

Studies regarding the influence of emergent vegetation on sediment transport are scarce and have mainly focused on flume *** fill this gap and also meet the international need,we aimed to evaluate the influence of emergent vegetation(Echinodorus macrophyllus) on sediment transport of Capibaribe River,*** and suspended sediment measurements were carried out using the US BLH 84 and US dH 48 samplers,*** of stem diameter,stem spacing and plant density were performed in conjunction with flow and sediment field *** on our results,0.45 m swas the threshold of mean flow velocity supported by *** under field *** value can be helpful for other rivers with gravel-bed river to armoured layer ratio(AR=d)/d=12.50)-natural conditions observed in Capibaribe River-or where the vegetation can provide positive effects,such as increase the bed stability,assist water restoration/rehabilitation and decrease water *** results can hopefully be used in engineering practice and ecosystem *** general,both the drag coefficient and drag force varied inversely and directly with the mean flow velocity and vegetation density,*** vegetation resistance force was inversely proportional to the bedload transport owing to the resistance caused by emergent *** finding was supported by the clear decoupling between nonvegetated and emergent vegetated conditions indicated by cluster *** study results provided a reasonable understanding of the interaction between emergent vegetation,water flow and sediment transport in the Capibaribe River.

关键词： Vegetation drag force Vegetation drag coefficient Plant Reynolds number Hierarchical cluster analysis and principal component analysis

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中国碳排放影响因素研究

中国碳排放影响因素研究

作者： dIAS dE barros JORGE ALBERTO 北京交通大学

学位级别：硕士

经济发展、人口结构变化和城市人口增长导致了能源消耗的大幅增加和各种交通方式的密集使用。这些因素对环境产生了不利影响,碳排放的比例也越来越大。2006年中国超越美国成为碳排放第一大国,2010年中国超过日本成为世界第二经济大国。... 详细信息

经济发展、人口结构变化和城市人口增长导致了能源消耗的大幅增加和各种交通方式的密集使用。这些因素对环境产生了不利影响,碳排放的比例也越来越大。2006年中国超越美国成为碳排放第一大国,2010年中国超过日本成为世界第二经济大国。尽管中国人均二氧化碳排放量比美国的低。2013-2017年统计数据也显示中国环境政策高效控制排放强度,但是国际初步核算显示自2018年中国碳排放量重新增长,因此“中国绿色发展”面临着巨大压力。本文综合STIRPAT模型理论基础、岭回归以及可行广义最小二乘方法的框架,研究影响对中国碳排放的因素。本文首先利用1978-2018年度时间序列数据,以中国为研究对象,基于扩展的STIRPAT模型,应用岭回归分析中国碳排放影响因素;其次选取1995-2018年中国30个省(除西藏外)的面板数据,运用修正的碳排放因子对中国各省市的八类能源消费碳排放进行测算。在此基础上,对比了全国与东、中、西部三个区域的碳排放发展趋势;运用面板数据回归模型与STIRPAT模型相结合的方法,从地区的角度对中国碳排放的影响因素进行了分析。在不同时间段,碳排放影响因素的实证分析结果表明,人口规模、城镇化率、人口年龄结构、城镇居民家庭人均可支配收入、铁路营业里程以及铁路客运量对碳排放都有显著的不同影响。近年来,尤其铁路发展与客运使用对中国碳排放的有显著抑制作用。在不同地区,碳排放的影响因素具有一定差异性。根据实证结果,本文提出了控制中国省市的碳排放的结论与建议。

关键词：碳排放 STIRPAT模型岭回归面板数据回归模影响因素

Plasma phospholipid transfer protein （PLTP） modulates adaptive immune functions through alternation of T helper cell polarization

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Cellular & Molecular Immunology 2016年第6期13卷 795-804页

作者： Catherine desrumau Stephanie Lemaire-Ewing Nicolas Ogier Akadiri Yessoufou Arlette Hammann Anabelle Sequeira-Le Grand Valerie deckert Jean-Paul Pais de barros Naig Le Guern Julien Guy Naim A Khan Laurent Lagrost INSERM UMR866 - F21079 dijon France Univ. Bourgogne Franche-Comte F-21000 Dijon France LipSTIC LabEx Fondation de Cooperation Scientifique Bourgogne-Franche Comte F-21000 Dijon France CHU Hopital du Bocage Dijon France plateforme de Cytometrie en Flux Universite de Bourgogne Dijon France

Objective： Plasma phospholipid transfer protein （PLTP） is a key determinant of lipoprotein metabolism, and both animal and human studies converge to indicate that PLTP promotes atherogenesis and its thromboembolic complications. Moreover, it has recently been reported that PLTP modulates inflammation and immune responses. Although earlier studies from our group demonstrated that PLTP can modify macrophage activation, the implication of PLTP in the modulation of T-cell-mediated immune responses has never been investigated and was therefore addressed in the present study. Approach and results： In the present study, we demonstrated that PLTP deficiency in mice has a profound effect on Cd4＋ ThO cell polarization, with a shift towards the anti-inflammatory Th2 phenotype under both normal and pathological conditions. In a model of contact hypersensitivity, a significantly impaired response to skin sensitization with the hapten-2,4-dinitrofluorobenzene （dNFB） was observed in PLTP-deficient mice compared to wild-type （WT） mice. Interestingly, PLTP deficiency in mice exerted no effect on the counts of total white blood cells, lymphocytes, granulocytes, or monocytes in the peripheral blood. Moreover, PLTP deficiency did not modify the amounts of Cd4＋ and Cd8＋ T lymphocyte subsets. However, PLTP-deficiency, associated with upregulation of the Th2 phenotype, was accompanied by a significant decrease in the production of the pro-Thl cytokine interleukin 18 by accessory cells. Conclusions： For the first time, this work reports a physiological role for PLTP in the polarization of Cd4＋ T cells toward the pro-inflammatory Th I phenotype.

关键词： lipid transfer protein lymphocyte polarization T cell